December 2013

Amyloid-like inclusions have been associated with Huntington's disease, and patients exhibit a high incidence of cardiovascular events. In this issue, Melkani and colleagues generated a Drosophila (fruit fly) model of cardiac amyloidosis. It displays accumulation of mutant Huntingtin aggregates and oxidative stress in myocardial cells upon heart-specific expression of Huntingtin protein fragments with disease-causing poly-glutamine repeats. Using genetic manipulation, the authors showed that modulation of both protein unfolding, and oxidative stress pathways, is required to ameliorate the detrimental mutant Huntingtin defects. The image shows reduced and disorganized myosin- (pink) and actin- (cyan) containing myofibrils along with mutant Huntingtin positive aggregates (green) in the heart. See Melkani et al.

Image Credit: Girish C. Melkani and colleagues

Perspectives

And Baby Makes Three: Genomic Imprinting in Plant Embryos

Hugh Dickinson, Stefan Scholten

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003981

Stressing the Importance of CHOP in Liver Cancer

Barrett L. Updegraff, Kathryn A. O'Donnell

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004045

The AmAZI1ng Roles of Centriolar Satellites during Development

Moe R. Mahjoub, Meng-Fu Bryan Tsou

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004070

Bugs in Transition: The Dynamic World of Wolbachia in Insects

Wolfgang J. Miller

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004069

Flies Get a Head Start on Meiosis

Cori K. Cahoon, R. Scott Hawley

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004051

Review

Cohesinopathies of a Feather Flock Together

Robert V. Skibbens, Jennifer M. Colquhoun, Megan J. Green, Cody A. Molnar, Danielle N. Sin, Brian J. Sullivan, Eden E. Tanzosh

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004036

Research Articles

CRIS—A Novel cAMP-Binding Protein Controlling Spermiogenesis and the Development of Flagellar Bending

Anke Miriam Krähling, Luis Alvarez, Katharina Debowski, Qui Van, Monika Gunkel, Stephan Irsen, Ashraf Al-Amoudi, Timo Strünker, Elisabeth Kremmer, Eberhard Krause, Ingo Voigt, Simone Wörtge, Ari Waisman, Ingo Weyand, Reinhard Seifert, Ulrich Benjamin Kaupp, Dagmar Wachten

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003960

Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

Ashish Kumar Maurya, Jin Ben, Zhonghua Zhao, Raymond Teck Ho Lee, Weixin Niah, Ashley Shu Mei Ng, Audrey Iyu, Weimiao Yu, Stone Elworthy, Fredericus J. M. van Eeden, Philip William Ingham

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003955

Selection on Plant Male Function Genes Identifies Candidates for Reproductive Isolation of Yellow Monkeyflowers

Jan E. Aagaard, Renee D. George, Lila Fishman, Michael J. MacCoss, Willie J. Swanson

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003965

Contributions of Protein-Coding and Regulatory Change to Adaptive Molecular Evolution in Murid Rodents

Daniel L. Halligan, Athanasios Kousathanas, Rob W. Ness, Bettina Harr, Lél Eöry, Thomas M. Keane, David J. Adams, Peter D. Keightley

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003995

Dual Regulation of the Mitotic Exit Network (MEN) by PP2A-Cdc55 Phosphatase

Barbara Baro, Jose-Antonio Rodriguez-Rodriguez, Ines Calabria, María Luisa Hernáez, Concha Gil, Ethel Queralt

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003966

Genome-Wide Screen Reveals Replication Pathway for Quasi-Palindrome Fragility Dependent on Homologous Recombination

Yu Zhang, Natalie Saini, Ziwei Sheng, Kirill S. Lobachev

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003979

Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila

Stanley M. Walls Jr, Steve J. Attle, Gregory B. Brulte, Marlena L. Walls, Kim D. Finley, Dale A. Chatfield, Deron R. Herr, Greg L. Harris

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003970

Genomic Imprinting in the Arabidopsis Embryo Is Partly Regulated by PRC2

Michael T. Raissig, Marian Bemer, Célia Baroux, Ueli Grossniklaus

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003862

Basolateral Mg²⁺ Extrusion via CNNM4 Mediates Transcellular Mg²⁺ Transport across Epithelia: A Mouse Model

Daisuke Yamazaki, Yosuke Funato, Jiro Miura, Sunao Sato, Satoru Toyosawa, Kazuharu Furutani, Yoshihisa Kurachi, Yoshihiro Omori, Takahisa Furukawa, Tetsuya Tsuda, Susumu Kuwabata, Shin Mizukami, Kazuya Kikuchi, Hiroaki Miki

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003983

Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis

Lucie P. Pellissier, Celso Henrique Alves, Peter M. Quinn, Rogier M. Vos, Naoyuki Tanimoto, Ditte M. S. Lundvig, Jacobus J. Dudok, Berend Hooibrink, Fabrice Richard, Susanne C. Beck, Gesine Huber, Vithiyanjali Sothilingam, Marina Garcia Garrido, André Le Bivic, Mathias W. Seeliger, Jan Wijnholds

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003976

Evidence That Masking of Synapsis Imperfections Counterbalances Quality Control to Promote Efficient Meiosis

Susanna Mlynarczyk-Evans, Baptiste Roelens, Anne M. Villeneuve

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003963

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain

Sebiha Cevik, Anna A. W. M. Sanders, Erwin Van Wijk, Karsten Boldt, Lara Clarke, Jeroen van Reeuwijk, Yuji Hori, Nicola Horn, Lisette Hetterschijt, Anita Wdowicz, Andrea Mullins, Katarzyna Kida, Oktay I. Kaplan, Sylvia E. C. van Beersum, Ka Man Wu, Stef J. F. Letteboer, Dorus A. Mans, Toshiaki Katada, Kenji Kontani, Marius Ueffing, Ronald Roepman, Hannie Kremer, Oliver E. Blacque

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003977

A Novel Intergenic ETnII-β Insertion Mutation Causes Multiple Malformations in Polypodia Mice

Jessica A. Lehoczky, Peedikayil E. Thomas, Kevin M. Patrie, Kailey M. Owens, Lisa M. Villarreal, Kenneth Galbraith, Joe Washburn, Craig N. Johnson, Bryant Gavino, Alexander D. Borowsky, Kathleen J. Millen, Paul Wakenight, William Law, Margaret L. Van Keuren, Galina Gavrilina, Elizabeth D. Hughes, Thomas L. Saunders, Lesil Brihn, Joseph H. Nadeau, Jeffrey W. Innis

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003967

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

Hannes Olauson, Karolina Lindberg, Risul Amin, Tadatoshi Sato, Ting Jia, Regina Goetz, Moosa Mohammadi, Göran Andersson, Beate Lanske, Tobias E. Larsson

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003975

Dual Regulation of Gene Expression Mediated by Extended MAPK Activation and Salicylic Acid Contributes to Robust Innate Immunity in Arabidopsis thaliana

Kenichi Tsuda, Akira Mine, Gerit Bethke, Daisuke Igarashi, Christopher J. Botanga, Yayoi Tsuda, Jane Glazebrook, Masanao Sato, Fumiaki Katagiri

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1004015

Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance

Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003986

Somatic mtDNA Mutation Spectra in the Aging Human Putamen

Siôn L. Williams, Deborah C. Mash, Stephan Züchner, Carlos T. Moraes

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1003990

A Trans-Acting Protein Effect Causes Severe Eye Malformation in the Mp Mouse

Joe Rainger, Margaret Keighren, Douglas R. Keene, Noe L. Charbonneau, Jacqueline K. Rainger, Malcolm Fisher, Sebastien Mella, Jeffrey T-J. Huang, Lorraine Rose, Rob van't Hof, Lynne Y. Sakai, Ian J. Jackson, David R. FitzPatrick

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003998

A Domesticated PiggyBac Transposase Interacts with Heterochromatin and Catalyzes Reproducible DNA Elimination in Tetrahymena

Alexander Vogt, Kazufumi Mochizuki

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1004032

Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs

Adam Auton, Ying Rui Li, Jeffrey Kidd, Kyle Oliveira, Julie Nadel, J. Kim Holloway, Jessica J. Hayward, Paula E. Cohen, John M. Greally, Jun Wang, Carlos D. Bustamante, Adam R. Boyko

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003984

A Global In Vivo Drosophila RNAi Screen Identifies a Key Role of Ceramide Phosphoethanolamine for Glial Ensheathment of Axons

Aniket Ghosh, Tina Kling, Nicolas Snaidero, Julio L. Sampaio, Andrej Shevchenko, Heribert Gras, Bart Geurten, Martin C. Göpfert, Jörg B. Schulz, Aaron Voigt, Mikael Simons

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003980

Expanding the Marine Virosphere Using Metagenomics

Carolina Megumi Mizuno, Francisco Rodriguez-Valera, Nikole E. Kimes, Rohit Ghai

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003987

Role of Tomato Lipoxygenase D in Wound-Induced Jasmonate Biosynthesis and Plant Immunity to Insect Herbivores

Liuhua Yan, Qingzhe Zhai, Jianing Wei, Shuyu Li, Bao Wang, Tingting Huang, Minmin Du, Jiaqiang Sun, Le Kang, Chang-Bao Li, Chuanyou Li

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003964

An Lmx1b-miR135a2 Regulatory Circuit Modulates Wnt1/Wnt Signaling and Determines the Size of the Midbrain Dopaminergic Progenitor Pool

Angela Anderegg, Hsin-Pin Lin, Jun-An Chen, Giuliana Caronia-Brown, Natalya Cherepanova, Beth Yun, Milan Joksimovic, Jason Rock, Brian D. Harfe, Randy Johnson, Rajeshwar Awatramani

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003973

Wolbachia Variants Induce Differential Protection to Viruses in Drosophila melanogaster: A Phenotypic and Phylogenomic Analysis

Ewa Chrostek, Marta S. P. Marialva, Sara S. Esteves, Lucy A. Weinert, Julien Martinez, Francis M. Jiggins, Luis Teixeira

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003896

The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis

Kyle G. Ingram, Carol D. Curtis, Robert Silasi-Mansat, Florea Lupu, Courtney T. Griffin

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1004031

Sumoylated NHR-25/NR5A Regulates Cell Fate during C. elegans Vulval Development

Jordan D. Ward, Nagagireesh Bojanala, Teresita Bernal, Kaveh Ashrafi, Masako Asahina, Keith R. Yamamoto

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003992

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis

Diane DeZwaan-McCabe, Jesse D. Riordan, Angela M. Arensdorf, Michael S. Icardi, Adam J. Dupuy, D. Thomas Rutkowski

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003937

Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia

Zeynep Kalender Atak, Valentina Gianfelici, Gert Hulselmans, Kim De Keersmaecker, Arun George Devasia, Ellen Geerdens, Nicole Mentens, Sabina Chiaretti, Kaat Durinck, Anne Uyttebroeck, Peter Vandenberghe, Iwona Wlodarska, Jacqueline Cloos, Robin Foà, Frank Speleman, Jan Cools, Stein Aerts

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003997

Tay Bridge Is a Negative Regulator of EGFR Signalling and Interacts with Erk and Mkp3 in the Drosophila melanogaster Wing

Cristina Molnar, Jose F. de Celis

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003982

A Hereditary Spastic Paraplegia Mouse Model Supports a Role of ZFYVE26/SPASTIZIN for the Endolysosomal System

Mukhran Khundadze, Katrin Kollmann, Nicole Koch, Christoph Biskup, Sandor Nietzsche, Geraldine Zimmer, J. Christopher Hennings, Antje K. Huebner, Judit Symmank, Amir Jahic, Elena I. Ilina, Kathrin Karle, Ludger Schöls, Michael Kessels, Thomas Braulke, Britta Qualmann, Ingo Kurth, Christian Beetz, Christian A. Hübner

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003988

Ethylene Promotes Hypocotyl Growth and HY5 Degradation by Enhancing the Movement of COP1 to the Nucleus in the Light

Yanwen Yu, Juan Wang, Zhijin Zhang, Ruidang Quan, Haiwen Zhang, Xing Wang Deng, Ligeng Ma, Rongfeng Huang

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1004025

Base Pairing Interaction between 5′- and 3′-UTRs Controls icaR mRNA Translation in Staphylococcus aureus

Igor Ruiz de los Mozos, Marta Vergara-Irigaray, Victor Segura, Maite Villanueva, Nerea Bitarte, Margarida Saramago, Susana Domingues, Cecilia M. Arraiano, Pierre Fechter, Pascale Romby, Jaione Valle, Cristina Solano, Iñigo Lasa, Alejandro Toledo-Arana

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004001

MAN1B1 Deficiency: An Unexpected CDG-II

Daisy Rymen, Romain Peanne, María B. Millón, Valérie Race, Luisa Sturiale, Domenico Garozzo, Philippa Mills, Peter Clayton, Carla G. Asteggiano, Dulce Quelhas, Ali Cansu, Esmeralda Martins, Marie-Cécile Nassogne, Miguel Gonçalves-Rocha, Haluk Topaloglu, Jaak Jaeken, François Foulquier, Gert Matthijs

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1003989

The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation

Jordi Solana, Chiara Gamberi, Yuliana Mihaylova, Stefanie Grosswendt, Chen Chen, Paul Lasko, Nikolaus Rajewsky, A. Aziz Aboobaker

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004003

Meiotic Crossover Control by Concerted Action of Rad51-Dmc1 in Homolog Template Bias and Robust Homeostatic Regulation

Jessica P. Lao, Veronica Cloud, Chu-Chun Huang, Jennifer Grubb, Drew Thacker, Chih-Ying Lee, Michael E. Dresser, Neil Hunter, Douglas K. Bishop

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003978

Phosphate Flow between Hybrid Histidine Kinases CheA₃ and CheS₃ Controls Rhodospirillum centenum Cyst Formation

Kuang He, Jeremiah N. Marden, Ellen M. Quardokus, Carl E. Bauer

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004002

Synaptonemal Complex Components Promote Centromere Pairing in Pre-meiotic Germ Cells

Nicolas Christophorou, Thomas Rubin, Jean-René Huynh

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004012

Detection of Slipped-DNAs at the Trinucleotide Repeats of the Myotonic Dystrophy Type I Disease Locus in Patient Tissues

Michelle M. Axford, Yuh-Hwa Wang, Masayuki Nakamori, Maria Zannis-Hadjopoulos, Charles A. Thornton, Christopher E. Pearson

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003866

Functional Analysis of the Interdependence between DNA Uptake Sequence and Its Cognate ComP Receptor during Natural Transformation in Neisseria Species

Jamie-Lee Berry, Ana Cehovin, Melanie A. McDowell, Susan M. Lea, Vladimir Pelicic

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004014

Germline Progenitors Escape the Widespread Phenomenon of Homolog Pairing during Drosophila Development

Eric F. Joyce, Nicholas Apostolopoulos, Brian J. Beliveau, C. -ting Wu

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004013

MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes

Takashi Shimbo, Ying Du, Sara A. Grimm, Archana Dhasarathy, Deepak Mav, Ruchir R. Shah, Huidong Shi, Paul A. Wade

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004028

TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

Annabel A. Ferguson, Sudipa Roy, Kaitlyn N. Kormanik, Yongsoon Kim, Kathleen J. Dumas, Vladimir B. Ritov, Dietrich Matern, Patrick J. Hu, Alfred L. Fisher

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004020

Cross-Modulation of Homeostatic Responses to Temperature, Oxygen and Carbon Dioxide in C. elegans

Eiji Kodama-Namba, Lorenz A. Fenk, Andrew J. Bretscher, Einav Gross, K. Emanuel Busch, Mario de Bono

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004011

Defining the Role of ATP Hydrolysis in Mitotic Segregation of Bacterial Plasmids

Yoan Ah-Seng, Jérôme Rech, David Lane, Jean-Yves Bouet

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003956

Transcription Factor Occupancy Can Mediate Active Turnover of DNA Methylation at Regulatory Regions

Angelika Feldmann, Robert Ivanek, Rabih Murr, Dimos Gaidatzis, Lukas Burger, Dirk Schübeler

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003994

Histone Methylation Restrains the Expression of Subtype-Specific Genes during Terminal Neuronal Differentiation in Caenorhabditis elegans

Chaogu Zheng, Siavash Karimzadegan, Victor Chiang, Martin Chalfie

PLOS Genetics: published December 12, 2013 | https://doi.org/10.1371/journal.pgen.1004017

Interaction between Foxc1 and Fgf8 during Mammalian Jaw Patterning and in the Pathogenesis of Syngnathia

Kimberly E. Inman, Patricia Purcell, Tsutomu Kume, Paul A. Trainor

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1003949

Binary Cell Fate Decisions and Fate Transformation in the Drosophila Larval Eye

Abhishek Kumar Mishra, Maria Tsachaki, Jens Rister, June Ng, Arzu Celik, Simon G. Sprecher

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004027

Autozygome Sequencing Expands the Horizon of Human Knockout Research and Provides Novel Insights into Human Phenotypic Variation

Ahmed B. Alsalem, Anason S. Halees, Shamsa Anazi, Shomoukh Alshamekh, Fowzan S. Alkuraya

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004030

ESCRT-I Mediates FLS2 Endosomal Sorting and Plant Immunity

Thomas Spallek, Martina Beck, Sara Ben Khaled, Susanne Salomon, Gildas Bourdais, Swen Schellmann, Silke Robatzek

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004035

Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model

Linyan Meng, Richard Erwin Person, Wei Huang, Ping Jun Zhu, Mauro Costa-Mattioli, Arthur L. Beaudet

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004039

Mutations in the UQCC1-Interacting Protein, UQCC2, Cause Human Complex III Deficiency Associated with Perturbed Cytochrome b Protein Expression

Elena J. Tucker, Bas F. J. Wanschers, Radek Szklarczyk, Hayley S. Mountford, Xiaonan W. Wijeyeratne, Mariël A. M. van den Brand, Anne M. Leenders, Richard J. Rodenburg, Boris Reljić, Alison G. Compton, Ann E. Frazier, Damien L. Bruno, John Christodoulou, Hitoshi Endo, Michael T. Ryan, Leo G. Nijtmans, Martijn A. Huynen, David R. Thorburn

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004034

Insulin/IGF-Regulated Size Scaling of Neuroendocrine Cells Expressing the bHLH Transcription Factor Dimmed in Drosophila

Jiangnan Luo, Yiting Liu, Dick R. Nässel

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004052

Reactivation of Chromosomally Integrated Human Herpesvirus-6 by Telomeric Circle Formation

Bhupesh K. Prusty, George Krohne, Thomas Rudel

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004033

Tomato Yield Heterosis Is Triggered by a Dosage Sensitivity of the Florigen Pathway That Fine-Tunes Shoot Architecture

Ke Jiang, Katie L. Liberatore, Soon Ju Park, John P. Alvarez, Zachary B. Lippman

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004043

Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart

Girish C. Melkani, Adriana S. Trujillo, Raul Ramos, Rolf Bodmer, Sanford I. Bernstein, Karen Ocorr

PLOS Genetics: published December 19, 2013 | https://doi.org/10.1371/journal.pgen.1004024

The Midline Protein Regulates Axon Guidance by Blocking the Reiteration of Neuroblast Rows within the Drosophila Ventral Nerve Cord

Mary Ann Manavalan, Ivana Gaziova, Krishna Moorthi Bhat

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004050

Reconstructing Native American Migrations from Whole-Genome and Whole-Exome Data

Simon Gravel, Fouad Zakharia, Andres Moreno-Estrada, Jake K. Byrnes, Marina Muzzio, Juan L. Rodriguez-Flores, Eimear E. Kenny, Christopher R. Gignoux, Brian K. Maples, Wilfried Guiblet, Julie Dutil, Marc Via, Karla Sandoval, Gabriel Bedoya, The 1000 Genomes Project, Taras K. Oleksyk, Andres Ruiz-Linares, Esteban G. Burchard, Juan Carlos Martinez-Cruzado, Carlos D. Bustamante

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004023

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

Piya Ghose, Eun Chan Park, Alexandra Tabakin, Nathaly Salazar-Vasquez, Christopher Rongo

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004063

Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions

Alice Copsey, Shangming Tang, Philip W. Jordan, Hannah G. Blitzblau, Sonya Newcombe, Andrew Chi-ho Chan, Louise Newnham, Zhaobo Li, Stephen Gray, Alex D. Herbert, Prakash Arumugam, Andreas Hochwagen, Neil Hunter, Eva Hoffmann

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004071

Molecular Characterization of Host-Specific Biofilm Formation in a Vertebrate Gut Symbiont

Steven A. Frese, Donald A. MacKenzie, Daniel A. Peterson, Robert Schmaltz, Teresa Fangman, You Zhou, Chaomei Zhang, Andrew K. Benson, Liz A. Cody, Francis Mulholland, Nathalie Juge, Jens Walter

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004057

Quantifying Missing Heritability at Known GWAS Loci

Alexander Gusev, Gaurav Bhatia, Noah Zaitlen, Bjarni J. Vilhjalmsson, Dorothée Diogo, Eli A. Stahl, Peter K. Gregersen, Jane Worthington, Lars Klareskog, Soumya Raychaudhuri, Robert M. Plenge, Bogdan Pasaniuc, Alkes L. Price

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1003993

The PAF Complex and Prf1/Rtf1 Delineate Distinct Cdk9-Dependent Pathways Regulating Transcription Elongation in Fission Yeast

Jean Mbogning, Stephen Nagy, Viviane Pagé, Beate Schwer, Stewart Shuman, Robert P. Fisher, Jason C. Tanny

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004029

Smc5/6-Mms21 Prevents and Eliminates Inappropriate Recombination Intermediates in Meiosis

Martin Xaver, Lingzhi Huang, Doris Chen, Franz Klein

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004067

Meiotic Cohesin SMC1β Provides Prophase I Centromeric Cohesion and Is Required for Multiple Synapsis-Associated Functions

Uddipta Biswas, Cornelia Wetzker, Julian Lange, Eleni G. Christodoulou, Michael Seifert, Andreas Beyer, Rolf Jessberger

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1003985

Clustering of Tissue-Specific Sub-TADs Accompanies the Regulation of HoxA Genes in Developing Limbs

Soizik Berlivet, Denis Paquette, Annie Dumouchel, David Langlais, Josée Dostie, Marie Kmita

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1004018

Low Frequency Variants, Collapsed Based on Biological Knowledge, Uncover Complexity of Population Stratification in 1000 Genomes Project Data

Carrie B. Moore, John R. Wallace, Daniel J. Wolfe, Alex T. Frase, Sarah A. Pendergrass, Kenneth M. Weiss, Marylyn D. Ritchie

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1003959

Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes

Emma A. Hall, Margaret Keighren, Matthew J. Ford, Tracey Davey, Andrew P. Jarman, Lee B. Smith, Ian J. Jackson, Pleasantine Mill

PLOS Genetics: published December 26, 2013 | https://doi.org/10.1371/journal.pgen.1003928

Deep Reads

Recommendations from Jane Gitschier's Bookshelf

Jane Gitschier

PLOS Genetics: published December 5, 2013 | https://doi.org/10.1371/journal.pgen.1004009

Cover

Genetic amelioration of Huntington's disease-induced cardiac amyloidosis.

Perspectives

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Review

Research Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Deep Reads