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Table of Contents

June 2010

Cover

Winged form of the peach-potato aphid Myzus persicae.
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The peach potato aphid Myzus persicae is the most economically important aphid pest in many regions of the world and has developed resistance to many classes of insecticide used for control. In this issue of PLoS Genetics, Puinean et al. made use of recent advances in genomics to quantify the expression of all genes encoding detoxification enzymes in an insecticide resistant strain of M. persicae. Resistance was associated with the over-expression of a single P450 gene, and the authors show, for the first time in an agriculturally important insect pest, that this is due to amplification of the gene.

Image Credit: Photograph courtesy of Rothamsted Research

Editorial

Consent and Internet-Enabled Human Genomics

Greg Gibson, Gregory P. Copenhaver

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000965

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Perspective

Understanding Adaptation in Large Populations

Nick Barton

PLOS Genetics: published June 17, 2010 | https://doi.org/10.1371/journal.pgen.1000987

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Research Articles

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

Nicholas Eriksson, J. Michael Macpherson, Joyce Y. Tung, Lawrence S. Hon, Brian Naughton, Serge Saxonov, Linda Avey, Anne Wojcicki, Itsik Pe'er, Joanna Mountain

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000993

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Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF–Dependent Transcription in Hypoxia

Andrés Dekanty, Nuria M. Romero, Agustina P. Bertolin, María G. Thomas, Claudia C. Leishman, Joel I. Perez-Perri, Graciela L. Boccaccio, Pablo Wappner

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000994

Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis

Jeffrey C. Francis, Afshan McCarthy, Martin K. Thomsen, Alan Ashworth, Amanda Swain

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000995

Endoreplication Controls Cell Fate Maintenance

Jonathan Bramsiepe, Katja Wester, Christina Weinl, Farshad Roodbarkelari, Remmy Kasili, John C. Larkin, Martin Hülskamp, Arp Schnittger

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000996

Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys

So-Yon Lim, Tiffany Chan, Rebecca S. Gelman, James B. Whitney, Kara L. O'Brien, Dan H. Barouch, David B. Goldstein, Barton F. Haynes, Norman L. Letvin

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000997

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Copy Number Variation and Transposable Elements Feature in Recent, Ongoing Adaptation at the Cyp6g1 Locus

Joshua M. Schmidt, Robert T. Good, Belinda Appleton, Jayne Sherrard, Greta C. Raymant, Michael R. Bogwitz, Jon Martin, Phillip J. Daborn, Mike E. Goddard, Philip Batterham, Charles Robin

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Amplification of a Cytochrome P450 Gene Is Associated with Resistance to Neonicotinoid Insecticides in the Aphid Myzus persicae

Alin M. Puinean, Stephen P. Foster, Linda Oliphant, Ian Denholm, Linda M. Field, Neil S. Millar, Martin S. Williamson, Chris Bass

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1000999

A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy

Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A. Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L. Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T. Neil Dear

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Non-Redundant Selector and Growth-Promoting Functions of Two Sister Genes, buttonhead and Sp1, in Drosophila Leg Development

Carlos Estella, Richard S. Mann

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Identification of a Functional Genetic Variant at 16q12.1 for Breast Cancer Risk: Results from the Asia Breast Cancer Consortium

Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Shimian Qu, Chun Li, Ying Zheng, Kai Gu, Wenjing Wang, Yong-Bing Xiang, Jiarong Cheng, Kexin Chen, Lina Zhang, Hong Zheng, Chen-Yang Shen, Chiun-Sheng Huang, Ming-Feng Hou, Hongbing Shen, Zhibin Hu, Furu Wang, Sandra L. Deming, Mark C. Kelley, Martha J. Shrubsole, Ui Soon Khoo, Kelvin Y. K. Chan, Sum Yin Chan, Christopher A. Haiman, Brian E. Henderson, Loic Le Marchand, Motoki Iwasaki, Yoshio Kasuga, Shoichiro Tsugane, Keitaro Matsuo, Kazuo Tajima, Hiroji Iwata, Bo Huang, Jiajun Shi, Guoliang Li, Wanqing Wen, Yu-Tang Gao, Wei Lu, Wei Zheng

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1001002

Tandem E2F Binding Sites in the Promoter of the p107 Cell Cycle Regulator Control p107 Expression and Its Cellular Functions

Deborah L. Burkhart, Stacey E. Wirt, Anne-Flore Zmoos, Michael S. Kareta, Julien Sage

PLOS Genetics: published June 24, 2010 | https://doi.org/10.1371/journal.pgen.1001003

Translational Selection Is Ubiquitous in Prokaryotes

Fran Supek, Nives Škunca, Jelena Repar, Kristian Vlahoviček, Tomislav Šmuc

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Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single Sites

Talia Karasov, Philipp W. Messer, Dmitri A. Petrov

PLOS Genetics: published June 17, 2010 | https://doi.org/10.1371/journal.pgen.1000924

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On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study

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Amal J. Johnston, Olga Kirioukhova, Philippa J. Barrell, Twan Rutten, James M. Moore, Ramamurthy Baskar, Ueli Grossniklaus, Wilhelm Gruissem

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The CYCLIN-A CYCA1;2/TAM Is Required for the Meiosis I to Meiosis II Transition and Cooperates with OSD1 for the Prophase to First Meiotic Division Transition

Isabelle d'Erfurth, Laurence Cromer, Sylvie Jolivet, Chloé Girard, Christine Horlow, Yujin Sun, Jennifer P. C. To, Luke E. Berchowitz, Gregory P. Copenhaver, Raphael Mercier

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Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

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Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

Nara L. M. Sobreira, Elizabeth T. Cirulli, Dimitrios Avramopoulos, Elizabeth Wohler, Gretchen L. Oswald, Eric L. Stevens, Dongliang Ge, Kevin V. Shianna, Jason P. Smith, Jessica M. Maia, Curtis E. Gumbs, Jonathan Pevsner, George Thomas, David Valle, Julie E. Hoover-Fong, David B. Goldstein

PLOS Genetics: published June 17, 2010 | https://doi.org/10.1371/journal.pgen.1000991

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An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

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A Genome-Wide Association Study of Optic Disc Parameters

Wishal D. Ramdas, Leonieke M. E. van Koolwijk, M. Kamran Ikram, Nomdo M. Jansonius, Paulus T. V. M. de Jong, Arthur A. B. Bergen, Aaron Isaacs, Najaf Amin, Yurii S. Aulchenko, Roger C. W. Wolfs, Albert Hofman, Fernando Rivadeneira, Ben A. Oostra, Andre G. Uitterlinden, Pirro Hysi, Christopher J. Hammond, Hans G. Lemij, Johannes R. Vingerling, Caroline C. W. Klaver, Cornelia M. van Duijn

PLOS Genetics: published June 10, 2010 | https://doi.org/10.1371/journal.pgen.1000978

The Transcription Factor REST Is Lost in Aggressive Breast Cancer

Matthew P. Wagoner, Kearney T. W. Gunsalus, Barry Schoenike, Andrea L. Richardson, Andreas Friedl, Avtar Roopra

PLOS Genetics: published June 10, 2010 | https://doi.org/10.1371/journal.pgen.1000979

Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice

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Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State

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The E1A-Associated p400 Protein Modulates Cell Fate Decisions by the Regulation of ROS Homeostasis

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siRNA–Mediated Methylation of Arabidopsis Telomeres

Jan Vrbsky, Svetlana Akimcheva, J. Matthew Watson, Thomas L. Turner, Lucia Daxinger, Boris Vyskot, Werner Aufsatz, Karel Riha

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The CFTR Met 470 Allele Is Associated with Lower Birth Rates in Fertile Men from a Population Isolate

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14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila

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