Irreversible effects of youthful choices in aged adults

Alana M. O’Reilly

PLOS Genetics: published July 11, 2019 | https://doi.org/10.1371/journal.pgen.1008218

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XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease

Katarzyna A. Piróg, Ella P. Dennis, Claire L. Hartley, Robert M. Jackson, Jamie Soul, Jean-Marc Schwartz, John F. Bateman, Raymond P. Boot-Handford, Michael D. Briggs

PLOS Genetics: published July 1, 2019 | https://doi.org/10.1371/journal.pgen.1008215

A secretion-enhancing cis regulatory targeting element (SECReTE) involved in mRNA localization and protein synthesis

Osnat Cohen-Zontag, Camila Baez, Lisha Qiu Jin Lim, Tsviya Olender, Dvir Schirman, Dvir Dahary, Yitzhak Pilpel, Jeffrey E. Gerst

PLOS Genetics: published July 1, 2019 | https://doi.org/10.1371/journal.pgen.1008248

scoreInvHap: Inversion genotyping for genome-wide association studies

Carlos Ruiz-Arenas, Alejandro Cáceres, Marcos López-Sánchez, Ignacio Tolosana, Luis Pérez-Jurado, Juan R. González

PLOS Genetics: published July 3, 2019 | https://doi.org/10.1371/journal.pgen.1008203

Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene

Aabida Saferali, Jeong H. Yun, Margaret M. Parker, Phuwanat Sakornsakolpat, Robert P. Chase, Andrew Lamb, Brian D. Hobbs, Marike H. Boezen, Xiangpeng Dai, Kim de Jong, Terri H. Beaty, Wenyi Wei, Xiaobo Zhou, Edwin K. Silverman, Michael H. Cho, Peter J. Castaldi, Craig P. Hersh, COPDGene Investigators, the International COPD Genetics Consortium Investigators

PLOS Genetics: published July 3, 2019 | https://doi.org/10.1371/journal.pgen.1008229

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals

Amy E. Rohlfing, Brian E. Eckenroth, Emily R. Forster, Yuzo Kevorkian, M. Lauren Donnelly, Hector Benito de la Puebla, Sylvie Doublié, Aimee Shen

PLOS Genetics: published July 5, 2019 | https://doi.org/10.1371/journal.pgen.1008224

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner

Lu M. Yang, Kathryn S. E. Cheah, Sung-Ho Huh, David M. Ornitz

PLOS Genetics: published July 5, 2019 | https://doi.org/10.1371/journal.pgen.1008254

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

Wilson Castillo-Tandazo, Monique F. Smeets, Vincent Murphy, Rui Liu, Charlotte Hodson, Jörg Heierhorst, Andrew J. Deans, Carl R. Walkley

PLOS Genetics: published July 5, 2019 | https://doi.org/10.1371/journal.pgen.1008266

Analysis of the genetic basis of height in large Jewish nuclear families

Danny Zeevi, Joshua S. Bloom, Meru J. Sadhu, Adi Ben Yehuda, David Zangen, Ephrat Levy-Lahad, Leonid Kruglyak

PLOS Genetics: published July 8, 2019 | https://doi.org/10.1371/journal.pgen.1008082

The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline

Simon Yuan Wang, Hui Mao, Hiroki Shibuya, Satoru Uzawa, Zach Klapholz O’Brown, Sage Wesenberg, Nara Shin, Takamune T. Saito, Jinmin Gao, Barbara J. Meyer, Monica P. Colaiácovo, Eric Lieberman Greer

PLOS Genetics: published July 8, 2019 | https://doi.org/10.1371/journal.pgen.1008252

A Cyclin A—Myb-MuvB—Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles

Michael D. Rotelli, Robert A. Policastro, Anna M. Bolling, Andrew W. Killion, Abraham J. Weinberg, Michael J. Dixon, Gabriel E. Zentner, Claire E. Walczak, Mary A. Lilly, Brian R. Calvi

PLOS Genetics: published July 10, 2019 | https://doi.org/10.1371/journal.pgen.1008253

Artificial selection on GmOLEO1 contributes to the increase in seed oil during soybean domestication

Dan Zhang, Hengyou Zhang, Zhenbin Hu, Shanshan Chu, Kaiye Yu, Lingling Lv, Yuming Yang, Xiangqian Zhang, Xi Chen, Guizhen Kan, Yang Tang, Yong-Qiang Charles An, Deyue Yu

PLOS Genetics: published July 10, 2019 | https://doi.org/10.1371/journal.pgen.1008267

Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment

Yi Chieh Chang, Hsin Tu, Jing-Yi Chen, Ching-Chin Chang, Shu Yuan Yang, Haiwei Pi

PLOS Genetics: published July 11, 2019 | https://doi.org/10.1371/journal.pgen.1008062

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Multilevel regulation of the glass locus during Drosophila eye development

Cornelia Fritsch, F. Javier Bernardo-Garcia, Tim-Henning Humberg, Abhishek Kumar Mishra, Sara Miellet, Silvia Almeida, Michael V. Frochaux, Bart Deplancke, Armin Huber, Simon G. Sprecher

PLOS Genetics: published July 12, 2019 | https://doi.org/10.1371/journal.pgen.1008269

A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression

Zachary F. Gerring, Eric R. Gamazon, Eske M. Derks, for the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

PLOS Genetics: published July 15, 2019 | https://doi.org/10.1371/journal.pgen.1008245

Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma

Christian Gluck, Alexandra Glathar, Maria Tsompana, Norma Nowak, Lee Ann Garrett-Sinha, Michael J. Buck, Satrajit Sinha

PLOS Genetics: published July 15, 2019 | https://doi.org/10.1371/journal.pgen.1008250

Novel protective and risk loci in hip dysplasia in German Shepherds

Lea I. Mikkola, Saila Holopainen, Anu K. Lappalainen, Tiina Pessa-Morikawa, Thomas J. P. Augustine, Meharji Arumilli, Marjo K. Hytönen, Osmo Hakosalo, Hannes Lohi, Antti Iivanainen

PLOS Genetics: published July 19, 2019 | https://doi.org/10.1371/journal.pgen.1008197

Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates

Ittai E. Eres, Kaixuan Luo, Chiaowen Joyce Hsiao, Lauren E. Blake, Yoav Gilad

PLOS Genetics: published July 19, 2019 | https://doi.org/10.1371/journal.pgen.1008278

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase

Shi-You Jiang, Jing-Jie Tang, Xu Xiao, Wei Qi, Suqian Wu, Chao Jiang, Jiaxu Hong, Jianjiang Xu, Bao-Liang Song, Jie Luo

PLOS Genetics: published July 19, 2019 | https://doi.org/10.1371/journal.pgen.1008289

DAF-16/FOXO promotes taste avoidance learning independently of axonal insulin-like signaling

Takashi Nagashima, Yuichi Iino, Masahiro Tomioka

PLOS Genetics: published July 19, 2019 | https://doi.org/10.1371/journal.pgen.1008297

Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal

Shekerah Primus, Caitlin Pozmanter, Kelly Baxter, Mark Van Doren

PLOS Genetics: published July 22, 2019 | https://doi.org/10.1371/journal.pgen.1007617

Recurrent gene co-amplification on Drosophila X and Y chromosomes

Christopher Ellison, Doris Bachtrog

PLOS Genetics: published July 22, 2019 | https://doi.org/10.1371/journal.pgen.1008251

The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes

Daniel Andergassen, Markus Muckenhuber, Philipp C. Bammer, Tomasz M. Kulinski, Hans-Christian Theussl, Takahiko Shimizu, Josef M. Penninger, Florian M. Pauler, Quanah J. Hudson

PLOS Genetics: published July 22, 2019 | https://doi.org/10.1371/journal.pgen.1008268

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BCDIN3D regulates tRNA^His 3’ fragment processing

Calder W. Reinsborough, Hélène Ipas, Nathan S. Abell, Ryan M. Nottingham, Jun Yao, Sravan K. Devanathan, Samantha B. Shelton, Alan M. Lambowitz, Blerta Xhemalçe

PLOS Genetics: published July 22, 2019 | https://doi.org/10.1371/journal.pgen.1008273

Genome-wide discovery of the daily transcriptome, DNA regulatory elements and transcription factor occupancy in the monarch butterfly brain

Aldrin B. Lugena, Ying Zhang, Jerome S. Menet, Christine Merlin

PLOS Genetics: published July 23, 2019 | https://doi.org/10.1371/journal.pgen.1008265

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

Yu-Yang Jiang, Wolfgang Maier, Ralf Baumeister, Gregory Minevich, Ewa Joachimiak, Dorota Wloga, Zheng Ruan, Natarajan Kannan, Stephen Bocarro, Anoosh Bahraini, Krishna Kumar Vasudevan, Karl Lechtreck, Eduardo Orias, Jacek Gaertig

PLOS Genetics: published July 24, 2019 | https://doi.org/10.1371/journal.pgen.1008099

polyamine uptake transporter 2 (put2) and decaying seeds enhance phyA-mediated germination by overcoming PIF1 repression of germination

Woohyun Kim, Sanja Ćavar Zeljković, Urszula Piskurewicz, Christian Megies, Petr Tarkowski, Luis Lopez-Molina

PLOS Genetics: published July 24, 2019 | https://doi.org/10.1371/journal.pgen.1008292

Quantifying immune-based counterselection of somatic mutations

Fan Yang, Dae-Kyum Kim, Hidewaki Nakagawa, Shuto Hayashi, Seiya Imoto, Lincoln Stein, Frederick P. Roth

PLOS Genetics: published July 25, 2019 | https://doi.org/10.1371/journal.pgen.1008227

Functionalization of CD36 cardiovascular disease and expression associated variants by interdisciplinary high throughput analysis

Namrata Madan, Andrew R. Ghazi, Xianguo Kong, Edward S. Chen, Chad A. Shaw, Leonard C. Edelstein

PLOS Genetics: published July 25, 2019 | https://doi.org/10.1371/journal.pgen.1008287

Calmodulin-binding transcription factor shapes the male courtship song in Drosophila

Kosei Sato, Md. Tanveer Ahsan, Manabu Ote, Masayuki Koganezawa, Daisuke Yamamoto

PLOS Genetics: published July 25, 2019 | https://doi.org/10.1371/journal.pgen.1008309

RPW8/HR repeats control NLR activation in Arabidopsis thaliana

Cristina A. Barragan, Rui Wu, Sang-Tae Kim, Wanyan Xi, Anette Habring, Jörg Hagmann, Anna-Lena Van de Weyer, Maricris Zaidem, William Wing Ho Ho, George Wang, Ilja Bezrukov, Detlef Weigel, Eunyoung Chae

PLOS Genetics: published July 25, 2019 | https://doi.org/10.1371/journal.pgen.1008313

The presence and impact of reference bias on population genomic studies of prehistoric human populations

Torsten Günther, Carl Nettelblad

PLOS Genetics: published July 26, 2019 | https://doi.org/10.1371/journal.pgen.1008302

miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2

Ye Niu, Zhenxing Liu, Xiaoge Nian, Xuehan Xu, Yong Zhang

PLOS Genetics: published July 29, 2019 | https://doi.org/10.1371/journal.pgen.1007655

Longevity is determined by ETS transcription factors in multiple tissues and diverse species

Adam J. Dobson, Richard Boulton-McDonald, Lara Houchou, Tatiana Svermova, Ziyu Ren, Jeremie Subrini, Mireya Vazquez-Prada, Mimoza Hoti, Maria Rodriguez-Lopez, Rita Ibrahim, Afroditi Gregoriou, Alexis Gkantiragas, Jürg Bähler, Marina Ezcurra, Nazif Alic

PLOS Genetics: published July 29, 2019 | https://doi.org/10.1371/journal.pgen.1008212

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

Aleksandra Pajak, Isabelle Laine, Paula Clemente, Najla El-Fissi, Florian A. Schober, Camilla Maffezzini, Javier Calvo-Garrido, Rolf Wibom, Roberta Filograna, Ashish Dhir, Anna Wedell, Christoph Freyer, Anna Wredenberg

PLOS Genetics: published July 31, 2019 | https://doi.org/10.1371/journal.pgen.1008240

Variation and selection on codon usage bias across an entire subphylum

Abigail L. LaBella, Dana A. Opulente, Jacob L. Steenwyk, Chris Todd Hittinger, Antonis Rokas

PLOS Genetics: published July 31, 2019 | https://doi.org/10.1371/journal.pgen.1008304

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Elisa Gómez-Gil, Alejandro Franco, Marisa Madrid, Beatriz Vázquez-Marín, Mariano Gacto, Jesualdo Fernández-Breis, Jero Vicente-Soler, Teresa Soto, José Cansado

PLOS Genetics: published July 19, 2019 | https://doi.org/10.1371/journal.pgen.1008282

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Correction: Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3

Anna Peters, Petra Krumbholz, Elisabeth Jäger, Anna Heintz-Buschart, Mehmet Volkan Çakir, Sven Rothemund, Alexander Gaudl, Uta Ceglarek, Torsten Schöneberg, Claudia Stäubert

PLOS Genetics: published July 19, 2019 | https://doi.org/10.1371/journal.pgen.1008283

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Correction: A Genetic Basis for a Postmeiotic X Versus Y Chromosome Intragenomic Conflict in the Mouse

Julie Cocquet, Peter J. I. Ellis, Shantha K. Mahadevaiah, Nabeel A. Affara, Daniel Vaiman, Paul S. Burgoyne

PLOS Genetics: published July 22, 2019 | https://doi.org/10.1371/journal.pgen.1008290

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Correction: Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo

Quira Zeidan, Feng He, Fan Zhang, Hongen Zhang, Allan Jacobson, Alan G. Hinnebusch

PLOS Genetics: published July 23, 2019 | https://doi.org/10.1371/journal.pgen.1008299

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Correction: Activation-induced deaminase (AID) localizes to the nucleus in brief pulses

The PLOS Genetics Staff

PLOS Genetics: published July 26, 2019 | https://doi.org/10.1371/journal.pgen.1008310

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