December 2012

In most echinoderms, the transition from larva to adult relies on an impressive left-right asymmetric process. During this process, an imaginal disc called the rudiment, from which most adult tissues derive, is formed on the left side of the larva. In this issue of PLOS Genetics, Bessodes et al. show that in the sea urchin larva, a group of Nodal-expressing cells located at the tip of the gastrula archenteron plays the role of a left-right organizer. They identify BMP, FGF, and Notch as key signals that regulate the asymmetric positioning of this organizer. The image shows a dorsal view of a four-week-old Paracentrotus lividus larva.

Image Credit: Véronique Duboc and Thierry Lepage, Observatoire Océanologique de Villefranche-sur-Mer.

Perspectives

A Mystery Unraveled: Essentiality of RNase III in Bacillus subtilis Is Caused by Resident Prophages

Fabian M. Commichau, Jörg Stülke

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003199

On Lung Function and Interactions Using Genome-Wide Data

Erik Melén, Matteo Bottai

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003174

Defining the Pathways Underlying the Prolonged PR Interval in Atrioventricular Conduction Disease

Jerry Curran, Peter J. Mohler

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003154

Research Articles

An Allele of an Ancestral Transcription Factor Dependent on a Horizontally Acquired Gene Product

H. Deborah Chen, Mollie W. Jewett, Eduardo A. Groisman

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003060

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

Tobias Wijshake, Liviu A. Malureanu, Darren J. Baker, Karthik B. Jeganathan, Bart van de Sluis, Jan M. van Deursen

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003138

Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C

Roxana del Rio, Ryan D. McAllister, Nathan D. Meeker, Emma H. Wall, Jeffrey P. Bond, Vasileios C. Kyttaris, George C. Tsokos, Kenneth S. K. Tung, Cory Teuscher

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003140

Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss

Andrea Calixto, Juan S. Jara, Felipe A. Court

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003141

Systems Genetic Analysis of Osteoblast-Lineage Cells

Gina Calabrese, Brian J. Bennett, Luz Orozco, Hyun M. Kang, Eleazar Eskin, Carlos Dombret, Olivier De Backer, Aldons J. Lusis, Charles R. Farber

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003150

Polycomb Controls Gliogenesis by Regulating the Transient Expression of the Gcm/Glide Fate Determinant

Anna Popkova, Roberto Bernardoni, Celine Diebold, Véronique Van de Bor, Bernd Schuettengruber, Inma González, Ana Busturia, Giacomo Cavalli, Angela Giangrande

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003159

Evidence for the Robustness of Protein Complexes to Inter-Species Hybridization

Jean-Baptiste Leducq, Guillaume Charron, Guillaume Diss, Isabelle Gagnon-Arsenault, Alexandre K. Dubé, Christian R. Landry

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003161

A Framework for the Establishment of a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification: The Inputs of ß-Catenin/TCF Signaling

Eric Röttinger, Paul Dahlin, Mark Q. Martindale

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003164

Approaching the Functional Annotation of Fungal Virulence Factors Using Cross-Species Genetic Interaction Profiling

Jessica C. S. Brown, Hiten D. Madhani

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003168

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex Reversals

Rowena Lavery, Anne-Amandine Chassot, Eva Pauper, Elodie P. Gregoire, Muriel Klopfenstein, Dirk G. de Rooij, Manuel Mark, Andreas Schedl, Norbert B. Ghyselinck, Marie-Christine Chaboissier

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003170

Excessive Astrocyte-Derived Neurotrophin-3 Contributes to the Abnormal Neuronal Dendritic Development in a Mouse Model of Fragile X Syndrome

Qi Yang, Bin Feng, Kun Zhang, Yan-yan Guo, Shui-bing Liu, Yu-mei Wu, Xiao-qiang Li, Ming-gao Zhao

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003172

The Essential Function of B. subtilis RNase III Is to Silence Foreign Toxin Genes

Sylvain Durand, Laetitia Gilet, Ciarán Condon

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003181

An Excess of Gene Expression Divergence on the X Chromosome in Drosophila Embryos: Implications for the Faster-X Hypothesis

Melek A. Kayserili, Dave T. Gerrard, Pavel Tomancak, Alex T. Kalinka

PLOS Genetics: published December 27, 2012 | https://doi.org/10.1371/journal.pgen.1003200

Population Genomics of Inversion Polymorphisms in Drosophila melanogaster

Russell B. Corbett-Detig, Daniel L. Hartl

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003056

Insertion/Deletion Polymorphisms in the ΔNp63 Promoter Are a Risk Factor for Bladder Exstrophy Epispadias Complex

Simon Wilkins, Ke Wei Zhang, Istiak Mahfuz, Renaud Quantin, Nancy D'Cruz, John Hutson, Michael Ee, Darius Bagli, Karen Aitken, Fion Nga-Yin Fong, Patrick Kwok-Shing Ng, Stephen Kwok-Wing Tsui, Wendy Yin-Wan Fung, Tahmina Banu, Atul Thakre, Kaid Johar, Enrique Jaureguizar, Long Li, Wei Cheng

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003070

Population Genomics of Sub-Saharan Drosophila melanogaster: African Diversity and Non-African Admixture

John E. Pool, Russell B. Corbett-Detig, Ryuichi P. Sugino, Kristian A. Stevens, Charis M. Cardeno, Marc W. Crepeau, Pablo Duchen, J. J. Emerson, Perot Saelao, David J. Begun, Charles H. Langley

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003080

Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster

Andrew H. Chan, Paul A. Jenkins, Yun S. Song

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003090

Genetic Adaptation Associated with Genome-Doubling in Autotetraploid Arabidopsis arenosa

Jesse D. Hollister, Brian J. Arnold, Elisabeth Svedin, Katherine S. Xue, Brian P. Dilkes, Kirsten Bomblies

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003093

Genes Contributing to Pain Sensitivity in the Normal Population: An Exome Sequencing Study

Frances M. K. Williams, Serena Scollen, Dandan Cao, Yasin Memari, Craig L. Hyde, Baohong Zhang, Benjamin Sidders, Daniel Ziemek, Yujian Shi, Juliette Harris, Ian Harrow, Brian Dougherty, Anders Malarstig, Robert McEwen, Joel C. Stephens, Ketan Patel, Cristina Menni, So-Youn Shin, Dylan Hodgkiss, Gabriela Surdulescu, Wen He, Xin Jin, Stephen B. McMahon, Nicole Soranzo, Sally John, Jun Wang, Tim D. Spector

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003095

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth, Medea Imboden, Beate Koch, Wendy L. McArdle, Albert V. Smith, Joanna Smolonska, Akshay Sood, Wenbo Tang, Jemma B. Wilk, Guangju Zhai, Jing Hua Zhao, Hugues Aschard, Kristin M. Burkart, Ivan Curjuric, Mark Eijgelsheim, Paul Elliott, Xiangjun Gu, Tamara B. Harris, Christer Janson, Georg Homuth, Pirro G. Hysi, Jason Z. Liu, Laura R. Loehr, Kurt Lohman, Ruth J. F. Loos, Alisa K. Manning, Kristin D. Marciante, Ma'en Obeidat, Dirkje S. Postma, Melinda C. Aldrich, Guy G. Brusselle, Ting-hsu Chen, Gudny Eiriksdottir, Nora Franceschini, Joachim Heinrich, Jerome I. Rotter, Cisca Wijmenga, O. Dale Williams, Amy R. Bentley, Albert Hofman, Cathy C. Laurie, Thomas Lumley, Alanna C. Morrison, Bonnie R. Joubert, Fernando Rivadeneira, David J. Couper, Stephen B. Kritchevsky, Yongmei Liu, Matthias Wjst, Louise V. Wain, Judith M. Vonk, André G. Uitterlinden, Thierry Rochat, Stephen S. Rich, Bruce M. Psaty, George T. O'Connor, Kari E. North, Daniel B. Mirel, Bernd Meibohm, Lenore J. Launer, Kay-Tee Khaw, Anna-Liisa Hartikainen, Christopher J. Hammond, Sven Gläser, Jonathan Marchini, Peter Kraft, Nicholas J. Wareham, Henry Völzke, Bruno H. C. Stricker, Timothy D. Spector, Nicole M. Probst-Hensch, Deborah Jarvis, Marjo-Riitta Jarvelin, Susan R. Heckbert, Vilmundur Gudnason, H. Marike Boezen, R. Graham Barr, Patricia A. Cassano, David P. Strachan, Myriam Fornage, Ian P. Hall, Josée Dupuis, Martin D. Tobin, Stephanie J. London

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003098

ATX1-Generated H3K4me3 Is Required for Efficient Elongation of Transcription, Not Initiation, at ATX1-Regulated Genes

Yong Ding, Ivan Ndamukong, Zaoshi Xu, Hanna Lapko, Michael Fromm, Zoya Avramova

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003111

Systematic Identification of Rhythmic Genes Reveals camk1gb as a New Element in the Circadian Clockwork

Adi Tovin, Shahar Alon, Zohar Ben-Moshe, Philipp Mracek, Gad Vatine, Nicholas S. Foulkes, Jasmine Jacob-Hirsch, Gideon Rechavi, Reiko Toyama, Steven L. Coon, David C. Klein, Eli Eisenberg, Yoav Gothilf

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003116

A New Isolation with Migration Model along Complete Genomes Infers Very Different Divergence Processes among Closely Related Great Ape Species

Thomas Mailund, Anders E. Halager, Michael Westergaard, Julien Y. Dutheil, Kasper Munch, Lars N. Andersen, Gerton Lunter, Kay Prüfer, Aylwyn Scally, Asger Hobolth, Mikkel H. Schierup

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003125

RecX Facilitates Homologous Recombination by Modulating RecA Activities

Paula P. Cárdenas, Begoña Carrasco, Clarisse Defeu Soufo, Carolina E. César, Katharina Herr, Miriam Kaufenstein, Peter L. Graumann, Juan C. Alonso

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003126

DNA Topoisomerases Maintain Promoters in a State Competent for Transcriptional Activation in Saccharomyces cerevisiae

Jakob Madsen Pedersen, Jacob Fredsoe, Morten Roedgaard, Lotte Andreasen, Kamilla Mundbjerg, Mogens Kruhøffer, Marie Brinch, Mikkel Heide Schierup, Lotte Bjergbaek, Anni Hangaard Andersen

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003128

Population Genomics of the Wolbachia Endosymbiont in Drosophila melanogaster

Mark F. Richardson, Lucy A. Weinert, John J. Welch, Raquel S. Linheiro, Michael M. Magwire, Francis M. Jiggins, Casey M. Bergman

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003129

PEP1 of Arabis alpina Is Encoded by Two Overlapping Genes That Contribute to Natural Genetic Variation in Perennial Flowering

Maria C. Albani, Loren Castaings, Stefan Wötzel, Julieta L. Mateos, Jörg Wunder, Renhou Wang, Mathieu Reymond, George Coupland

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003130

Genes That Act Downstream of Sensory Neurons to Influence Longevity, Dauer Formation, and Pathogen Responses in Caenorhabditis elegans

Marta M. Gaglia, Dae-Eun Jeong, Eun-A Ryu, Dongyeop Lee, Cynthia Kenyon, Seung-Jae Lee

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003133

A Polycomb Group Protein Is Retained at Specific Sites on Chromatin in Mitosis

Nicole E. Follmer, Ajazul H. Wani, Nicole J. Francis

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003135

Chromosome Fragile Sites in Arabidopsis Harbor Matrix Attachment Regions That May Be Associated with Ancestral Chromosome Rearrangement Events

Joelle S. dela Paz, Patti E. Stronghill, Scott J. Douglas, Sandy Saravia, Clare A. Hasenkampf, C. Daniel Riggs

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003136

Genome-Wide Association Study Implicates Testis-Sperm Specific FKBP6 as a Susceptibility Locus for Impaired Acrosome Reaction in Stallions

Terje Raudsepp, Molly E. McCue, Pranab J. Das, Lauren Dobson, Monika Vishnoi, Krista L. Fritz, Robert Schaefer, Aaron K. Rendahl, James N. Derr, Charles C. Love, Dickson D. Varner, Bhanu P. Chowdhary

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003139

Dynamic and Differential Regulation of Stem Cell Factor FoxD3 in the Neural Crest Is Encrypted in the Genome

Marcos S. Simões-Costa, Sonja J. McKeown, Joanne Tan-Cabugao, Tatjana Sauka-Spengler, Marianne E. Bronner

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003142

Dnmt3a Protects Active Chromosome Domains against Cancer-Associated Hypomethylation

Günter Raddatz, Qing Gao, Sebastian Bender, Rudolf Jaenisch, Frank Lyko

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003146

Pre-Disposition and Epigenetics Govern Variation in Bacterial Survival upon Stress

Ming Ni, Antoine L. Decrulle, Fanette Fontaine, Alice Demarez, Francois Taddei, Ariel B. Lindner

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003148

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie, Claude Gazin, Sung Mi Park, Lihua J. Zhu, Marie-anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David Lapointe, Stephane Gobeil, Ching-Man Virbasius, Michael R. Green

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003151

Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

Flávia C. Costa, Halyna Fedosyuk, Allen M. Chazelle, Renee Y. Neades, Kenneth R. Peterson

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003155

Long-Range Regulatory Polymorphisms Affecting a GABA Receptor Constitute a Quantitative Trait Locus (QTL) for Social Behavior in Caenorhabditis elegans

Andres Bendesky, Jason Pitts, Matthew V. Rockman, William C. Chen, Man-Wah Tan, Leonid Kruglyak, Cornelia I. Bargmann

PLOS Genetics: published December 20, 2012 | https://doi.org/10.1371/journal.pgen.1003157

The Effective Population Size of Malaria Mosquitoes: Large Impact of Vector Control

Giridhar Athrey, Theresa K. Hodges, Michael R. Reddy, Hans J. Overgaard, Abrahan Matias, Frances C. Ridl, Immo Kleinschmidt, Adalgisa Caccone, Michel A. Slotman

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003097

The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans

Xiao Xu, Stuart K. Kim

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003108

A Genome-Wide RNAi Screen Reveals MAP Kinase Phosphatases as Key ERK Pathway Regulators during Embryonic Stem Cell Differentiation

Shen-Hsi Yang, Tuzer Kalkan, Claire Morrisroe, Austin Smith, Andrew D. Sharrocks

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003112

Histone Deacetylase HDA6 Is Functionally Associated with AS1 in Repression of KNOX Genes in Arabidopsis

Ming Luo, Chun-Wei Yu, Fang-Fang Chen, Linmao Zhao, Gang Tian, Xuncheng Liu, Yuhai Cui, Jun-Yi Yang, Keqiang Wu

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003114

SLI-1 Cbl Inhibits the Engulfment of Apoptotic Cells in C. elegans through a Ligase-Independent Function

Courtney Anderson, Shan Zhou, Emma Sawin, H. Robert Horvitz, Michael E. Hurwitz

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003115

A Mechanism of Gene Amplification Driven by Small DNA Fragments

Kuntal Mukherjee, Francesca Storici

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003119

Reciprocal Signaling between the Ectoderm and a Mesendodermal Left-Right Organizer Directs Left-Right Determination in the Sea Urchin Embryo

Nathalie Bessodes, Emmanuel Haillot, Véronique Duboc, Eric Röttinger, François Lahaye, Thierry Lepage

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003121

Translation in Giant Viruses: A Unique Mixture of Bacterial and Eukaryotic Termination Schemes

Sandra Jeudy, Chantal Abergel, Jean-Michel Claverie, Matthieu Legendre

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003122

Spreading of Heterochromatin Is Limited to Specific Families of Maize Retrotransposons

Steven R. Eichten, Nathanael A. Ellis, Irina Makarevitch, Cheng-Ting Yeh, Jonathan I. Gent, Lin Guo, Karen M. McGinnis, Xiaoyu Zhang, Patrick S. Schnable, Matthew W. Vaughn, R. Kelly Dawe, Nathan M. Springer

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003127

Wheat TILLING Mutants Show That the Vernalization Gene VRN1 Down-Regulates the Flowering Repressor VRN2 in Leaves but Is Not Essential for Flowering

Andrew Chen, Jorge Dubcovsky

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003134

Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

Kin Chan, Joan F. Sterling, Steven A. Roberts, Ashok S. Bhagwat, Michael A. Resnick, Dmitry A. Gordenin

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003149

The Chromosomal Proteins JIL-1 and Z4/Putzig Regulate the Telomeric Chromatin in Drosophila melanogaster

Rute Silva-Sousa, Elisenda López-Panadès, David Piñeyro, Elena Casacuberta

PLOS Genetics: published December 13, 2012 | https://doi.org/10.1371/journal.pgen.1003153

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems

Josep M. Mercader, Montserrat Puiggros, Ayellet V. Segrè, Evarist Planet, Eleonora Sorianello, David Sebastian, Sergio Rodriguez-Cuenca, Vicent Ribas, Sílvia Bonàs-Guarch, Sorin Draghici, Chenjing Yang, Sílvia Mora, Antoni Vidal-Puig, Josée Dupuis, DIAGRAM Consortium, Jose C. Florez, MITIN Consortium, Antonio Zorzano, David Torrents

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003046

Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing–Based Approach

Dong Ding, Xiaoyan Lou, Dasong Hua, Wei Yu, Lisha Li, Jun Wang, Feng Gao, Na Zhao, Guoping Ren, Lanjuan Li, Biaoyang Lin

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003065

Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception

G. Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S. Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J. Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J. Andrew Pospisilik, Emilio Hirsch, Ian Q. Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J. Woolf, Josef M. Penninger

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003071

Recessive Mutations in SPTBN2 Implicate β-III Spectrin in Both Cognitive and Motor Development

Stefano Lise, Yvonne Clarkson, Emma Perkins, Alexandra Kwasniewska, Elham Sadighi Akha, Ricardo Parolin Schnekenberg, Daumante Suminaite, Jilly Hope, Ian Baker, Lorna Gregory, Angie Green, Chris Allan, Sarah Lamble, Sandeep Jayawant, Gerardine Quaghebeur, M. Zameel Cader, Sarah Hughes, Richard J. E. Armstrong, Alexander Kanapin, Andrew Rimmer, Gerton Lunter, Iain Mathieson, Jean-Baptiste Cazier, David Buck, Jenny C. Taylor, David Bentley, Gilean McVean, Peter Donnelly, Samantha J. L. Knight, Mandy Jackson, Jiannis Ragoussis, Andrea H. Németh

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003074

A Yeast GSK-3 Kinase Mck1 Promotes Cdc6 Degradation to Inhibit DNA Re-Replication

Amy E. Ikui, Valentina Rossio, Lea Schroeder, Satoshi Yoshida

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003099

Deciphering the Transcriptional-Regulatory Network of Flocculation in Schizosaccharomyces pombe

Eun-Joo Gina Kwon, Amy Laderoute, Kate Chatfield-Reed, Lianne Vachon, Jim Karagiannis, Gordon Chua

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003104

Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets

Zhidong Tu, Mark P. Keller, Chunsheng Zhang, Mary E. Rabaglia, Danielle M. Greenawalt, Xia Yang, I-Ming Wang, Hongyue Dai, Matthew D. Bruss, Pek Y. Lum, Yun-Ping Zhou, Daniel M. Kemp, Christina Kendziorski, Brian S. Yandell, Alan D. Attie, Eric E. Schadt, Jun Zhu

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003107

The Genetic Architecture of Adaptations to High Altitude in Ethiopia

Gorka Alkorta-Aranburu, Cynthia M. Beall, David B. Witonsky, Amha Gebremedhin, Jonathan K. Pritchard, Anna Di Rienzo

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003110

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

Elisabeth M. Lodder, Brendon P. Scicluna, Annalisa Milano, Albert Y. Sun, Hao Tang, Carol Ann Remme, Perry D. Moerland, Michael W. T. Tanck, Geoffrey S. Pitt, Douglas A. Marchuk, Connie R. Bezzina

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003113

A Histone Deacetylase Adjusts Transcription Kinetics at Coding Sequences during Candida albicans Morphogenesis

Denes Hnisz, Anaïs F. Bardet, Clarissa J. Nobile, Andriy Petryshyn, Walter Glaser, Ulrike Schöck, Alexander Stark, Karl Kuchler

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003118

Natural Variation at the FRD3 MATE Transporter Locus Reveals Cross-Talk between Fe Homeostasis and Zn Tolerance in Arabidopsis thaliana

Christophe Pineau, Stéphanie Loubet, Cécile Lefoulon, Claude Chalies, Cécile Fizames, Benoit Lacombe, Marina Ferrand, Olivier Loudet, Pierre Berthomieu, Odile Richard

PLOS Genetics: published December 6, 2012 | https://doi.org/10.1371/journal.pgen.1003120

Cover

Left-right asymmetric positioning of the rudiment in a sea urchin larva.

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