Systems genetics approach reveals cross-talk between bile acids and intestinal microbes

Jingyuan Fu, Folkert Kuipers

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008307

Related Articles

1. Genetic determinants of gut microbiota composition and bile acid profiles in mice

Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome

Amanda Vlahos, Toby Mansell, Richard Saffery, Boris Novakovic

PLOS Genetics: published August 1, 2019 | https://doi.org/10.1371/journal.pgen.1008236

Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants

Wan-Yu Lin, Chang-Chuan Chan, Yu-Li Liu, Albert C. Yang, Shih-Jen Tsai, Po-Hsiu Kuo

PLOS Genetics: published August 1, 2019 | https://doi.org/10.1371/journal.pgen.1008277

Ddc2^ATRIP promotes Mec1^ATR activation at RPA-ssDNA tracts

Himadri Biswas, Greicy Goto, Weibin Wang, Patrick Sung, Katsunori Sugimoto

PLOS Genetics: published August 1, 2019 | https://doi.org/10.1371/journal.pgen.1008294

Empty Pericarp21 encodes a novel PPR-DYW protein that is required for mitochondrial RNA editing at multiple sites, complexes I and V biogenesis, and seed development in maize

Yong Wang, Xin-Yuan Liu, Yan-Zhuo Yang, Jin Huang, Feng Sun, Jishan Lin, Zhi-Qun Gu, Aqib Sayyed, Chunhui Xu, Bao-Cai Tan

PLOS Genetics: published August 2, 2019 | https://doi.org/10.1371/journal.pgen.1008305

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia

Kazuki Okuyama, Tobias Strid, Jacob Kuruvilla, Rajesh Somasundaram, Susana Cristobal, Emma Smith, Mahadesh Prasad, Thoas Fioretos, Henrik Lilljebjörn, Shamit Soneji, Stefan Lang, Jonas Ungerbäck, Mikael Sigvardsson

PLOS Genetics: published August 5, 2019 | https://doi.org/10.1371/journal.pgen.1008280

Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats

Xiaoli Li, Xuejiao Jin, Sushma Sharma, Xiaojing Liu, Jiaxin Zhang, Yanling Niu, Jiani Li, Zhen Li, Jingjing Zhang, Qinhong Cao, Wenya Hou, Li-Lin Du, Beidong Liu, Huiqiang Lou

PLOS Genetics: published August 5, 2019 | https://doi.org/10.1371/journal.pgen.1008136

Related Articles

1. Mck1 kinase is a new player in the DNA damage checkpoint pathway

Methyl-CpG-binding domain 9 (MBD9) is required for H2A.Z incorporation into chromatin at a subset of H2A.Z-enriched regions in the Arabidopsis genome

Paja Sijacic, Dylan H. Holder, Marko Bajic, Roger B. Deal

PLOS Genetics: published August 5, 2019 | https://doi.org/10.1371/journal.pgen.1008326

Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response

Andrew A. Kelso, Felicia Wednesday Lopezcolorado, Ragini Bhargava, Jeremy M. Stark

PLOS Genetics: published August 5, 2019 | https://doi.org/10.1371/journal.pgen.1008319

Glial response to hypoxia in mutants of NPAS1/3 homolog Trachealess through Wg signaling to modulate synaptic bouton organization

Pei-Yi Chen, Yi-Wei Tsai, Ying-Ju Cheng, Angela Giangrande, Cheng-Ting Chien

PLOS Genetics: published August 5, 2019 | https://doi.org/10.1371/journal.pgen.1007980

Differential requirements of tubulin genes in mammalian forebrain development

Elizabeth Bittermann, Zakia Abdelhamed, Ryan P. Liegel, Chelsea Menke, Andrew Timms, David R. Beier, Rolf W. Stottmann

PLOS Genetics: published August 6, 2019 | https://doi.org/10.1371/journal.pgen.1008243

Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies

Sangeun Park, Sei-Kyoung Park, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Tatyana A. Shelkovnikova, Susan W. Liebman

PLOS Genetics: published August 7, 2019 | https://doi.org/10.1371/journal.pgen.1008308

The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response

Alexis S. Hill, Poorva Jain, Nicole E. Folan, Yehuda Ben-Shahar

PLOS Genetics: published August 8, 2019 | https://doi.org/10.1371/journal.pgen.1008288

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Victoria J. Butler, Fuying Gao, Christian I. Corrales, Wilian A. Cortopassi, Benjamin Caballero, Mihir Vohra, Kaveh Ashrafi, Ana Maria Cuervo, Matthew P. Jacobson, Giovanni Coppola, Aimee W. Kao

PLOS Genetics: published August 9, 2019 | https://doi.org/10.1371/journal.pgen.1008295

The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis

Jie Li, Bo Zhang, Liguang Zhou, Lei Qi, Lei Yue, Wenting Zhang, Huicai Cheng, William B. Whitman, Xiuzhu Dong

PLOS Genetics: published August 12, 2019 | https://doi.org/10.1371/journal.pgen.1008328

The steroid hormone 20-hydroxyecdysone binds to dopamine receptor to repress lepidopteran insect feeding and promote pupation

Xin-Le Kang, Jun-Ying Zhang, Di Wang, Yu-Meng Zhao, Xiao-Lin Han, Jin-Xing Wang, Xiao-Fan Zhao

PLOS Genetics: published August 14, 2019 | https://doi.org/10.1371/journal.pgen.1008331

A RID-like putative cytosine methyltransferase homologue controls sexual development in the fungus Podospora anserina

Pierre Grognet, Hélène Timpano, Florian Carlier, Jinane Aït-Benkhali, Véronique Berteaux-Lecellier, Robert Debuchy, Frédérique Bidard, Fabienne Malagnac

PLOS Genetics: published August 14, 2019 | https://doi.org/10.1371/journal.pgen.1008086

Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome

Erica Hasten, Bernice E. Morrow

PLOS Genetics: published August 14, 2019 | https://doi.org/10.1371/journal.pgen.1008301

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Sven Lang, Tyler A. Hilsabeck, Kenneth A. Wilson, Amit Sharma, Neelanjan Bose, Deanna J. Brackman, Jennifer N. Beck, Ling Chen, Mark A. Watson, David W. Killilea, Sunita Ho, Arnold Kahn, Kathleen Giacomini, Marshall L. Stoller, Thomas Chi, Pankaj Kapahi

PLOS Genetics: published August 15, 2019 | https://doi.org/10.1371/journal.pgen.1008318

Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus

Emilie Trachsel, Peter Redder, Patrick Linder, Joshua Armitano

PLOS Genetics: published August 15, 2019 | https://doi.org/10.1371/journal.pgen.1008336

Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organism

Jane Usher, Ken Haynes

PLOS Genetics: published August 19, 2019 | https://doi.org/10.1371/journal.pgen.1008259

An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations

Alexander Platt, Alyssa Pivirotto, Jared Knoblauch, Jody Hey

PLOS Genetics: published August 19, 2019 | https://doi.org/10.1371/journal.pgen.1008340

Separate Polycomb Response Elements control chromatin state and activation of the vestigial gene

Kami Ahmad, Amy E. Spens

PLOS Genetics: published August 19, 2019 | https://doi.org/10.1371/journal.pgen.1007877

Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice

Abigail R. Moye, Nicola Bedoni, Jessica G. Cunningham, Urikhan Sanzhaeva, Eric S. Tucker, Peter Mathers, Virginie G. Peter, Mathieu Quinodoz, Liliana P. Paris, Luísa Coutinho-Santos, Pedro Camacho, Madeleine G. Purcell, Abbie C. Winkelmann, James A. Foster, Elena N. Pugacheva, Carlo Rivolta, Visvanathan Ramamurthy

PLOS Genetics: published August 19, 2019 | https://doi.org/10.1371/journal.pgen.1008315

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila

Juan A. Sanchez, Duarte Mesquita, María C. Ingaramo, Federico Ariel, Marco Milán, Andrés Dekanty

PLOS Genetics: published August 19, 2019 | https://doi.org/10.1371/journal.pgen.1008133

NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition

Wei Zhang, Qiannan Guo, Guoying Liu, Fang Zheng, Jianing Chen, Di Huang, Linxiaoxiao Ding, Xing Yang, Erwei Song, Yanqun Xiang, Herui Yao

PLOS Genetics: published August 20, 2019 | https://doi.org/10.1371/journal.pgen.1008325

Related Articles

1. Expression of Concern: NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition

SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilis

Yannick R. Brunet, Xindan Wang, David Z. Rudner

PLOS Genetics: published August 22, 2019 | https://doi.org/10.1371/journal.pgen.1008296

Related Articles

1. Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae

Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae

Hoong Chuin Lim, Joel W. Sher, Frances P. Rodriguez-Rivera, Coralie Fumeaux, Carolyn R. Bertozzi, Thomas G. Bernhardt

PLOS Genetics: published August 22, 2019 | https://doi.org/10.1371/journal.pgen.1008284

Related Articles

1. SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilis

The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility

Laura Gómez-H, Natalia Felipe-Medina, Yazmine B. Condezo, Rodrigo Garcia-Valiente, Isabel Ramos, José Angel Suja, José Luis Barbero, Ignasi Roig, Manuel Sánchez-Martín, Dirk G. de Rooij, Elena Llano, Alberto M. Pendas

PLOS Genetics: published August 22, 2019 | https://doi.org/10.1371/journal.pgen.1008316

Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation

Qiaowei Pan, Romain Feron, Ayaka Yano, René Guyomard, Elodie Jouanno, Estelle Vigouroux, Ming Wen, Jean-Mickaël Busnel, Julien Bobe, Jean-Paul Concordet, Hugues Parrinello, Laurent Journot, Christophe Klopp, Jérôme Lluch, Céline Roques, John Postlethwait, Manfred Schartl, Amaury Herpin, Yann Guiguen

PLOS Genetics: published August 22, 2019 | https://doi.org/10.1371/journal.pgen.1008013

Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome

Jason Talkish, Haller Igel, Rhonda J. Perriman, Lily Shiue, Sol Katzman, Elizabeth M. Munding, Robert Shelansky, John Paul Donohue, Manuel Ares Jr.

PLOS Genetics: published August 22, 2019 | https://doi.org/10.1371/journal.pgen.1008249

Related Articles

1. Correction: Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome

A first genetic portrait of synaptonemal complex variation

Richard J. Wang, Beth L. Dumont, Peicheng Jing, Bret A. Payseur

PLOS Genetics: published August 26, 2019 | https://doi.org/10.1371/journal.pgen.1008337

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

Nicolas Giguère, Benoît Delignat-Lavaud, Freja Herborg, Aurore Voisin, Yuan Li, Vincent Jacquemet, Madhu Anand-Srivastava, Ulrik Gether, Bruno Giros, Louis-Éric Trudeau

PLOS Genetics: published August 26, 2019 | https://doi.org/10.1371/journal.pgen.1008352

Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast

Hiroyuki Irie, Io Yamamoto, Yusuke Tarumoto, Sanki Tashiro, Kurt W. Runge, Fuyuki Ishikawa

PLOS Genetics: published August 27, 2019 | https://doi.org/10.1371/journal.pgen.1008335

A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure

Mingguang Li, Ryan D. Fine, Manikarna Dinda, Stefan Bekiranov, Jeffrey S. Smith

PLOS Genetics: published August 28, 2019 | https://doi.org/10.1371/journal.pgen.1008339

Genetic determinants of gut microbiota composition and bile acid profiles in mice

Julia H. Kemis, Vanessa Linke, Kelsey L. Barrett, Frederick J. Boehm, Lindsay L. Traeger, Mark P. Keller, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Daniel M. Gatti, Gary A. Churchill, Daniel Amador-Noguez, Jason D. Russell, Brian S. Yandell, Karl W. Broman, Joshua J. Coon, Alan D. Attie, Federico E. Rey

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008073

Related Articles

1. Systems genetics approach reveals cross-talk between bile acids and intestinal microbes

Reshuffling yeast chromosomes with CRISPR/Cas9

Aubin Fleiss, Samuel O'Donnell, Téo Fournier, Wenqing Lu, Nicolas Agier, Stéphane Delmas, Joseph Schacherer, Gilles Fischer

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008332

The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus

Alison Wood, Sophie E. Irving, Daniel J. Bennison, Rebecca M. Corrigan

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008346

BZU2/ZmMUTE controls symmetrical division of guard mother cell and specifies neighbor cell fate in maize

Hongliang Wang, Siyi Guo, Xin Qiao, Jianfei Guo, Zuliang Li, Yusen Zhou, Shenglong Bai, Zhiyong Gao, Daojie Wang, Pengcheng Wang, David W. Galbraith, Chun-Peng Song

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008377

SMAX1/SMXL2 regulate root and root hair development downstream of KAI2-mediated signalling in Arabidopsis

José Antonio Villaécija-Aguilar, Maxime Hamon-Josse, Samy Carbonnel, Annika Kretschmar, Christian Schmidt, Corinna Dawid, Tom Bennett, Caroline Gutjahr

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008327

SSD1 suppresses phenotypes induced by the lack of Elongator-dependent tRNA modifications

Fu Xu, Anders S. Byström, Marcus J. O. Johansson

PLOS Genetics: published August 29, 2019 | https://doi.org/10.1371/journal.pgen.1008117

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

Cavin Wong, Fei Chen, Najmeh Alirezaie, Yifan Wang, Adeline Cuggia, Ayelet Borgida, Spring Holter, Tatiana Lenko, Celine Domecq, Alzheimer’s Disease Neuroimaging Initiative, Gloria M. Petersen, Sapna Syngal, Randall Brand, Anil K. Rustgi, Michele L. Cote, Elena Stoffel, Sara H. Olson, Nicholas J. Roberts, Mohammad R. Akbari, Jacek Majewski, Alison P. Klein, Celia M. T. Greenwood, Steven Gallinger, George Zogopoulos

PLOS Genetics: published August 30, 2019 | https://doi.org/10.1371/journal.pgen.1008344

GRAM: A GeneRAlized Model to predict the molecular effect of a non-coding variant in a cell-type specific manner

Shaoke Lou, Kellie A. Cotter, Tianxiao Li, Jin Liang, Hussein Mohsen, Jason Liu, Jing Zhang, Sandra Cohen, Jinrui Xu, Haiyuan Yu, Mark A. Rubin, Mark Gerstein

PLOS Genetics: published August 30, 2019 | https://doi.org/10.1371/journal.pgen.1007860

The alternative reality of plant mitochondrial DNA: One ring does not rule them all

Alexander Kozik, Beth A. Rowan, Dean Lavelle, Lidija Berke, M. Eric Schranz, Richard W. Michelmore, Alan C. Christensen

PLOS Genetics: published August 30, 2019 | https://doi.org/10.1371/journal.pgen.1008373

Correction: Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses

Regula Hauswirth, Bianca Haase, Marlis Blatter, Samantha A. Brooks, Dominik Burger, Cord Drögemüller, Vincent Gerber, Diana Henke, Jozef Janda, Rony Jude, K. Gary Magdesian, Jacqueline M. Matthews, Pierre-André Poncet, Vilhjálmur Svansson, Teruaki Tozaki, Lorna Wilkinson-White, M. Cecilia T. Penedo, Stefan Rieder, Tosso Leeb

PLOS Genetics: published August 2, 2019 | https://doi.org/10.1371/journal.pgen.1008321

Related Articles

1. Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses