April 2014

Streptococcus pneumoniae cells display an ovoid shape due to the coordinated synthesis of septal (for division) and peripheral (for elongation) peptidoglycan. Upon deletion of the gpsB gene, we show that cells aberrantly elongate together with hampered cell division. We have used this mutant as a trick to further decipher how the pneumococcus manages cell elongation before constriction and separation. We notably observe that elongated cells display a FtsZ helical organization. Together with other observations, we propose that a single peptidoglycan synthesis machinery organized by FtsZ is finely tuned to allow successful division and elongation of pneumococcal cells. See Fleurie et al.

Image Credit: Aurore Fleurie, Bases Moléculaires et Structurales des Systèmes Infectieux, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon I, France.

Interview

In Pursuit of the Gene: An Interview with James Schwartz

Jane Gitschier

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004308

Viewpoints

The Challenges of Mitochondrial Replacement

Patrick F. Chinnery, Lyndsey Craven, Shoukhrat Mitalipov, James B. Stewart, Mary Herbert, Douglass M. Turnbull

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004315

Perspective

Concocting Cholinergy

Artur Kania

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004313

Reviews

Phenotype Ontologies and Cross-Species Analysis for Translational Research

Peter N. Robinson, Caleb Webber

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004268

Epigenetic Regulation by Heritable RNA

Reinhard Liebers, Minoo Rassoulzadegan, Frank Lyko

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004296

Research Articles

DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

Christopher D. Putnam, Katielee Pallis, Tikvah K. Hayes, Richard D. Kolodner

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004277

RNA Editome in Rhesus Macaque Shaped by Purifying Selection

Jia-Yu Chen, Zhiyu Peng, Rongli Zhang, Xin-Zhuang Yang, Bertrand Chin-Ming Tan, Huaying Fang, Chu-Jun Liu, Mingming Shi, Zhi-Qiang Ye, Yong E. Zhang, Minghua Deng, Xiuqin Zhang, Chuan-Yun Li

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004274

A Central Role for GRB10 in Regulation of Islet Function in Man

Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S. Albert Salehi, Peter Almgren, Peter Osmark, Nabila Bouatia-Naji, Nils Wierup, Tove Fall, Alena Stančáková, Adam Barker, Vasiliki Lagou, Clive Osmond, Weijia Xie, Jari Lahti, Anne U. Jackson, Yu-Ching Cheng, Jie Liu, Jeffrey R. O'Connell, Paul A. Blomstedt, Joao Fadista, Sami Alkayyali, Tasnim Dayeh, Emma Ahlqvist, Jalal Taneera, Cecile Lecoeur, Ashish Kumar, Ola Hansson, Karin Hansson, Benjamin F. Voight, Hyun Min Kang, Claire Levy-Marchal, Vincent Vatin, Aarno Palotie, Ann-Christine Syvänen, Andrea Mari, Michael N. Weedon, Ruth J. F. Loos, Ken K. Ong, Peter Nilsson, Bo Isomaa, Tiinamaija Tuomi, Nicholas J. Wareham, Michael Stumvoll, Elisabeth Widen, Timo A. Lakka, Claudia Langenberg, Anke Tönjes, Rainer Rauramaa, Johanna Kuusisto, Timothy M. Frayling, Philippe Froguel, Mark Walker, Johan G. Eriksson, Charlotte Ling, Peter Kovacs, Erik Ingelsson, Mark I. McCarthy, Alan R. Shuldiner, Kristi D. Silver, Markku Laakso, Leif Groop, Valeriya Lyssenko

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004235

Protein Quantitative Trait Loci Identify Novel Candidates Modulating Cellular Response to Chemotherapy

Amy L. Stark, Ronald J. Hause Jr, Lidija K. Gorsic, Nirav N. Antao, Shan S. Wong, Sophie H. Chung, Daniel F. Gill, Hae K. Im, Jamie L. Myers, Kevin P. White, Richard Baker Jones, M. Eileen Dolan

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004192

Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models

Chidambaram Ramanathan, Haiyan Xu, Sanjoy K. Khan, Yang Shen, Paula J. Gitis, David K. Welsh, John B. Hogenesch, Andrew C. Liu

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004244

Methylome Diversification through Changes in DNA Methyltransferase Sequence Specificity

Yoshikazu Furuta, Hiroe Namba-Fukuyo, Tomoko F. Shibata, Tomoaki Nishiyama, Shuji Shigenobu, Yutaka Suzuki, Sumio Sugano, Mitsuyasu Hasebe, Ichizo Kobayashi

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004272

Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Robust Behavioral Circadian Rhythms in Drosophila melanogaster

Ron Weiss, Osnat Bartok, Shaul Mezan, Yuval Malka, Sebastian Kadener

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004252

Ras GTPase-Like Protein MglA, a Controller of Bacterial Social-Motility in Myxobacteria, Has Evolved to Control Bacterial Predation by Bdellovibrio

David S. Milner, Rob Till, Ian Cadby, Andrew L. Lovering, Sarah M. Basford, Emma B. Saxon, Susan Liddell, Laura E. Williams, R. Elizabeth Sockett

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004253

The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals

David W. Johnson, Jesse R. Llop, Sara F. Farrell, Jie Yuan, Lindsay R. Stolzenburg, Andrew V. Samuelson

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004278

CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia

Francisco J. Arjona, Jeroen H. F. de Baaij, Karl P. Schlingmann, Anke L. L. Lameris, Erwin van Wijk, Gert Flik, Sabrina Regele, G. Christoph Korenke, Birgit Neophytou, Stephan Rust, Nadine Reintjes, Martin Konrad, René J. M. Bindels, Joost G. J. Hoenderop

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004267

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Ana Osorio, Roger L. Milne, Karoline Kuchenbaecker, Tereza Vaclová, Guillermo Pita, Rosario Alonso, Paolo Peterlongo, Ignacio Blanco, Miguel de la Hoya, Mercedes Duran, Orland Díez, Teresa Ramón y Cajal, Irene Konstantopoulou, Cristina Martínez-Bouzas, Raquel Andrés Conejero, Penny Soucy, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, SWE-BRCA, Brita Arver, Johanna Rantala, Niklas Loman, Hans Ehrencrona, Olufunmilayo I. Olopade, Mary S. Beattie, Susan M. Domchek, Katherine Nathanson, Timothy R. Rebbeck, Banu K. Arun, Beth Y. Karlan, Christine Walsh, Jenny Lester, Esther M. John, Alice S. Whittemore, Mary B. Daly, Melissa Southey, John Hopper, Mary B. Terry, Saundra S. Buys, Ramunas Janavicius, Cecilia M. Dorfling, Elizabeth J. van Rensburg, Linda Steele, Susan L. Neuhausen, Yuan Chun Ding, Thomas v. O. Hansen, Lars Jønson, Bent Ejlertsen, Anne-Marie Gerdes, Mar Infante, Belén Herráez, Leticia Thais Moreno, Jeffrey N. Weitzel, Josef Herzog, Kisa Weeman, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Giulietta Scuvera, Bernardo Bonanni, Frederique Mariette, Sara Volorio, Alessandra Viel, Liliana Varesco, Laura Papi, Laura Ottini, Maria Grazia Tibiletti, Paolo Radice, Drakoulis Yannoukakos, Judy Garber, Steve Ellis, Debra Frost, Radka Platte, Elena Fineberg, Gareth Evans, Fiona Lalloo, Louise Izatt, Ros Eeles, Julian Adlard, Rosemarie Davidson, Trevor Cole, Diana Eccles, Jackie Cook, Shirley Hodgson, Carole Brewer, Marc Tischkowitz, Fiona Douglas, Mary Porteous, Lucy Side, Lisa Walker, Patrick Morrison, Alan Donaldson, John Kennedy, Claire Foo, Andrew K. Godwin, Rita Katharina Schmutzler, Barbara Wappenschmidt, Kerstin Rhiem, Christoph Engel, Alfons Meindl, Nina Ditsch, Norbert Arnold, Hans Jörg Plendl, Dieter Niederacher, Christian Sutter, Shan Wang-Gohrke, Doris Steinemann, Sabine Preisler-Adams, Karin Kast, Raymonda Varon-Mateeva, Andrea Gehrig, Dominique Stoppa-Lyonnet, Olga M. Sinilnikova, Sylvie Mazoyer, Francesca Damiola, Bruce Poppe, Kathleen Claes, Marion Piedmonte, Kathy Tucker, Floor Backes, Gustavo Rodríguez, Wendy Brewster, Katie Wakeley, Thomas Rutherford, Trinidad Caldés, Heli Nevanlinna, Kristiina Aittomäki, Matti A. Rookus, Theo A. M. van Os, Lizet van der Kolk, J. L. de Lange, Hanne E. J. Meijers-Heijboer, A. H. van der Hout, Christi J. van Asperen, Encarna B. Gómez Garcia, Nicoline Hoogerbrugge, J. Margriet Collée, Carolien H. M. van Deurzen, Rob B. van der Luijt, Peter Devilee, HEBON, Edith Olah, Conxi Lázaro, Alex Teulé, Mireia Menéndez, Anna Jakubowska, Cezary Cybulski, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Oskar Th. Johannsson, Christine Maugard, Marco Montagna, Silvia Tognazzo, Manuel R. Teixeira, Sue Healey, KConFab Investigators, Curtis Olswold, Lucia Guidugli, Noralane Lindor, Susan Slager, Csilla I. Szabo, Joseph Vijai, Mark Robson, Noah Kauff, Liying Zhang, Rohini Rau-Murthy, Anneliese Fink-Retter, Christian F. Singer, Christine Rappaport, Daphne Geschwantler Kaulich, Georg Pfeiler, Muy-Kheng Tea, Andreas Berger, Catherine M. Phelan, Mark H. Greene, Phuong L. Mai, Flavio Lejbkowicz, Irene Andrulis, Anna Marie Mulligan, Gord Glendon, Amanda Ewart Toland, Anders Bojesen, Inge Sokilde Pedersen, Lone Sunde, Mads Thomassen, Torben A. Kruse, Uffe Birk Jensen, Eitan Friedman, Yael Laitman, Shani Paluch Shimon, Jacques Simard, Douglas F. Easton, Kenneth Offit, Fergus J. Couch, Georgia Chenevix-Trench, Antonis C. Antoniou, Javier Benitez

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004256

Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples

Peter M. Visscher, Gibran Hemani, Anna A. E. Vinkhuyzen, Guo-Bo Chen, Sang Hong Lee, Naomi R. Wray, Michael E. Goddard, Jian Yang

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004269

Interaction between Two Timing MicroRNAs Controls Trichome Distribution in Arabidopsis

Xue-Yi Xue, Bo Zhao, Lu-Men Chao, Dian-Yang Chen, Wen-Rui Cui, Ying-Bo Mao, Ling-Jian Wang, Xiao-Ya Chen

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004266

Sox5 Functions as a Fate Switch in Medaka Pigment Cell Development

Yusuke Nagao, Takao Suzuki, Atsushi Shimizu, Tetsuaki Kimura, Ryoko Seki, Tomoko Adachi, Chikako Inoue, Yoshihiro Omae, Yasuhiro Kamei, Ikuyo Hara, Yoshihito Taniguchi, Kiyoshi Naruse, Yuko Wakamatsu, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004246

Widespread Use of Non-productive Alternative Splice Sites in Saccharomyces cerevisiae

Tadashi Kawashima, Stephen Douglass, Jason Gabunilas, Matteo Pellegrini, Guillaume F. Chanfreau

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004249

Chromatin Landscapes of Retroviral and Transposon Integration Profiles

Johann de Jong, Waseem Akhtar, Jitendra Badhai, Alistair G. Rust, Roland Rad, John Hilkens, Anton Berns, Maarten van Lohuizen, Lodewyk F. A. Wessels, Jeroen de Ridder

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004250

Determining the Control Circuitry of Redox Metabolism at the Genome-Scale

Stephen Federowicz, Donghyuk Kim, Ali Ebrahim, Joshua Lerman, Harish Nagarajan, Byung-kwan Cho, Karsten Zengler, Bernhard Palsson

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004264

Unexpected Role of the Steroid-Deficiency Protein Ecdysoneless in Pre-mRNA Splicing

Ann-Katrin Claudius, Patrizia Romani, Tobias Lamkemeyer, Marek Jindra, Mirka Uhlirova

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004287

A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence

Zena T. Wolf, Elizabeth J. Leslie, Boaz Arzi, Kartika Jayashankar, Nili Karmi, Zhonglin Jia, Douglas J. Rowland, Amy Young, Noa Safra, Saundra Sliskovic, Jeffrey C. Murray, Claire M. Wade, Danika L. Bannasch

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004257

Interplay of the Serine/Threonine-Kinase StkP and the Paralogs DivIVA and GpsB in Pneumococcal Cell Elongation and Division

Aurore Fleurie, Sylvie Manuse, Chao Zhao, Nathalie Campo, Caroline Cluzel, Jean-Pierre Lavergne, Céline Freton, Christophe Combet, Sébastien Guiral, Boumediene Soufi, Boris Macek, Erkin Kuru, Michael S. VanNieuwenhze, Yves V. Brun, Anne-Marie Di Guilmi, Jean-Pierre Claverys, Anne Galinier, Christophe Grangeasse

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004275

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

Feng-Yang Zong, Xing Fu, Wen-Juan Wei, Ya-Ge Luo, Monika Heiner, Li-Juan Cao, Zhaoyuan Fang, Rong Fang, Daru Lu, Hongbin Ji, Jingyi Hui

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004289

The Mechanism of Gene Targeting in Human Somatic Cells

Yinan Kan, Brian Ruis, Sherry Lin, Eric A. Hendrickson

PLOS Genetics: published April 3, 2014 | https://doi.org/10.1371/journal.pgen.1004251

Uncoupling Transcription from Covalent Histone Modification

Hesheng Zhang, Lu Gao, Jayamani Anandhakumar, David S. Gross

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004202

Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region

Erick W. Loomis, Lionel A. Sanz, Frédéric Chédin, Paul J. Hagerman

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004294

Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer

Jane C. Figueiredo, Li Hsu, Carolyn M. Hutter, Yi Lin, Peter T. Campbell, John A. Baron, Sonja I. Berndt, Shuo Jiao, Graham Casey, Barbara Fortini, Andrew T. Chan, Michelle Cotterchio, Mathieu Lemire, Steven Gallinger, Tabitha A. Harrison, Loic Le Marchand, Polly A. Newcomb, Martha L. Slattery, Bette J. Caan, Christopher S. Carlson, Brent W. Zanke, Stephanie A. Rosse, Hermann Brenner, Edward L. Giovannucci, Kana Wu, Jenny Chang-Claude, Stephen J. Chanock, Keith R. Curtis, David Duggan, Jian Gong, Robert W. Haile, Richard B. Hayes, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Laurence N. Kolonel, Conghui Qu, Anja Rudolph, Robert E. Schoen, Fredrick R. Schumacher, Daniela Seminara, Deanna L. Stelling, Stephen N. Thibodeau, Mark Thornquist, Greg S. Warnick, Brian E. Henderson, Cornelia M. Ulrich, W. James Gauderman, John D. Potter, Emily White, Ulrike Peters, on behalf of CCFR, and GECCO

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004228

Three Groups of Transposable Elements with Contrasting Copy Number Dynamics and Host Responses in the Maize (Zea mays ssp. mays) Genome

Concepcion M. Diez, Esteban Meca, Maud I. Tenaillon, Brandon S. Gaut

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004298

Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Guilhem Janbon, Kate L. Ormerod, Damien Paulet, Edmond J. Byrnes III, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, Chung-Chau Hon, R. Blake Billmyre, François Brunel, Yong-Sun Bahn, Weidong Chen, Yuan Chen, Eve W. L. Chow, Jean-Yves Coppée, Anna Floyd-Averette, Claude Gaillardin, Kimberly J. Gerik, Jonathan Goldberg, Sara Gonzalez-Hilarion, Sharvari Gujja, Joyce L. Hamlin, Yen-Ping Hsueh, Giuseppe Ianiri, Steven Jones, Chinnappa D. Kodira, Lukasz Kozubowski, Woei Lam, Marco Marra, Larry D. Mesner, Piotr A. Mieczkowski, Frédérique Moyrand, Kirsten Nielsen, Caroline Proux, Tristan Rossignol, Jacqueline E. Schein, Sheng Sun, Carolin Wollschlaeger, Ian A. Wood, Qiandong Zeng, Cécile Neuvéglise, Carol S. Newlon, John R. Perfect, Jennifer K. Lodge, Alexander Idnurm, Jason E. Stajich, James W. Kronstad, Kaustuv Sanyal, Joseph Heitman, James A. Fraser, Christina A. Cuomo, Fred S. Dietrich

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004261

Fine Mapping of Dominant X-Linked Incompatibility Alleles in Drosophila Hybrids

Daniel R. Matute, Jackie Gavin-Smyth

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004270

A Synthetic Community Approach Reveals Plant Genotypes Affecting the Phyllosphere Microbiota

Natacha Bodenhausen, Miriam Bortfeld-Miller, Martin Ackermann, Julia A. Vorholt

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004283

Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast

Elinor Sawyer, Rebecca Roylance, Christos Petridis, Mark N. Brook, Salpie Nowinski, Efterpi Papouli, Olivia Fletcher, Sarah Pinder, Andrew Hanby, Kelly Kohut, Patricia Gorman, Michele Caneppele, Julian Peto, Isabel dos Santos Silva, Nichola Johnson, Ruth Swann, Miriam Dwek, Katherine-Anne Perkins, Cheryl Gillett, Richard Houlston, Gillian Ross, Paolo De Ieso, Melissa C. Southey, John L. Hopper, Elena Provenzano, Carmel Apicella, Jelle Wesseling, Sten Cornelissen, Renske Keeman, Peter A. Fasching, Sebastian M. Jud, Arif B. Ekici, Matthias W. Beckmann, Michael J. Kerin, Federick Marme, Andreas Schneeweiss, Christof Sohn, Barbara Burwinkel, Pascal Guénel, Therese Truong, Pierre Laurent-Puig, Pierre Kerbrat, Stig E. Bojesen, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Roger L. Milne, Jose Ignacio Arias Perez, Primitiva Menéndez, Javier Benitez, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Alfons Meindl, Peter Lichtner, Rita K. Schmutzler, Magdalena Lochmann, Hiltrud Brauch, Hans-Peter Fischer, Yon-Dschun Ko, The GENICA Network, Heli Nevanlinna, Taru A. Muranen, Kristiina Aittomäki, Carl Blomqvist, Natalia V. Bogdanova, Thilo Dörk, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Georgia Chenevix-Trench, KConFab Investigators, Diether Lambrechts, Caroline Weltens, Erik Van Limbergen, Sigrid Hatse, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, Sara Volorio, Graham G. Giles, Gianluca Severi, Laura Baglietto, Catriona A. Mclean, Christopher A. Haiman, Brian E. Henderson, Fredrick Schumacher, Loic Le Marchand, Jacques Simard, Mark S. Goldberg, France Labrèche, Martine Dumont, Vessela Kristensen, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Saila Kauppila, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Peter Devillee, Rob A. E. M. Tollenaar, Caroline M. Seynaeve, Mieke Kriege, Jonine Figueroa, Stephen J. Chanock, Mark E. Sherman, Maartje J. Hooning, Antoinette Hollestelle, Ans M. W. van den Ouweland, Carolien H. M. van Deurzen, Jingmei Li, Kamila Czene, Keith Humphreys, Angela Cox, Simon S. Cross, Malcolm W. R. Reed, Mitul Shah, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Anthony Swerdlow, Alan Ashworth, Nicholas Orr, Minouk Schoemaker, Fergus J. Couch, Emily Hallberg, Anna González-Neira, Guillermo Pita, M. Rosario Alonso, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Alison M. Dunning, Per Hall, Doug Easton, Paul Pharoah, Marjanka K. Schmidt, Ian Tomlinson, Montserrat Garcia-Closas

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004285

Mouse Pulmonary Adenoma Susceptibility 1 Locus Is an Expression QTL Modulating Kras-4A

Alice Dassano, Francesca Colombo, Gaia Trincucci, Elisa Frullanti, Antonella Galvan, Angela Pettinicchio, Loris De Cecco, Andrea Borrego, Olga Célia Martinez Ibañez, Tommaso A. Dragani, Giacomo Manenti

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004307

Evolutionarily Diverged Regulation of X-chromosomal Genes as a Primal Event in Mouse Reproductive Isolation

Ayako Oka, Toyoyuki Takada, Hironori Fujisawa, Toshihiko Shiroishi

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004301

A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific Abortifacients

Joshua B. Benoit, Geoffrey M. Attardo, Veronika Michalkova, Tyler B. Krause, Jana Bohova, Qirui Zhang, Aaron A. Baumann, Paul O. Mireji, Peter Takáč, David L. Denlinger, Jose M. Ribeiro, Serap Aksoy

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1003874

A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

Jared O'Connell, Deepti Gurdasani, Olivier Delaneau, Nicola Pirastu, Sheila Ulivi, Massimiliano Cocca, Michela Traglia, Jie Huang, Jennifer E. Huffman, Igor Rudan, Ruth McQuillan, Ross M. Fraser, Harry Campbell, Ozren Polasek, Gershim Asiki, Kenneth Ekoru, Caroline Hayward, Alan F. Wright, Veronique Vitart, Pau Navarro, Jean-Francois Zagury, James F. Wilson, Daniela Toniolo, Paolo Gasparini, Nicole Soranzo, Manjinder S. Sandhu, Jonathan Marchini

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004234

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

Yujia A. Chan, Maria J. Aristizabal, Phoebe Y. T. Lu, Zongli Luo, Akil Hamza, Michael S. Kobor, Peter C. Stirling, Philip Hieter

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004288

The Sequence-Specific Transcription Factor c-Jun Targets Cockayne Syndrome Protein B to Regulate Transcription and Chromatin Structure

Robert J. Lake, Erica L. Boetefuer, Pei-Fang Tsai, Jieun Jeong, Inchan Choi, Kyoung-Jae Won, Hua-Ying Fan

PLOS Genetics: published April 17, 2014 | https://doi.org/10.1371/journal.pgen.1004284

FRA2A Is a CGG Repeat Expansion Associated with Silencing of AFF3

Sofie Metsu, Liesbeth Rooms, Jacqueline Rainger, Martin S. Taylor, Hemant Bengani, David I. Wilson, Chandra Sekhar Reddy Chilamakuri, Harris Morrison, Geert Vandeweyer, Edwin Reyniers, Evelyn Douglas, Geoffrey Thompson, Eric Haan, Jozef Gecz, David R. FitzPatrick, R. Frank Kooy

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004242

Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic

Laura A. Cotton, Xiaomei T. Kuang, Anh Q. Le, Jonathan M. Carlson, Benjamin Chan, Denis R. Chopera, Chanson J. Brumme, Tristan J. Markle, Eric Martin, Aniqa Shahid, Gursev Anmole, Philip Mwimanzi, Pauline Nassab, Kali A. Penney, Manal A. Rahman, M.-J. Milloy, Martin T. Schechter, Martin Markowitz, Mary Carrington, Bruce D. Walker, Theresa Wagner, Susan Buchbinder, Jonathan Fuchs, Beryl Koblin, Kenneth H. Mayer, P. Richard Harrigan, Mark A. Brockman, Art F. Y. Poon, Zabrina L. Brumme

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004295

A Quality Control Mechanism Coordinates Meiotic Prophase Events to Promote Crossover Assurance

Alison J. Deshong, Alice L. Ye, Piero Lamelza, Needhi Bhalla

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004291

Proper Actin Ring Formation and Septum Constriction Requires Coordinated Regulation of SIN and MOR Pathways through the Germinal Centre Kinase MST-1

Yvonne Heilig, Anne Dettmann, Rosa R. Mouriño-Pérez, Kerstin Schmitt, Oliver Valerius, Stephan Seiler

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004306

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

Elite Possik, Zahra Jalali, Yann Nouët, Ming Yan, Marie-Claude Gingras, Kathrin Schmeisser, Lorena Panaite, Fanny Dupuy, Dmitri Kharitidi, Laëtitia Chotard, Russell G. Jones, David H. Hall, Arnim Pause

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004273

Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans

Yun C. Chang, Ami Khanal Lamichhane, H. Martin Garraffo, Peter J. Walter, Maarten Leerkes, Kyung J. Kwon-Chung

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004292

Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

Hyong-Ho Cho, Francesca Cargnin, Yujin Kim, Bora Lee, Ryuk-Jun Kwon, Heejin Nam, Rongkun Shen, Anthony P. Barnes, Jae W. Lee, Seunghee Lee, Soo-Kyung Lee

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004280

Rad51–Rad52 Mediated Maintenance of Centromeric Chromatin in Candida albicans

Sreyoshi Mitra, Jonathan Gómez-Raja, Germán Larriba, Dharani Dhar Dubey, Kaustuv Sanyal

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004344

Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression

Anna Y. Zinovyeva, Samir Bouasker, Martin J. Simard, Christopher M. Hammell, Victor Ambros

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004286

Drosophila Embryogenesis Scales Uniformly across Temperature in Developmentally Diverse Species

Steven G. Kuntz, Michael B. Eisen

PLOS Genetics: published April 24, 2014 | https://doi.org/10.1371/journal.pgen.1004293

Corrections

Correction: Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis

The PLOS Genetics Staff

PLOS Genetics: published April 4, 2014 | https://doi.org/10.1371/journal.pgen.1004350

Correction: ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

The PLOS Genetics Staff

PLOS Genetics: published April 4, 2014 | https://doi.org/10.1371/journal.pgen.1004352

Correction: Regulation of Synaptic nlg-1/Neuroligin Abundance by the skn-1/Nrf Stress Response Pathway Protects against Oxidative Stress

The PLOS Genetics Staff

PLOS Genetics: published April 10, 2014 | https://doi.org/10.1371/journal.pgen.1004361

Correction: DUF1220 Dosage Is Linearly Associated with Increasing Severity of the Three Primary Symptoms of Autism

The PLOS Genetics Staff

PLOS Genetics: published April 11, 2014 | https://doi.org/10.1371/journal.pgen.1004373

Correction: Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning

The PLOS Genetics Staff

PLOS Genetics: published April 14, 2014 | https://doi.org/10.1371/journal.pgen.1004374

Cover

Uncontrolled elongation of the rugby-ball-shaped bacterium Streptococcus pneumoniae induces FtsZ spiraling.

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**Uncontrolled elongation of the rugby-ball-shaped bacterium Streptococcus pneumoniae induces FtsZ spiraling.**