June 2009

The garland cells are one of two groups of athrocytes in Drosophila in which extracellular serpin-family inhibitors involved in the innate immune response are taken up and degraded (see Soukup et al., 10.1371/journal.pgen.1000532). The image shows a broken ring of garland cells encircling the oesophagus above the proventriculus (Z-series reconstruction). Endocytosis has been frozen using a Dynamin^ts mutation, allowing Necrotic (red) to be detected within the cortical labyrinthine channels of the garland cells. In a normal fly, Necrotic is endocytosed via the LpR1 trafficking receptor, processed through multi-vesicular bodies, and delivered to the lysosome for degradation.

Image Credit: Picture taken by Dr. Sandra Soukup in the laboratory of Dr. David Gubb (CICbioGUNE Institute, Derio, Spain).

Perspectives

The Mysteries of Chromosome Evolution in Gibbons: Methylation Is a Prime Suspect

Judith D. Brown, Rachel J. O'Neill

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000501

Cytoplasmic Streaming in Neurospora: Disperse the Plug To Increase the Flow?

Michael Plamann

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000526

Review

Pervasive Natural Selection in the Drosophila Genome?

Guy Sella, Dmitri A. Petrov, Molly Przeworski, Peter Andolfatto

PLOS Genetics: published June 5, 2009 | https://doi.org/10.1371/journal.pgen.1000495

Research Articles

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Cecilia M. Lindgren, Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerdur Steinthorsdottir, Lu Qi, Elizabeth K. Speliotes, Gudmar Thorleifsson, Cristen J. Willer, Blanca M. Herrera, Anne U. Jackson, Noha Lim, Paul Scheet, Nicole Soranzo, Najaf Amin, Yurii S. Aulchenko, John C. Chambers, Alexander Drong, Jian'an Luan, Helen N. Lyon, Fernando Rivadeneira, Serena Sanna, Nicholas J. Timpson, M. Carola Zillikens, Jing Hua Zhao, Peter Almgren, Stefania Bandinelli, Amanda J. Bennett, Richard N. Bergman, Lori L. Bonnycastle, Suzannah J. Bumpstead, Stephen J. Chanock, Lynn Cherkas, Peter Chines, Lachlan Coin, Cyrus Cooper, Gabriel Crawford, Angela Doering, Anna Dominiczak, Alex S. F. Doney, Shah Ebrahim, Paul Elliott, Michael R. Erdos, Karol Estrada, Luigi Ferrucci, Guido Fischer, Nita G. Forouhi, Christian Gieger, Harald Grallert, Christopher J. Groves, Scott Grundy, Candace Guiducci, David Hadley, Anders Hamsten, Aki S. Havulinna, Albert Hofman, Rolf Holle, John W. Holloway, Thomas Illig, Bo Isomaa, Leonie C. Jacobs, Karen Jameson, Pekka Jousilahti, Fredrik Karpe, Johanna Kuusisto, Jaana Laitinen, G. Mark Lathrop, Debbie A. Lawlor, Massimo Mangino, Wendy L. McArdle, Thomas Meitinger, Mario A. Morken, Andrew P. Morris, Patricia Munroe, Narisu Narisu, Anna Nordström, Peter Nordström, Ben A. Oostra, Colin N. A. Palmer, Felicity Payne, John F. Peden, Inga Prokopenko, Frida Renström, Aimo Ruokonen, Veikko Salomaa, Manjinder S. Sandhu, Laura J. Scott, Angelo Scuteri, Kaisa Silander, Kijoung Song, Xin Yuan, Heather M. Stringham, Amy J. Swift, Tiinamaija Tuomi, Manuela Uda, Peter Vollenweider, Gerard Waeber, Chris Wallace, G. Bragi Walters, Michael N. Weedon, The Wellcome Trust Case Control Consortium, Jacqueline C. M. Witteman, Cuilin Zhang, Weihua Zhang, Mark J. Caulfield, Francis S. Collins, George Davey Smith, Ian N. M. Day, Paul W. Franks, Andrew T. Hattersley, Frank B. Hu, Marjo-Riitta Jarvelin, Augustine Kong, Jaspal S. Kooner, Markku Laakso, Edward Lakatta, Vincent Mooser, Andrew D. Morris, Leena Peltonen, Nilesh J. Samani, Timothy D. Spector, David P. Strachan, Toshiko Tanaka, Jaakko Tuomilehto, André G. Uitterlinden, Cornelia M. van Duijn, Nicholas J. Wareham, Hugh Watkins for the PROCARDIS consortia, Dawn M. Waterworth, Michael Boehnke, Panos Deloukas, Leif Groop, David J. Hunter, Unnur Thorsteinsdottir, David Schlessinger, H.-Erich Wichmann, Timothy M. Frayling, Gonçalo R. Abecasis, Joel N. Hirschhorn, Ruth J. F. Loos, Kari Stefansson, Karen L. Mohlke, Inês Barroso, Mark I. McCarthy for the GIANT consortium

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000508

Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits

Frank Johannes, Emmanuelle Porcher, Felipe K. Teixeira, Vera Saliba-Colombani, Matthieu Simon, Nicolas Agier, Agnès Bulski, Juliette Albuisson, Fabiana Heredia, Pascal Audigier, David Bouchez, Christine Dillmann, Philippe Guerche, Frédéric Hospital, Vincent Colot

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000530

Forging Links between Human Mental Retardation–Associated CNVs and Mouse Gene Knockout Models

Caleb Webber, Jayne Y. Hehir-Kwa, Duc-Quang Nguyen, Bert B. A. de Vries, Joris A. Veltman, Chris P. Ponting

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000531

Uptake of the Necrotic Serpin in Drosophila melanogaster via the Lipophorin Receptor-1

Sandra Fausia Soukup, Joaquim Culi, David Gubb

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000532

Evolution of Mutational Robustness in the Yeast Genome: A Link to Essential Genes and Meiotic Recombination Hotspots

Philipp J. Keller, Michael Knop

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000533

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

Soumya Raychaudhuri, Robert M. Plenge, Elizabeth J. Rossin, Aylwin C. Y. Ng, International Schizophrenia Consortium, Shaun M. Purcell, Pamela Sklar, Edward M. Scolnick, Ramnik J. Xavier, David Altshuler, Mark J. Daly

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000534

Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae

Xiao-Fen Chen, Fei-Long Meng, Jin-Qiu Zhou

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000535

Genome-Wide Analyses of Exonic Copy Number Variants in a Family-Based Study Point to Novel Autism Susceptibility Genes

Maja Bucan, Brett S. Abrahams, Kai Wang, Joseph T. Glessner, Edward I. Herman, Lisa I. Sonnenblick, Ana I. Alvarez Retuerto, Marcin Imielinski, Dexter Hadley, Jonathan P. Bradfield, Cecilia Kim, Nicole B. Gidaya, Ingrid Lindquist, Ted Hutman, Marian Sigman, Vlad Kustanovich, Clara M. Lajonchere, Andrew Singleton, Junhyong Kim, Thomas H. Wassink, William M. McMahon, Thomas Owley, John A. Sweeney, Hilary Coon, John I. Nurnberger Jr, Mingyao Li, Rita M. Cantor, Nancy J. Minshew, James S. Sutcliffe, Edwin H. Cook, Geraldine Dawson, Joseph D. Buxbaum, Struan F. A. Grant, Gerard D. Schellenberg, Daniel H. Geschwind, Hakon Hakonarson

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000536

An Integrated Strategy to Study Muscle Development and Myofilament Structure in Caenorhabditis elegans

Barbara Meissner, Adam Warner, Kim Wong, Nicholas Dube, Adam Lorch, Sheldon J. McKay, Jaswinder Khattra, Teresa Rogalski, Aruna Somasiri, Iasha Chaudhry, Rebecca M. Fox, David M. Miller III, David L. Baillie, Robert A. Holt, Steven J. M. Jones, Marco A. Marra, Donald G. Moerman

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000537

Evolutionary Breakpoints in the Gibbon Suggest Association between Cytosine Methylation and Karyotype Evolution

Lucia Carbone, R. Alan Harris, Gery M. Vessere, Alan R. Mootnick, Sean Humphray, Jane Rogers, Sung K. Kim, Jeffrey D. Wall, David Martin, Jerzy Jurka, Aleksandar Milosavljevic, Pieter J. de Jong

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000538

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa, Thor Aspelund, Gudny Eiriksdottir, Melissa Garcia, Lenore J. Launer, Albert V. Smith, Braxton D. Mitchell, Patrick F. McArdle, Alan R. Shuldiner, Suzette J. Bielinski, Eric Boerwinkle, Fred Brancati, Ellen W. Demerath, James S. Pankow, Alice M. Arnold, Yii-Der Ida Chen, Nicole L. Glazer, Barbara McKnight, Bruce M. Psaty, Jerome I. Rotter, Najaf Amin, Harry Campbell, Ulf Gyllensten, Cristian Pattaro, Peter P. Pramstaller, Igor Rudan, Maksim Struchalin, Veronique Vitart, Xiaoyi Gao, Aldi Kraja, Michael A. Province, Qunyuan Zhang, Larry D. Atwood, Josée Dupuis, Joel N. Hirschhorn, Cashell E. Jaquish, Christopher J. O'Donnell, Ramachandran S. Vasan, Charles C. White, Yurii S. Aulchenko, Karol Estrada, Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden, Jacqueline C. M. Witteman, Ben A. Oostra, Robert C. Kaplan, Vilmundur Gudnason, Jeffrey R. O'Connell, Ingrid B. Borecki, Cornelia M. van Duijn, L. Adrienne Cupples, Caroline S. Fox, Kari E. North

PLOS Genetics: published June 26, 2009 | https://doi.org/10.1371/journal.pgen.1000539

The Maternal-Effect Gene cellular island Encodes Aurora B Kinase and Is Essential for Furrow Formation in the Early Zebrafish Embryo

Taijiro Yabe, Xiaoyan Ge, Robin Lindeman, Sreelaja Nair, Greg Runke, Mary C. Mullins, Francisco Pelegri

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000518

Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations

Alkes L. Price, Arti Tandon, Nick Patterson, Kathleen C. Barnes, Nicholas Rafaels, Ingo Ruczinski, Terri H. Beaty, Rasika Mathias, David Reich, Simon Myers

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000519

Avoiding Dangerous Missense: Thermophiles Display Especially Low Mutation Rates

John W. Drake

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000520

A Tether for Woronin Body Inheritance Is Associated with Evolutionary Variation in Organelle Positioning

Seng Kah Ng, Fangfang Liu, Julian Lai, Wilson Low, Gregory Jedd

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000521

Disease-Causing 7.4 kb Cis-Regulatory Deletion Disrupting Conserved Non-Coding Sequences and Their Interaction with the FOXL2 Promotor: Implications for Mutation Screening

Barbara D'haene, Catia Attanasio, Diane Beysen, Josée Dostie, Edmond Lemire, Philippe Bouchard, Michael Field, Kristie Jones, Birgit Lorenz, Björn Menten, Karen Buysse, Filip Pattyn, Marc Friedli, Catherine Ucla, Colette Rossier, Carine Wyss, Frank Speleman, Anne De Paepe, Job Dekker, Stylianos E. Antonarakis, Elfride De Baere

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000522

Genetic Variation of Promoter Sequence Modulates XBP1 Expression and Genetic Risk for Vitiligo

Yunqing Ren, Sen Yang, Shengxin Xu, Min Gao, Wei Huang, Tianwen Gao, Qiaoyun Fang, Cheng Quan, Chi Zhang, Liangdan Sun, Yanhua Liang, Jianwen Han, Zhimin Wang, Fengyu Zhang, Youwen Zhou, Jianjun Liu, Xuejun Zhang

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000523

Peroxiredoxin Tsa1 Is the Key Peroxidase Suppressing Genome Instability and Protecting against Cell Death in Saccharomyces cerevisiae

Ismail Iraqui, Guy Kienda, Jérémie Soeur, Gérard Faye, Giuseppe Baldacci, Richard D. Kolodner, Meng-Er Huang

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000524

Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila

Kasper Daniel Hansen, Liana F. Lareau, Marco Blanchette, Richard E. Green, Qi Meng, Jan Rehwinkel, Fabian L. Gallusser, Elisa Izaurralde, Donald C. Rio, Sandrine Dudoit, Steven E. Brenner

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000525

A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen

Dashnamoorthy Ravi, Amy M. Wiles, Selvaraj Bhavani, Jianhua Ruan, Philip Leder, Alexander J. R. Bishop

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000527

Comprehensive Linkage and Association Analyses Identify Haplotype, Near to the TNFSF15 Gene, Significantly Associated with Spondyloarthritis

Elena Zinovieva, Catherine Bourgain, Amir Kadi, Franck Letourneur, Brigitte Izac, Roula Said-Nahal, Nicolas Lebrun, Nicolas Cagnard, Agathe Vigier, Sébastien Jacques, Corinne Miceli-Richard, Henri-Jean Garchon, Simon Heath, Céline Charon, Delphine Bacq, Anne Boland, Diana Zelenika, Gilles Chiocchia, Maxime Breban

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000528

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

Bryan N. Howie, Peter Donnelly, Jonathan Marchini

PLOS Genetics: published June 19, 2009 | https://doi.org/10.1371/journal.pgen.1000529

A Mechanistic Basis for the Coordinated Regulation of Pharyngeal Morphogenesis in Caenorhabditis elegans by LIN-35/Rb and UBC-18–ARI-1

Kumaran Mani, David S. Fay

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000510

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

Stephen N. Sansom, Dean S. Griffiths, Andrea Faedo, Dirk-Jan Kleinjan, Youlin Ruan, James Smith, Veronica van Heyningen, John L. Rubenstein, Frederick J. Livesey

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000511

Copy Number Variation in Intron 1 of SOX5 Causes the Pea-comb Phenotype in Chickens

Dominic Wright, Henrik Boije, Jennifer R. S. Meadows, Bertrand Bed'hom, David Gourichon, Agathe Vieaud, Michèle Tixier-Boichard, Carl-Johan Rubin, Freyja Imsland, Finn Hallböök, Leif Andersson

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000512

Differential Regulation of Horizontally Acquired and Core Genome Genes by the Bacterial Modulator H-NS

Rosa C. Baños, Aitziber Vivero, Sonia Aznar, Jesús García, Miquel Pons, Cristina Madrid, Antonio Juárez

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000513

Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis

Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yang

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000514

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

Taavi K. Neklesa, Ronald W. Davis

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000515

Change of Gene Structure and Function by Non-Homologous End-Joining, Homologous Recombination, and Transposition of DNA

Wolfgang Goettel, Joachim Messing

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000516

Complex Adaptations Can Drive the Evolution of the Capacitor [PSI⁺], Even with Realistic Rates of Yeast Sex

Cortland K. Griswold, Joanna Masel

PLOS Genetics: published June 12, 2009 | https://doi.org/10.1371/journal.pgen.1000517

The Role of Geography in Human Adaptation

Graham Coop, Joseph K. Pickrell, John Novembre, Sridhar Kudaravalli, Jun Li, Devin Absher, Richard M. Myers, Luigi Luca Cavalli-Sforza, Marcus W. Feldman, Jonathan K. Pritchard

PLOS Genetics: published June 5, 2009 | https://doi.org/10.1371/journal.pgen.1000500

Systematic Identification of Balanced Transposition Polymorphisms in Saccharomyces cerevisiae

Dina A. Faddah, Eric W. Ganko, Caroline McCoach, Joseph K. Pickrell, Sean E. Hanlon, Frederick G. Mann, Joanna O. Mieczkowska, Corbin D. Jones, Jason D. Lieb, Todd J. Vision

PLOS Genetics: published June 5, 2009 | https://doi.org/10.1371/journal.pgen.1000502

Caenorhabditis elegans Genomic Response to Soil Bacteria Predicts Environment-Specific Genetic Effects on Life History Traits

Joseph D. Coolon, Kenneth L. Jones, Timothy C. Todd, Bryanua C. Carr, Michael A. Herman

PLOS Genetics: published June 5, 2009 | https://doi.org/10.1371/journal.pgen.1000503

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

Melanie Kolz, Toby Johnson, Serena Sanna, Alexander Teumer, Veronique Vitart, Markus Perola, Massimo Mangino, Eva Albrecht, Chris Wallace, Martin Farrall, Åsa Johansson, Dale R. Nyholt, Yurii Aulchenko, Jacques S. Beckmann, Sven Bergmann, Murielle Bochud, Morris Brown, Harry Campbell, for the EUROSPAN Consortium, John Connell, Anna Dominiczak, Georg Homuth, Claudia Lamina, Mark I. McCarthy, for the ENGAGE Consortium, Thomas Meitinger, Vincent Mooser, Patricia Munroe, Matthias Nauck, John Peden, Holger Prokisch, Perttu Salo, Veikko Salomaa, Nilesh J. Samani, David Schlessinger, Manuela Uda, Uwe Völker, Gérard Waeber, Dawn Waterworth, Rui Wang-Sattler, Alan F. Wright, Jerzy Adamski, John B. Whitfield, Ulf Gyllensten, James F. Wilson, Igor Rudan, Peter Pramstaller, Hugh Watkins, for the PROCARDIS Consortium, Angela Doering, H.-Erich Wichmann, for the KORA Study, Tim D. Spector, Leena Peltonen, Henry Völzke, Ramaiah Nagaraja, Peter Vollenweider, Mark Caulfield, for the WTCCC, Thomas Illig, Christian Gieger

PLOS Genetics: published June 5, 2009 | https://doi.org/10.1371/journal.pgen.1000504

Cover

Necrotic protein uptake in garland cells.

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