September 2014

An unbiased, systematic search for developmental regulators in the jellyfish Clytia by comparative transcriptomics of Wnt-manipulated embryos allowed identification of genes coding for both evolutionarily conserved and novel proteins. Expression analysis and knockdown studies for a subset of these confirmed their involvement in regulating embryogenesis. In this image, morpholino–mediated knockdown of the novel, hydrozoan-restricted gene WegD1 is seen to cause severe disruption of larval morphology characterized by disruption of the basal lamina between the endoderm and ectoderm layers, as demonstrated by confocal microscopy following visualization of cell contours (blue) and nuclei (purple). See Lapébie et al.

Image Credit: Sandra Chevalier and Evelyn Houliston

Perspective

Translational Regulation of the Drosophila Post-Translational Circadian Mechanism

Jeffrey L. Price

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004628

Reviews

Trans-kingdom Cross-Talk: Small RNAs on the Move

Marijn Knip, Maria E. Constantin, Hans Thordal-Christensen

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004602

Out of Balance: R-loops in Human Disease

Matthias Groh, Natalia Gromak

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004630

Research Articles

Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

Relja Popovic, Eva Martinez-Garcia, Eugenia G. Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y. Shah, Yupeng Zheng, Christine M. Will, Eliza C. Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A. Calogero, William L. Kath, Neil L. Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D. Licht

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004566

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

Claire S. Leblond, Caroline Nava, Anne Polge, Julie Gauthier, Guillaume Huguet, Serge Lumbroso, Fabienne Giuliano, Coline Stordeur, Christel Depienne, Kevin Mouzat, Dalila Pinto, Jennifer Howe, Nathalie Lemière, Christelle M. Durand, Jessica Guibert, Elodie Ey, Roberto Toro, Hugo Peyre, Alexandre Mathieu, Frédérique Amsellem, Maria Rastam, I. Carina Gillberg, Gudrun A. Rappold, Richard Holt, Anthony P. Monaco, Elena Maestrini, Pilar Galan, Delphine Heron, Aurélia Jacquette, Alexandra Afenjar, Agnès Rastetter, Alexis Brice, Françoise Devillard, Brigitte Assouline, Fanny Laffargue, James Lespinasse, Jean Chiesa, François Rivier, Dominique Bonneau, Beatrice Regnault, Diana Zelenika, Marc Delepine, Mark Lathrop, Damien Sanlaville, Caroline Schluth-Bolard, Patrick Edery, Laurence Perrin, Anne Claude Tabet, Michael J. Schmeisser, Tobias M. Boeckers, Mary Coleman, Daisuke Sato, Peter Szatmari, Stephen W. Scherer, Guy A. Rouleau, Catalina Betancur, Marion Leboyer, Christopher Gillberg, Richard Delorme, Thomas Bourgeron

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004580

Eliminating Both Canonical and Short-Patch Mismatch Repair in Drosophila melanogaster Suggests a New Meiotic Recombination Model

K. Nicole Crown, Susan McMahan, Jeff Sekelsky

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004583

Bipartite Recognition of DNA by TCF/Pangolin Is Remarkably Flexible and Contributes to Transcriptional Responsiveness and Tissue Specificity of Wingless Signaling

Hilary C. Archbold, Chris Broussard, Mikyung V. Chang, Ken M. Cadigan

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004591

PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase C

Ines Teichert, Eva Katharina Steffens, Nicole Schnaß, Benjamin Fränzel, Christoph Krisp, Dirk A. Wolters, Ulrich Kück

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004582

Role for Circadian Clock Genes in Seasonal Timing: Testing the Bünning Hypothesis

Mirko Pegoraro, Joao S. Gesto, Charalambos P. Kyriacou, Eran Tauber

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004603

Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster

Michael J. Williams, Philip Goergen, Jayasimman Rajendran, Galina Zheleznyakova, Maria G. Hägglund, Emelie Perland, Sonchita Bagchi, Argyro Kalogeropoulou, Zaid Khan, Robert Fredriksson, Helgi B. Schiöth

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004499

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

Gary W. Beecham, Kara Hamilton, Adam C. Naj, Eden R. Martin, Matt Huentelman, Amanda J. Myers, Jason J. Corneveaux, John Hardy, Jean-Paul Vonsattel, Steven G. Younkin, David A. Bennett, Philip L. De Jager, Eric B. Larson, Paul K. Crane, M. Ilyas Kamboh, Julia K. Kofler, Deborah C. Mash, Linda Duque, John R. Gilbert, Harry Gwirtsman, Joseph D. Buxbaum, Patricia Kramer, Dennis W. Dickson, Lindsay A. Farrer, Matthew P. Frosch, Bernardino Ghetti, Jonathan L. Haines, Bradley T. Hyman, Walter A. Kukull, Richard P. Mayeux, Margaret A. Pericak-Vance, Julie A. Schneider, John Q. Trojanowski, Eric M. Reiman, the Alzheimer's Disease Genetics Consortium (ADGC), Gerard D. Schellenberg, Thomas J. Montine

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004606

Tissue-Specific RNA Expression Marks Distant-Acting Developmental Enhancers

Han Wu, Alex S. Nord, Jennifer A. Akiyama, Malak Shoukry, Veena Afzal, Edward M. Rubin, Len A. Pennacchio, Axel Visel

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004610

The Olfactory Transcriptomes of Mice

Ximena Ibarra-Soria, Maria O. Levitin, Luis R. Saraiva, Darren W. Logan

PLOS Genetics: published September 4, 2014 | https://doi.org/10.1371/journal.pgen.1004593

Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells

Bingqing Zhang, Sonam Mehrotra, Wei Lun Ng, Brian R. Calvi

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004581

Hydroxymethylated Cytosines Are Associated with Elevated C to G Transversion Rates

Fran Supek, Ben Lehner, Petra Hajkova, Tobias Warnecke

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004585

Genome Wide Association Studies Using a New Nonparametric Model Reveal the Genetic Architecture of 17 Agronomic Traits in an Enlarged Maize Association Panel

Ning Yang, Yanli Lu, Xiaohong Yang, Juan Huang, Yang Zhou, Farhan Ali, Weiwei Wen, Jie Liu, Jiansheng Li, Jianbing Yan

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004573

Arabidopsis RRP6L1 and RRP6L2 Function in FLOWERING LOCUS C Silencing via Regulation of Antisense RNA Synthesis

Jun-Hye Shin, Julia A. Chekanova

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004612

BMPs Regulate msx Gene Expression in the Dorsal Neuroectoderm of Drosophila and Vertebrates by Distinct Mechanisms

Francisco F. Esteves, Alexander Springhorn, Erika Kague, Erika Taylor, George Pyrowolakis, Shannon Fisher, Ethan Bier

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004625

Identification of a Regulatory Variant That Binds FOXA1 and FOXA2 at the CDC123/CAMK1D Type 2 Diabetes GWAS Locus

Marie P. Fogarty, Maren E. Cannon, Swarooparani Vadlamudi, Kyle J. Gaulton, Karen L. Mohlke

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004633

Hidden Diversity in Honey Bee Gut Symbionts Detected by Single-Cell Genomics

Philipp Engel, Ramunas Stepanauskas, Nancy A. Moran

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004596

Causal Variation in Yeast Sporulation Tends to Reside in a Pathway Bottleneck

Kim Lorenz, Barak A. Cohen

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004634

Co-regulated Transcripts Associated to Cooperating eSNPs Define Bi-fan Motifs in Human Gene Networks

Anat Kreimer, Itsik Pe'er

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004587

Interspecific Tests of Allelism Reveal the Evolutionary Timing and Pattern of Accumulation of Reproductive Isolation Mutations

Natasha A. Sherman, Anna Victorine, Richard J. Wang, Leonie C. Moyle

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004623

Regulation of Arabidopsis Flowering by the Histone Mark Readers MRG1/2 via Interaction with CONSTANS to Modulate FT Expression

Zhongyuan Bu, Yu Yu, Zepeng Li, Yanchao Liu, Wen Jiang, Ying Huang, Ai-Wu Dong

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004617

Targeted H3R26 Deimination Specifically Facilitates Estrogen Receptor Binding by Modifying Nucleosome Structure

Michael J. Guertin, Xuesen Zhang, Lynne Anguish, Sohyoung Kim, Lyuba Varticovski, John T. Lis, Gordon L. Hager, Scott A. Coonrod

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004613

Rejuvenation of Meiotic Cohesion in Oocytes during Prophase I Is Required for Chiasma Maintenance and Accurate Chromosome Segregation

Katherine A. Weng, Charlotte A. Jeffreys, Sharon E. Bickel

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004607

Unkempt Is Negatively Regulated by mTOR and Uncouples Neuronal Differentiation from Growth Control

Amélie Avet-Rochex, Nancy Carvajal, Christina P. Christoforou, Kelvin Yeung, Katja T. Maierbrugger, Carl Hobbs, Giovanna Lalli, Umut Cagin, Cedric Plachot, Helen McNeill, Joseph M. Bateman

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004624

Positive Selection and Multiple Losses of the LINE-1-Derived L1TD1 Gene in Mammals Suggest a Dual Role in Genome Defense and Pluripotency

Richard N. McLaughlin Jr., Janet M. Young, Lei Yang, Rafik Neme, Holly A. Wichman, Harmit S. Malik

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004531

Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization

Peter Meinke, Elisabetta Mattioli, Farhana Haque, Susumu Antoku, Marta Columbaro, Kees R. Straatman, Howard J. Worman, Gregg G. Gundersen, Giovanna Lattanzi, Manfred Wehnert, Sue Shackleton

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004605

Translational Regulation of the DOUBLETIME/CKIδ/ε Kinase by LARK Contributes to Circadian Period Modulation

Yanmei Huang, Gerard P. McNeil, F. Rob Jackson

PLOS Genetics: published September 11, 2014 | https://doi.org/10.1371/journal.pgen.1004536

HEATR2 Plays a Conserved Role in Assembly of the Ciliary Motile Apparatus

Christine P. Diggle, Daniel J. Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R. Halachev, Philippe Gautier, Patricia L. Yeyati, David T. Bonthron, Ian M. Carr, Bruce Hayward, Alexander F. Markham, Jilly E. Hope, Alex von Kriegsheim, Hannah M. Mitchison, Ian J. Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P. Jarman, Pleasantine Mill

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004577

Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria

Shiori Akabane, Takuya Ueda, Knud H. Nierhaus, Nono Takeuchi

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004616

Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

Nazif Alic, Maria E. Giannakou, Irene Papatheodorou, Matthew P. Hoddinott, T. Daniel Andrews, Ekin Bolukbasi, Linda Partridge

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004619

tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

Mayumi Okamoto, Mamoru Fujiwara, Masato Hori, Kaoru Okada, Futoshi Yazama, Hiroaki Konishi, Yegui Xiao, Guangying Qi, Fumio Shimamoto, Takahide Ota, Achim Temme, Masaaki Tatsuka

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004639

Atkinesin-13A Modulates Cell-Wall Synthesis and Cell Expansion in Arabidopsis thaliana via the THESEUS1 Pathway

Ushio Fujikura, Lore Elsaesser, Holger Breuninger, Clara Sánchez-Rodríguez, Alexander Ivakov, Thomas Laux, Kim Findlay, Staffan Persson, Michael Lenhard

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004627

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

Ya-Juan Wang, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, the COGENT BP consortium, Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting-Wei Mu, Xiaofeng Zhu

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004641

SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene

Xin-Hua Cheng, Markaisa Black, Vladimir Ustiyan, Tien Le, Logan Fulford, Anusha Sridharan, Mario Medvedovic, Vladimir V. Kalinichenko, Jeffrey A. Whitsett, Tanya V. Kalin

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004656

Myosin Vb Mediated Plasma Membrane Homeostasis Regulates Peridermal Cell Size and Maintains Tissue Homeostasis in the Zebrafish Epidermis

Sonal, Jaydeep Sidhaye, Mandar Phatak, Shamik Banerjee, Aditya Mulay, Ojas Deshpande, Sourabh Bhide, Tressa Jacob, Ines Gehring, Christiane Nuesslein-Volhard, Mahendra Sonawane

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004614

Widespread Genome Reorganization of an Obligate Virus Mutualist

Gaelen R. Burke, Kimberly K. O. Walden, James B. Whitfield, Hugh M. Robertson, Michael R. Strand

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004660

Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels

Nicholas E. Banovich, Xun Lan, Graham McVicker, Bryce van de Geijn, Jacob F. Degner, John D. Blischak, Julien Roux, Jonathan K. Pritchard, Yoav Gilad

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004663

The Actomyosin Machinery Is Required for Drosophila Retinal Lumen Formation

Jing Nie, Simpla Mahato, Andrew C. Zelhof

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004608

The Tandem Repeats Enabling Reversible Switching between the Two Phases of β-Lactamase Substrate Spectrum

Hyojeong Yi, Han Song, Junghyun Hwang, Karan Kim, William C. Nierman, Heenam Stanley Kim

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004640

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Laura C. Greaves, Marco Nooteboom, Joanna L. Elson, Helen A. L. Tuppen, Geoffrey A. Taylor, Daniel M. Commane, Ramesh P. Arasaradnam, Konstantin Khrapko, Robert W. Taylor, Thomas B. L. Kirkwood, John C. Mathers, Douglass M. Turnbull

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004620

The Proprotein Convertase KPC-1/Furin Controls Branching and Self-avoidance of Sensory Dendrites in Caenorhabditis elegans

Yehuda Salzberg, Nelson J. Ramirez-Suarez, Hannes E. Bülow

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004657

Stress-Induced Nuclear RNA Degradation Pathways Regulate Yeast Bromodomain Factor 2 to Promote Cell Survival

Kevin Roy, Guillaume Chanfreau

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004661

Admixture in Latin America: Geographic Structure, Phenotypic Diversity and Self-Perception of Ancestry Based on 7,342 Individuals

Andrés Ruiz-Linares, Kaustubh Adhikari, Victor Acuña-Alonzo, Mirsha Quinto-Sanchez, Claudia Jaramillo, William Arias, Macarena Fuentes, María Pizarro, Paola Everardo, Francisco de Avila, Jorge Gómez-Valdés, Paola León-Mimila, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Mari-Wyn Burley, Esra Konca, Marcelo Zagonel de Oliveira, Mauricio Roberto Veronez, Marta Rubio-Codina, Orazio Attanasio, Sahra Gibbon, Nicolas Ray, Carla Gallo, Giovanni Poletti, Javier Rosique, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, David Balding, Rolando Gonzalez-José

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004572

Requirement for Drosophila SNMP1 for Rapid Activation and Termination of Pheromone-Induced Activity

Zhengzheng Li, Jinfei D. Ni, Jia Huang, Craig Montell

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004600

A Genetic Assay for Transcription Errors Reveals Multilayer Control of RNA Polymerase II Fidelity

Jordan D. Irvin, Maria L. Kireeva, Deanna R. Gotte, Brenda K. Shafer, Ingold Huang, Mikhail Kashlev, Jeffrey N. Strathern

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004532

GLD-4-Mediated Translational Activation Regulates the Size of the Proliferative Germ Cell Pool in the Adult C. elegans Germ Line

Sophia Millonigg, Ryuji Minasaki, Marco Nousch, Christian R. Eckmann

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004647

The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine

Sveta Chakrabarti, Mickaël Poidevin, Bruno Lemaitre

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004659

An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement

Evan G. Williams, Laurent Mouchiroud, Michael Frochaux, Ashutosh Pandey, Pénélope A. Andreux, Bart Deplancke, Johan Auwerx

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004673

Local Effect of Enhancer of Zeste-Like Reveals Cooperation of Epigenetic and cis-Acting Determinants for Zygotic Genome Rearrangements

Maoussi Lhuillier-Akakpo, Andrea Frapporti, Cyril Denby Wilkes, Mélody Matelot, Michel Vervoort, Linda Sperling, Sandra Duharcourt

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004665

Differential Responses to Wnt and PCP Disruption Predict Expression and Developmental Function of Conserved and Novel Genes in a Cnidarian

Pascal Lapébie, Antonella Ruggiero, Carine Barreau, Sandra Chevalier, Patrick Chang, Philippe Dru, Evelyn Houliston, Tsuyoshi Momose

PLOS Genetics: published September 18, 2014 | https://doi.org/10.1371/journal.pgen.1004590

Derlin-1 Regulates Mutant VCP-Linked Pathogenesis and Endoplasmic Reticulum Stress-Induced Apoptosis

Cyong-Jhih Liang, Ya-Chu Chang, Henry C. Chang, Chung-Kang Wang, Yu-Chien Hung, Ying-Er Lin, Chia-Ching Chan, Chun-Hong Chen, Hui-Yun Chang, Tzu-Kang Sang

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004675

Neurospora WC-1 Recruits SWI/SNF to Remodel frequency and Initiate a Circadian Cycle

Bin Wang, Arminja N. Kettenbach, Scott A. Gerber, Jennifer J. Loros, Jay C. Dunlap

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004599

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

Erik Södersten, Michael Feyder, Mads Lerdrup, Ana-Luisa Gomes, Hanna Kryh, Giada Spigolon, Jocelyne Caboche, Gilberto Fisone, Klaus Hansen

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004574

Evidence for Widespread Positive and Negative Selection in Coding and Conserved Noncoding Regions of Capsella grandiflora

Robert J. Williamson, Emily B. Josephs, Adrian E. Platts, Khaled M. Hazzouri, Annabelle Haudry, Mathieu Blanchette, Stephen I. Wright

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004622

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

David Zada, Adi Tovin, Tali Lerer-Goldshtein, Gad David Vatine, Lior Appelbaum

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004615

The Vip1 Inositol Polyphosphate Kinase Family Regulates Polarized Growth and Modulates the Microtubule Cytoskeleton in Fungi

Jennifer Pöhlmann, Carmen Risse, Constanze Seidel, Thomas Pohlmann, Visnja Jakopec, Eva Walla, Pascal Ramrath, Norio Takeshita, Sebastian Baumann, Michael Feldbrügge, Reinhard Fischer, Ursula Fleig

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004586

Memory and Fitness Optimization of Bacteria under Fluctuating Environments

Guillaume Lambert, Edo Kussell

PLOS Genetics: published September 25, 2014 | https://doi.org/10.1371/journal.pgen.1004556

Correction

Correction: Hypersensitivity of Primordial Germ Cells to Compromised Replication-Associated DNA Repair Involves ATM-p53-p21 Signaling

The PLOS Genetics Staff

PLOS Genetics: published September 12, 2014 | https://doi.org/10.1371/journal.pgen.1004730

Cover

Identification of cnidarian-restricted and metazoan-conserved genes that regulate embryogenesis.

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