May 2015

Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest. The transitions from anagen (growth), to catagen (regression), to telogen (rest) involve a physiological involution of the HF. This process is likely coordinated by a variety of mechanisms including apoptosis and loss of growth factor signaling. However, the precise molecular mechanisms underlying follicle involution after hair keratinocyte differentiation and hair shaft assembly remain poorly understood. Here we demonstrate that a highly conserved microRNA, miR-22 is markedly upregulated during catagen and peaks in telogen. Yuan et al.

Image Credit: Yuan and colleagues

Interviews

The Whole of a Scientific Career: An Interview with Oliver Smithies

Jane Gitschier

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005224

The Philosophical Approach: An Interview with Ford Doolittle

Jane Gitschier

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005173

Perspectives

Trading Places—Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffold

Dennis R. Dean, Patricia C. Dos Santos

PLOS Genetics: published May 21, 2015 | https://doi.org/10.1371/journal.pgen.1005192

Yeast Killer Elements Hold Their Hosts Hostage

Reed B. Wickner, Herman K. Edskes

PLOS Genetics: published May 14, 2015 | https://doi.org/10.1371/journal.pgen.1005139

Keeping in Shape the Dogma of Mitochondrial DNA Maternal Inheritance

Valerio Carelli

PLOS Genetics: published May 14, 2015 | https://doi.org/10.1371/journal.pgen.1005179

Research Articles

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis

Renate Voit, Jeanette Seiler, Ingrid Grummt

PLOS Genetics: published May 29, 2015 | https://doi.org/10.1371/journal.pgen.1005246

Genetic Regulation of Bone Metabolism in the Chicken: Similarities and Differences to Mammalian Systems

Martin Johnsson, Kenneth B. Jonsson, Leif Andersson, Per Jensen, Dominic Wright

PLOS Genetics: published May 29, 2015 | https://doi.org/10.1371/journal.pgen.1005250

Genetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations

Yunfang Li, David C. Mair, Randy M. Schuller, Ling Li, Jianming Wu

PLOS Genetics: published May 29, 2015 | https://doi.org/10.1371/journal.pgen.1005255

Auxin-Mediated Transcriptional System with a Minimal Set of Components Is Critical for Morphogenesis through the Life Cycle in Marchantia polymorpha

Hirotaka Kato, Kimitsune Ishizaki, Masaru Kouno, Makoto Shirakawa, John L. Bowman, Ryuichi Nishihama, Takayuki Kohchi

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005084

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

Sylvia T. Nurnberg, Karen Cheng, Azad Raiesdana, Ramendra Kundu, Clint L. Miller, Juyong B. Kim, Komal Arora, Ivan Carcamo-Oribe, Yiqin Xiong, Nikhil Tellakula, Vivek Nanda, Nikitha Murthy, William A. Boisvert, Ulf Hedin, Ljubica Perisic, Silvia Aldi, Lars Maegdefessel, Milos Pjanic, Gary K. Owens, Michelle D. Tallquist, Thomas Quertermous

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005155

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

Olga Sazonova, Yuqi Zhao, Sylvia Nürnberg, Clint Miller, Milos Pjanic, Victor G. Castano, Juyong B. Kim, Elias L. Salfati, Anshul B. Kundaje, Gill Bejerano, Themistocles Assimes, Xia Yang, Thomas Quertermous

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005202

Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes

Yann C. Klimentidis, Akshay Chougule, Amit Arora, Alexis C. Frazier-Wood, Chiu-Hsieh Hsu

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005204

A Simple Auxin Transcriptional Response System Regulates Multiple Morphogenetic Processes in the Liverwort Marchantia polymorpha

Eduardo Flores-Sandoval, D. Magnus Eklund, John L. Bowman

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005207

β-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates

Dany Gaillard, Mingang Xu, Fei Liu, Sarah E. Millar, Linda A. Barlow

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005208

The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster

Hiroko Sano, Akira Nakamura, Michael J. Texada, James W. Truman, Hiroshi Ishimoto, Azusa Kamikouchi, Yutaka Nibu, Kazuhiko Kume, Takanori Ida, Masayasu Kojima

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005209

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

Leah Cushing, Stefan Costinean, Wei Xu, Zhihua Jiang, Lindsey Madden, Pingping Kuang, Jingshu Huang, Alexandra Weisman, Akiko Hata, Carlo M. Croce, Jining Lü

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005238

Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

Shukai Yuan, Feifei Li, Qingyong Meng, Yiqiang Zhao, Lei Chen, Hongquan Zhang, Lixiang Xue, Xiuqing Zhang, Christopher Lengner, Zhengquan Yu

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005253

In Vitro Whole Genome DNA Binding Analysis of the Bacterial Replication Initiator and Transcription Factor DnaA

Janet L. Smith, Alan D. Grossman

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005258

Dissecting the Function and Assembly of Acentriolar Microtubule Organizing Centers in Drosophila Cells In Vivo

Janina Baumbach, Zsofia Anna Novak, Jordan W. Raff, Alan Wainman

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005261

Phylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence Divergence

Kacy L. Gordon, Robert K. Arthur, Ilya Ruvinsky

PLOS Genetics: published May 28, 2015 | https://doi.org/10.1371/journal.pgen.1005268

The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans

Dena H. S. Block, Kwame Twumasi-Boateng, Hae Sung Kang, Jolie A. Carlisle, Alexandru Hanganu, Ty Yu-Jen Lai, Michael Shapira

PLOS Genetics: published May 27, 2015 | https://doi.org/10.1371/journal.pgen.1005265

Notch Is Required in Adult Drosophila Sensory Neurons for Morphological and Functional Plasticity of the Olfactory Circuit

Simon Kidd, Gary Struhl, Toby Lieber

PLOS Genetics: published May 26, 2015 | https://doi.org/10.1371/journal.pgen.1005244

Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1^+/- Mice

Rana Mroue, Brian Huang, Steve Braunstein, Ari J. Firestone, Jean L. Nakamura

PLOS Genetics: published May 22, 2015 | https://doi.org/10.1371/journal.pgen.1005235

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model

Shamim H. Rahman, Johannes Kuehle, Christian Reimann, Tafadzwa Mlambo, Jamal Alzubi, Morgan L. Maeder, Heimo Riedel, Paul Fisch, Tobias Cantz, Cornelia Rudolph, Claudio Mussolino, J. Keith Joung, Axel Schambach, Toni Cathomen

PLOS Genetics: published May 22, 2015 | https://doi.org/10.1371/journal.pgen.1005239

Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination

Isabelle Robert, Léa Gaudot, Mélanie Rogier, Vincent Heyer, Aurélia Noll, Françoise Dantzer, Bernardo Reina-San-Martin

PLOS Genetics: published May 22, 2015 | https://doi.org/10.1371/journal.pgen.1005240

The Centrosomal Linker and Microtubules Provide Dual Levels of Spatial Coordination of Centrosomes

Marko Panic, Shoji Hata, Annett Neuner, Elmar Schiebel

PLOS Genetics: published May 22, 2015 | https://doi.org/10.1371/journal.pgen.1005243

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

John L. Goodier, Gavin C. Pereira, Ling E. Cheung, Rebecca J. Rose, Haig H. Kazazian Jr.

PLOS Genetics: published May 22, 2015 | https://doi.org/10.1371/journal.pgen.1005252

Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila

Yeliz Yuva-Aydemir, Xia-Lian Xu, Ozkan Aydemir, Eduardo Gascon, Serkan Sayin, Wenke Zhou, Yang Hong, Fen-Biao Gao

PLOS Genetics: published May 22, 2015 | https://doi.org/10.1371/journal.pgen.1005264

Turning Escherichia coli into a Frataxin-Dependent Organism

Béatrice Roche, Rym Agrebi, Allison Huguenot, Sandrine Ollagnier de Choudens, Frédéric Barras, Béatrice Py

PLOS Genetics: published May 21, 2015 | https://doi.org/10.1371/journal.pgen.1005134

Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism

Heeyong Yoon, Simon A. B. Knight, Alok Pandey, Jayashree Pain, Serdar Turkarslan, Debkumar Pain, Andrew Dancis

PLOS Genetics: published May 21, 2015 | https://doi.org/10.1371/journal.pgen.1005135

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

George Dialynas, Om K. Shrestha, Jessica M. Ponce, Monika Zwerger, Dylan A. Thiemann, Grant H. Young, Steven A. Moore, Liping Yu, Jan Lammerding, Lori L. Wallrath

PLOS Genetics: published May 21, 2015 | https://doi.org/10.1371/journal.pgen.1005231

Clustering and Negative Feedback by Endocytosis in Planar Cell Polarity Signaling Is Modulated by Ubiquitinylation of Prickle

Bomsoo Cho, Gandhy Pierre-Louis, Andreas Sagner, Suzanne Eaton, Jeffrey D. Axelrod

PLOS Genetics: published May 21, 2015 | https://doi.org/10.1371/journal.pgen.1005259

Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila

Sekyu Choi, Dae-Sik Lim, Jongkyeong Chung

PLOS Genetics: published May 21, 2015 | https://doi.org/10.1371/journal.pgen.1005263

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation

Naina Phadnis, Lubos Cipak, Silvia Polakova, Randy W. Hyppa, Ingrid Cipakova, Dorothea Anrather, Lucia Karvaiova, Karl Mechtler, Gerald R. Smith, Juraj Gregan

PLOS Genetics: published May 20, 2015 | https://doi.org/10.1371/journal.pgen.1005225

Y Fuse? Sex Chromosome Fusions in Fishes and Reptiles

Matthew W. Pennell, Mark Kirkpatrick, Sarah P. Otto, Jana C. Vamosi, Catherine L. Peichel, Nicole Valenzuela, Jun Kitano

PLOS Genetics: published May 20, 2015 | https://doi.org/10.1371/journal.pgen.1005237

CTXφ Replication Depends on the Histone-Like HU Protein and the UvrD Helicase

Eriel Martínez, Evelyne Paly, François-Xavier Barre

PLOS Genetics: published May 20, 2015 | https://doi.org/10.1371/journal.pgen.1005256

MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells

Bruno Mugat, Abdou Akkouche, Vincent Serrano, Claudia Armenise, Blaise Li, Christine Brun, Tudor A. Fulga, David Van Vactor, Alain Pélisson, Séverine Chambeyron

PLOS Genetics: published May 19, 2015 | https://doi.org/10.1371/journal.pgen.1005194

A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum

Uchechi E. Ukaegbu, Xu Zhang, Adina R. Heinberg, Mamadou Wele, Qijun Chen, Kirk W. Deitsch

PLOS Genetics: published May 19, 2015 | https://doi.org/10.1371/journal.pgen.1005234

Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1

Qian Xiao, Yan Jiang, Qingbo Liu, Jiao Yue, Chunying Liu, Xiaotong Zhao, Yuemei Qiao, Hongbin Ji, Jianfeng Chen, Gaoxiang Ge

PLOS Genetics: published May 19, 2015 | https://doi.org/10.1371/journal.pgen.1005249

Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity

Arko Dasgupta, Chen-Hui Chen, ChangHwan Lee, Amy S. Gladfelter, Jay C. Dunlap, Jennifer J. Loros

PLOS Genetics: published May 15, 2015 | https://doi.org/10.1371/journal.pgen.1005215

Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids

Zhiyu Liu, Herong Shi, Lindsey C. Szymczak, Taner Aydin, Sijung Yun, Katharine Constas, Arielle Schaeffer, Sinthu Ranjan, Saad Kubba, Emad Alam, Devin E. McMahon, Jingpeng He, Neta Shwartz, Chenxi Tian, Yevgeniy Plavskin, Amanda Lindy, Nimra Amir Dad, Sunny Sheth, Nirav M. Amin, Stephanie Zimmerman, Dennis Liu, Erich M. Schwarz, Harold Smith, Michael W. Krause, Jun Liu

PLOS Genetics: published May 15, 2015 | https://doi.org/10.1371/journal.pgen.1005221

Cell Cycle Control by the Master Regulator CtrA in Sinorhizobium meliloti

Francesco Pini, Nicole J. De Nisco, Lorenzo Ferri, Jon Penterman, Antonella Fioravanti, Matteo Brilli, Alessio Mengoni, Marco Bazzicalupo, Patrick H. Viollier, Graham C. Walker, Emanuele G. Biondi

PLOS Genetics: published May 15, 2015 | https://doi.org/10.1371/journal.pgen.1005232

Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA

Tobias Schmid, L. Basten Snoek, Erika Fröhli, M. Leontien van der Bent, Jan Kammenga, Alex Hajnal

PLOS Genetics: published May 15, 2015 | https://doi.org/10.1371/journal.pgen.1005236

Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma

Yongjun Yin, Angela M. Castro, Marrit Hoekstra, Thomas J. Yan, Ajay C. Kanakamedala, Louis P. Dehner, D. Ashley Hill, David M. Ornitz

PLOS Genetics: published May 15, 2015 | https://doi.org/10.1371/journal.pgen.1005242

Autoselection of Cytoplasmic Yeast Virus Like Elements Encoding Toxin/Antitoxin Systems Involves a Nuclear Barrier for Immunity Gene Expression

Alene Kast, Raphael Voges, Michael Schroth, Raffael Schaffrath, Roland Klassen, Friedhelm Meinhardt

PLOS Genetics: published May 14, 2015 | https://doi.org/10.1371/journal.pgen.1005005

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans

Angela Pyle, Gavin Hudson, Ian J. Wilson, Jonathan Coxhead, Tania Smertenko, Mary Herbert, Mauro Santibanez-Koref, Patrick F. Chinnery

PLOS Genetics: published May 14, 2015 | https://doi.org/10.1371/journal.pgen.1005040

Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model

Ashley P. Ng, Yifang Hu, Donald Metcalf, Craig D. Hyland, Helen Ierino, Belinda Phipson, Di Wu, Tracey M. Baldwin, Maria Kauppi, Hiu Kiu, Ladina Di Rago, Douglas J. Hilton, Gordon K. Smyth, Warren S. Alexander

PLOS Genetics: published May 14, 2015 | https://doi.org/10.1371/journal.pgen.1005211

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

Lydia M. Castelli, David Talavera, Christopher J. Kershaw, Sarah S. Mohammad-Qureshi, Joseph L. Costello, William Rowe, Paul F. G. Sims, Christopher M. Grant, Simon J. Hubbard, Mark P. Ashe, Graham D. Pavitt

PLOS Genetics: published May 14, 2015 | https://doi.org/10.1371/journal.pgen.1005233

Cell Specific eQTL Analysis without Sorting Cells

Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J. Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P. Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K. Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G. Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R. Wood, David Melzer, Luigi Ferrucci, Andrew B. Singleton, Dena G. Hernandez, Julian C. Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, De Yun Wang, Leonard H. van den Berg, Jan H. Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B. J. van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C. Jansen, Lude Franke

PLOS Genetics: published May 8, 2015 | https://doi.org/10.1371/journal.pgen.1005223

Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at High Temperatures in Arabidopsis thaliana

Wangsheng Zhu, Israel Ausin, Andrei Seleznev, Belén Méndez-Vigo, F. Xavier Picó, Sridevi Sureshkumar, Vignesh Sundaramoorthi, Dieter Bulach, David Powell, Torsten Seemann, Carlos Alonso-Blanco, Sureshkumar Balasubramanian

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005085

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

John B. Moldovan, John V. Moran

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005121

Drosophila Spaghetti and Doubletime Link the Circadian Clock and Light to Caspases, Apoptosis and Tauopathy

John C. Means, Anandakrishnan Venkatesan, Bryan Gerdes, Jin-Yuan Fan, Edward S. Bjes, Jeffrey L. Price

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005171

Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans

Li Zhao, Janneke Wit, Nicolas Svetec, David J. Begun

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005184

PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses

Junqi Song, Brian D. Keppler, Robert R. Wise, Andrew F. Bent

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005200

Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast

Gábor Csárdi, Alexander Franks, David S. Choi, Edoardo M. Airoldi, D. Allan Drummond

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005206

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature

Samantha M. Thomas, Courtney Kagan, Bryan J. Pavlovic, Jonathan Burnett, Kristen Patterson, Jonathan K. Pritchard, Yoav Gilad

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005216

Burden Analysis of Rare Microdeletions Suggests a Strong Impact of Neurodevelopmental Genes in Genetic Generalised Epilepsies

Dennis Lal, Ann-Kathrin Ruppert, Holger Trucks, Herbert Schulz, Carolien G. de Kovel, Dorothée Kasteleijn-Nolst Trenité, Anja C. M. Sonsma, Bobby P. Koeleman, Dick Lindhout, Yvonne G. Weber, Holger Lerche, Claudia Kapser, Christoph J. Schankin, Wolfram S. Kunz, Rainer Surges, Christian E. Elger, Verena Gaus, Bettina Schmitz, Ingo Helbig, Hiltrud Muhle, Ulrich Stephani, Karl M. Klein, Felix Rosenow, Bernd A. Neubauer, Eva M. Reinthaler, Fritz Zimprich, Martha Feucht, Rikke S. Møller, Helle Hjalgrim, Peter De Jonghe, Arvid Suls, Wolfgang Lieb, Andre Franke, Konstantin Strauch, Christian Gieger, Claudia Schurmann, Ulf Schminke, Peter Nürnberg, EPICURE Consortium, Thomas Sander

PLOS Genetics: published May 7, 2015 | https://doi.org/10.1371/journal.pgen.1005226

Epistasis Is a Major Determinant of the Additive Genetic Variance in Mimulus guttatus

Patrick J. Monnahan, John K. Kelly

PLOS Genetics: published May 6, 2015 | https://doi.org/10.1371/journal.pgen.1005201

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

Lifen Wang, Hyung Don Ryoo, Yanyan Qi, Heinrich Jasper

PLOS Genetics: published May 6, 2015 | https://doi.org/10.1371/journal.pgen.1005220

Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer

Jie Sun, Yuxia Wang, Yisui Xia, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Huiqiang Lou, Yuntao Xie

PLOS Genetics: published May 6, 2015 | https://doi.org/10.1371/journal.pgen.1005228

Genomic Heritability: What Is It?

Gustavo de los Campos, Daniel Sorensen, Daniel Gianola

PLOS Genetics: published May 5, 2015 | https://doi.org/10.1371/journal.pgen.1005048

Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

Dustin C. Hancks, Melissa K. Hartley, Celia Hagan, Nathan L. Clark, Nels C. Elde

PLOS Genetics: published May 5, 2015 | https://doi.org/10.1371/journal.pgen.1005203

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

Artem G. Lada, Sergei F. Kliver, Alok Dhar, Dmitrii E. Polev, Alexey E. Masharsky, Igor B. Rogozin, Youri I. Pavlov

PLOS Genetics: published May 5, 2015 | https://doi.org/10.1371/journal.pgen.1005217

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

Louis S. Ates, Roy Ummels, Susanna Commandeur, Robert van der Weerd, Marion Sparrius, Eveline Weerdenburg, Marina Alber, Rainer Kalscheuer, Sander R. Piersma, Abdallah M. Abdallah, Moataz Abd El Ghany, Alyaa M. Abdel-Haleem, Arnab Pain, Connie R. Jiménez, Wilbert Bitter, Edith N.G. Houben

PLOS Genetics: published May 4, 2015 | https://doi.org/10.1371/journal.pgen.1005190

Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster

Lauren M. Dembeck, Wen Huang, Michael M. Magwire, Faye Lawrence, Richard F. Lyman, Trudy F. C. Mackay

PLOS Genetics: published May 1, 2015 | https://doi.org/10.1371/journal.pgen.1005163

Regulation of Active DNA Demethylation by a Methyl-CpG-Binding Domain Protein in Arabidopsis thaliana

Qi Li, Xiaokang Wang, Han Sun, Jun Zeng, Zhendong Cao, Yan Li, Weiqiang Qian

PLOS Genetics: published May 1, 2015 | https://doi.org/10.1371/journal.pgen.1005210

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Post-transcriptional Regulation of Hair Cycling by miR-22.

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**Post-transcriptional Regulation of Hair Cycling by miR-22.**