The drawing depicts the importance of admixture for fast and repeated evolution of two ecotypes of the saltmarsh beetle Pogonus chalceus. Long- and short-winged ecotypes of P. chalceus have diverged repeatedly along the Atlantic European coast in response to contrasting hydrological regimes. The repeated evolution is driven by an initial ancient and singular divergence of the short-winged ecotype, after which it admixed with the ancestral long-winged population. This admixture resulted in a polymorphic population that survived during the most recent glacial maxima and from which both ecotypes currently diverge rapidly and repeatedly by the reassembly of these ancient alleles when habitats become available. See Van Belleghem et al.
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Image Credit: Steven M. Van Belleghem and Frederik Hendrickx
Perspectives
Allele-specific expression elucidates cis-regulatory logic
PLOS Genetics: published November 1, 2018 | https://doi.org/10.1371/journal.pgen.1007690
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The many fates of tissue regeneration
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Research Articles
Spatially varying cis-regulatory divergence in Drosophila embryos elucidates cis-regulatory logic
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BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis
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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans
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Slower environmental change hinders adaptation from standing genetic variation
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How many individuals share a mitochondrial genome?
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Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster
PLOS Genetics: published November 1, 2018 | https://doi.org/10.1371/journal.pgen.1007777
Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
PLOS Genetics: published November 2, 2018 | https://doi.org/10.1371/journal.pgen.1007427
Control of nongenetic heterogeneity in growth rate and stress tolerance of Saccharomyces cerevisiae by cyclic AMP-regulated transcription factors
PLOS Genetics: published November 2, 2018 | https://doi.org/10.1371/journal.pgen.1007744
Association analysis using somatic mutations
PLOS Genetics: published November 2, 2018 | https://doi.org/10.1371/journal.pgen.1007746
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An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera
PLOS Genetics: published November 2, 2018 | https://doi.org/10.1371/journal.pgen.1007770
Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish
PLOS Genetics: published November 2, 2018 | https://doi.org/10.1371/journal.pgen.1007775
A variably imprinted epiallele impacts seed development
PLOS Genetics: published November 5, 2018 | https://doi.org/10.1371/journal.pgen.1007469
Functional equivalence of germ plasm organizers
PLOS Genetics: published November 6, 2018 | https://doi.org/10.1371/journal.pgen.1007696
Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
PLOS Genetics: published November 6, 2018 | https://doi.org/10.1371/journal.pgen.1007735
Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors
PLOS Genetics: published November 7, 2018 | https://doi.org/10.1371/journal.pgen.1007749
Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis
PLOS Genetics: published November 7, 2018 | https://doi.org/10.1371/journal.pgen.1007753
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations
PLOS Genetics: published November 9, 2018 | https://doi.org/10.1371/journal.pgen.1007779
Population genomics of grey wolves and wolf-like canids in North America
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007745
A fast and agnostic method for bacterial genome-wide association studies: Bridging the gap between k-mers and genetic events
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007758
The zinc finger protein DCM1 is required for male meiotic cytokinesis by preserving callose in rice
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007769
Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007772
Replicative and non-replicative mechanisms in the formation of clustered CNVs are indicated by whole genome characterization
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007780
Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007783
Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007788
Arabidopsis class I formins control membrane-originated actin polymerization at pollen tube tips
PLOS Genetics: published November 12, 2018 | https://doi.org/10.1371/journal.pgen.1007789
Evolution at two time frames: Polymorphisms from an ancient singular divergence event fuel contemporary parallel evolution
PLOS Genetics: published November 13, 2018 | https://doi.org/10.1371/journal.pgen.1007796
Conditional mutagenesis by oligonucleotide-mediated integration of loxP sites in zebrafish
PLOS Genetics: published November 14, 2018 | https://doi.org/10.1371/journal.pgen.1007754
Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise
PLOS Genetics: published November 14, 2018 | https://doi.org/10.1371/journal.pgen.1007793
Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends
PLOS Genetics: published November 15, 2018 | https://doi.org/10.1371/journal.pgen.1007782
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A single class of ARF GTPase activated by several pathway-specific ARF-GEFs regulates essential membrane traffic in Arabidopsis
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Capitalizing on the heterogeneous effects of CFTR nonsense and frameshift variants to inform therapeutic strategy for cystic fibrosis
PLOS Genetics: published November 16, 2018 | https://doi.org/10.1371/journal.pgen.1007723
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus
PLOS Genetics: published November 16, 2018 | https://doi.org/10.1371/journal.pgen.1007755
The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity
PLOS Genetics: published November 19, 2018 | https://doi.org/10.1371/journal.pgen.1007462
Spen limits intestinal stem cell self-renewal
PLOS Genetics: published November 19, 2018 | https://doi.org/10.1371/journal.pgen.1007773
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Genetic variants influence on the placenta regulatory landscape
PLOS Genetics: published November 19, 2018 | https://doi.org/10.1371/journal.pgen.1007785
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FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation
PLOS Genetics: published November 19, 2018 | https://doi.org/10.1371/journal.pgen.1007787
Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima
PLOS Genetics: published November 19, 2018 | https://doi.org/10.1371/journal.pgen.1007794
Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ
PLOS Genetics: published November 19, 2018 | https://doi.org/10.1371/journal.pgen.1007805
Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish
PLOS Genetics: published November 20, 2018 | https://doi.org/10.1371/journal.pgen.1007743
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Evidence for gene-environment correlation in child feeding: Links between common genetic variation for BMI in children and parental feeding practices
PLOS Genetics: published November 20, 2018 | https://doi.org/10.1371/journal.pgen.1007757
Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin
PLOS Genetics: published November 20, 2018 | https://doi.org/10.1371/journal.pgen.1007767
Population sequencing reveals clonal diversity and ancestral inbreeding in the grapevine cultivar Chardonnay
PLOS Genetics: published November 20, 2018 | https://doi.org/10.1371/journal.pgen.1007807
Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila
PLOS Genetics: published November 21, 2018 | https://doi.org/10.1371/journal.pgen.1007659
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Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity
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Bacterial group II introns generate genetic diversity by circularization and trans-splicing from a population of intron-invaded mRNAs
PLOS Genetics: published November 21, 2018 | https://doi.org/10.1371/journal.pgen.1007792
TOR-autophagy branch signaling via Imp1 dictates plant-microbe biotrophic interface longevity
PLOS Genetics: published November 21, 2018 | https://doi.org/10.1371/journal.pgen.1007814
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Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development
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Interactions between the mRNA and Rps3/uS3 at the entry tunnel of the ribosomal small subunit are important for no-go decay
PLOS Genetics: published November 26, 2018 | https://doi.org/10.1371/journal.pgen.1007818
Anisotropic Crb accumulation, modulated by Src42A, is coupled to polarised epithelial tube growth in Drosophila
PLOS Genetics: published November 26, 2018 | https://doi.org/10.1371/journal.pgen.1007824
A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
PLOS Genetics: published November 26, 2018 | https://doi.org/10.1371/journal.pgen.1007836
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine
PLOS Genetics: published November 28, 2018 | https://doi.org/10.1371/journal.pgen.1007812
Nucleosome positions establish an extended mutation signature in melanoma
PLOS Genetics: published November 28, 2018 | https://doi.org/10.1371/journal.pgen.1007823
A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability
PLOS Genetics: published November 29, 2018 | https://doi.org/10.1371/journal.pgen.1007802
BLM prevents instability of structure-forming DNA sequences at common fragile sites
PLOS Genetics: published November 29, 2018 | https://doi.org/10.1371/journal.pgen.1007816
SPOC domain-containing protein Leaf inclination3 interacts with LIP1 to regulate rice leaf inclination through auxin signaling
PLOS Genetics: published November 29, 2018 | https://doi.org/10.1371/journal.pgen.1007829
Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80
PLOS Genetics: published November 29, 2018 | https://doi.org/10.1371/journal.pgen.1007832
Danger signals activate a putative innate immune system during regeneration in a filamentous fungus
PLOS Genetics: published November 30, 2018 | https://doi.org/10.1371/journal.pgen.1007390
De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay
PLOS Genetics: published November 30, 2018 | https://doi.org/10.1371/journal.pgen.1007671
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Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators
PLOS Genetics: published November 30, 2018 | https://doi.org/10.1371/journal.pgen.1007797
Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition
PLOS Genetics: published November 30, 2018 | https://doi.org/10.1371/journal.pgen.1007826
Correction
Correction: Drosophila species learn dialects through communal living
PLOS Genetics: published November 27, 2018 | https://doi.org/10.1371/journal.pgen.1007825
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Topic Page
Selfish genetic elements
PLOS Genetics: published November 15, 2018 | https://doi.org/10.1371/journal.pgen.1007700