The Sox2-Cre—mediated conditional knockout (cKO) of Fam20c leads to significant skeletal defects. X-ray imaging of 5-month-old cKO mice (right) shows smaller stature, distorted spine, and hypomineralized skeleton when compared with their wild type littermates (left). The skeletal defects along with lower phosphorus and higher FGF23 levels in the serum of cKO mice are consistent with a diagnosis of hypophosphatemic rickets, indicating that FAM20C plays an essential role in biomineralization and maintenance of total body phosphorus homeostasis. See Wang et al.
Image Credit: Xiaofang Wang (Texas A&M Health Science Center, Baylor College of Dentistry).
Interview
Scientist Citizen: An Interview with Bruce Alberts
PLOS Genetics: published May 31, 2012 | https://doi.org/10.1371/journal.pgen.1002743
Perspectives
Chromosome Pairing: A Hidden Treasure No More
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Histone H3 Localizes to the Centromeric DNA in Budding Yeast
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Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
PLOS Genetics: published May 31, 2012 | https://doi.org/10.1371/journal.pgen.1002741
Genome-Wide Analysis of GLD-1–Mediated mRNA Regulation Suggests a Role in mRNA Storage
PLOS Genetics: published May 31, 2012 | https://doi.org/10.1371/journal.pgen.1002742
Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator
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Drosophila Activated Cdc42 Kinase Has an Anti-Apoptotic Function
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Loss of Gnas Imprinting Differentially Affects REM/NREM Sleep and Cognition in Mice
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The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
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Bmps and Id2a Act Upstream of Twist1 To Restrict Ectomesenchyme Potential of the Cranial Neural Crest
PLOS Genetics: published May 10, 2012 | https://doi.org/10.1371/journal.pgen.1002710
Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone
PLOS Genetics: published May 10, 2012 | https://doi.org/10.1371/journal.pgen.1002711
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PLOS Genetics: published May 10, 2012 | https://doi.org/10.1371/journal.pgen.1002712
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PLOS Genetics: published May 3, 2012 | https://doi.org/10.1371/journal.pgen.1002647
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PLOS Genetics: published May 3, 2012 | https://doi.org/10.1371/journal.pgen.1002658
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PLOS Genetics: published May 3, 2012 | https://doi.org/10.1371/journal.pgen.1002668
Downregulation of Chloroplast RPS1 Negatively Modulates Nuclear Heat-Responsive Expression of HsfA2 and Its Target Genes in Arabidopsis
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LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes
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