May 2017

Multifunctional glial support by Semper cells in the Drosophila retina

Mark A. Charlton-Perkins, Edward D. Sendler, Elke K. Buschbeck, Tiffany A. Cook

PLOS Genetics: published May 31, 2017 | https://doi.org/10.1371/journal.pgen.1006782

Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination

Hang Su, Zhihao Cheng, Jiyue Huang, Juan Lin, Gregory P. Copenhaver, Hong Ma, Yingxiang Wang

PLOS Genetics: published May 31, 2017 | https://doi.org/10.1371/journal.pgen.1006827

MicroRNA319-regulated TCPs interact with FBHs and PFT1 to activate CO transcription and control flowering time in Arabidopsis

Jie Liu, Xiliu Cheng, Pan Liu, Dayong Li, Tao Chen, Xiaofeng Gu, Jiaqiang Sun

PLOS Genetics: published May 30, 2017 | https://doi.org/10.1371/journal.pgen.1006833

Amino acid metabolites that regulate G protein signaling during osmotic stress

James P. Shellhammer, Elizabeth Morin-Kensicki, Jacob P. Matson, Guowei Yin, Daniel G. Isom, Sharon L. Campbell, Robert P. Mohney, Henrik G. Dohlman

PLOS Genetics: published May 30, 2017 | https://doi.org/10.1371/journal.pgen.1006829

Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

Jun-Ho Cho, Goo-Young Kim, Chi-Jiunn Pan, Javier Anduaga, Eui-Ju Choi, Brian C. Mansfield, Janice Y. Chou

PLOS Genetics: published May 30, 2017 | https://doi.org/10.1371/journal.pgen.1006819

Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function

Qiuling Li, David A. Kellner, Hayden A. M. Hatch, Tomohiro Yumita, Sandrine Sanchez, Robert P. Machold, C. Andrew Frank, Nicholas Stavropoulos

PLOS Genetics: published May 30, 2017 | https://doi.org/10.1371/journal.pgen.1006815

The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan

Justin Minnerly, Jiuli Zhang, Thomas Parker, Tiffany Kaul, Kailiang Jia

PLOS Genetics: published May 30, 2017 | https://doi.org/10.1371/journal.pgen.1006764

Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae

Amanda Hurley, Bonnie L. Bassler

PLOS Genetics: published May 26, 2017 | https://doi.org/10.1371/journal.pgen.1006826

Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA

Jens Verbeeren, Bhupendra Verma, Elina H. Niemelä, Karen Yap, Eugene V. Makeyev, Mikko J. Frilander

PLOS Genetics: published May 26, 2017 | https://doi.org/10.1371/journal.pgen.1006824

C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation

Wenjing Qi, Yijian Yan, Dietmar Pfeifer, Erika Donner v. Gromoff, Yimin Wang, Wolfgang Maier, Ralf Baumeister

PLOS Genetics: published May 26, 2017 | https://doi.org/10.1371/journal.pgen.1006801

MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae

Lianwei Li, Xiaolin Chen, Shengpei Zhang, Jun Yang, Deng Chen, Muxing Liu, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Youliang Peng, Zhengguang Zhang

PLOS Genetics: published May 25, 2017 | https://doi.org/10.1371/journal.pgen.1006814

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Kelly Beagan, Robin L. Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E. Baker, Orlando D. Schärer, Mitch McVey

PLOS Genetics: published May 25, 2017 | https://doi.org/10.1371/journal.pgen.1006813

Human mutations in integrator complex subunits link transcriptome integrity to brain development

Renske Oegema, David Baillat, Rachel Schot, Leontine M. van Unen, Alice Brooks, Sima Kheradmand Kia, A. Jeannette M. Hoogeboom, Zheng Xia, Wei Li, Matteo Cesaroni, Maarten H. Lequin, Marjon van Slegtenhorst, William B. Dobyns, Irenaeus F. M. de Coo, Frans W. Verheijen, Andreas Kremer, Peter J. van der Spek, Daphne Heijsman, Eric J. Wagner, Maarten Fornerod, Grazia M. S. Mancini

PLOS Genetics: published May 25, 2017 | https://doi.org/10.1371/journal.pgen.1006809

Two extended haplotype blocks are associated with adaptation to high altitude habitats in East African honey bees

Andreas Wallberg, Caspar Schöning, Matthew T. Webster, Martin Hasselmann

PLOS Genetics: published May 25, 2017 | https://doi.org/10.1371/journal.pgen.1006792

Identifying pathogenicity of human variants via paralog-based yeast complementation

Fan Yang, Song Sun, Guihong Tan, Michael Costanzo, David E. Hill, Marc Vidal, Brenda J. Andrews, Charles Boone, Frederick P. Roth

PLOS Genetics: published May 25, 2017 | https://doi.org/10.1371/journal.pgen.1006779

Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile

Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer

PLOS Genetics: published May 25, 2017 | https://doi.org/10.1371/journal.pgen.1006756

Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host

Maite Echeverz, Begoña García, Amaia Sabalza, Jaione Valle, Toni Gabaldón, Cristina Solano, Iñigo Lasa

PLOS Genetics: published May 24, 2017 | https://doi.org/10.1371/journal.pgen.1006816

Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation

Sunny Sharma, Jun Yang, Rob van Nues, Peter Watzinger, Peter Kötter, Denis L. J. Lafontaine, Sander Granneman, Karl-Dieter Entian

PLOS Genetics: published May 24, 2017 | https://doi.org/10.1371/journal.pgen.1006804

Polymorphisms in the yeast galactose sensor underlie a natural continuum of nutrient-decision phenotypes

Kayla B. Lee, Jue Wang, Julius Palme, Renan Escalante-Chong, Bo Hua, Michael Springer

PLOS Genetics: published May 24, 2017 | https://doi.org/10.1371/journal.pgen.1006766

Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis

Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F. Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria O’Donovan, Nick J. Gay, the OCCAMS Consortium, Rebecca C. Fitzgerald

PLOS Genetics: published May 22, 2017 | https://doi.org/10.1371/journal.pgen.1006808

Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis

Sei-Kyoung Park, Joo Y. Hong, Fatih Arslan, Vydehi Kanneganti, Basant Patel, Alex Tietsort, Elizabeth M. H. Tank, Xingli Li, Sami J. Barmada, Susan W. Liebman

PLOS Genetics: published May 22, 2017 | https://doi.org/10.1371/journal.pgen.1006805

Evolutionary forces affecting synonymous variations in plant genomes

Yves Clément, Gautier Sarah, Yan Holtz, Felix Homa, Stéphanie Pointet, Sandy Contreras, Benoit Nabholz, François Sabot, Laure Sauné, Morgane Ardisson, Roberto Bacilieri, Guillaume Besnard, Angélique Berger, Céline Cardi, Fabien De Bellis, Olivier Fouet, Cyril Jourda, Bouchaib Khadari, Claire Lanaud, Thierry Leroy, David Pot, Christopher Sauvage, Nora Scarcelli, James Tregear, Yves Vigouroux, Nabila Yahiaoui, Manuel Ruiz, Sylvain Santoni, Jean-Pierre Labouisse, Jean-Louis Pham, Jacques David, Sylvain Glémin

PLOS Genetics: published May 22, 2017 | https://doi.org/10.1371/journal.pgen.1006799

Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba

Rebekah L. Rogers, Ling Shao, Kevin R. Thornton

PLOS Genetics: published May 22, 2017 | https://doi.org/10.1371/journal.pgen.1006795

Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicity

Hellen Houlleberghs, Anne Goverde, Jarnick Lusseveld, Marleen Dekker, Marco J. Bruno, Fred H. Menko, Arjen R. Mensenkamp, Manon C. W. Spaander, Anja Wagner, Robert M. W. Hofstra, Hein te Riele

PLOS Genetics: published May 22, 2017 | https://doi.org/10.1371/journal.pgen.1006765

Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli

Sylvie Létoffé, Sabina Chalabaev, José Dugay, Franziska Stressmann, Bianca Audrain, Jean-Charles Portais, Fabien Letisse, Jean-Marc Ghigo

PLOS Genetics: published May 19, 2017 | https://doi.org/10.1371/journal.pgen.1006800

Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam

Trupti Panchal, Xi Chen, Ekaterina Alchits, Youjin Oh, James Poon, Jane Kouptsova, Frank A. Laski, Dorothea Godt

PLOS Genetics: published May 19, 2017 | https://doi.org/10.1371/journal.pgen.1006790

Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations

Karen Ocorr, Alexander Zambon, Yoav Nudell, Santiago Pineda, Soda Diop, Min Tang, Takeshi Akasaka, Erika Taylor

PLOS Genetics: published May 19, 2017 | https://doi.org/10.1371/journal.pgen.1006786

Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans

Rosalind Hussey, Jon Stieglitz, Jaleh Mesgarzadeh, Tiffany T. Locke, Ying K. Zhang, Frank C. Schroeder, Supriya Srinivasan

PLOS Genetics: published May 18, 2017 | https://doi.org/10.1371/journal.pgen.1006806

Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma

Lee D. McDaniel, Karina L. Conkrite, Xiao Chang, Mario Capasso, Zalman Vaksman, Derek A. Oldridge, Anna Zachariou, Millicent Horn, Maura Diamond, Cuiping Hou, Achille Iolascon, Hakon Hakonarson, Nazneen Rahman, Marcella Devoto, Sharon J. Diskin

PLOS Genetics: published May 18, 2017 | https://doi.org/10.1371/journal.pgen.1006787

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control

Kazunori Kume, Helena Cantwell, Frank R. Neumann, Andrew W. Jones, Ambrosius P. Snijders, Paul Nurse

PLOS Genetics: published May 18, 2017 | https://doi.org/10.1371/journal.pgen.1006767

The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain

Yen-Chi Wu, Kyu-Sun Lee, Yan Song, Stephan Gehrke, Bingwei Lu

PLOS Genetics: published May 17, 2017 | https://doi.org/10.1371/journal.pgen.1006785

Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd

Shin-ichi Tokuhiro, Miki Tokuoka, Kenji Kobayashi, Atsushi Kubo, Izumi Oda-Ishii, Yutaka Satou

PLOS Genetics: published May 17, 2017 | https://doi.org/10.1371/journal.pgen.1006741

The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure

Fioranna Renda, Claudia Pellacani, Anton Strunov, Elisabetta Bucciarelli, Valeria Naim, Giuseppe Bosso, Elena Kiseleva, Silvia Bonaccorsi, David J. Sharp, Alexey Khodjakov, Maurizio Gatti, Maria Patrizia Somma

PLOS Genetics: published May 15, 2017 | https://doi.org/10.1371/journal.pgen.1006784

Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness

Adi Hendler, Edgar M. Medina, Anastasiya Kishkevich, Mehtap Abu-Qarn, Steffi Klier, Nicolas E. Buchler, Robertus A. M. de Bruin, Amir Aharoni

PLOS Genetics: published May 15, 2017 | https://doi.org/10.1371/journal.pgen.1006778

Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

Corentin Claeys Bouuaert, Scott Keeney

PLOS Genetics: published May 15, 2017 | https://doi.org/10.1371/journal.pgen.1006722

MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain

Sabine Lagger, John C. Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H. Ramsahoye, Miao Yu, Chuan He, Guido Sanguinetti, Lawrence C. Sowers, Malcolm D. Walkinshaw, Adrian Bird

PLOS Genetics: published May 12, 2017 | https://doi.org/10.1371/journal.pgen.1006793

USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis

Arindam Das, Jin Qian, William Y. Tsang

PLOS Genetics: published May 12, 2017 | https://doi.org/10.1371/journal.pgen.1006791

Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition

Gabriele Wagner, Nishant Singhal, Dario Nicetto, Tobias Straub, Elisabeth Kremmer, Ralph A. W. Rupp

PLOS Genetics: published May 12, 2017 | https://doi.org/10.1371/journal.pgen.1006757

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

Jingjing Liang, Thu H. Le, Digna R. Velez Edwards, Bamidele O. Tayo, Kyle J. Gaulton, Jennifer A. Smith, Yingchang Lu, Richard A. Jensen, Guanjie Chen, Lisa R. Yanek, Karen Schwander, Salman M. Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A. McKenzie, Ervin Fox, Michael A. Nalls, J. Hunter Young, Yan V. Sun, Jacqueline M. Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K. Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W. Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K. Evans, Alanna C. Morrison, Lisa W. Martin, Kerri L. Wiggins, Qin Hui, Wei Zhao, Rebecca D. Jackson, Erin B. Ware, Jessica D. Faul, Alex P. Reiner, Michael Bray, Joshua C. Denny, Thomas H. Mosley, Walter Palmas, Xiuqing Guo, George J. Papanicolaou, Alan D. Penman, Joseph F. Polak, Kenneth Rice, Ken D. Taylor, Eric Boerwinkle, Erwin P. Bottinger, Kiang Liu, Neil Risch, Steven C. Hunt, Charles Kooperberg, Alan B. Zonderman, Cathy C. Laurie, Diane M. Becker, Jianwen Cai, Ruth J. F. Loos, Bruce M. Psaty, David R. Weir, Sharon L. R. Kardia, Donna K. Arnett, Sungho Won, Todd L. Edwards, Susan Redline, Richard S. Cooper, D. C. Rao, Jerome I. Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini

PLOS Genetics: published May 12, 2017 | https://doi.org/10.1371/journal.pgen.1006728

Amplifying recombination genome-wide and reshaping crossover landscapes in Brassicas

Alexandre Pelé, Matthieu Falque, Gwenn Trotoux, Frédérique Eber, Sylvie Nègre, Marie Gilet, Virginie Huteau, Maryse Lodé, Thibaut Jousseaume, Sylvain Dechaumet, Jérôme Morice, Charles Poncet, Olivier Coriton, Olivier C. Martin, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre

PLOS Genetics: published May 11, 2017 | https://doi.org/10.1371/journal.pgen.1006794

Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor

Vandana Sharma, Anuj K. Pandey, Ajay Kumar, Snigdha Misra, Himanshu P. K. Gupta, Snigdha Gupta, Anshuman Singh, Norene A. Buehner, Kristipati Ravi Ram

PLOS Genetics: published May 11, 2017 | https://doi.org/10.1371/journal.pgen.1006788

Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains

Edward E. Large, Raghavendra Padmanabhan, Kathie L. Watkins, Richard F. Campbell, Wen Xu, Patrick T. McGrath

PLOS Genetics: published May 11, 2017 | https://doi.org/10.1371/journal.pgen.1006769

Power provides protection: Genetic robustness in yeast depends on the capacity to generate energy

Marcin Plech, Katarzyna Tomala, Hanna Tutaj, Dominika Ewa Piwcewicz, J. Arjan G. M. de Visser, Ryszard Korona

PLOS Genetics: published May 11, 2017 | https://doi.org/10.1371/journal.pgen.1006768

Global analysis of double-strand break processing reveals in vivo properties of the helicase-nuclease complex AddAB

Anjana Badrinarayanan, Tung B. K. Le, Jan-Hendrik Spille, Ibrahim I. Cisse, Michael T. Laub

PLOS Genetics: published May 10, 2017 | https://doi.org/10.1371/journal.pgen.1006783

Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature

Nils Johan Fredriksson, Kerryn Elliott, Stefan Filges, Jimmy Van den Eynden, Anders Ståhlberg, Erik Larsson

PLOS Genetics: published May 10, 2017 | https://doi.org/10.1371/journal.pgen.1006773

An R2R3-type MYB transcription factor, GmMYB29, regulates isoflavone biosynthesis in soybean

Shanshan Chu, Jiao Wang, Ying Zhu, Shulin Liu, Xiaoqiong Zhou, Huairen Zhang, Chun-e Wang, Wenming Yang, Zhixi Tian, Hao Cheng, Deyue Yu

PLOS Genetics: published May 10, 2017 | https://doi.org/10.1371/journal.pgen.1006770

Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants

Clara Serra-Juhé, Gabriel Á. Martos-Moreno, Francesc Bou de Pieri, Raquel Flores, Juan R. González, Benjamín Rodríguez-Santiago, Jesús Argente, Luis A. Pérez-Jurado

PLOS Genetics: published May 10, 2017 | https://doi.org/10.1371/journal.pgen.1006657

Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains

Stéphane Duigou, Frédéric Boccard

PLOS Genetics: published May 9, 2017 | https://doi.org/10.1371/journal.pgen.1006758

PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast

Yasukazu Daigaku, Thomas J. Etheridge, Yuka Nakazawa, Mayumi Nakayama, Adam T. Watson, Izumi Miyabe, Tomoo Ogi, Mark A. Osborne, Antony M. Carr

PLOS Genetics: published May 8, 2017 | https://doi.org/10.1371/journal.pgen.1006789

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

Juyong Brian Kim, Milos Pjanic, Trieu Nguyen, Clint L. Miller, Dharini Iyer, Boxiang Liu, Ting Wang, Olga Sazonova, Ivan Carcamo-Orive, Ljubica Perisic Matic, Lars Maegdefessel, Ulf Hedin, Thomas Quertermous

PLOS Genetics: published May 8, 2017 | https://doi.org/10.1371/journal.pgen.1006750

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

Sandra Muñoz-Galván, María García-Rubio, Pedro Ortega, Jose F. Ruiz, Sonia Jimeno, Benjamin Pardo, Belén Gómez-González, Andrés Aguilera

PLOS Genetics: published May 5, 2017 | https://doi.org/10.1371/journal.pgen.1006781

SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion

Minghua Nie, Bettina A. Moser, Toru M. Nakamura, Michael N. Boddy

PLOS Genetics: published May 5, 2017 | https://doi.org/10.1371/journal.pgen.1006776

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless

Heiko Praxenthaler, Anja C. Nagel, Adriana Schulz, Mirjam Zimmermann, Markus Meier, Hannes Schmid, Anette Preiss, Dieter Maier

PLOS Genetics: published May 5, 2017 | https://doi.org/10.1371/journal.pgen.1006774

Long-range control of gene expression via RNA-directed DNA methylation

M. Jordan Rowley, M. Hafiz Rothi, Gudrun Böhmdorfer, Jan Kuciński, Andrzej T. Wierzbicki

PLOS Genetics: published May 5, 2017 | https://doi.org/10.1371/journal.pgen.1006749

Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump

Toke Jost Isaksen, Lieke Kros, Natascia Vedovato, Thomas Hellesøe Holm, Ariel Vitenzon, David C. Gadsby, Kamran Khodakhah, Karin Lykke-Hartmann

PLOS Genetics: published May 4, 2017 | https://doi.org/10.1371/journal.pgen.1006763

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Nucleocytoplasmic transport and nuclear membrane expansion are critical for nuclear size control.

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