March 2013

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

Carmen I. Nussbaum-Krammer, Kyung-Won Park, Liming Li, Ronald Melki, Richard I. Morimoto

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003351

Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery

Juliette J. Kahle, George P. Souroullas, Peng Yu, Fabian Zohren, Yoontae Lee, Chad A. Shaw, Huda Y. Zoghbi, Margaret A. Goodell

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003359

Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs

Ignacio Rubio-Somoza, Detlef Weigel

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003374

CRL2^LRR-1 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Caenorhabditis elegans Germline

Julien Burger, Jorge Merlet, Nicolas Tavernier, Bénédicte Richaudeau, Andreas Arnold, Rafal Ciosk, Bruce Bowerman, Lionel Pintard

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003375

The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line

Keiko Muraki, Limei Han, Douglas Miller, John P. Murnane

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003386

A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen Bartonella

Lionel Guy, Björn Nystedt, Christina Toft, Katarzyna Zaremba-Niedzwiedzka, Eva C. Berglund, Fredrik Granberg, Kristina Näslund, Ann-Sofie Eriksson, Siv G. E. Andersson

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003393

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

Jing Cui, Eli A. Stahl, Saedis Saevarsdottir, Corinne Miceli, Dorothee Diogo, Gosia Trynka, Towfique Raj, Maša Umiċeviċ Mirkov, Helena Canhao, Katsunori Ikari, Chikashi Terao, Yukinori Okada, Sara Wedrén, Johan Askling, Hisashi Yamanaka, Shigeki Momohara, Atsuo Taniguchi, Koichiro Ohmura, Fumihiko Matsuda, Tsuneyo Mimori, Namrata Gupta, Manik Kuchroo, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Marieke Herenius, Marieke E. Doorenspleet, Paul-Peter Tak, J. Bart A. Crusius, Irene E. van der Horst-Bruinsma, Gert Jan Wolbink, Piet L. C. M. van Riel, Mart van de Laar, Henk-Jan Guchelaar, Nancy A. Shadick, Cornelia F. Allaart, Tom W. J. Huizinga, Rene E. M. Toes, Robert P. Kimberly, S. Louis Bridges Jr, Lindsey A. Criswell, Larry W. Moreland, João Eurico Fonseca, Niek de Vries, Barbara E. Stranger, Philip L. De Jager, Soumya Raychaudhuri, Michael E. Weinblatt, Peter K. Gregersen, Xavier Mariette, Anne Barton, Leonid Padyukov, Marieke J. H. Coenen, Elizabeth W. Karlson, Robert M. Plenge

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003394

A Novel Function for the Hox Gene Abd-B in the Male Accessory Gland Regulates the Long-Term Female Post-Mating Response in Drosophila

Dragan Gligorov, Jessica L. Sitnik, Robert K. Maeda, Mariana F. Wolfner, François Karch

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003395

Robust Prediction of Expression Differences among Human Individuals Using Only Genotype Information

Ohad Manor, Eran Segal

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003396

Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions

Thomas Wallach, Katja Schellenberg, Bert Maier, Ravi Kiran Reddy Kalathur, Pablo Porras, Erich E. Wanker, Matthias E. Futschik, Achim Kramer

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003398

The Tomato Yellow Leaf Curl Virus Resistance Genes Ty-1 and Ty-3 Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases

Maarten G. Verlaan, Samuel F. Hutton, Ragy M. Ibrahem, Richard Kormelink, Richard G. F. Visser, John W. Scott, Jeremy D. Edwards, Yuling Bai

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003399

Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV Syncytin, Captured for a Function in Placentation

Cécile Esnault, Guillaume Cornelis, Odile Heidmann, Thierry Heidmann

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003400

Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Drosophila melanogaster Muscle Hypercontraction Mutants

Stephen M. Pronovost, Mary C. Beckerle, Julie L. Kadrmas

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003406

A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit

Danielle M. Karyadi, Eric Karlins, Brennan Decker, Bridgett M. vonHoldt, Gretchen Carpintero-Ramirez, Heidi G. Parker, Robert K. Wayne, Elaine A. Ostrander

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003409

The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci

Jun-Hye Shin, Hsiao-Lin V. Wang, Jinwon Lee, Brandon L. Dinwiddie, Dmitry A. Belostotsky, Julia A. Chekanova

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003411

Statistical Analysis Reveals Co-Expression Patterns of Many Pairs of Genes in Yeast Are Jointly Regulated by Interacting Loci

Lin Wang, Wei Zheng, Hongyu Zhao, Minghua Deng

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003414

A Single Cohesin Complex Performs Mitotic and Meiotic Functions in the Protist Tetrahymena

Rachel A. Howard-Till, Agnieszka Lukaszewicz, Maria Novatchkova, Josef Loidl

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003418

Genome-Wide Testing of Putative Functional Exonic Variants in Relationship with Breast and Prostate Cancer Risk in a Multiethnic Population

Christopher A. Haiman, Ying Han, Ye Feng, Lucy Xia, Chris Hsu, Xin Sheng, Loreall C. Pooler, Yesha Patel, Laurence N. Kolonel, Erin Carter, Karen Park, Loic Le Marchand, David Van Den Berg, Brian E. Henderson, Daniel O. Stram

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003419

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease

James W. Westmoreland, Michael A. Resnick

PLOS Genetics: published March 28, 2013 | https://doi.org/10.1371/journal.pgen.1003420

Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

Mia M. Gaudet, Karoline B. Kuchenbaecker, Joseph Vijai, Robert J. Klein, Tomas Kirchhoff, Lesley McGuffog, Daniel Barrowdale, Alison M. Dunning, Andrew Lee, Joe Dennis, Sue Healey, Ed Dicks, Penny Soucy, Olga M. Sinilnikova, Vernon S. Pankratz, Xianshu Wang, Ronald C. Eldridge, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Frans B. L. Hogervorst, Susan Peock, Dominique Stoppa-Lyonnet, KConFab Investigators, Paolo Peterlongo, Rita K. Schmutzler, Katherine L. Nathanson, Marion Piedmonte, Christian F. Singer, Mads Thomassen, Ontario Cancer Genetics Network, Thomas v. O. Hansen, Susan L. Neuhausen, Ignacio Blanco, Mark H. Greene, Judith Garber, Jeffrey N. Weitzel, Irene L. Andrulis, David E. Goldgar, Emma D'Andrea, Trinidad Caldes, Heli Nevanlinna, Ana Osorio, Elizabeth J. van Rensburg, Adalgeir Arason, Gad Rennert, Ans M. W. van den Ouweland, Annemarie H. van der Hout, Carolien M. Kets, Cora M. Aalfs, Juul T. Wijnen, Margreet G. E. M. Ausems, HEBON, EMBRACE, Debra Frost, Steve Ellis, Elena Fineberg, Radka Platte, D. Gareth Evans, Chris Jacobs, Julian Adlard, Marc Tischkowitz, Mary E. Porteous, Francesca Damiola, GEMO Study Collaborators, Lisa Golmard, Laure Barjhoux, Michel Longy, Muriel Belotti, Sandra Fert Ferrer, Sylvie Mazoyer, Amanda B. Spurdle, Siranoush Manoukian, Monica Barile, Maurizio Genuardi, Norbert Arnold, Alfons Meindl, Christian Sutter, Barbara Wappenschmidt, Susan M. Domchek, Georg Pfeiler, Eitan Friedman, Uffe Birk Jensen, Mark Robson, Sohela Shah, Conxi Lazaro, Phuong L. Mai, Javier Benitez, Melissa C. Southey, Marjanka K. Schmidt, Peter A. Fasching, Julian Peto, Manjeet K. Humphreys, Qin Wang, Kyriaki Michailidou, Elinor J. Sawyer, Barbara Burwinkel, Pascal Guénel, Stig E. Bojesen, Roger L. Milne, Hermann Brenner, Magdalena Lochmann, The GENICA Network, Kristiina Aittomäki, Thilo Dörk, Sara Margolin, Arto Mannermaa, Diether Lambrechts, Jenny Chang-Claude, Paolo Radice, Graham G. Giles, Christopher A. Haiman, Robert Winqvist, Peter Devillee, Montserrat García-Closas, Nils Schoof, Maartje J. Hooning, Angela Cox, Paul D. P. Pharoah, Anna Jakubowska, Nick Orr, Anna González-Neira, Guillermo Pita, M. Rosario Alonso, Per Hall, Fergus J. Couch, Jacques Simard, David Altshuler, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Kenneth Offit

PLOS Genetics: published March 27, 2013 | https://doi.org/10.1371/journal.pgen.1003173

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Fergus J. Couch, Xianshu Wang, Lesley McGuffog, Andrew Lee, Curtis Olswold, Karoline B. Kuchenbaecker, Penny Soucy, Zachary Fredericksen, Daniel Barrowdale, Joe Dennis, Mia M. Gaudet, Ed Dicks, Matthew Kosel, Sue Healey, Olga M. Sinilnikova, Adam Lee, François Bacot, Daniel Vincent, Frans B. L. Hogervorst, Susan Peock, Dominique Stoppa-Lyonnet, Anna Jakubowska, kConFab Investigators, Paolo Radice, Rita Katharina Schmutzler, SWE-BRCA, Susan M. Domchek, Marion Piedmonte, Christian F. Singer, Eitan Friedman, Mads Thomassen, Ontario Cancer Genetics Network, Thomas V. O. Hansen, Susan L. Neuhausen, Csilla I. Szabo, Ignacio Blanco, Mark H. Greene, Beth Y. Karlan, Judy Garber, Catherine M. Phelan, Jeffrey N. Weitzel, Marco Montagna, Edith Olah, Irene L. Andrulis, Andrew K. Godwin, Drakoulis Yannoukakos, David E. Goldgar, Trinidad Caldes, Heli Nevanlinna, Ana Osorio, Mary Beth Terry, Mary B. Daly, Elizabeth J. van Rensburg, Ute Hamann, Susan J. Ramus, Amanda Ewart Toland, Maria A. Caligo, Olufunmilayo I. Olopade, Nadine Tung, Kathleen Claes, Mary S. Beattie, Melissa C. Southey, Evgeny N. Imyanitov, Marc Tischkowitz, Ramunas Janavicius, Esther M. John, Ava Kwong, Orland Diez, Judith Balmaña, Rosa B. Barkardottir, Banu K. Arun, Gad Rennert, Soo-Hwang Teo, Patricia A. Ganz, Ian Campbell, Annemarie H. van der Hout, Carolien H. M. van Deurzen, Caroline Seynaeve, Encarna B. Gómez Garcia, Flora E. van Leeuwen, Hanne E. J. Meijers-Heijboer, Johannes J. P. Gille, Margreet G. E. M. Ausems, Marinus J. Blok, Marjolijn J. L. Ligtenberg, Matti A. Rookus, Peter Devilee, Senno Verhoef, Theo A. M. van Os, Juul T. Wijnen, HEBON, EMBRACE, Debra Frost, Steve Ellis, Elena Fineberg, Radka Platte, D. Gareth Evans, Louise Izatt, Rosalind A. Eeles, Julian Adlard, Diana M. Eccles, Jackie Cook, Carole Brewer, Fiona Douglas, Shirley Hodgson, Patrick J. Morrison, Lucy E. Side, Alan Donaldson, Catherine Houghton, Mark T. Rogers, Huw Dorkins, Jacqueline Eason, Helen Gregory, Emma McCann, Alex Murray, Alain Calender, Agnès Hardouin, Pascaline Berthet, Capucine Delnatte, Catherine Nogues, Christine Lasset, Claude Houdayer, Dominique Leroux, Etienne Rouleau, Fabienne Prieur, Francesca Damiola, Hagay Sobol, Isabelle Coupier, Laurence Venat-Bouvet, Laurent Castera, Marion Gauthier-Villars, Mélanie Léoné, Pascal Pujol, Sylvie Mazoyer, Yves-Jean Bignon, GEMO Study Collaborators, Elżbieta Złowocka-Perłowska, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska, Tomasz Huzarski, Amanda B. Spurdle, Alessandra Viel, Bernard Peissel, Bernardo Bonanni, Giulia Melloni, Laura Ottini, Laura Papi, Liliana Varesco, Maria Grazia Tibiletti, Paolo Peterlongo, Sara Volorio, Siranoush Manoukian, Valeria Pensotti, Norbert Arnold, Christoph Engel, Helmut Deissler, Dorothea Gadzicki, Andrea Gehrig, Karin Kast, Kerstin Rhiem, Alfons Meindl, Dieter Niederacher, Nina Ditsch, Hansjoerg Plendl, Sabine Preisler-Adams, Stefanie Engert, Christian Sutter, Raymonda Varon-Mateeva, Barbara Wappenschmidt, Bernhard H. F. Weber, Brita Arver, Marie Stenmark-Askmalm, Niklas Loman, Richard Rosenquist, Zakaria Einbeigi, Katherine L. Nathanson, Timothy R. Rebbeck, Stephanie V. Blank, David E. Cohn, Gustavo C. Rodriguez, Laurie Small, Michael Friedlander, Victoria L. Bae-Jump, Anneliese Fink-Retter, Christine Rappaport, Daphne Gschwantler-Kaulich, Georg Pfeiler, Muy-Kheng Tea, Noralane M. Lindor, Bella Kaufman, Shani Shimon Paluch, Yael Laitman, Anne-Bine Skytte, Anne-Marie Gerdes, Inge Sokilde Pedersen, Sanne Traasdahl Moeller, Torben A. Kruse, Uffe Birk Jensen, Joseph Vijai, Kara Sarrel, Mark Robson, Noah Kauff, Anna Marie Mulligan, Gord Glendon, Hilmi Ozcelik, Bent Ejlertsen, Finn C. Nielsen, Lars Jønson, Mette K. Andersen, Yuan Chun Ding, Linda Steele, Lenka Foretova, Alex Teulé, Conxi Lazaro, Joan Brunet, Miquel Angel Pujana, Phuong L. Mai, Jennifer T. Loud, Christine Walsh, Jenny Lester, Sandra Orsulic, Steven A. Narod, Josef Herzog, Sharon R. Sand, Silvia Tognazzo, Simona Agata, Tibor Vaszko, Joellen Weaver, Alexandra V. Stavropoulou, Saundra S. Buys, Atocha Romero, Miguel de la Hoya, Kristiina Aittomäki, Taru A. Muranen, Mercedes Duran, Wendy K. Chung, Adriana Lasa, Cecilia M. Dorfling, Alexander Miron, BCFR, Javier Benitez, Leigha Senter, Dezheng Huo, Salina B. Chan, Anna P. Sokolenko, Jocelyne Chiquette, Laima Tihomirova, Tara M. Friebel, Bjarni A. Agnarsson, Karen H. Lu, Flavio Lejbkowicz, Paul A. James, Per Hall, Alison M. Dunning, Daniel Tessier, Julie Cunningham, Susan L. Slager, Chen Wang, Steven Hart, Kristen Stevens, Jacques Simard, Tomi Pastinen, Vernon S. Pankratz, Kenneth Offit, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, on behalf of CIMBA

PLOS Genetics: published March 27, 2013 | https://doi.org/10.1371/journal.pgen.1003212

Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

Stefan Nickels, Thérèse Truong, Rebecca Hein, Kristen Stevens, Katharina Buck, Sabine Behrens, Ursula Eilber, Martina Schmidt, Lothar Häberle, Alina Vrieling, Mia Gaudet, Jonine Figueroa, Nils Schoof, Amanda B. Spurdle, Anja Rudolph, Peter A. Fasching, John L. Hopper, Enes Makalic, Daniel F. Schmidt, Melissa C. Southey, Matthias W. Beckmann, Arif B. Ekici, Olivia Fletcher, Lorna Gibson, Isabel dos Santos Silva, Julian Peto, Manjeet K. Humphreys, Jean Wang, Emilie Cordina-Duverger, Florence Menegaux, Børge G. Nordestgaard, Stig E. Bojesen, Charlotte Lanng, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina A. Clarke, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Brüning, Volker Harth, The GENICA Network, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, kConFab, AOCS Management Group, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Robert Paridaens, Dieter Flesch-Janys, Nadia Obi, Shan Wang-Gohrke, Fergus J. Couch, Janet E. Olson, Celine M. Vachon, Graham G. Giles, Gianluca Severi, Laura Baglietto, Kenneth Offit, Esther M. John, Alexander Miron, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Stephen J. Chanock, Jolanta Lissowska, Jianjun Liu, Angela Cox, Helen Cramp, Dan Connley, Sabapathy Balasubramanian, Alison M. Dunning, Mitul Shah, Amy Trentham-Dietz, Polly Newcomb, Linda Titus, Kathleen Egan, Elizabeth K. Cahoon, Preetha Rajaraman, Alice J. Sigurdson, Michele M. Doody, Pascal Guénel, Paul D. P. Pharoah, Marjanka K. Schmidt, Per Hall, Doug F. Easton, Montserrat Garcia-Closas, Roger L. Milne, Jenny Chang-Claude

PLOS Genetics: published March 27, 2013 | https://doi.org/10.1371/journal.pgen.1003284

Power and Predictive Accuracy of Polygenic Risk Scores

Frank Dudbridge

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003348

Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene DMRT1

Alexandra M. Lopes, Kenneth I. Aston, Emma Thompson, Filipa Carvalho, João Gonçalves, Ni Huang, Rune Matthiesen, Michiel J. Noordam, Inés Quintela, Avinash Ramu, Catarina Seabra, Amy B. Wilfert, Juncheng Dai, Jonathan M. Downie, Susana Fernandes, Xuejiang Guo, Jiahao Sha, António Amorim, Alberto Barros, Angel Carracedo, Zhibin Hu, Matthew E. Hurles, Sergey Moskovtsev, Carole Ober, Darius A. Paduch, Joshua D. Schiffman, Peter N. Schlegel, Mário Sousa, Douglas T. Carrell, Donald F. Conrad

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003349

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype

Gianluca Occhi, Daniela Regazzo, Giampaolo Trivellin, Francesca Boaretto, Denis Ciato, Sara Bobisse, Sergio Ferasin, Filomena Cetani, Elena Pardi, Márta Korbonits, Natalia S. Pellegata, Viktoryia Sidarovich, Alessandro Quattrone, Giuseppe Opocher, Franco Mantero, Carla Scaroni

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003350

NODULE INCEPTION Directly Targets NF-Y Subunit Genes to Regulate Essential Processes of Root Nodule Development in Lotus japonicus

Takashi Soyano, Hiroshi Kouchi, Atsuko Hirota, Makoto Hayashi

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003352

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

Trisha A. Staab, Trevor C. Griffen, Connor Corcoran, Oleg Evgrafov, James A. Knowles, Derek Sieburth

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003354

Astakine 2—the Dark Knight Linking Melatonin to Circadian Regulation in Crustaceans

Apiruck Watthanasurorot, Netnapa Saelee, Amornrat Phongdara, Sittiruk Roytrakul, Pikul Jiravanichpaisal, Kenneth Söderhäll, Irene Söderhäll

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003361

Fine Characterisation of a Recombination Hotspot at the DPY19L2 Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population

Charles Coutton, Farid Abada, Thomas Karaouzene, Damien Sanlaville, Véronique Satre, Joël Lunardi, Pierre-Simon Jouk, Christophe Arnoult, Nicolas Thierry-Mieg, Pierre F. Ray

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003363

Recurrent Rearrangement during Adaptive Evolution in an Interspecific Yeast Hybrid Suggests a Model for Rapid Introgression

Barbara Dunn, Terry Paulish, Alison Stanbery, Jeff Piotrowski, Gregory Koniges, Evgueny Kroll, Edward J. Louis, Gianni Liti, Gavin Sherlock, Frank Rosenzweig

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003366

A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating p21/Cdkn1a/Cip1/Waf1 mRNA Stability

Laetitia Davidovic, Nelly Durand, Olfa Khalfallah, Ricardo Tabet, Pascal Barbry, Bernard Mari, Sabrina Sacconi, Hervé Moine, Barbara Bardoni

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003367

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

Vidisha Tripathi, Zhen Shen, Arindam Chakraborty, Sumanprava Giri, Susan M. Freier, Xiaolin Wu, Yongqing Zhang, Myriam Gorospe, Supriya G. Prasanth, Ashish Lal, Kannanganattu V. Prasanth

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003368

MTL–Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and Filamentation

Allison M. Porman, Matthew P. Hirakawa, Stephen K. Jones, Na Wang, Richard J. Bennett

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003369

Genetic Architecture of Skin and Eye Color in an African-European Admixed Population

Sandra Beleza, Nicholas A. Johnson, Sophie I. Candille, Devin M. Absher, Marc A. Coram, Jailson Lopes, Joana Campos, Isabel Inês Araújo, Tovi M. Anderson, Bjarni J. Vilhjálmsson, Magnus Nordborg, António Correia e Silva, Mark D. Shriver, Jorge Rocha, Gregory S. Barsh, Hua Tang

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003372

Association Mapping and the Genomic Consequences of Selection in Sunflower

Jennifer R. Mandel, Savithri Nambeesan, John E. Bowers, Laura F. Marek, Daniel Ebert, Loren H. Rieseberg, Steven J. Knapp, John M. Burke

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003378

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Ying Wu, Lindsay L. Waite, Anne U. Jackson, Wayne H-H. Sheu, Steven Buyske, Devin Absher, Donna K. Arnett, Eric Boerwinkle, Lori L. Bonnycastle, Cara L. Carty, Iona Cheng, Barbara Cochran, Damien C. Croteau-Chonka, Logan Dumitrescu, Charles B. Eaton, Nora Franceschini, Xiuqing Guo, Brian E. Henderson, Lucia A. Hindorff, Eric Kim, Leena Kinnunen, Pirjo Komulainen, Wen-Jane Lee, Loic Le Marchand, Yi Lin, Jaana Lindström, Oddgeir Lingaas-Holmen, Sabrina L. Mitchell, Narisu Narisu, Jennifer G. Robinson, Fred Schumacher, Alena Stančáková, Jouko Sundvall, Yun-Ju Sung, Amy J. Swift, Wen-Chang Wang, Lynne Wilkens, Tom Wilsgaard, Alicia M. Young, Linda S. Adair, Christie M. Ballantyne, Petra Bůžková, Aravinda Chakravarti, Francis S. Collins, David Duggan, Alan B. Feranil, Low-Tone Ho, Yi-Jen Hung, Steven C. Hunt, Kristian Hveem, Jyh-Ming J. Juang, Antero Y. Kesäniemi, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, I-Te Lee, Mark F. Leppert, Tara C. Matise, Leena Moilanen, Inger Njølstad, Ulrike Peters, Thomas Quertermous, Rainer Rauramaa, Jerome I. Rotter, Jouko Saramies, Jaakko Tuomilehto, Matti Uusitupa, Tzung-Dau Wang, Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North, Karen L. Mohlke

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003379

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Antoine Reginensi, Rizaldy P. Scott, Alex Gregorieff, Mazdak Bagherie-Lachidan, Chaeuk Chung, Dae-Sik Lim, Tony Pawson, Jeff Wrana, Helen McNeill

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003380

Genome-Wide Control of RNA Polymerase II Activity by Cohesin

Cheri A. Schaaf, Hojoong Kwak, Amanda Koenig, Ziva Misulovin, David W. Gohara, Audrey Watson, Yanjiao Zhou, John T. Lis, Dale Dorsett

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003382

Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis

Michel F. Guiraldelli, Craig Eyster, Joseph L. Wilkerson, Michael E. Dresser, Roberto J. Pezza

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003383

Divergent Selection Drives Genetic Differentiation in an R2R3-MYB Transcription Factor That Contributes to Incipient Speciation in Mimulus aurantiacus

Matthew A. Streisfeld, Wambui N. Young, James M. Sobel

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003385

Ancient Evolutionary Trade-Offs between Yeast Ploidy States

Enikö Zörgö, Karolina Chwialkowska, Arne B. Gjuvsland, Elena Garré, Per Sunnerhagen, Gianni Liti, Anders Blomberg, Stig W. Omholt, Jonas Warringer

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003388

Molecular Networks of Human Muscle Adaptation to Exercise and Age

Bethan E. Phillips, John P. Williams, Thomas Gustafsson, Claude Bouchard, Tuomo Rankinen, Steen Knudsen, Kenneth Smith, James A. Timmons, Philip J. Atherton

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003389

Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression

Aishe Sarshad, Fatemeh Sadeghifar, Emilie Louvet, Raffaele Mori, Stefanie Böhm, Bader Al-Muzzaini, Anna Vintermist, Nathalie Fomproix, Ann-Kristin Östlund, Piergiorgio Percipalle

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003397

A Feed-Forward Loop Coupling Extracellular BMP Transport and Morphogenesis in Drosophila Wing

Shinya Matsuda, Jorge Blanco, Osamu Shimmi

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003403

Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest

Joshua W. Vincentz, Beth A. Firulli, Andrea Lin, Douglas B. Spicer, Marthe J. Howard, Anthony B. Firulli

PLOS Genetics: published March 21, 2013 | https://doi.org/10.1371/journal.pgen.1003405

Complex Patterns of Genomic Admixture within Southern Africa

Desiree C. Petersen, Ondrej Libiger, Elizabeth A. Tindall, Rae-Anne Hardie, Linda I. Hannick, Richard H. Glashoff, Mitali Mukerji, Indian Genome Variation Consortium, Pedro Fernandez, Wilfrid Haacke, Nicholas J. Schork, Vanessa M. Hayes

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003309

The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity

Bruce R. Levin, Sylvain Moineau, Mary Bushman, Rodolphe Barrangou

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003312

Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

Katrina Mitchel, Kevin Lehner, Sue Jinks-Robertson

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003340

Genomic Evidence for Island Population Conversion Resolves Conflicting Theories of Polar Bear Evolution

James A. Cahill, Richard E. Green, Tara L. Fulton, Mathias Stiller, Flora Jay, Nikita Ovsyanikov, Rauf Salamzade, John St. John, Ian Stirling, Montgomery Slatkin, Beth Shapiro

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003345

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

Eva D. Runkel, Shu Liu, Ralf Baumeister, Ekkehard Schulze

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003346

Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans

Shaun E. Hunter, Emily F. Finnegan, Dimitrios G. Zisoulis, Michael T. Lovci, Katya V. Melnik-Martinez, Gene W. Yeo, Amy E. Pasquinelli

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003353

Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

Min Jeong Ryu, Soung Jung Kim, Yong Kyung Kim, Min Jeong Choi, Surendar Tadi, Min Hee Lee, Seong Eun Lee, Hyo Kyun Chung, Saet Byel Jung, Hyun-Jin Kim, Young Suk Jo, Koon Soon Kim, Sang-Hee Lee, Jin Man Kim, Gi Ryang Kweon, Ki Cheol Park, Jung Uee Lee, Young Yun Kong, Chul-Ho Lee, Jongkyeong Chung, Minho Shong

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003356

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204

Ohad Shaham, Karen Gueta, Eyal Mor, Pazit Oren-Giladi, Dina Grinberg, Qing Xie, Ales Cvekl, Noam Shomron, Noa Davis, Maya Keydar-Prizant, Shaul Raviv, Metsada Pasmanik-Chor, Rachel E. Bell, Carmit Levy, Raffaella Avellino, Sandro Banfi, Ivan Conte, Ruth Ashery-Padan

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003357

Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the FOXL2 Gene or Its Regulatory Domain

Hannah Verdin, Barbara D'haene, Diane Beysen, Yana Novikova, Björn Menten, Tom Sante, Pablo Lapunzina, Julian Nevado, Claudia M. B. Carvalho, James R. Lupski, Elfride De Baere

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003358

Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome

Tom Stiff, Meryem Alagoz, Diana Alcantara, Emily Outwin, Han G. Brunner, Ernie M. H. F. Bongers, Mark O'Driscoll, Penny A. Jeggo

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003360

Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression

Marcela Preininger, Dalia Arafat, Jinhee Kim, Artika P. Nath, Youssef Idaghdour, Kenneth L. Brigham, Greg Gibson

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003362

Rare Copy Number Variants Are a Common Cause of Short Stature

Diana Zahnleiter, Steffen Uebe, Arif B. Ekici, Juliane Hoyer, Antje Wiesener, Dagmar Wieczorek, Erdmute Kunstmann, André Reis, Helmuth-Guenther Doerr, Anita Rauch, Christian T. Thiel

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003365

DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast

Ulrika Norman-Axelsson, Mickaël Durand-Dubief, Punit Prasad, Karl Ekwall

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003371

Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes

Alexandra N. Marshall, Maria Camila Montealegre, Claudia Jiménez-López, Michael C. Lorenz, Ambro van Hoof

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003376

Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse

Pengpeng Ma, Richard M. Schultz

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003377

The U-Box E3 Ubiquitin Ligase TUD1 Functions with a Heterotrimeric G α Subunit to Regulate Brassinosteroid-Mediated Growth in Rice

Xingming Hu, Qian Qian, Ting Xu, Yu'e Zhang, Guojun Dong, Ting Gao, Qi Xie, Yongbiao Xue

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003391

A Conserved Upstream Motif Orchestrates Autonomous, Germline-Enriched Expression of Caenorhabditis elegans piRNAs

Allison C. Billi, Mallory A. Freeberg, Amanda M. Day, Sang Young Chun, Vishal Khivansara, John K. Kim

PLOS Genetics: published March 14, 2013 | https://doi.org/10.1371/journal.pgen.1003392

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

Fernando Gómez-Herreros, Rocío Romero-Granados, Zhihong Zeng, Alejandro Álvarez-Quilón, Cristina Quintero, Limei Ju, Lieve Umans, Liesbeth Vermeire, Danny Huylebroeck, Keith W. Caldecott, Felipe Cortés-Ledesma

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003226

Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism

James Hughes, Sandra Piltz, Nicholas Rogers, Dale McAninch, Lynn Rowley, Paul Thomas

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003290

Distinct Molecular Strategies for Hox-Mediated Limb Suppression in Drosophila: From Cooperativity to Dispensability/Antagonism in TALE Partnership

Nagraj Sambrani, Bruno Hudry, Corinne Maurel-Zaffran, Amel Zouaz, Rakesh Mishra, Samir Merabet, Yacine Graba

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003307

Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status

Gianpiero Di Leva, Claudia Piovan, Pierluigi Gasparini, Apollinaire Ngankeu, Cristian Taccioli, Daniel Briskin, Douglas G. Cheung, Brad Bolon, Laura Anderlucci, Hansjuerg Alder, Gerard Nuovo, Meng Li, Marilena V. Iorio, Marco Galasso, Santhanam Ramasamy, Guido Marcucci, Danilo Perrotti, Kimerly A. Powell, Anna Bratasz, Michela Garofalo, Kenneth P. Nephew, Carlo M. Croce

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003311

HIV Infection Disrupts the Sympatric Host–Pathogen Relationship in Human Tuberculosis

Lukas Fenner, Matthias Egger, Thomas Bodmer, Hansjakob Furrer, Marie Ballif, Manuel Battegay, Peter Helbling, Jan Fehr, Thomas Gsponer, Hans L. Rieder, Marcel Zwahlen, Matthias Hoffmann, Enos Bernasconi, Matthias Cavassini, Alexandra Calmy, Marisa Dolina, Reno Frei, Jean-Paul Janssens, Sonia Borrell, David Stucki, Jacques Schrenzel, Erik C. Böttger, Sebastien Gagneux, for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003318

Polycomb Group Gene OsFIE2 Regulates Rice (Oryza sativa) Seed Development and Grain Filling via a Mechanism Distinct from Arabidopsis

Babi Ramesh Reddy Nallamilli, Jian Zhang, Hana Mujahid, Brandon M. Malone, Susan M. Bridges, Zhaohua Peng

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003322

RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in Caenorhabditis elegans

Yusu Xie, Mustapha Moussaif, Sunju Choi, Lu Xu, Ji Ying Sze

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003324

Role of the DSC1 Channel in Regulating Neuronal Excitability in Drosophila melanogaster: Extending Nervous System Stability under Stress

Tianxiang Zhang, Zhe Wang, Lingxin Wang, Ningguang Luo, Lan Jiang, Zhiqi Liu, Chun-Fang Wu, Ke Dong

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003327

A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

Elizabeth X. Kwan, Eric J. Foss, Scott Tsuchiyama, Gina M. Alvino, Leonid Kruglyak, Matt Kaeberlein, M. K. Raghuraman, Bonita J. Brewer, Brian K. Kennedy, Antonio Bedalov

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003329

Matefin/SUN-1 Phosphorylation Is Part of a Surveillance Mechanism to Coordinate Chromosome Synapsis and Recombination with Meiotic Progression and Chromosome Movement

Alexander Woglar, Anahita Daryabeigi, Adele Adamo, Cornelia Habacher, Thomas Machacek, Adriana La Volpe, Verena Jantsch

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003335

A Role for the Malignant Brain Tumour (MBT) Domain Protein LIN-61 in DNA Double-Strand Break Repair by Homologous Recombination

Nicholas M. Johnson, Bennie B. L. G. Lemmens, Marcel Tijsterman

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003339

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans

Daniel P. Denning, Victoria Hatch, H. Robert Horvitz

PLOS Genetics: published March 7, 2013 | https://doi.org/10.1371/journal.pgen.1003341

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