January 2016

Invadopodia are small F-actin rich, membrane associated structures that invasive cells use in development and cancer to breach basement membrane barriers to enter tissues. Shown here is the Caenorhabditis elegans anchor cell (cyan) invading across the basement membrane (magenta) and entering the vulval tissue. Using anchor cell invasion, we conducted the first genome-wide screen for genes that regulate invadopodia in vivo and reveal that the small GTPase cdc-42 seeds new invadopodia, while the guanine dissociation inhibitor gdi-1 controls the trafficking of the specialized invadopodial membrane to sites of invadopodia construction. See Lohmer, Clay et al.

Image Credit: Matthew Clay, Sherwood Lab, Duke University

Viewpoints

Consent Codes: Upholding Standard Data Use Conditions

Stephanie O. M. Dyke, Anthony A. Philippakis, Jordi Rambla De Argila, Dina N. Paltoo, Erin S. Luetkemeier, Bartha M. Knoppers, Anthony J. Brookes, J. Dylan Spalding, Mark Thompson, Marco Roos, Kym M. Boycott, Michael Brudno, Matthew Hurles, Heidi L. Rehm, Andreas Matern, Marc Fiume, Stephen T. Sherry

PLOS Genetics: published January 21, 2016 | https://doi.org/10.1371/journal.pgen.1005772

Research Articles

Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier

Emma Bondy-Chorney, Tara E. Crawford Parks, Aymeric Ravel-Chapuis, Roscoe Klinck, Lynda Rocheleau, Martin Pelchat, Benoit Chabot, Bernard J. Jasmin, Jocelyn Côté

PLOS Genetics: published January 29, 2016 | https://doi.org/10.1371/journal.pgen.1005827

Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation

Maximilian G. Plach, Bernd Reisinger, Reinhard Sterner, Rainer Merkl

PLOS Genetics: published January 29, 2016 | https://doi.org/10.1371/journal.pgen.1005836

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia

J. Pedro Fernández-Murray, Sergey V. Prykhozhij, J. Noelia Dufay, Shelby L. Steele, Daniel Gaston, Gheyath K. Nasrallah, Andrew J. Coombs, Robert S. Liwski, Conrad V. Fernandez, Jason N. Berman, Christopher R. McMaster

PLOS Genetics: published January 28, 2016 | https://doi.org/10.1371/journal.pgen.1005783

Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation

Long Guo, Hiroshi Yamashita, Ikuyo Kou, Aki Takimoto, Makiko Meguro-Horike, Shin-ichi Horike, Tetsushi Sakuma, Shigenori Miura, Taiji Adachi, Takashi Yamamoto, Shiro Ikegawa, Yuji Hiraki, Chisa Shukunami

PLOS Genetics: published January 28, 2016 | https://doi.org/10.1371/journal.pgen.1005802

Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility

Tuomo Mantere, Robert Winqvist, Saila Kauppila, Mervi Grip, Arja Jukkola-Vuorinen, Anna Tervasmäki, Katrin Rapakko, Katri Pylkäs

PLOS Genetics: published January 28, 2016 | https://doi.org/10.1371/journal.pgen.1005816

A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction

Mikolaj J. Sulkowski, Tae Hee Han, Carolyn Ott, Qi Wang, Esther M. Verheyen, Jennifer Lippincott-Schwartz, Mihaela Serpe

PLOS Genetics: published January 27, 2016 | https://doi.org/10.1371/journal.pgen.1005810

Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis

Pablo Pulido, Ernesto Llamas, Briardo Llorente, Salvador Ventura, Louwrance P. Wright, Manuel Rodríguez-Concepción

PLOS Genetics: published January 27, 2016 | https://doi.org/10.1371/journal.pgen.1005824

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs

Courtney K. Burrows, Nicholas E. Banovich, Bryan J. Pavlovic, Kristen Patterson, Irene Gallego Romero, Jonathan K. Pritchard, Yoav Gilad

PLOS Genetics: published January 26, 2016 | https://doi.org/10.1371/journal.pgen.1005793

Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development

Nuno D. Pires, Marian Bemer, Lena M. Müller, Célia Baroux, Charles Spillane, Ueli Grossniklaus

PLOS Genetics: published January 26, 2016 | https://doi.org/10.1371/journal.pgen.1005806

ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

John R. Pearson, Federico Zurita, Laura Tomás-Gallardo, Alfonsa Díaz-Torres, María del Carmen Díaz de la Loza, Kristian Franze, María D. Martín-Bermudo, Acaimo González-Reyes

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005763

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

Michèle Telorack, Michael Meyer, Irina Ingold, Marcus Conrad, Wilhelm Bloch, Sabine Werner

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005800

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

Yunpeng Wang, Wesley K. Thompson, Andrew J. Schork, Dominic Holland, Chi-Hua Chen, Francesco Bettella, Rahul S. Desikan, Wen Li, Aree Witoelar, Verena Zuber, Anna Devor, Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, Enhancing Neuro Imaging Genetics through Meta Analysis Consortium, Markus M. Nöthen, Marcella Rietschel, Qiang Chen, Thomas Werge, Sven Cichon, Daniel R. Weinberger, Srdjan Djurovic, Michael O’Donovan, Peter M. Visscher, Ole A. Andreassen, Anders M. Dale

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005803

Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila

Hsueh-Yen Ku, Vamsi K. Gangaraju, Hongying Qi, Na Liu, Haifan Lin

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005813

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis

Julia E. Draper, Patrycja Sroczynska, Olga Tsoulaki, Hui Sun Leong, Muhammad Z. H. Fadlullah, Crispin Miller, Valerie Kouskoff, Georges Lacaud

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005814

Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis

Marc Amoyel, Jason Anderson, Annabelle Suisse, Johanna Glasner, Erika A. Bach

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005815

Innovation of a Regulatory Mechanism Modulating Semi-determinate Stem Growth through Artificial Selection in Soybean

Yunfeng Liu, Dajian Zhang, Jieqing Ping, Shuai Li, Zhixiang Chen, Jianxin Ma

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005818

Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7

Farhoud Faraji, Ying Hu, Howard H. Yang, Maxwell P. Lee, G. Sebastian Winkler, Markus Hafner, Kent W. Hunter

PLOS Genetics: published January 25, 2016 | https://doi.org/10.1371/journal.pgen.1005820

Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress

Michelle L. Oeser, Triana Amen, Cory M. Nadel, Amanda I. Bradley, Benjamin J. Reed, Ramon D. Jones, Janani Gopalan, Daniel Kaganovich, Richard G. Gardner

PLOS Genetics: published January 22, 2016 | https://doi.org/10.1371/journal.pgen.1005809

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

David Reynolds, Brigitte T. Hofmeister, Laura Cliffe, Magdy Alabady, T. Nicolai Siegel, Robert J. Schmitz, Robert Sabatini

PLOS Genetics: published January 21, 2016 | https://doi.org/10.1371/journal.pgen.1005758

Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei

Danae Schulz, Maryam Zaringhalam, F. Nina Papavasiliou, Hee-Sook Kim

PLOS Genetics: published January 21, 2016 | https://doi.org/10.1371/journal.pgen.1005762

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

Elvir Becirovic, Sybille Böhm, Ong Nam Phuong Nguyen, Lisa Maria Riedmayr, Mirja Annika Koch, Elisabeth Schulze, Susanne Kohl, Oliver Borsch, Tiago Santos-Ferreira, Marius Ader, Stylianos Michalakis, Martin Biel

PLOS Genetics: published January 21, 2016 | https://doi.org/10.1371/journal.pgen.1005811

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

Rumi Satoh, Kiyokazu Kakugawa, Takuwa Yasuda, Hisahiro Yoshida, Maria Sibilia, Yoshimoto Katsura, Ben Levi, Jakub Abramson, Yoko Koseki, Haruhiko Koseki, Willem van Ewijk, Georg A. Hollander, Hiroshi Kawamoto

PLOS Genetics: published January 20, 2016 | https://doi.org/10.1371/journal.pgen.1005776

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells

Dakshayani Lomada, Manju Jain, Michelle Bolner, Kaitlin A. G. Reeh, Rhea Kang, Madhava C. Reddy, John DiGiovanni, Ellen R. Richie

PLOS Genetics: published January 20, 2016 | https://doi.org/10.1371/journal.pgen.1005777

H-NS Facilitates Sequence Diversification of Horizontally Transferred DNAs during Their Integration in Host Chromosomes

Koichi Higashi, Toru Tobe, Akinori Kanai, Ebru Uyar, Shu Ishikawa, Yutaka Suzuki, Naotake Ogasawara, Ken Kurokawa, Taku Oshima

PLOS Genetics: published January 20, 2016 | https://doi.org/10.1371/journal.pgen.1005796

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

Madalena C. Carneiro, Catarina M. Henriques, Joana Nabais, Tânia Ferreira, Tânia Carvalho, Miguel Godinho Ferreira

PLOS Genetics: published January 20, 2016 | https://doi.org/10.1371/journal.pgen.1005798

SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification

Amel Alqadah, Yi-Wen Hsieh, Jennifer A. Schumacher, Xiaohong Wang, Sean A. Merrill, Grethel Millington, Brittany Bayne, Erik M. Jorgensen, Chiou-Fen Chuang

PLOS Genetics: published January 15, 2016 | https://doi.org/10.1371/journal.pgen.1005654

A Spatial Framework for Understanding Population Structure and Admixture

Gideon S. Bradburd, Peter L. Ralph, Graham M. Coop

PLOS Genetics: published January 15, 2016 | https://doi.org/10.1371/journal.pgen.1005703

Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila

Arunesh Saras, Mark A. Tanouye

PLOS Genetics: published January 15, 2016 | https://doi.org/10.1371/journal.pgen.1005784

The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa

Evelina Y. Basenko, Masayuki Kamei, Lexiang Ji, Robert J. Schmitz, Zachary A. Lewis

PLOS Genetics: published January 15, 2016 | https://doi.org/10.1371/journal.pgen.1005790

A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity

Qingyun Li, Scott Barish, Sumie Okuwa, Abigail Maciejewski, Alicia T. Brandt, Dominik Reinhold, Corbin D. Jones, Pelin Cayirlioglu Volkan

PLOS Genetics: published January 14, 2016 | https://doi.org/10.1371/journal.pgen.1005780

A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation

Lauren L. Lohmer, Matthew R. Clay, Kaleb M. Naegeli, Qiuyi Chi, Joshua W. Ziel, Elliott J. Hagedorn, Jieun E. Park, Ranjay Jayadev, David R. Sherwood

PLOS Genetics: published January 14, 2016 | https://doi.org/10.1371/journal.pgen.1005786

Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation

Gongshi Bai, Marcus B. Smolka, John C. Schimenti

PLOS Genetics: published January 14, 2016 | https://doi.org/10.1371/journal.pgen.1005787

Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks

María Belén Federico, María Belén Vallerga, Analía Radl, Natalia Soledad Paviolo, José Luis Bocco, Marina Di Giorgio, Gastón Soria, Vanesa Gottifredi

PLOS Genetics: published January 14, 2016 | https://doi.org/10.1371/journal.pgen.1005792

PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation

Yan Yang, Wencheng Li, Mainul Hoque, Liming Hou, Steven Shen, Bin Tian, Brian D. Dynlacht

PLOS Genetics: published January 14, 2016 | https://doi.org/10.1371/journal.pgen.1005794

P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality

Erin A. Ronayne, Y. C. Serena Wan, Beth A. Boudreau, Robert Landick, Michael M. Cox

PLOS Genetics: published January 14, 2016 | https://doi.org/10.1371/journal.pgen.1005797

Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools

Omar Soukarieh, Pascaline Gaildrat, Mohamad Hamieh, Aurélie Drouet, Stéphanie Baert-Desurmont, Thierry Frébourg, Mario Tosi, Alexandra Martins

PLOS Genetics: published January 13, 2016 | https://doi.org/10.1371/journal.pgen.1005756

Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements

Hua Wang, Chunmei Liu, Jingfei Cheng, Jian Liu, Lei Zhang, Chongsheng He, Wen-Hui Shen, Hong Jin, Lin Xu, Yijing Zhang

PLOS Genetics: published January 13, 2016 | https://doi.org/10.1371/journal.pgen.1005771

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria

Ilaria Dalla Rosa, Yolanda Cámara, Romina Durigon, Chloe F. Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A. Johnson, Sarah Grocott, Liya Wang, David R. Thorburn, Michio Hirano, Joanna Poulton, Robert W. Taylor, Greg Elgar, Ramon Martí, Peter Voshol, Ian J. Holt, Antonella Spinazzola

PLOS Genetics: published January 13, 2016 | https://doi.org/10.1371/journal.pgen.1005779

Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster

Sibylle Chantal Vonesch, David Lamparter, Trudy F. C. Mackay, Sven Bergmann, Ernst Hafen

PLOS Genetics: published January 11, 2016 | https://doi.org/10.1371/journal.pgen.1005616

A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity

Timothy Read, Phillip A. Richmond, Robin D. Dowell

PLOS Genetics: published January 11, 2016 | https://doi.org/10.1371/journal.pgen.1005746

The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts

Simona Cugusi, Yujing Li, Peng Jin, John C. Lucchesi

PLOS Genetics: published January 11, 2016 | https://doi.org/10.1371/journal.pgen.1005761

Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis

Nicolas Galtier

PLOS Genetics: published January 11, 2016 | https://doi.org/10.1371/journal.pgen.1005774

CFLAP1 and CFLAP2 Are Two bHLH Transcription Factors Participating in Synergistic Regulation of AtCFL1-Mediated Cuticle Development in Arabidopsis

Shibai Li, Xiaochen Wang, Shan He, Jieru Li, Qingpei Huang, Takato Imaizumi, Leqing Qu, Genji Qin, Li-Jia Qu, Hongya Gu

PLOS Genetics: published January 8, 2016 | https://doi.org/10.1371/journal.pgen.1005744

Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression

Jie-Li Mao, Zi-Qing Miao, Zhen Wang, Lin-Hui Yu, Xiao-Teng Cai, Cheng-Bin Xiang

PLOS Genetics: published January 8, 2016 | https://doi.org/10.1371/journal.pgen.1005760

A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development

Jingyue Xu, Han Liu, Yu Lan, Bruce J. Aronow, Vladimir V. Kalinichenko, Rulang Jiang

PLOS Genetics: published January 8, 2016 | https://doi.org/10.1371/journal.pgen.1005769

A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies

Masakazu Kohda, Yoshimi Tokuzawa, Yoshihito Kishita, Hiromi Nyuzuki, Yohsuke Moriyama, Yosuke Mizuno, Tomoko Hirata, Yukiko Yatsuka, Yzumi Yamashita-Sugahara, Yutaka Nakachi, Hidemasa Kato, Akihiko Okuda, Shunsuke Tamaru, Nurun Nahar Borna, Kengo Banshoya, Toshiro Aigaki, Yukiko Sato-Miyata, Kohei Ohnuma, Tsutomu Suzuki, Asuteka Nagao, Hazuki Maehata, Fumihiko Matsuda, Koichiro Higasa, Masao Nagasaki, Jun Yasuda, Masayuki Yamamoto, Takuya Fushimi, Masaru Shimura, Keiko Kaiho-Ichimoto, Hiroko Harashima, Taro Yamazaki, Masato Mori, Kei Murayama, Akira Ohtake, Yasushi Okazaki

PLOS Genetics: published January 7, 2016 | https://doi.org/10.1371/journal.pgen.1005679

Cover

Building invadopodia in vivo

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