The Connection between Space and Thinking: An Interview with Rafael Viñoly

Jane Gitschier

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002445

An Anti-Checkpoint Activity for Rif1

Yaniv Harari, Linda Rubinstein, Martin Kupiec

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002421

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The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

Adam M. Saffer, Dong Hyun Kim, Alexander van Oudenaarden, H. Robert Horvitz

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002418

Transcription Is Required to Establish Maternal Imprinting at the Prader-Willi Syndrome and Angelman Syndrome Locus

Emily Y. Smith, Christopher R. Futtner, Stormy J. Chamberlain, Karen A. Johnstone, James L. Resnick

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002422

Substitutions in the Amino-Terminal Tail of Neurospora Histone H3 Have Varied Effects on DNA Methylation

Keyur K. Adhvaryu, Emanuela Berge, Hisashi Tamaru, Michael Freitag, Eric U. Selker

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002423

Duox, Flotillin-2, and Src42A Are Required to Activate or Delimit the Spread of the Transcriptional Response to Epidermal Wounds in Drosophila

Michelle T. Juarez, Rachel A. Patterson, Efren Sandoval-Guillen, William McGinnis

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002424

Autosomal Recessive Dilated Cardiomyopathy due to DOLK Mutations Results from Abnormal Dystroglycan O-Mannosylation

Dirk J. Lefeber, Arjan P. M. de Brouwer, Eva Morava, Moniek Riemersma, Janneke H. M. Schuurs-Hoeijmakers, Birgit Absmanner, Kiek Verrijp, Willem M. R. van den Akker, Karin Huijben, Gerry Steenbergen, Jeroen van Reeuwijk, Adam Jozwiak, Nili Zucker, Avraham Lorber, Martin Lammens, Carlos Knopf, Hans van Bokhoven, Stephanie Grünewald, Ludwig Lehle, Livia Kapusta, Hanna Mandel, Ron A. Wevers

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002427

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

Wei Zhang, Barry J. Thompson, Ville Hietakangas, Stephen M. Cohen

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002429

The RNA Silencing Enzyme RNA Polymerase V Is Required for Plant Immunity

Ana López, Vicente Ramírez, Javier García-Andrade, Victor Flors, Pablo Vera

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002434

Interspecific Sex in Grass Smuts and the Genetic Diversity of Their Pheromone-Receptor System

Ronny Kellner, Evelyn Vollmeister, Michael Feldbrügge, Dominik Begerow

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002436

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A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

M. Catarina Silva, Susan Fox, Monica Beam, Happy Thakkar, Margarida D. Amaral, Richard I. Morimoto

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002438

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Lars Vatten, Aki S. Havulinna, Frank Skorpen, Kirsti Kvaløy, Kaisa Silander, Thutrang T. Nguyen, Cristen Willer, Michael Boehnke, Markus Perola, Aarno Palotie, Veikko Salomaa, Kristian Hveem, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002439

DNA Methylation of the Gonadal Aromatase (cyp19a) Promoter Is Involved in Temperature-Dependent Sex Ratio Shifts in the European Sea Bass

Laia Navarro-Martín, Jordi Viñas, Laia Ribas, Noelia Díaz, Arantxa Gutiérrez, Luciano Di Croce, Francesc Piferrer

PLOS Genetics: published December 29, 2011 | https://doi.org/10.1371/journal.pgen.1002447

Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1

You-Ying Chau, David Brownstein, Heidi Mjoseng, Wen-Chin Lee, Natalija Buza-Vidas, Claus Nerlov, Sten Eirik Jacobsen, Paul Perry, Rachel Berry, Anna Thornburn, David Sexton, Nik Morton, Peter Hohenstein, Elisabeth Freyer, Kay Samuel, Rob van't Hof, Nicholas Hastie

PLOS Genetics: published December 22, 2011 | https://doi.org/10.1371/journal.pgen.1002404

A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken

Ben Dorshorst, Anna-Maja Molin, Carl-Johan Rubin, Anna M. Johansson, Lina Strömstedt, Manh-Hung Pham, Chih-Feng Chen, Finn Hallböök, Chris Ashwell, Leif Andersson

PLOS Genetics: published December 22, 2011 | https://doi.org/10.1371/journal.pgen.1002412

Candidate Gene Screen in the Red Flour Beetle Tribolium Reveals Six3 as Ancient Regulator of Anterior Median Head and Central Complex Development

Nico Posnien, Nikolaus Dieter Bernhard Koniszewski, Hendrikje Jeannette Hein, Gregor Bucher

PLOS Genetics: published December 22, 2011 | https://doi.org/10.1371/journal.pgen.1002416

Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation

Xiaoxi Wang, Lei Pan, Su Wang, Jian Zhou, William McDowell, Jungeun Park, Jeff Haug, Karen Staehling, Hong Tang, Ting Xie

PLOS Genetics: published December 22, 2011 | https://doi.org/10.1371/journal.pgen.1002426

Ror2 Enhances Polarity and Directional Migration of Primordial Germ Cells

Diana J. Laird, Svetlana Altshuler-Keylin, Michael D. Kissner, Xin Zhou, Kathryn V. Anderson

PLOS Genetics: published December 22, 2011 | https://doi.org/10.1371/journal.pgen.1002428

Azospirillum Genomes Reveal Transition of Bacteria from Aquatic to Terrestrial Environments

Florence Wisniewski-Dyé, Kirill Borziak, Gurusahai Khalsa-Moyers, Gladys Alexandre, Leonid O. Sukharnikov, Kristin Wuichet, Gregory B. Hurst, W. Hayes McDonald, Jon S. Robertson, Valérie Barbe, Alexandra Calteau, Zoé Rouy, Sophie Mangenot, Claire Prigent-Combaret, Philippe Normand, Mickaël Boyer, Patricia Siguier, Yves Dessaux, Claudine Elmerich, Guy Condemine, Ganisan Krishnen, Ivan Kennedy, Andrew H. Paterson, Victor González, Patrick Mavingui, Igor B. Zhulin

PLOS Genetics: published December 22, 2011 | https://doi.org/10.1371/journal.pgen.1002430

A High-Resolution Whole-Genome Map of Key Chromatin Modifications in the Adult Drosophila melanogaster

Hang Yin, Sarah Sweeney, Debasish Raha, Michael Snyder, Haifan Lin

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002380

Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development

Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck, Andrew Best, Yilei Liu, Miriam Jakubik, Ylva Mende, Ingrid Ehrmann, Tomaz Curk, Kristina Rossbach, Cyril F. Bourgeois, James Stévenin, David Grellscheid, Michael S. Jackson, Brunhilde Wirth, David J. Elliott

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002390

HIF-1 Regulates Iron Homeostasis in Caenorhabditis elegans by Activation and Inhibition of Genes Involved in Iron Uptake and Storage

Steven Joshua Romney, Ben S. Newman, Colin Thacker, Elizabeth A. Leibold

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002394

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone

Jane I. Lin, Naomi C. Mitchell, Marina Kalcina, Elly Tchoubrieva, Mary J. Stewart, Steven J. Marygold, Cherryl D. Walker, George Thomas, Sally J. Leevers, Richard B. Pearson, Leonie M. Quinn, Ross D. Hannan

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002408

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

Nicolas Siaud, Maria A. Barbera, Akinori Egashira, Isabel Lam, Nicole Christ, Katharina Schlacher, Bing Xia, Maria Jasin

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002409

Ancestral Components of Admixed Genomes in a Mexican Cohort

Nicholas A. Johnson, Marc A. Coram, Mark D. Shriver, Isabelle Romieu, Gregory S. Barsh, Stephanie J. London, Hua Tang

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002410

A Functional Phylogenomic View of the Seed Plants

Ernest K. Lee, Angelica Cibrian-Jaramillo, Sergios-Orestis Kolokotronis, Manpreet S. Katari, Alexandros Stamatakis, Michael Ott, Joanna C. Chiu, Damon P. Little, Dennis Wm. Stevenson, W. Richard McCombie, Robert A. Martienssen, Gloria Coruzzi, Rob DeSalle

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002411

Target Site Recognition by a Diversity-Generating Retroelement

Huatao Guo, Longping V. Tse, Angela W. Nieh, Elizabeth Czornyj, Steven Williams, Sabrina Oukil, Vincent B. Liu, Jeff F. Miller

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002414

A Densely Interconnected Genome-Wide Network of MicroRNAs and Oncogenic Pathways Revealed Using Gene Expression Signatures

Chia Huey Ooi, Hue Kian Oh, Hannah Zhu'Ai Wang, Angie Lay Keng Tan, Jeanie Wu, Minghui Lee, Sun Young Rha, Hyun Cheol Chung, David Marc Virshup, Patrick Tan

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002415

A Novel Checkpoint and RPA Inhibitory Pathway Regulated by Rif1

Yuan Xue, Michael D. Rushton, Laura Maringele

PLOS Genetics: published December 15, 2011 | https://doi.org/10.1371/journal.pgen.1002417

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Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types

Michael J. Ziller, Fabian Müller, Jing Liao, Yingying Zhang, Hongcang Gu, Christoph Bock, Patrick Boyle, Charles B. Epstein, Bradley E. Bernstein, Thomas Lengauer, Andreas Gnirke, Alexander Meissner

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002389

Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol

Sumeet A. Khetarpal, Andrew C. Edmondson, Avanthi Raghavan, Hemanth Neeli, Weijun Jin, Karen O. Badellino, Serkalem Demissie, Alisa K. Manning, Stephanie L. DerOhannessian, Megan L. Wolfe, L. Adrienne Cupples, Mingyao Li, Sekar Kathiresan, Daniel J. Rader

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002393

The FGFR4-G388R Polymorphism Promotes Mitochondrial STAT3 Serine Phosphorylation to Facilitate Pituitary Growth Hormone Cell Tumorigenesis

Toru Tateno, Sylvia L. Asa, Lei Zheng, Thomas Mayr, Axel Ullrich, Shereen Ezzat

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002400

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

Laure Escoubet-Lozach, Christopher Benner, Minna U. Kaikkonen, Jean Lozach, Sven Heinz, Nathan J. Spann, Andrea Crotti, Josh Stender, Serena Ghisletti, Donna Reichart, Christine S. Cheng, Rosa Luna, Colleen Ludka, Roman Sasik, Ivan Garcia-Bassets, Alexander Hoffmann, Shankar Subramaniam, Gary Hardiman, Michael G. Rosenfeld, Christopher K. Glass

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002401

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

Dick Jaarsma, Ingrid van der Pluijm, Monique C. de Waard, Elize D. Haasdijk, Renata Brandt, Marcel Vermeij, Yvonne Rijksen, Alex Maas, Harry van Steeg, Jan H. J. Hoeijmakers, Gijsbertus T. J. van der Horst

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002405

A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap

Paula S. Ramos, Lindsey A. Criswell, Kathy L. Moser, Mary E. Comeau, Adrienne H. Williams, Nicholas M. Pajewski, Sharon A. Chung, Robert R. Graham, Raphael Zidovetzki, Jennifer A. Kelly, Kenneth M. Kaufman, Chaim O. Jacob, Timothy J. Vyse, Betty P. Tsao, Robert P. Kimberly, Patrick M. Gaffney, Marta E. Alarcón-Riquelme, John B. Harley, Carl D. Langefeld, for The International Consortium on the Genetics of Systemic Erythematosus (SLEGEN)

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002406

An Assessment of the Individual and Collective Effects of Variants on Height Using Twins and a Developmentally Informative Study Design

Scott I. Vrieze, Matt McGue, Michael B. Miller, Lisa N. Legrand, Nicholas J. Schork, William G. Iacono

PLOS Genetics: published December 8, 2011 | https://doi.org/10.1371/journal.pgen.1002413

Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

Maxime Rotival, Tanja Zeller, Philipp S. Wild, Seraya Maouche, Silke Szymczak, Arne Schillert, Raphaele Castagné, Arne Deiseroth, Carole Proust, Jessy Brocheton, Tiphaine Godefroy, Claire Perret, Marine Germain, Medea Eleftheriadis, Christoph R. Sinning, Renate B. Schnabel, Edith Lubos, Karl J. Lackner, Heidi Rossmann, Thomas Münzel, Augusto Rendon, Cardiogenics Consortium, Jeanette Erdmann, Panos Deloukas, Christian Hengstenberg, Patrick Diemert, Gilles Montalescot, Willem H. Ouwehand, Nilesh J. Samani, Heribert Schunkert, David-Alexandre Tregouet, Andreas Ziegler, Alison H. Goodall, François Cambien, Laurence Tiret, Stefan Blankenberg

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002367

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

Michael Blatzer, Bridget M. Barker, Sven D. Willger, Nicola Beckmann, Sara J. Blosser, Elizabeth J. Cornish, Aurelien Mazurie, Nora Grahl, Hubertus Haas, Robert A. Cramer

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002374

Hierarchical Generalized Linear Models for Multiple Groups of Rare and Common Variants: Jointly Estimating Group and Individual-Variant Effects

Nengjun Yi, Nianjun Liu, Degui Zhi, Jun Li

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002382

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

A. P. Jason de Koning, Wanjun Gu, Todd A. Castoe, Mark A. Batzer, David D. Pollock

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002384

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

María S. Domínguez-Sánchez, Sonia Barroso, Belén Gómez-González, Rosa Luna, Andrés Aguilera

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002386

The Fission Yeast Stress-Responsive MAPK Pathway Promotes Meiosis via the Phosphorylation of Pol II CTD in Response to Environmental and Feedback Cues

Yuko Sukegawa, Akira Yamashita, Masayuki Yamamoto

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002387

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

Kyudong Han, Dianne I. Lou, Sara L. Sawyer

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002388

A Population Genetics-Phylogenetics Approach to Inferring Natural Selection in Coding Sequences

Daniel J. Wilson, Ryan D. Hernandez, Peter Andolfatto, Molly Przeworski

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002395

Targeted Proteolysis of Plectin Isoform 1a Accounts for Hemidesmosome Dysfunction in Mice Mimicking the Dominant Skin Blistering Disease EBS-Ogna

Gernot Walko, Nevena Vukasinovic, Karin Gross, Irmgard Fischer, Sabrina Sibitz, Peter Fuchs, Siegfried Reipert, Ute Jungwirth, Walter Berger, Ulrich Salzer, Oliviero Carugo, Maria J. Castañón, Gerhard Wiche

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002396

Widespread Cotranslational Formation of Protein Complexes

Caia D. S. Duncan, Juan Mata

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002398

Charcot-Marie-Tooth–Linked Mutant GARS Is Toxic to Peripheral Neurons Independent of Wild-Type GARS Levels

William W. Motley, Kevin L. Seburn, Mir Hussain Nawaz, Kathy E. Miers, Jun Cheng, Anthony Antonellis, Eric D. Green, Kevin Talbot, Xiang-Lei Yang, Kenneth H. Fischbeck, Robert W. Burgess

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002399

Genome-Wide Meta-Analysis of Five Asian Cohorts Identifies PDGFRA as a Susceptibility Locus for Corneal Astigmatism

Qiao Fan, Xin Zhou, Chiea-Chuen Khor, Ching-Yu Cheng, Liang-Kee Goh, Xueling Sim, Wan-Ting Tay, Yi-Ju Li, Rick Twee-Hee Ong, Chen Suo, Belinda Cornes, Mohammad Kamran Ikram, Kee-Seng Chia, Mark Seielstad, Jianjun Liu, Eranga Vithana, Terri L. Young, E.-Shyong Tai, Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002402

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

Sandra Blanco, Agata Kurowski, Jennifer Nichols, Fiona M. Watt, Salvador Aznar Benitah, Michaela Frye

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002403

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

Izumi Miyabe, Thomas A. Kunkel, Antony M. Carr

PLOS Genetics: published December 1, 2011 | https://doi.org/10.1371/journal.pgen.1002407