February 2020

The wtf meiotic driver genes of Schizosaccharomyces pombe are selfish genes that destroy the products of meiosis (spores) that do not inherit them. This spore killing is only observed when wtf drivers are heterozygous and results in biased transmission of the wtf driver into the progeny. Each driver encodes two proteins, a poison and an antidote, that are used to selectively execute spores. Despite incredibly high divergence, wtf meiotic drivers show similarly high levels of meiotic drive. Thus, a wide breadth of sequences can be used to construct these selfish spore killers. See Bravo Núñez et al.

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Image Credit: Mark Miller

Review

Magnetic genes: Studying the genetics of biomineralization in magnetotactic bacteria

Hayley C. McCausland, Arash Komeili

PLOS Genetics: published February 13, 2020 | https://doi.org/10.1371/journal.pgen.1008499

Research Articles

Evolutionary dynamics of microRNA target sites across vertebrate evolution

Alfred Simkin, Rene Geissler, Alexa B. R. McIntyre, Andrew Grimson

PLOS Genetics: published February 3, 2020 | https://doi.org/10.1371/journal.pgen.1008285

Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1

Yuichi Shichino, Yoko Otsubo, Masayuki Yamamoto, Akira Yamashita

PLOS Genetics: published February 3, 2020 | https://doi.org/10.1371/journal.pgen.1008598

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs

Satesh Ramdhani, Elisa Navarro, Evan Udine, Anastasia G. Efthymiou, Brian M. Schilder, Madison Parks, Alison Goate, Towfique Raj

PLOS Genetics: published February 3, 2020 | https://doi.org/10.1371/journal.pgen.1008549

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer

Hu Fang, Jayne A. Barbour, Rebecca C. Poulos, Riku Katainen, Lauri A. Aaltonen, Jason W. H. Wong

PLOS Genetics: published February 3, 2020 | https://doi.org/10.1371/journal.pgen.1008572

Parallel and nonparallel genomic responses contribute to herbicide resistance in Ipomoea purpurea, a common agricultural weed

Megan Van Etten, Kristin M. Lee, Shu-Mei Chang, Regina S. Baucom

PLOS Genetics: published February 3, 2020 | https://doi.org/10.1371/journal.pgen.1008593

Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition

Esther A. Epum, Michael J. Mohan, Nicholas P. Ruppe, Katherine L. Friedman

PLOS Genetics: published February 3, 2020 | https://doi.org/10.1371/journal.pgen.1008608

PRH1 mediates ARF7-LBD dependent auxin signaling to regulate lateral root development in Arabidopsis thaliana

Feng Zhang, Wenqing Tao, Ruiqi Sun, Junxia Wang, Cuiling Li, Xiangpei Kong, Huiyu Tian, Zhaojun Ding

PLOS Genetics: published February 7, 2020 | https://doi.org/10.1371/journal.pgen.1008044

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Wei-Chun Au, Tianyi Zhang, Prashant K. Mishra, Jessica R. Eisenstatt, Robert L. Walker, Josefina Ocampo, Anthony Dawson, Jack Warren, Michael Costanzo, Anastasia Baryshnikova, Karin Flick, David J. Clark, Paul S. Meltzer, Richard E. Baker, Chad Myers, Charles Boone, Peter Kaiser, Munira A. Basrai

PLOS Genetics: published February 7, 2020 | https://doi.org/10.1371/journal.pgen.1008597

Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency

María Angélica Bravo Núñez, Ibrahim M. Sabbarini, Michael T. Eickbush, Yue Liang, Jeffrey J. Lange, Aubrey M. Kent, Sarah E. Zanders

PLOS Genetics: published February 7, 2020 | https://doi.org/10.1371/journal.pgen.1008350

RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium

Magnus Stårsta, Disa L. Hammarlöf, Marcus Wäneskog, Susan Schlegel, Feifei Xu, Arvid Heden Gynnå, Malin Borg, Sten Herschend, Sanna Koskiniemi

PLOS Genetics: published February 13, 2020 | https://doi.org/10.1371/journal.pgen.1008607

NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models

Mayanglambam Dhruba Singh, Matthew Jensen, Micaela Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar, Sydney Kim, Janani Iyer, Diego E. Rincon-Limas, Laura Anne Lowery, Santhosh Girirajan

PLOS Genetics: published February 13, 2020 | https://doi.org/10.1371/journal.pgen.1008590

A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria

Ernest Diez Benavente, Monica Campos, Jody Phelan, Debbie Nolder, Jamille G. Dombrowski, Claudio R. F. Marinho, Kanlaya Sriprawat, Aimee R. Taylor, James Watson, Cally Roper, Francois Nosten, Colin J. Sutherland, Susana Campino, Taane G. Clark

PLOS Genetics: published February 13, 2020 | https://doi.org/10.1371/journal.pgen.1008576

Rab11 activation by Ik2 kinase is required for dendrite pruning in Drosophila sensory neurons

Tzu Lin, Hao-Hsiang Kao, Che-Hsuan Chou, Chih-Yu Chou, Yu-Ching Liao, Hsiu-Hsiang Lee

PLOS Genetics: published February 14, 2020 | https://doi.org/10.1371/journal.pgen.1008626

Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry

Jiao Yuan, Kevin H. Kensler, Zhongyi Hu, Youyou Zhang, Tianli Zhang, Junjie Jiang, Mu Xu, Yutian Pan, Meixiao Long, Kathleen T. Montone, Janos L. Tanyi, Yi Fan, Rugang Zhang, Xiaowen Hu, Timothy R. Rebbeck, Lin Zhang

PLOS Genetics: published February 14, 2020 | https://doi.org/10.1371/journal.pgen.1008641

Identifying neural substrates of competitive interactions and sequence transitions during mechanosensory responses in Drosophila

Jean-Baptiste Masson, François Laurent, Albert Cardona, Chloé Barré, Nicolas Skatchkovsky, Marta Zlatic, Tihana Jovanic

PLOS Genetics: published February 14, 2020 | https://doi.org/10.1371/journal.pgen.1008589

The persimmon genome reveals clues to the evolution of a lineage-specific sex determination system in plants

Takashi Akagi, Kenta Shirasawa, Hideki Nagasaki, Hideki Hirakawa, Ryutaro Tao, Luca Comai, Isabelle M. Henry

PLOS Genetics: published February 18, 2020 | https://doi.org/10.1371/journal.pgen.1008566

Control of clathrin-mediated endocytosis by NIMA family kinases

Braveen B. Joseph, Yu Wang, Phil Edeen, Vladimir Lažetić, Barth D. Grant, David S. Fay

PLOS Genetics: published February 18, 2020 | https://doi.org/10.1371/journal.pgen.1008633

Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor

Ana Sofia Brito, Benjamin Neuhäuser, René Wintjens, Anna Maria Marini, Mélanie Boeckstaens

PLOS Genetics: published February 18, 2020 | https://doi.org/10.1371/journal.pgen.1008634

Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment

Nicole Lindsay-Mosher, Andy Chan, Bret J. Pearson

PLOS Genetics: published February 20, 2020 | https://doi.org/10.1371/journal.pgen.1008613

Evolution of Ty1 copy number control in yeast by horizontal transfer and recombination

Wioletta Czaja, Douda Bensasson, Hyo Won Ahn, David J. Garfinkel, Casey M. Bergman

PLOS Genetics: published February 21, 2020 | https://doi.org/10.1371/journal.pgen.1008632

Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes

Rudo Kieft, Yang Zhang, Alexandre P. Marand, Jose Dagoberto Moran, Robert Bridger, Lance Wells, Robert J. Schmitz, Robert Sabatini

PLOS Genetics: published February 21, 2020 | https://doi.org/10.1371/journal.pgen.1008390

A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans

Yuehui Zhao, Lijiang Long, Jason Wan, Shweta Biliya, Shannon C. Brady, Daehan Lee, Akinade Ojemakinde, Erik C. Andersen, Fredrik O. Vannberg, Hang Lu, Patrick T. McGrath

PLOS Genetics: published February 24, 2020 | https://doi.org/10.1371/journal.pgen.1008606

Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome

Terren K. Niethamer, Teng Teng, Melanie Franco, Yu Xin Du, Christopher J. Percival, Jeffrey O. Bush

PLOS Genetics: published February 24, 2020 | https://doi.org/10.1371/journal.pgen.1008300

Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes

Kazumasa Takemoto, Yukiko Imai, Kenji Saito, Toshihiro Kawasaki, Peter M. Carlton, Kei-ichiro Ishiguro, Noriyoshi Sakai

PLOS Genetics: published February 24, 2020 | https://doi.org/10.1371/journal.pgen.1008640

Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons

Lewis M. Sherer, Elizabeth Catudio Garrett, Hannah R. Morgan, Edmond D. Brewer, Lucy A. Sirrs, Harold K. Shearin, Jessica L. Williams, Brian D. McCabe, R. Steven Stowers, Sarah J. Certel

PLOS Genetics: published February 25, 2020 | https://doi.org/10.1371/journal.pgen.1008609

Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice

Yoichi Wada, Atsuo Kikuchi, Akimune Kaga, Naoki Shimizu, Junya Ito, Ryo Onuma, Fumiyoshi Fujishima, Eriko Totsune, Ryo Sato, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Kota Sato, Toru Nakazawa, Keiko Nakayama, Yoko Aoki, Setsuya Aiba, Kiyotaka Nakagawa, Shigeo Kure

PLOS Genetics: published February 26, 2020 | https://doi.org/10.1371/journal.pgen.1008628

Cover

wtf meiotic drivers