May 2016

African trypanosome parasites are densely coated in a single Variant Surface Glycoprotein (VSG - visualized here by immunofluorescence microscopy, DAPI staining are shown). While growing in the bloodstream of humans and other mammals, Trypanosoma brucei species evade the host immune response by switching from the expression of one VSG coat to another. This requires selection and activation of a single new VSG gene from a huge number of possible VSG variants encoded throughout the genome. In this study, we showed that selection of VSG donors from the genomic archive requires a specific repetitive DNA element and defined its critical features. See Hovel-Miner et al.

Image Credit: Mark Field, University of Cambridge

Viewpoints

Genomic Imprinting: A New Epigenetic Perspective of Sleep Regulation

Valter Tucci

PLOS Genetics: published May 26, 2016 | https://doi.org/10.1371/journal.pgen.1006004

Perspectives

Animal Models Are Valid to Uncover Disease Mechanisms

Wolfgang Wurst

PLOS Genetics: published May 26, 2016 | https://doi.org/10.1371/journal.pgen.1006013

Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3′UTRs

Oliver Mühlemann

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1005979

Hypothalamic Leptin Resistance: From BBB to BBSome

Miguel López

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1005980

Review

Exploiting Genetic Interference for Antiviral Therapy

Elizabeth J. Tanner, Karla A. Kirkegaard, Leor S. Weinberger

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1005986

Research Articles

The Great Migration and African-American Genomic Diversity

Soheil Baharian, Maxime Barakatt, Christopher R. Gignoux, Suyash Shringarpure, Jacob Errington, William J. Blot, Carlos D. Bustamante, Eimear E. Kenny, Scott M. Williams, Melinda C. Aldrich, Simon Gravel

PLOS Genetics: published May 27, 2016 | https://doi.org/10.1371/journal.pgen.1006059

Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

Wenhua Li, Aiyu Yao, Hui Zhi, Kuldeep Kaur, Yong-chuan Zhu, Mingyue Jia, Hui Zhao, Qifu Wang, Shan Jin, Guoli Zhao, Zhi-Qi Xiong, Yong Q. Zhang

PLOS Genetics: published May 27, 2016 | https://doi.org/10.1371/journal.pgen.1006062

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein

Nirmalya Chatterjee, Min Tian, Kerstin Spirohn, Michael Boutros, Dirk Bohmann

PLOS Genetics: published May 27, 2016 | https://doi.org/10.1371/journal.pgen.1006072

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Sveta Chakrabarti, Jan Paul Dudzic, Xiaoxue Li, Esther Jeanne Collas, Jean-Phillipe Boquete, Bruno Lemaitre

PLOS Genetics: published May 27, 2016 | https://doi.org/10.1371/journal.pgen.1006089

The Gene Expression Program for the Formation of Wing Cuticle in Drosophila

Lukasz F. Sobala, Paul N. Adler

PLOS Genetics: published May 27, 2016 | https://doi.org/10.1371/journal.pgen.1006100

Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution

Jeremy B. Rothschild, Panagiotis Tsimiklis, Eric D. Siggia, Paul François

PLOS Genetics: published May 26, 2016 | https://doi.org/10.1371/journal.pgen.1006052

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion

Zuopeng Wu, Rong Liang, Thomas Ohnesorg, Vicky Cho, Wesley Lam, Walter P. Abhayaratna, Paul A. Gatenby, Chandima Perera, Yafei Zhang, Belinda Whittle, Andrew Sinclair, Christopher C. Goodnow, Matthew Field, T. Daniel Andrews, Matthew C. Cook

PLOS Genetics: published May 26, 2016 | https://doi.org/10.1371/journal.pgen.1006067

The Contribution of GWAS Loci in Familial Dyslipidemias

Pietari Ripatti, Joel T. Rämö, Sanni Söderlund, Ida Surakka, Niina Matikainen, Matti Pirinen, Päivi Pajukanta, Antti-Pekka Sarin, Susan K. Service, Pirkka-Pekka Laurila, Christian Ehnholm, Veikko Salomaa, Richard K. Wilson, Aarno Palotie, Nelson B. Freimer, Marja-Riitta Taskinen, Samuli Ripatti

PLOS Genetics: published May 26, 2016 | https://doi.org/10.1371/journal.pgen.1006078

Molecular Basis and Therapeutic Strategies to Rescue Factor IX Variants That Affect Splicing and Protein Function

Mojca Tajnik, Malgorzata Ewa Rogalska, Erica Bussani, Elena Barbon, Dario Balestra, Mirko Pinotti, Franco Pagani

PLOS Genetics: published May 26, 2016 | https://doi.org/10.1371/journal.pgen.1006082

NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans

Jason C. Campbell, Lauren F. Polan-Couillard, Ian D. Chin-Sang, William G. Bendena

PLOS Genetics: published May 25, 2016 | https://doi.org/10.1371/journal.pgen.1006050

miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga

Ana Laura De Lella Ezcurra, Agustina Paola Bertolin, Kevin Kim, Maximiliano Javier Katz, Lautaro Gándara, Tvisha Misra, Stefan Luschnig, Norbert Perrimon, Mariana Melani, Pablo Wappner

PLOS Genetics: published May 25, 2016 | https://doi.org/10.1371/journal.pgen.1006073

High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree

Linnéa Smeds, Carina F. Mugal, Anna Qvarnström, Hans Ellegren

PLOS Genetics: published May 24, 2016 | https://doi.org/10.1371/journal.pgen.1006044

The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase Variation

Kyle P. Obergfell, H. Steven Seifert

PLOS Genetics: published May 23, 2016 | https://doi.org/10.1371/journal.pgen.1006069

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus

Dorota Skotnicka, Gregory T. Smaldone, Tobias Petters, Eleftheria Trampari, Jennifer Liang, Volkhard Kaever, Jacob G. Malone, Mitchell Singer, Lotte Søgaard-Andersen

PLOS Genetics: published May 23, 2016 | https://doi.org/10.1371/journal.pgen.1006080

Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma

Yung-Feng Lin, Ling-Hui Li, Chih-Hung Lin, Mei-Hua Tsou, Ming-Tai Kiffer Chuang, Keh-Ming Wu, Tsai-Lien Liao, Jian-Chiuan Li, Wei-Jie Wang, Angela Tomita, Beverly Tomita, Shiu-Feng Huang, Shih-Feng Tsai

PLOS Genetics: published May 20, 2016 | https://doi.org/10.1371/journal.pgen.1006051

Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells

Liyong Zeng, Cheguo Cai, Shan Li, Wenjuan Wang, Yaping Li, Jiangye Chen, Xueliang Zhu, Yi Arial Zeng

PLOS Genetics: published May 20, 2016 | https://doi.org/10.1371/journal.pgen.1006055

Antimicrobial Functions of Lactoferrin Promote Genetic Conflicts in Ancient Primates and Modern Humans

Matthew F. Barber, Zev Kronenberg, Mark Yandell, Nels C. Elde

PLOS Genetics: published May 20, 2016 | https://doi.org/10.1371/journal.pgen.1006063

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

Xudong Liu, Chuan-En Wang, Yan Hong, Ting Zhao, Guohao Wang, Marta A. Gaertig, Miao Sun, Shihua Li, Xiao-Jiang Li

PLOS Genetics: published May 20, 2016 | https://doi.org/10.1371/journal.pgen.1006083

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

Heshan Peiris, Michael D. Duffield, Joao Fadista, Claire F. Jessup, Vinder Kashmir, Amanda J. Genders, Sean L. McGee, Alyce M. Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A. Cousin, Alexandros C. Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A. Hough, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Jorge Busciglio, Pinar E. Coskun, Ann Becker, Pavel V. Belichenko, William C. Mobley, Michael T. Ryan, Jeng Yie Chan, D. Ross Laybutt, P. Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A. Pritchard, Damien J. Keating

PLOS Genetics: published May 19, 2016 | https://doi.org/10.1371/journal.pgen.1006033

The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer

Anne-Mette Hartung, Jeff Swensen, Inaki E. Uriz, Morten Lapin, Karen Kristjansdottir, Ulrika S. S. Petersen, Jeanne Mari V. Bang, Barbara Guerra, Henriette Skovgaard Andersen, Steven F. Dobrowolski, John C. Carey, Ping Yu, Cecily Vaughn, Amy Calhoun, Martin R. Larsen, Lars Dyrskjøt, David A. Stevenson, Brage S. Andresen

PLOS Genetics: published May 19, 2016 | https://doi.org/10.1371/journal.pgen.1006039

Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

Tongchao Li, Junkai Fan, Bernardo Blanco-Sánchez, Nikolaos Giagtzoglou, Guang Lin, Shinya Yamamoto, Manish Jaiswal, Kuchuan Chen, Jie Zhang, Wei Wei, Michael T. Lewis, Andrew K. Groves, Monte Westerfield, Jianhang Jia, Hugo J. Bellen

PLOS Genetics: published May 19, 2016 | https://doi.org/10.1371/journal.pgen.1006054

Additive Expression of Consolidated Memory through Drosophila Mushroom Body Subsets

Chu-Huai Yang, Meng-Fu Maxwell Shih, Ching-Ching Chang, Meng-Hsuan Chiang, Hsiang-Wen Shih, Ya-Lun Tsai, Ann-Shyn Chiang, Tsai-Feng Fu, Chia-Lin Wu

PLOS Genetics: published May 19, 2016 | https://doi.org/10.1371/journal.pgen.1006061

Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking

Katarzyna M. Kowalczyk, Janni Petersen

PLOS Genetics: published May 18, 2016 | https://doi.org/10.1371/journal.pgen.1006041

Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling

Joo Yeun Lee, Jessica Y. Chen, Jillian L. Shaw, Karen T. Chang

PLOS Genetics: published May 18, 2016 | https://doi.org/10.1371/journal.pgen.1006043

The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles

Irini Topalidou, Jérôme Cattin-Ortolá, Andrea L. Pappas, Kirsten Cooper, Gennifer E. Merrihew, Michael J. MacCoss, Michael Ailion

PLOS Genetics: published May 18, 2016 | https://doi.org/10.1371/journal.pgen.1006074

Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes

Marjo K. Hytönen, Meharji Arumilli, Anu K. Lappalainen, Marta Owczarek-Lipska, Vidhya Jagannathan, Sruthi Hundi, Elina Salmela, Patrick Venta, Eva Sarkiala, Tarja Jokinen, Daniela Gorgas, Juha Kere, Pekka Nieminen, Cord Drögemüller, Hannes Lohi

PLOS Genetics: published May 17, 2016 | https://doi.org/10.1371/journal.pgen.1006037

A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior

Anne-Lyse Denizot, Vanessa Besson, Rosa Maria Correra, Alessia Mazzola, Izolina Lopes, Jean-Remy Courbard, Giovanna Marazzi, David A. Sassoon

PLOS Genetics: published May 17, 2016 | https://doi.org/10.1371/journal.pgen.1006053

Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation

Ana Bratic, Paula Clemente, Javier Calvo-Garrido, Camilla Maffezzini, Andrea Felser, Rolf Wibom, Anna Wedell, Christoph Freyer, Anna Wredenberg

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006028

The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa

Gaël Chambonnier, Lorène Roux, David Redelberger, Firas Fadel, Alain Filloux, Melissa Sivaneson, Sophie de Bentzmann, Christophe Bordi

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006032

Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder

Christine B. Peterson, Susan K. Service, Anna J. Jasinska, Fuying Gao, Ivette Zelaya, Terri M. Teshiba, Carrie E. Bearden, Rita M. Cantor, Victor I. Reus, Gabriel Macaya, Carlos López-Jaramillo, Marina Bogomolov, Yoav Benjamini, Eleazar Eskin, Giovanni Coppola, Nelson B. Freimer, Chiara Sabatti

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006046

The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis

Yemima Budirahardja, Pei Yi Tan, Thang Doan, Peter Weisdepp, Ronen Zaidel-Bar

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006048

A Genetic Screen Identifies a Requirement for Cysteine-Rich–Receptor-Like Kinases in Rice NH1 (OsNPR1)-Mediated Immunity

Mawsheng Chern, Qiufang Xu, Rebecca S. Bart, Wei Bai, Deling Ruan, Wing Hoi Sze-To, Patrick E. Canlas, Rashmi Jain, Xuewei Chen, Pamela C. Ronald

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006049

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

Benoît Vanderperre, Sébastien Herzig, Petra Krznar, Manuel Hörl, Zeinab Ammar, Sylvie Montessuit, Sandra Pierredon, Nicola Zamboni, Jean-Claude Martinou

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006056

A Ploidy-Sensitive Mechanism Regulates Aperture Formation on the Arabidopsis Pollen Surface and Guides Localization of the Aperture Factor INP1

Sarah H. Reeder, Byung Ha Lee, Ronald Fox, Anna A. Dobritsa

PLOS Genetics: published May 13, 2016 | https://doi.org/10.1371/journal.pgen.1006060

Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes

C. Jake Harris, Dylan Husmann, Wanlu Liu, Farid El Kasmi, Haifeng Wang, Ashot Papikian, William A. Pastor, Guillaume Moissiard, Ajay A. Vashisht, Jeffery L. Dangl, James A. Wohlschlegel, Steven E. Jacobsen

PLOS Genetics: published May 12, 2016 | https://doi.org/10.1371/journal.pgen.1005998

Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development—Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

Katarina Truvé, Peter Dickinson, Anqi Xiong, Daniel York, Kartika Jayashankar, Gerli Pielberg, Michele Koltookian, Eva Murén, Hans-Henrik Fuxelius, Holger Weishaupt, Fredrik J. Swartling, Göran Andersson, Åke Hedhammar, Erik Bongcam-Rudloff, Karin Forsberg-Nilsson, Danika Bannasch, Kerstin Lindblad-Toh

PLOS Genetics: published May 12, 2016 | https://doi.org/10.1371/journal.pgen.1006000

Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome

Hafez El Sayyed, Ludovic Le Chat, Elise Lebailly, Elise Vickridge, Carine Pages, Francois Cornet, Marco Cosentino Lagomarsino, Olivier Espéli

PLOS Genetics: published May 12, 2016 | https://doi.org/10.1371/journal.pgen.1006025

Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis

Zhang-Wei Liu, Jin-Xing Zhou, Huan-Wei Huang, Yong-Qiang Li, Chang-Rong Shao, Lin Li, Tao Cai, She Chen, Xin-Jian He

PLOS Genetics: published May 12, 2016 | https://doi.org/10.1371/journal.pgen.1006026

A Mouse Model for Conditional Secretion of Specific Single-Chain Antibodies Provides Genetic Evidence for Regulation of Cortical Plasticity by a Non-cell Autonomous Homeoprotein Transcription Factor

Clémence Bernard, Clémentine Vincent, Damien Testa, Eva Bertini, Jérôme Ribot, Ariel A. Di Nardo, Michel Volovitch, Alain Prochiantz

PLOS Genetics: published May 12, 2016 | https://doi.org/10.1371/journal.pgen.1006035

DNA Sequence Evolution and Rare Homoeologous Conversion in Tetraploid Cotton

Justin T. Page, Zach S. Liechty, Rich H. Alexander, Kimberly Clemons, Amanda M. Hulse-Kemp, Hamid Ashrafi, Allen Van Deynze, David M. Stelly, Joshua A. Udall

PLOS Genetics: published May 11, 2016 | https://doi.org/10.1371/journal.pgen.1006012

BOD1 Is Required for Cognitive Function in Humans and Drosophila

Sahar Esmaeeli-Nieh, Michaela Fenckova, Iain M. Porter, M. Mahdi Motazacker, Bonnie Nijhof, Anna Castells-Nobau, Zoltan Asztalos, Robert Weißmann, Farkhondeh Behjati, Andreas Tzschach, Ute Felbor, Harry Scherthan, Seyed Morteza Sayfati, H. Hilger. Ropers, Kimia Kahrizi, Hossein Najmabadi, Jason R. Swedlow, Annette Schenck, Andreas W. Kuss

PLOS Genetics: published May 11, 2016 | https://doi.org/10.1371/journal.pgen.1006022

Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States

Konrad L. M. Rudolph, Bianca M. Schmitt, Diego Villar, Robert J. White, John C. Marioni, Claudia Kutter, Duncan T. Odom

PLOS Genetics: published May 11, 2016 | https://doi.org/10.1371/journal.pgen.1006024

The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function

Weili Cai, Youheng Wei, Michal Jarnik, John Reich, Mary A. Lilly

PLOS Genetics: published May 11, 2016 | https://doi.org/10.1371/journal.pgen.1006036

Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours

Malin Melin, Patricio Rivera, Maja Arendt, Ingegerd Elvers, Eva Murén, Ulla Gustafson, Mike Starkey, Kaja Sverdrup Borge, Frode Lingaas, Jens Häggström, Sara Saellström, Henrik Rönnberg, Kerstin Lindblad-Toh

PLOS Genetics: published May 9, 2016 | https://doi.org/10.1371/journal.pgen.1006029

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

Anthony R. Isles, Andrés Ingason, Chelsea Lowther, James Walters, Micha Gawlick, Gerald Stöber, Elliott Rees, Joanna Martin, Rosie B. Little, Harry Potter, Lyudmila Georgieva, Lucilla Pizzo, Norio Ozaki, Branko Aleksic, Itaru Kushima, Masashi Ikeda, Nakao Iwata, Douglas F. Levinson, Pablo V. Gejman, Jianxin Shi, Alan R. Sanders, Jubao Duan, Joseph Willis, Sanjay Sisodiya, Gregory Costain, Thomas M. Werge, Franziska Degenhardt, Ina Giegling, Dan Rujescu, Stefan J. Hreidarsson, Evald Saemundsen, Joo Wook Ahn, Caroline Ogilvie, Santhosh D. Girirajan, Hreinn Stefansson, Kari Stefansson, Michael C. O’Donovan, Michael J. Owen, Anne Bassett, George Kirov

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1005993

Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of Nematodes

Kevin Lebrigand, Le D. He, Nishant Thakur, Marie-Jeanne Arguel, Jolanta Polanowska, Bernard Henrissat, Eric Record, Ghislaine Magdelenat, Valérie Barbe, Sylvain Raffaele, Pascal Barbry, Jonathan J. Ewbank

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1006017

PABPN1-Dependent mRNA Processing Induces Muscle Wasting

Muhammad Riaz, Yotam Raz, Maaike van Putten, Guillem Paniagua-Soriano, Yvonne D. Krom, Bogdan I. Florea, Vered Raz

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1006031

Testing Rare-Variant Association without Calling Genotypes Allows for Systematic Differences in Sequencing between Cases and Controls

Yi-Juan Hu, Peizhou Liao, H. Richard Johnston, Andrew S. Allen, Glen A. Satten

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1006040

Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease

Chan Chung, Matthew J. Elrick, James M. Dell’Orco, Zhaohui S. Qin, Shanker Kalyana-Sundaram, Arul M. Chinnaiyan, Vikram G. Shakkottai, Andrew P. Lieberman

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1006042

A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo

Izumi Oda-Ishii, Atsushi Kubo, Willi Kari, Nobuhiro Suzuki, Ute Rothbächer, Yutaka Satou

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1006045

Enhancement of Transcription by a Splicing-Competent Intron Is Dependent on Promoter Directionality

Neha Agarwal, Athar Ansari

PLOS Genetics: published May 6, 2016 | https://doi.org/10.1371/journal.pgen.1006047

Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay

Grigorios Fanourgakis, Mathias Lesche, Müge Akpinar, Andreas Dahl, Rolf Jessberger

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1005857

UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

Jianqiang Bao, Kristoffer Vitting-Seerup, Johannes Waage, Chong Tang, Ying Ge, Bo T. Porse, Wei Yan

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1005863

A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive

Galadriel Hovel-Miner, Monica R. Mugnier, Benjamin Goldwater, George A. M. Cross, F. Nina Papavasiliou

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1005994

The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa

Macarena Toll-Riera, Alvaro San Millan, Andreas Wagner, R. Craig MacLean

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1006005

Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene

Dan Vodo, Ofer Sarig, Shamir Geller, Edna Ben-Asher, Tsviya Olender, Ron Bochner, Ilan Goldberg, Judith Nosgorodsky, Anna Alkelai, Pavel Tatarskyy, Alon Peled, Sharon Baum, Aviv Barzilai, Saleh M. Ibrahim, Detlef Zillikens, Doron Lancet, Eli Sprecher

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1006008

Recombination-Independent Recognition of DNA Homology for Repeat-Induced Point Mutation (RIP) Is Modulated by the Underlying Nucleotide Sequence

Eugene Gladyshev, Nancy Kleckner

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1006015

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

Kay-Marie Lamar, Sasha Bogdanovich, Brandon B. Gardner, Quan Q. Gao, Tamari Miller, Judy U. Earley, Michele Hadhazy, Andy H. Vo, Lisa Wren, Jeffery D. Molkentin, Elizabeth M. McNally

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1006019

Germline Defects Caused by Smed-boule RNA-Interference Reveal That Egg Capsule Deposition Occurs Independently of Fertilization, Ovulation, Mating, or the Presence of Gametes in Planarian Flatworms

Jessica Kathryne Steiner, Junichi Tasaki, Labib Rouhana

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1006030

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

J. Gustav Smith, Janine F. Felix, Alanna C. Morrison, Andreas Kalogeropoulos, Stella Trompet, Jemma B. Wilk, Olof Gidlöf, Xinchen Wang, Michael Morley, Michael Mendelson, Roby Joehanes, Symen Ligthart, Xiaoyin Shan, Joshua C. Bis, Ying A. Wang, Marketa Sjögren, Julius Ngwa, Jeffrey Brandimarto, David J. Stott, David Aguilar, Kenneth M. Rice, Howard D. Sesso, Serkalem Demissie, Brendan M. Buckley, Kent D. Taylor, Ian Ford, Chen Yao, Chunyu Liu, CHARGE-SCD consortium, EchoGen consortium, QT-IGC consortium, CHARGE-QRS consortium, Nona Sotoodehnia, Pim van der Harst, Bruno H. Ch. Stricker, Stephen B. Kritchevsky, Yongmei Liu, J. Michael Gaziano, Albert Hofman, Christine S. Moravec, André G. Uitterlinden, Manolis Kellis, Joyce B. van Meurs, Kenneth B. Margulies, Abbas Dehghan, Daniel Levy, Björn Olde, Bruce M. Psaty, L. Adrienne Cupples, J. Wouter Jukema, Luc Djousse, Oscar H. Franco, Eric Boerwinkle, Laurie A. Boyer, Christopher Newton-Cheh, Javed Butler, Ramachandran S. Vasan, Thomas P. Cappola, Nicholas L. Smith

PLOS Genetics: published May 5, 2016 | https://doi.org/10.1371/journal.pgen.1006034

Bayesian Inference of Reticulate Phylogenies under the Multispecies Network Coalescent

Dingqiao Wen, Yun Yu, Luay Nakhleh

PLOS Genetics: published May 4, 2016 | https://doi.org/10.1371/journal.pgen.1006006

An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension

Matthew J. Anderson, Thomas Schimmang, Mark Lewandoski

PLOS Genetics: published May 4, 2016 | https://doi.org/10.1371/journal.pgen.1006018

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones

Matthias C. Truttmann, Victor E. Cruz, Xuanzong Guo, Christoph Engert, Thomas U. Schwartz, Hidde L. Ploegh

PLOS Genetics: published May 3, 2016 | https://doi.org/10.1371/journal.pgen.1006023

The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Krüppel-Homolog 1 and Broad-Complex

Enric Ureña, Silvia Chafino, Cristina Manjón, Xavier Franch-Marro, David Martín

PLOS Genetics: published May 2, 2016 | https://doi.org/10.1371/journal.pgen.1006020

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70-bp repeats control antigen gene selection in Trypanosoma brucei.

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**70-bp repeats control antigen gene selection in Trypanosoma brucei.**