July 2018

A light microscope image of dissected Drosophila ovary where DNA (white) reveals perfectly round nurse and follicle cell nuclei of intact egg chambers in addition to bright-staining, condensed fragmented DNA from apoptotic nurse cells expressing activated caspases (red). The outline of egg surfaces is labelled by wheatgerm agglutinin (green). Predatory wasps inject their eggs into Drosophila larvae, but adult female flies can see the predator, or simply be informed by other flies exposed to wasps, and flies deprive this predator of larvae by triggering death of its own oocytes and halting egg production. See Kacsoh et al.

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Image Credit: Balint Z. Kacsoh, Geisel School of Medicine at Dartmouth

Perspectives

Multiculturalism is good for flies, too

J. Robert Manak

PLOS Genetics: published July 19, 2018 | https://doi.org/10.1371/journal.pgen.1007480

C. elegans germline cell death, live!

Gabriela Huelgas Morales, David Greenstein

PLOS Genetics: published July 19, 2018 | https://doi.org/10.1371/journal.pgen.1007425

The anatomy of a nucleus: As revealed by chromosome painting

Brian D. Slaughter, R. Scott Hawley

PLOS Genetics: published July 12, 2018 | https://doi.org/10.1371/journal.pgen.1007445

Research Articles

High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor

Tetsuji Yamashita, Fei Zheng, David Finkelstein, Zoe Kellard, Robert Carter, Celeste D. Rosencrance, Ken Sugino, John Easton, Charles Gawad, Jian Zuo

PLOS Genetics: published July 31, 2018 | https://doi.org/10.1371/journal.pgen.1007552

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling

Olivia F. Duncan, Lucy Granat, Ramya Ranganathan, Vandana K. Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G. Ballard, Joseph M. Bateman

PLOS Genetics: published July 30, 2018 | https://doi.org/10.1371/journal.pgen.1007567

The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock

Elena Garre, Vicent Pelechano, Manuel Sánchez del Pino, Paula Alepuz, Per Sunnerhagen

PLOS Genetics: published July 30, 2018 | https://doi.org/10.1371/journal.pgen.1007563

DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF

Rémy Bétous, Théo Goullet de Rugy, Alessandra Luiza Pelegrini, Sophie Queille, Jean-Pierre de Villartay, Jean-Sébastien Hoffmann

PLOS Genetics: published July 30, 2018 | https://doi.org/10.1371/journal.pgen.1007541

Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes

Fergal M. Waldron, Graham N. Stone, Darren J. Obbard

PLOS Genetics: published July 30, 2018 | https://doi.org/10.1371/journal.pgen.1007533

Ancestral polymorphisms explain the role of chromosomal inversions in speciation

Zachary L. Fuller, Christopher J. Leonard, Randee E. Young, Stephen W. Schaeffer, Nitin Phadnis

PLOS Genetics: published July 30, 2018 | https://doi.org/10.1371/journal.pgen.1007526

Relationships between estimated autozygosity and complex traits in the UK Biobank

Emma C. Johnson, Luke M. Evans, Matthew C. Keller

PLOS Genetics: published July 27, 2018 | https://doi.org/10.1371/journal.pgen.1007556

Small GTPase Rab7-mediated FgAtg9 trafficking is essential for autophagy-dependent development and pathogenicity in Fusarium graminearum

Huawei Zheng, Pengfei Miao, Xiaolian Lin, Lingping Li, Congxian Wu, Xiaomin Chen, Yakubu Saddeeq Abubakar, Justice Norvienyeku, Guangpu Li, Jie Zhou, Zonghua Wang, Wenhui Zheng

PLOS Genetics: published July 25, 2018 | https://doi.org/10.1371/journal.pgen.1007546

Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism

Karl G. Thieme, Jennifer Gerke, Christoph Sasse, Oliver Valerius, Sabine Thieme, Razieh Karimi, Antje K. Heinrich, Florian Finkernagel, Kristina Smith, Helge B. Bode, Michael Freitag, Arthur F. J. Ram, Gerhard H. Braus

PLOS Genetics: published July 25, 2018 | https://doi.org/10.1371/journal.pgen.1007511

Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli

Yvonne Göpel, Boris Görke

PLOS Genetics: published July 24, 2018 | https://doi.org/10.1371/journal.pgen.1007547

Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment

Laura Whitton, Galina Apostolova, Dietmar Rieder, Georg Dechant, Stephen Rea, Gary Donohoe, Derek W. Morris

PLOS Genetics: published July 24, 2018 | https://doi.org/10.1371/journal.pgen.1007515

Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci

Celja J. Uebel, Dorian C. Anderson, Lisa M. Mandarino, Kevin I. Manage, Stephan Aynaszyan, Carolyn M. Phillips

PLOS Genetics: published July 23, 2018 | https://doi.org/10.1371/journal.pgen.1007542

Evolutionary plasticity in the innate immune function of Akirin

Jolanta Polanowska, Jia-Xuan Chen, Julien Soulé, Shizue Omi, Jerome Belougne, Clara Taffoni, Nathalie Pujol, Matthias Selbach, Olivier Zugasti, Jonathan J. Ewbank

PLOS Genetics: published July 23, 2018 | https://doi.org/10.1371/journal.pgen.1007494

Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized

Steven W. Miller, James W. Posakony

PLOS Genetics: published July 20, 2018 | https://doi.org/10.1371/journal.pgen.1007528

Binary addition in a living cell based on riboregulation

Arantxa Rosado, Teresa Cordero, Guillermo Rodrigo

PLOS Genetics: published July 19, 2018 | https://doi.org/10.1371/journal.pgen.1007548

Rad51 recruitment and exclusion of non-homologous end joining during homologous recombination at a Tus/Ter mammalian replication fork barrier

Nicholas A. Willis, Arvind Panday, Erin E. Duffey, Ralph Scully

PLOS Genetics: published July 19, 2018 | https://doi.org/10.1371/journal.pgen.1007486

Drosophila species learn dialects through communal living

Balint Z. Kacsoh, Julianna Bozler, Giovanni Bosco

PLOS Genetics: published July 19, 2018 | https://doi.org/10.1371/journal.pgen.1007430

Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis

Stephan A. Raiders, Michael D. Eastwood, Meghan Bacher, James R. Priess

PLOS Genetics: published July 19, 2018 | https://doi.org/10.1371/journal.pgen.1007417

Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σ^V in response to lysozyme

Lincoln T. Lewerke, Paige J. Kies, Ute Müh, Craig D. Ellermeier

PLOS Genetics: published July 18, 2018 | https://doi.org/10.1371/journal.pgen.1007527

Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans

Hans M. Dalton, Sean P. Curran

PLOS Genetics: published July 18, 2018 | https://doi.org/10.1371/journal.pgen.1007520

Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae

Norah Owiti, Shanqiao Wei, Ashok S. Bhagwat, Nayun Kim

PLOS Genetics: published July 17, 2018 | https://doi.org/10.1371/journal.pgen.1007516

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

Yu Jiang, Sai Chen, Daniel McGuire, Fang Chen, Mengzhen Liu, William G. Iacono, John K. Hewitt, John E. Hokanson, Kenneth Krauter, Markku Laakso, Kevin W. Li, Sharon M. Lutz, Matthew McGue, Anita Pandit, Gregory J. M. Zajac, Michael Boehnke, Goncalo R. Abecasis, Scott I. Vrieze, Xiaowei Zhan, Bibo Jiang, Dajiang J. Liu

PLOS Genetics: published July 17, 2018 | https://doi.org/10.1371/journal.pgen.1007452

The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility

Robert K. Maeda, Jessica L. Sitnik, Yohan Frei, Elodie Prince, Dragan Gligorov, Mariana F. Wolfner, François Karch

PLOS Genetics: published July 16, 2018 | https://doi.org/10.1371/journal.pgen.1007519

Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster

Paola Cusumano, Alberto Biscontin, Federica Sandrelli, Gabriella M. Mazzotta, Claudia Tregnago, Cristiano De Pittà, Rodolfo Costa

PLOS Genetics: published July 16, 2018 | https://doi.org/10.1371/journal.pgen.1007500

Sequence features governing aggregation or degradation of prion-like proteins

Sean M. Cascarina, Kacy R. Paul, Satoshi Machihara, Eric D. Ross

PLOS Genetics: published July 13, 2018 | https://doi.org/10.1371/journal.pgen.1007517

Stabilization of Bacillus subtilis Spx under cell wall stress requires the anti-adaptor protein YirB

Daniel F. Rojas-Tapias, John D. Helmann

PLOS Genetics: published July 12, 2018 | https://doi.org/10.1371/journal.pgen.1007531

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development

Jérôme Mastio, Célestine Simand, Giovanni Cova, Philippe Kastner, Susan Chan, Peggy Kirstetter

PLOS Genetics: published July 12, 2018 | https://doi.org/10.1371/journal.pgen.1007485

BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors

Ken Honjo, W. Daniel Tracey Jr

PLOS Genetics: published July 12, 2018 | https://doi.org/10.1371/journal.pgen.1007464

Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Johanna M. Huusko, Minna K. Karjalainen, Britney E. Graham, Ge Zhang, Emily G. Farrow, Neil A. Miller, Bo Jacobsson, Haley R. Eidem, Jeffrey C. Murray, Bruce Bedell, Patrick Breheny, Noah W. Brown, Frans L. Bødker, Nadia K. Litterman, Pan-Pan Jiang, Laura Russell, David A. Hinds, Youna Hu, the 23andMe Research Team, Antonis Rokas, Kari Teramo, Kaare Christensen, Scott M. Williams, Mika Rämet, Stephen F. Kingsmore, Kelli K. Ryckman, Mikko Hallman, Louis J. Muglia

PLOS Genetics: published July 12, 2018 | https://doi.org/10.1371/journal.pgen.1007394

Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei

Leah F. Rosin, Son C. Nguyen, Eric F. Joyce

PLOS Genetics: published July 12, 2018 | https://doi.org/10.1371/journal.pgen.1007393

Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability

Delphine Dardalhon-Cuménal, Jérôme Deraze, Camille A. Dupont, Valérie Ribeiro, Anne Coléno-Costes, Juliette Pouch, Stéphane Le Crom, Hélène Thomassin, Vincent Debat, Neel B. Randsholt, Frédérique Peronnet

PLOS Genetics: published July 11, 2018 | https://doi.org/10.1371/journal.pgen.1007498

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

Lucia Carolina Leal-Esteban, Benjamin Rothé, Simon Fortier, Manuela Isenschmid, Daniel B. Constam

PLOS Genetics: published July 11, 2018 | https://doi.org/10.1371/journal.pgen.1007487

Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

Fabio Lino Gratani, Petra Horvatek, Tobias Geiger, Marina Borisova, Christoph Mayer, Iwan Grin, Samuel Wagner, Wieland Steinchen, Gert Bange, Ana Velic, Boris Maček, Christiane Wolz

PLOS Genetics: published July 9, 2018 | https://doi.org/10.1371/journal.pgen.1007514

No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice

Vivek Iyer, Katharina Boroviak, Mark Thomas, Brendan Doe, Laura Riva, Edward Ryder, David J. Adams

PLOS Genetics: published July 9, 2018 | https://doi.org/10.1371/journal.pgen.1007503

GROWTH-REGULATING FACTOR 9 negatively regulates arabidopsis leaf growth by controlling ORG3 and restricting cell proliferation in leaf primordia

Mohammad Amin Omidbakhshfard, Ushio Fujikura, Justyna Jadwiga Olas, Gang-Ping Xue, Salma Balazadeh, Bernd Mueller-Roeber

PLOS Genetics: published July 9, 2018 | https://doi.org/10.1371/journal.pgen.1007484

Discovery of a dual protease mechanism that promotes DNA damage checkpoint recovery

Peter E. Burby, Zackary W. Simmons, Jeremy W. Schroeder, Lyle A. Simmons

PLOS Genetics: published July 6, 2018 | https://doi.org/10.1371/journal.pgen.1007512

Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy

Caroline Choquet, Thi Hong Minh Nguyen, Pierre Sicard, Emeline Buttigieg, Thi Thom Tran, Frank Kober, Isabelle Varlet, Rachel Sturny, Mauro W. Costa, Richard P. Harvey, Catherine Nguyen, Pascal Rihet, Sylvain Richard, Monique Bernard, Robert G. Kelly, Nathalie Lalevée, Lucile Miquerol

PLOS Genetics: published July 6, 2018 | https://doi.org/10.1371/journal.pgen.1007502

Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms

Phu Van Nguyen, Otakar Hlaváček, Jana Maršíková, Libuše Váchová, Zdena Palková

PLOS Genetics: published July 2, 2018 | https://doi.org/10.1371/journal.pgen.1007495

RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics

Antoine Claessens, Lynne M. Harris, Slavica Stanojcic, Lia Chappell, Adam Stanton, Nada Kuk, Pamela Veneziano-Broccia, Yvon Sterkers, Julian C. Rayner, Catherine J. Merrick

PLOS Genetics: published July 2, 2018 | https://doi.org/10.1371/journal.pgen.1007490

Cover

Fruit flies trigger oocyte apoptosis after exposure to predatory wasp.

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