October 2015

Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector

Sulaiman S. Ibrahim, Jacob M. Riveron, Jaclyn Bibby, Helen Irving, Cristina Yunta, Mark J. I. Paine, Charles S. Wondji

PLOS Genetics: published October 30, 2015 | https://doi.org/10.1371/journal.pgen.1005618

SCARN a Novel Class of SCAR Protein That Is Required for Root-Hair Infection during Legume Nodulation

Liping Qiu, Jie-shun Lin, Ji Xu, Shusei Sato, Martin Parniske, Trevor L. Wang, J. Allan Downie, Fang Xie

PLOS Genetics: published October 30, 2015 | https://doi.org/10.1371/journal.pgen.1005623

The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis

Leszek P. Pryszcz, Tibor Németh, Ester Saus, Ewa Ksiezopolska, Eva Hegedűsová, Jozef Nosek, Kenneth H. Wolfe, Attila Gacser, Toni Gabaldón

PLOS Genetics: published October 30, 2015 | https://doi.org/10.1371/journal.pgen.1005626

Single Strand Annealing Plays a Major Role in RecA-Independent Recombination between Repeated Sequences in the Radioresistant Deinococcus radiodurans Bacterium

Solenne Ithurbide, Esma Bentchikou, Geneviève Coste, Bruno Bost, Pascale Servant, Suzanne Sommer

PLOS Genetics: published October 30, 2015 | https://doi.org/10.1371/journal.pgen.1005636

Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation

Hélène Royo, Hervé Seitz, Elias ElInati, Antoine H. F. M. Peters, Michael B. Stadler, James M. A. Turner

PLOS Genetics: published October 28, 2015 | https://doi.org/10.1371/journal.pgen.1005461

Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals

Jeffrey M. Cloutier, Shantha K. Mahadevaiah, Elias ElInati, André Nussenzweig, Attila Tóth, James M. A. Turner

PLOS Genetics: published October 28, 2015 | https://doi.org/10.1371/journal.pgen.1005462

The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells

Alexander C. Cerny, André Altendorfer, Krystina Schopf, Karla Baltner, Nathalie Maag, Elisabeth Sehn, Uwe Wolfrum, Armin Huber

PLOS Genetics: published October 28, 2015 | https://doi.org/10.1371/journal.pgen.1005578

Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection

Musa A. Hassan, Kirk D. Jensen, Vincent Butty, Kenneth Hu, Erwan Boedec, Pjotr Prins, Jeroen P. J. Saeij

PLOS Genetics: published October 28, 2015 | https://doi.org/10.1371/journal.pgen.1005619

Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease

Hong-Hee Won, Pradeep Natarajan, Amanda Dobbyn, Daniel M. Jordan, Panos Roussos, Kasper Lage, Soumya Raychaudhuri, Eli Stahl, Ron Do

PLOS Genetics: published October 28, 2015 | https://doi.org/10.1371/journal.pgen.1005622

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

Antje Müller, Jana Winkler, Franziska Fiedler, Tania Sastradihardja, Claudia Binder, Ralf Schnabel, Jana Kungel, Sven Rothemund, Christian Hennig, Torsten Schöneberg, Simone Prömel

PLOS Genetics: published October 27, 2015 | https://doi.org/10.1371/journal.pgen.1005624

Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2

Nitya Ramkumar, Beth M. Harvey, Jeffrey D. Lee, Heather L. Alcorn, Nancy F. Silva-Gagliardi, C. Jane McGlade, Timothy H. Bestor, Jan Wijnholds, Robert S. Haltiwanger, Kathryn V. Anderson

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005551

LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice

Krista A. Geister, Michelle L. Brinkmeier, Leonard Y. Cheung, Jennifer Wendt, Melissa J. Oatley, Daniel L. Burgess, Kenneth M. Kozloff, James D. Cavalcoli, Jon M. Oatley, Sally A. Camper

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005569

A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis

Margit Fuchs, Carole Luthold, Solenn M. Guilbert, Alice Anaïs Varlet, Herman Lambert, Alexandra Jetté, Sabine Elowe, Jacques Landry, Josée N. Lavoie

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005582

Genome-Wide Association Analysis of Adaptation Using Environmentally Predicted Traits

Joost van Heerwaarden, Martijn van Zanten, Willem Kruijer

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005594

ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration

Paula Santabárbara-Ruiz, Mireya López-Santillán, Irene Martínez-Rodríguez, Anahí Binagui-Casas, Lídia Pérez, Marco Milán, Montserrat Corominas, Florenci Serras

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005595

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition

Maria J. Aristizabal, Gian Luca Negri, Michael S. Kobor

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005608

Virus Satellites Drive Viral Evolution and Ecology

Belén Frígols, Nuria Quiles-Puchalt, Ignacio Mir-Sanchis, Jorge Donderis, Santiago F. Elena, Angus Buckling, Richard P. Novick, Alberto Marina, José R. Penadés

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005609

Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function

Cristian Del Campo, Alexander Bartholomäus, Ivan Fedyunin, Zoya Ignatova

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005613

Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes

Patompon Wongtrakoongate, Gregory Riddick, Suthat Fucharoen, Gary Felsenfeld

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005615

DCA1 Acts as a Transcriptional Co-activator of DST and Contributes to Drought and Salt Tolerance in Rice

Long-Gang Cui, Jun-Xiang Shan, Min Shi, Ji-Ping Gao, Hong-Xuan Lin

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005617

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse

Shu Ly Lim, Zhi Peng Qu, R. Daniel Kortschak, David M. Lawrence, Joel Geoghegan, Anna-Lena Hempfling, Martin Bergmann, Christopher C. Goodnow, Christopher J. Ormandy, Lee Wong, Jeff Mann, Hamish S. Scott, Duangporn Jamsai, David L. Adelson, Moira K. O’Bryan

PLOS Genetics: published October 23, 2015 | https://doi.org/10.1371/journal.pgen.1005620

MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis

Cheng-Guo Duan, Xingang Wang, Kai Tang, Huiming Zhang, Satendra K. Mangrauthia, Mingguang Lei, Chuan-Chih Hsu, Yueh-Ju Hou, Chunguo Wang, Yan Li, W. Andy Tao, Jian-Kang Zhu

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005559

Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis

Eun Young Yu, José Pérez-Martín, William K. Holloman, Neal F. Lue

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005570

A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans

Yung-Hsiang Yi, Tian-Hsiang Ma, Li-Wei Lee, Pey-Tsyr Chiou, Po-Hsiang Chen, Ching-Ming Lee, Yu-De Chu, Hsiang Yu, Kuei-Ching Hsiung, Yi-Tzang Tsai, Chi-Chang Lee, Yu-Sun Chang, Shih-Peng Chan, Bertrand Chin-Ming Tan, Szecheng J. Lo

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005580

DNA Methylation Landscapes of Human Fetal Development

Roderick C. Slieker, Matthias S. Roost, Liesbeth van Iperen, H. Eka D. Suchiman, Elmar W. Tobi, Françoise Carlotti, Eelco J. P. de Koning, P. Eline Slagboom, Bastiaan T. Heijmans, Susana M. Chuva de Sousa Lopes

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005583

Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity

Vicente Ramírez, Beatriz Gonzalez, Ana López, María José Castelló, María José Gil, Bo Zheng, Peng Chen, Pablo Vera

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005586

Modulation of Ambient Temperature-Dependent Flowering in Arabidopsis thaliana by Natural Variation of FLOWERING LOCUS M

Ulrich Lutz, David Posé, Matthias Pfeifer, Heidrun Gundlach, Jörg Hagmann, Congmao Wang, Detlef Weigel, Klaus F. X. Mayer, Markus Schmid, Claus Schwechheimer

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005588

The Rise and Fall of an Evolutionary Innovation: Contrasting Strategies of Venom Evolution in Ancient and Young Animals

Kartik Sunagar, Yehu Moran

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005596

Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development

Rajiv C. McCoy, Zachary P. Demko, Allison Ryan, Milena Banjevic, Matthew Hill, Styrmir Sigurjonsson, Matthew Rabinowitz, Dmitri A. Petrov

PLOS Genetics: published October 22, 2015 | https://doi.org/10.1371/journal.pgen.1005601

Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans

Amanda L. Zacharias, Travis Walton, Elicia Preston, John Isaac Murray

PLOS Genetics: published October 21, 2015 | https://doi.org/10.1371/journal.pgen.1005585

NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish

Margo Dona, Ruxandra Bachmann-Gagescu, Yves Texier, Grischa Toedt, Lisette Hetterschijt, Edith L. Tonnaer, Theo A. Peters, Sylvia E. C. van Beersum, Judith G. M. Bergboer, Nicola Horn, Erik de Vrieze, Ralph W. N. Slijkerman, Jeroen van Reeuwijk, Gert Flik, Jan E. Keunen, Marius Ueffing, Toby J. Gibson, Ronald Roepman, Karsten Boldt, Hannie Kremer, Erwin van Wijk

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005574

The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking

Ruxandra Bachmann-Gagescu, Margo Dona, Lisette Hetterschijt, Edith Tonnaer, Theo Peters, Erik de Vrieze, Dorus A. Mans, Sylvia E. C. van Beersum, Ian G. Phelps, Heleen H. Arts, Jan E. Keunen, Marius Ueffing, Ronald Roepman, Karsten Boldt, Dan Doherty, Cecilia B. Moens, Stephan C. F. Neuhauss, Hannie Kremer, Erwin van Wijk

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005575

Sex Bias and Maternal Contribution to Gene Expression Divergence in Drosophila Blastoderm Embryos

Mathilde Paris, Jacqueline E. Villalta, Michael B. Eisen, Susan E. Lott

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005592

Axon Regeneration Is Regulated by Ets–C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca²⁺ Signaling Pathways

Chun Li, Naoki Hisamoto, Kunihiro Matsumoto

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005603

Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions

Matthew B. Taylor, Ian M. Ehrenreich

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005606

Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs

Stefan M. Bresson, Olga V. Hunter, Allyson C. Hunter, Nicholas K. Conrad

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005610

Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria

Shimon Bershtein, Adrian W. R. Serohijos, Sanchari Bhattacharyya, Michael Manhart, Jeong-Mo Choi, Wanmeng Mu, Jingwen Zhou, Eugene I. Shakhnovich

PLOS Genetics: published October 20, 2015 | https://doi.org/10.1371/journal.pgen.1005612

Hsp90-Associated Immunophilin Homolog Cpr7 Is Required for the Mitotic Stability of [URE3] Prion in Saccharomyces cerevisiae

Navinder Kumar, Deepika Gaur, Arpit Gupta, Anuradhika Puri, Deepak Sharma

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005567

Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation

Vanessa Khemici, Julien Prados, Patrick Linder, Peter Redder

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005577

Inter-population Differences in Retrogene Loss and Expression in Humans

Michał Kabza, Magdalena Regina Kubiak, Agnieszka Danek, Wojciech Rosikiewicz, Sebastian Deorowicz, Andrzej Polański, Izabela Makałowska

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005579

Pelle Modulates dFoxO-Mediated Cell Death in Drosophila

Chenxi Wu, Yujun Chen, Feng Wang, Changyan Chen, Shiping Zhang, Chaojie Li, Wenzhe Li, Shian Wu, Lei Xue

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005589

Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans

Jiyoti Verma-Gaur, Yue Qu, Paul F. Harrison, Tricia L. Lo, Tara Quenault, Michael J. Dagley, Matthew Bellousoff, David R. Powell, Traude H. Beilharz, Ana Traven

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005590

Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D. Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J. Snider, Yusuf A. Hannun, Lina M. Obeid, Cungui Mao

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005591

A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers

Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Michelle Hanna, David A. Eccles, Melanie A. Carless, Geoffrey K. Chambers, Claire Bellis, Harald H. Goring, Joanne E. Curran, Jacquie L. Harper, Gregory Gibson, John Blangero, Lyn R. Griffiths

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005593

"Missing" G x E Variation Controls Flowering Time in Arabidopsis thaliana

Eriko Sasaki, Pei Zhang, Susanna Atwell, Dazhe Meng, Magnus Nordborg

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005597

The Roles of Arabidopsis CDF2 in Transcriptional and Posttranscriptional Regulation of Primary MicroRNAs

Zhenfei Sun, Tongtong Guo, Yin Liu, Qi Liu, Yuda Fang

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005598

Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB

Boris R. Belitsky, Shaun R. Brinsmade, Abraham L. Sonenshein

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005600

A Follicle Rupture Assay Reveals an Essential Role for Follicular Adrenergic Signaling in Drosophila Ovulation

Lylah D. Deady, Jianjun Sun

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005604

Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes

Sarah J. Radford, Tranchau L. Hoang, A. Agata Głuszek, Hiroyuki Ohkura, Kim S. McKim

PLOS Genetics: published October 16, 2015 | https://doi.org/10.1371/journal.pgen.1005605

Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules

Dimitri Bieli, Oguz Kanca, David Requena, Fisun Hamaratoglu, Daryl Gohl, Paul Schedl, Markus Affolter, Matthew Slattery, Martin Müller, Carlos Estella

PLOS Genetics: published October 15, 2015 | https://doi.org/10.1371/journal.pgen.1005376

Regulation of Clostridium difficile Spore Formation by the SpoIIQ and SpoIIIA Proteins

Kelly A. Fimlaid, Owen Jensen, M. Lauren Donnelly, M. Sloan Siegrist, Aimee Shen

PLOS Genetics: published October 14, 2015 | https://doi.org/10.1371/journal.pgen.1005562

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

Yannick R. Brunet, Abdelrahim Zoued, Frédéric Boyer, Badreddine Douzi, Eric Cascales

PLOS Genetics: published October 13, 2015 | https://doi.org/10.1371/journal.pgen.1005545

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

Lisa E. Gralinski, Martin T. Ferris, David L. Aylor, Alan C. Whitmore, Richard Green, Matthew B. Frieman, Damon Deming, Vineet D. Menachery, Darla R. Miller, Ryan J. Buus, Timothy A. Bell, Gary A. Churchill, David W. Threadgill, Michael G. Katze, Leonard McMillan, William Valdar, Mark T. Heise, Fernando Pardo-Manuel de Villena, Ralph S. Baric

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005504

A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis

Raymond Liang, Genís Campreciós, Yan Kou, Kathleen McGrath, Roberta Nowak, Seana Catherman, Carolina L. Bigarella, Pauline Rimmelé, Xin Zhang, Merlin Nithya Gnanapragasam, James J. Bieker, Dmitri Papatsenko, Avi Ma’ayan, Emery Bresnick, Velia Fowler, James Palis, Saghi Ghaffari

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005526

The Ty1 Retrotransposon Restriction Factor p22 Targets Gag

Jessica M. Tucker, Morgan E. Larango, Lucas P. Wachsmuth, Natarajan Kannan, David J. Garfinkel

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005571

Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults

Hagit Hochner, Catherine Allard, Einat Granot-Hershkovitz, Jinbo Chen, Colleen M. Sitlani, Sandra Sazdovska, Thomas Lumley, Barbara McKnight, Kenneth Rice, Daniel A. Enquobahrie, James B. Meigs, Pui Kwok, Marie-France Hivert, Ingrid B. Borecki, Felicia Gomez, Ting Wang, Cornelia van Duijn, Najaf Amin, Jerome I. Rotter, John Stamatoyannopoulos, Vardiella Meiner, Orly Manor, Josée Dupuis, Yechiel Friedlander, David S. Siscovick

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005573

IBR5 Modulates Temperature-Dependent, R Protein CHS3-Mediated Defense Responses in Arabidopsis

Jingyan Liu, Haibian Yang, Fei Bao, Kevin Ao, Xiaoyan Zhang, Yuelin Zhang, Shuhua Yang

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005584

Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish

Miki Takeuchi, Shingo Yamaguchi, Shigenobu Yonemura, Kisa Kakiguchi, Yoshikatsu Sato, Tetsuya Higashiyama, Takashi Shimizu, Masahiko Hibi

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005587

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate

Melissa M. Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A. Tollini, Susan K. Murphy, Joseph Lucas, Deborah M. Muoio, So Young Kim, Jen-Tsan Chi

PLOS Genetics: published October 9, 2015 | https://doi.org/10.1371/journal.pgen.1005599

Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data

Frederick E. Dewey, Megan E. Grove, James R. Priest, Daryl Waggott, Prag Batra, Clint L. Miller, Matthew Wheeler, Amin Zia, Cuiping Pan, Konrad J. Karzcewski, Christina Miyake, Michelle Whirl-Carrillo, Teri E. Klein, Somalee Datta, Russ B. Altman, Michael Snyder, Thomas Quertermous, Euan A. Ashley

PLOS Genetics: published October 8, 2015 | https://doi.org/10.1371/journal.pgen.1005496

Fungal Infection Induces Sex-Specific Transcriptional Changes and Alters Sexual Dimorphism in the Dioecious Plant Silene latifolia

Niklaus Zemp, Raquel Tavares, Alex Widmer

PLOS Genetics: published October 8, 2015 | https://doi.org/10.1371/journal.pgen.1005536

A Novel Route Controlling Begomovirus Resistance by the Messenger RNA Surveillance Factor Pelota

Moshe Lapidot, Uri Karniel, Dana Gelbart, Doron Fogel, Dalia Evenor, Yaarit Kutsher, Zion Makhbash, Sahadia Nahon, Haviva Shlomo, Lea Chen, Moshe Reuveni, Ilan Levin

PLOS Genetics: published October 8, 2015 | https://doi.org/10.1371/journal.pgen.1005538

Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution

Namhee Kim, Chungoo Park, Yongsu Jeong, Mi-Ryoung Song

PLOS Genetics: published October 8, 2015 | https://doi.org/10.1371/journal.pgen.1005560

Large-Scale Analysis of Kinase Signaling in Yeast Pseudohyphal Development Identifies Regulation of Ribonucleoprotein Granules

Christian A. Shively, Hye Kyong Kweon, Kaitlyn L. Norman, Dattatreya Mellacheruvu, Tao Xu, Daniel T. Sheidy, Craig J. Dobry, Ivan Sabath, Eric E. P. Cosky, Elizabeth J. Tran, Alexey Nesvizhskii, Philip C. Andrews, Anuj Kumar

PLOS Genetics: published October 8, 2015 | https://doi.org/10.1371/journal.pgen.1005564

The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site

Benjamin Pillet, Juan J. García-Gómez, Patrick Pausch, Laurent Falquet, Gert Bange, Jesús de la Cruz, Dieter Kressler

PLOS Genetics: published October 8, 2015 | https://doi.org/10.1371/journal.pgen.1005565

The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia

José F. Muñoz, Gregory M. Gauthier, Christopher A. Desjardins, Juan E. Gallo, Jason Holder, Thomas D. Sullivan, Amber J. Marty, John C. Carmen, Zehua Chen, Li Ding, Sharvari Gujja, Vincent Magrini, Elizabeth Misas, Makedonka Mitreva, Margaret Priest, Sakina Saif, Emily A. Whiston, Sarah Young, Qiandong Zeng, William E. Goldman, Elaine R. Mardis, John W. Taylor, Juan G. McEwen, Oliver K. Clay, Bruce S. Klein, Christina A. Cuomo

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005493

FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores

Elite Possik, Andrew Ajisebutu, Sanaz Manteghi, Marie-Claude Gingras, Tarika Vijayaraghavan, Mathieu Flamand, Barry Coull, Kathrin Schmeisser, Thomas Duchaine, Maurice van Steensel, David H. Hall, Arnim Pause

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005520

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms

Garry L. Coles, Laurel A. Baglia, Kate G. Ackerman

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005525

EP4 Receptor–Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis

Masato Nakatsuji, Manabu Minami, Hiroshi Seno, Mika Yasui, Hideyuki Komekado, Sei Higuchi, Risako Fujikawa, Yuki Nakanishi, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Toru Kita, Peter Libby, Hiroki Ikeuchi, Masayuki Yokode, Tsutomu Chiba

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005542

Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis

Ranen Aviner, Anjana Shenoy, Orna Elroy-Stein, Tamar Geiger

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005554

Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells

Dana Koludrovic, Patrick Laurette, Thomas Strub, Céline Keime, Madeleine Le Coz, Sebastien Coassolo, Gabrielle Mengus, Lionel Larue, Irwin Davidson

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005555

Identification of a Single Strand Origin of Replication in the Integrative and Conjugative Element ICEBs1 of Bacillus subtilis

Laurel D. Wright, Christopher M. Johnson, Alan D. Grossman

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005556

PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis

Yong-Sheng Cheng, Oksana Seibert, Nora Klöting, Arne Dietrich, Katrin Straßburger, Sonia Fernández-Veledo, Joan J. Vendrell, Antonio Zorzano, Matthias Blüher, Stephan Herzig, Mauricio Berriel Diaz, Aurelio A. Teleman

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005561

The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster

Justin Schleede, Seth S. Blair

PLOS Genetics: published October 6, 2015 | https://doi.org/10.1371/journal.pgen.1005576

A New Method for Detecting Associations with Rare Copy-Number Variants

Jung-Ying Tzeng, Patrik K. E. Magnusson, Patrick F. Sullivan, The Swedish Schizophrenia Consortium, Jin P. Szatkiewicz

PLOS Genetics: published October 2, 2015 | https://doi.org/10.1371/journal.pgen.1005403

Cationic Peptides Facilitate Iron-induced Mutagenesis in Bacteria

Alexandro Rodríguez-Rojas, Olga Makarova, Uta Müller, Jens Rolff

PLOS Genetics: published October 2, 2015 | https://doi.org/10.1371/journal.pgen.1005546

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

Maria Castella, Celine Jacquemont, Elizabeth L. Thompson, Jung Eun Yeo, Ronald S. Cheung, Jen-Wei Huang, Alexandra Sobeck, Eric A. Hendrickson, Toshiyasu Taniguchi

PLOS Genetics: published October 2, 2015 | https://doi.org/10.1371/journal.pgen.1005563

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata, Mary F. Feitosa, Su Chu, Jacek Czajkowski, Tõnu Esko, Tove Fall, Tuomas O. Kilpeläinen, Yingchang Lu, Reedik Mägi, Evelin Mihailov, Tune H. Pers, Sina Rüeger, Alexander Teumer, Georg B. Ehret, Teresa Ferreira, Nancy L. Heard-Costa, Juha Karjalainen, Vasiliki Lagou, Anubha Mahajan, Michael D. Neinast, Inga Prokopenko, Jeannette Simino, Tanya M. Teslovich, Rick Jansen, Harm-Jan Westra, Charles C. White, Devin Absher, Tarunveer S. Ahluwalia, Shafqat Ahmad, Eva Albrecht, Alexessander Couto Alves, Jennifer L. Bragg-Gresham, Anton J. M. de Craen, Joshua C. Bis, Amélie Bonnefond, Gabrielle Boucher, Gemma Cadby, Yu-Ching Cheng, Charleston W. K. Chiang, Graciela Delgado, Ayse Demirkan, Nicole Dueker, Niina Eklund, Gudny Eiriksdottir, Joel Eriksson, Bjarke Feenstra, Krista Fischer, Francesca Frau, Tessel E. Galesloot, Frank Geller, Anuj Goel, Mathias Gorski, Tanja B. Grammer, Stefan Gustafsson, Saskia Haitjema, Jouke-Jan Hottenga, Jennifer E. Huffman, Anne U. Jackson, Kevin B. Jacobs, Åsa Johansson, Marika Kaakinen, Marcus E. Kleber, Jari Lahti, Irene Mateo Leach, Benjamin Lehne, Youfang Liu, Ken Sin Lo, Mattias Lorentzon, Jian'an Luan, Pamela A. F. Madden, Massimo Mangino, Barbara McKnight, Carolina Medina-Gomez, Keri L. Monda, May E. Montasser, Gabriele Müller, Martina Müller-Nurasyid, Ilja M. Nolte, Kalliope Panoutsopoulou, Laura Pascoe, Lavinia Paternoster, Nigel W. Rayner, Frida Renström, Federica Rizzi, Lynda M. Rose, Kathy A. Ryan, Perttu Salo, Serena Sanna, Hubert Scharnagl, Jianxin Shi, Albert Vernon Smith, Lorraine Southam, Alena Stančáková, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Yun Ju Sung, Ioanna Tachmazidou, Toshiko Tanaka, Gudmar Thorleifsson, Stella Trompet, Natalia Pervjakova, Jonathan P. Tyrer, Liesbeth Vandenput, Sander W van der Laan, Nathalie van der Velde, Jessica van Setten, Jana V. van Vliet-Ostaptchouk, Niek Verweij, Efthymia Vlachopoulou, Lindsay L. Waite, Sophie R. Wang, Zhaoming Wang, Sarah H. Wild, Christina Willenborg, James F. Wilson, Andrew Wong, Jian Yang, Loïc Yengo, Laura M. Yerges-Armstrong, Lei Yu, Weihua Zhang, Jing Hua Zhao, Ehm A. Andersson, Stephan J. L. Bakker, Damiano Baldassarre, Karina Banasik, Matteo Barcella, Cristina Barlassina, Claire Bellis, Paola Benaglio, John Blangero, Matthias Blüher, Fabrice Bonnet, Lori L. Bonnycastle, Heather A. Boyd, Marcel Bruinenberg, Aron S Buchman, Harry Campbell, Yii-Der Ida Chen, Peter S. Chines, Simone Claudi-Boehm, John Cole, Francis S. Collins, Eco J. C. de Geus, Lisette C. P. G. M. de Groot, Maria Dimitriou, Jubao Duan, Stefan Enroth, Elodie Eury, Aliki-Eleni Farmaki, Nita G. Forouhi, Nele Friedrich, Pablo V. Gejman, Bruna Gigante, Nicola Glorioso, Alan S. Go, Omri Gottesman, Jürgen Gräßler, Harald Grallert, Niels Grarup, Yu-Mei Gu, Linda Broer, Annelies C. Ham, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas Hastie, Andrew T. Hattersley, Andrew C. Heath, Anjali K. Henders, Dena Hernandez, Hans Hillege, Oddgeir Holmen, Kees G Hovingh, Jennie Hui, Lise L. Husemoen, Nina Hutri-Kähönen, Pirro G. Hysi, Thomas Illig, Philip L. De Jager, Shapour Jalilzadeh, Torben Jørgensen, J. Wouter Jukema, Markus Juonala, Stavroula Kanoni, Maria Karaleftheri, Kay Tee Khaw, Leena Kinnunen, Steven J. Kittner, Wolfgang Koenig, Ivana Kolcic, Peter Kovacs, Nikolaj T. Krarup, Wolfgang Kratzer, Janine Krüger, Diana Kuh, Meena Kumari, Theodosios Kyriakou, Claudia Langenberg, Lars Lannfelt, Chiara Lanzani, Vaneet Lotay, Lenore J. Launer, Karin Leander, Jaana Lindström, Allan Linneberg, Yan-Ping Liu, Stéphane Lobbens, Robert Luben, Valeriya Lyssenko, Satu Männistö, Patrik K. Magnusson, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Lili Milani, Grant W. Montgomery, Andrew P. Morris, Narisu Narisu, Mari Nelis, Ken K. Ong, Aarno Palotie, Louis Pérusse, Irene Pichler, Maria G. Pilia, Anneli Pouta, Myriam Rheinberger, Rasmus Ribel-Madsen, Marcus Richards, Kenneth M. Rice, Treva K. Rice, Carlo Rivolta, Veikko Salomaa, Alan R. Sanders, Mark A. Sarzynski, Salome Scholtens, Robert A. Scott, William R. Scott, Sylvain Sebert, Sebanti Sengupta, Bengt Sennblad, Thomas Seufferlein, Angela Silveira, P. Eline Slagboom, Jan H. Smit, Thomas H. Sparsø, Kathleen Stirrups, Ronald P. Stolk, Heather M. Stringham, Morris A Swertz, Amy J. Swift, Ann-Christine Syvänen, Sian-Tsung Tan, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Emmanouil Tsafantakis, Peter J. van der Most, Uwe Völker, Marie-Claude Vohl, Judith M. Vonk, Melanie Waldenberger, Ryan W. Walker, Roman Wennauer, Elisabeth Widén, Gonneke Willemsen, Tom Wilsgaard, Alan F. Wright, M. Carola Zillikens, Suzanne C. van Dijk, Natasja M. van Schoor, Folkert W. Asselbergs, Paul I. W. de Bakker, Jacques S. Beckmann, John Beilby, David A. Bennett, Richard N. Bergman, Sven Bergmann, Carsten A. Böger, Bernhard O. Boehm, Eric Boerwinkle, Dorret I. Boomsma, Stefan R. Bornstein, Erwin P. Bottinger, Claude Bouchard, John C. Chambers, Stephen J. Chanock, Daniel I. Chasman, Francesco Cucca, Daniele Cusi, George Dedoussis, Jeanette Erdmann, Johan G. Eriksson, Denis A. Evans, Ulf de Faire, Martin Farrall, Luigi Ferrucci, Ian Ford, Lude Franke, Paul W. Franks, Philippe Froguel, Ron T. Gansevoort, Christian Gieger, Henrik Grönberg, Vilmundur Gudnason, Ulf Gyllensten, Per Hall, Anders Hamsten, Pim van der Harst, Caroline Hayward, Markku Heliövaara, Christian Hengstenberg, Andrew A Hicks, Aroon Hingorani, Albert Hofman, Frank Hu, Heikki V. Huikuri, Kristian Hveem, Alan L. James, Joanne M. Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Sekar Kathiresan, Lambertus A. L. M. Kiemeney, Mika Kivimaki, Paul B. Knekt, Heikki A. Koistinen, Jaspal S. Kooner, Seppo Koskinen, Johanna Kuusisto, Winfried Maerz, Nicholas G Martin, Markku Laakso, Timo A. Lakka, Terho Lehtimäki, Guillaume Lettre, Douglas F. Levinson, Lars Lind, Marja-Liisa Lokki, Pekka Mäntyselkä, Mads Melbye, Andres Metspalu, Braxton D. Mitchell, Frans L. Moll, Jeffrey C. Murray, Arthur W. Musk, Markku S. Nieminen, Inger Njølstad, Claes Ohlsson, Albertine J. Oldehinkel, Ben A. Oostra, Lyle J Palmer, James S. Pankow, Gerard Pasterkamp, Nancy L. Pedersen, Oluf Pedersen, Brenda W. Penninx, Markus Perola, Annette Peters, Ozren Polašek, Peter P. Pramstaller, Bruce M. Psaty, Lu Qi, Thomas Quertermous, Olli T. Raitakari, Tuomo Rankinen, Rainer Rauramaa, Paul M. Ridker, John D. Rioux, Fernando Rivadeneira, Jerome I. Rotter, Igor Rudan, Hester M. den Ruijter, Juha Saltevo, Naveed Sattar, Heribert Schunkert, Peter E. H. Schwarz, Alan R. Shuldiner, Juha Sinisalo, Harold Snieder, Thorkild I. A. Sørensen, Tim D. Spector, Jan A. Staessen, Bandinelli Stefania, Unnur Thorsteinsdottir, Michael Stumvoll, Jean-Claude Tardif, Elena Tremoli, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, André L. M. Verbeek, Sita H. Vermeulen, Jorma S. Viikari, Veronique Vitart, Henry Völzke, Peter Vollenweider, Gérard Waeber, Mark Walker, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, Eleftheria Zeggini, CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium, Aravinda Chakravarti, Deborah J. Clegg, L. Adrienne Cupples, Penny Gordon-Larsen, Cashell E. Jaquish, D. C. Rao, Goncalo R. Abecasis, Themistocles L. Assimes, Inês Barroso, Sonja I. Berndt, Michael Boehnke, Panos Deloukas, Caroline S. Fox, Leif C. Groop, David J. Hunter, Erik Ingelsson, Robert C. Kaplan, Mark I. McCarthy, Karen L. Mohlke, Jeffrey R. O'Connell, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Joel N. Hirschhorn, Cecilia M. Lindgren, Iris M. Heid, Kari E. North, Ingrid B. Borecki, Zoltán Kutalik, Ruth J. F. Loos

PLOS Genetics: published October 1, 2015 | https://doi.org/10.1371/journal.pgen.1005378

Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript

Marta Puig, David Castellano, Lorena Pantano, Carla Giner-Delgado, David Izquierdo, Magdalena Gayà-Vidal, José Ignacio Lucas-Lledó, Tõnu Esko, Chikashi Terao, Fumihiko Matsuda, Mario Cáceres

PLOS Genetics: published October 1, 2015 | https://doi.org/10.1371/journal.pgen.1005495

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor

Aurore Gely-Pernot, Mathilde Raverdeau, Marius Teletin, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Christine Dennefeld, Irwin Davidson, Gérard Benoit, Manuel Mark, Norbert B. Ghyselinck

PLOS Genetics: published October 1, 2015 | https://doi.org/10.1371/journal.pgen.1005501

Genome-Scale Mapping of Escherichia coli σ⁵⁴ Reveals Widespread, Conserved Intragenic Binding

Richard P. Bonocora, Carol Smith, Pascal Lapierre, Joseph T. Wade

PLOS Genetics: published October 1, 2015 | https://doi.org/10.1371/journal.pgen.1005552

Cover

Fungal infection induces sex-specific transcriptional changes and alters sexual dimorphism in the dioecious plant Silene latifolia.

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**Fungal infection induces sex-specific transcriptional changes and alters sexual dimorphism in the dioecious plant Silene latifolia.**