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Table of Contents

March 2008

Cover

Silencing of the FMR1 Gene in Fragile X Mental Retardation Syndrome
Issue Image

Artistic representation of events occurring during gene silencing in Fragile X mental retardation syndrome (FXS). The FMR1 gene, which is on the X chromosome, colocalizes with a fragile site seen in FXS cells that gives this disorder its name. FXS alleles become associated with SIRT1. SIRT1, a class III histone deacetylase, deacetylates lysine 9 of histone H3 and lysine 16 of histone H4, ultimately leading to chromatin compaction and gene silencing (see Biacsi et al., e1000017).

Image Credit: Image by Dr. Marian L. Miller (Journal-Cover-Art.com).

Interview

Imagine: An Interview with Svante Pääbo

Jane Gitschier

PLOS Genetics: published March 28, 2008 | https://doi.org/10.1371/journal.pgen.1000035

Research Articles

ruvA Mutants That Resolve Holliday Junctions but Do Not Reverse Replication Forks

Zeynep Baharoglu, Alison Sylvia Bradley, Marie Le Masson, Irina Tsaneva, Bénédicte Michel

PLOS Genetics: published March 7, 2008 | https://doi.org/10.1371/journal.pgen.1000012

GADD45A Does Not Promote DNA Demethylation

Seung-Gi Jin, Cai Guo, Gerd P. Pfeifer

PLOS Genetics: published March 7, 2008 | https://doi.org/10.1371/journal.pgen.1000013

Role of Duplicate Genes in Robustness against Deleterious Human Mutations

Tzu-Lin Hsiao, Dennis Vitkup

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000014

Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

Daan Noordermeer, Miguel R. Branco, Erik Splinter, Petra Klous, Wilfred van IJcken, Sigrid Swagemakers, Manousos Koutsourakis, Peter van der Spek, Ana Pombo, Wouter de Laat

PLOS Genetics: published March 7, 2008 | https://doi.org/10.1371/journal.pgen.1000016

Related Articles

  1. Correction: Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

Rea Biacsi, Daman Kumari, Karen Usdin

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000017

Functional Characterization of Variations on Regulatory Motifs

Lapidot Michal, Orna Mizrahi-Man, Yitzhak Pilpel

PLOS Genetics: published March 7, 2008 | https://doi.org/10.1371/journal.pgen.1000018

Related Articles

  1. Correction: Functional Characterization of Variations on Regulatory Motifs

Evolution of a Core Gene Network for Skeletogenesis in Chordates

Jochen Hecht, Sigmar Stricker, Ulrike Wiecha, Asita Stiege, Georgia Panopoulou, Lars Podsiadlowski, Albert J. Poustka, Christoph Dieterich, Siegfried Ehrich, Julia Suvorova, Stefan Mundlos, Volkhard Seitz

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000025

Leukocyte Tyrosine Kinase Functions in Pigment Cell Development

Susana S. Lopes, Xueyan Yang, Jeanette Müller, Thomas J. Carney, Anthony R. McAdow, Gerd-Jörg Rauch, Arie S. Jacoby, Laurence D. Hurst, Mariana Delfino-Machín, Pascal Haffter, Robert Geisler, Stephen L. Johnson, Andrew Ward, Robert N. Kelsh

PLOS Genetics: published March 7, 2008 | https://doi.org/10.1371/journal.pgen.1000026

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

Tjakko J. van Ham, Karen L. Thijssen, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, Ellen A. A. Nollen

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000027

Gene Activation Using FLP Recombinase in C. elegans

M. Wayne Davis, J. Jason Morton, Dana Carroll, Erik M. Jorgensen

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000028

From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

David L. Aylor, Zhao-Bang Zeng

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000029

Related Articles

  1. Correction: From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

The Mating-Type Chromosome in the Filamentous Ascomycete Neurospora tetrasperma Represents a Model for Early Evolution of Sex Chromosomes

Audrius Menkis, David J. Jacobson, Tim Gustafsson, Hanna Johannesson

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000030

An Abundant Evolutionarily Conserved CSB-PiggyBac Fusion Protein Expressed in Cockayne Syndrome

John C. Newman, Arnold D. Bailey, Hua-Ying Fan, Thomas Pavelitz, Alan M. Weiner

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000031

Global Analysis of Genetic, Epigenetic and Transcriptional Polymorphisms in Arabidopsis thaliana Using Whole Genome Tiling Arrays

Xu Zhang, Shinhan Shiu, Andrew Cal, Justin O. Borevitz

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000032

Related Articles

  1. Correction: Global Analysis of Genetic, Epigenetic and Transcriptional Polymorphisms in Arabidopsis thaliana Using Whole Genome Tiling Arrays

New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

Tiffany Renee Oliver, Eleanor Feingold, Kai Yu, Vivian Cheung, Stuart Tinker, Maneesha Yadav-Shah, Nirupama Masse, Stephanie L. Sherman

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000033

Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

Christine T. Ferrara, Ping Wang, Elias Chaibub Neto, Robert D. Stevens, James R. Bain, Brett R. Wenner, Olga R. Ilkayeva, Mark P. Keller, Daniel A. Blasiole, Christina Kendziorski, Brian S. Yandell, Christopher B. Newgard, Alan D. Attie

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000034

Related Articles

  1. Correction: Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

Transcriptional Profiling Uncovers a Network of Cholesterol-Responsive Atherosclerosis Target Genes

Josefin Skogsberg, Jesper Lundström, Alexander Kovacs, Roland Nilsson, Peri Noori, Shohreh Maleki, Marina Köhler, Anders Hamsten, Jesper Tegnér, Johan Björkegren

PLOS Genetics: published March 14, 2008 | https://doi.org/10.1371/journal.pgen.1000036

Geographic Patterns of Genome Admixture in Latin American Mestizos

Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M. Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Cátira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, José E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Andrés Ruiz-Linares

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000037

Fine Mapping of the Psoriasis Susceptibility Locus PSORS1 Supports HLA-C as the Susceptibility Gene in the Han Chinese Population

Xing Fan, Sen Yang, Wei Huang, Zhi-Min Wang, Liang-Dan Sun, Yan-Hua Liang, Min Gao, Yue-Qing Ren, Kai-Yue Zhang, Wen-Hui Du, Yu-Jun Shen, Jian-Jun Liu, Xue-Jun Zhang

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000038

Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells

Lee E. Finlan, Duncan Sproul, Inga Thomson, Shelagh Boyle, Elizabeth Kerr, Paul Perry, Bauke Ylstra, Jonathan R. Chubb, Wendy A. Bickmore

PLOS Genetics: published March 21, 2008 | https://doi.org/10.1371/journal.pgen.1000039

ZIP4H (TEX11) Deficiency in the Mouse Impairs Meiotic Double Strand Break Repair and the Regulation of Crossing Over

Carrie A. Adelman, John H. J. Petrini

PLOS Genetics: published March 28, 2008 | https://doi.org/10.1371/journal.pgen.1000042

Phospholipase C-ε Regulates Epidermal Morphogenesis in Caenorhabditis elegans

Rafael P. Vázquez-Manrique, Anikó I. Nagy, James C. Legg, Olivia A. M. Bales, Sung Ly, Howard A. Baylis

PLOS Genetics: published March 28, 2008 | https://doi.org/10.1371/journal.pgen.1000043

An Essential Role for DYF-11/MIP-T3 in Assembling Functional Intraflagellar Transport Complexes

Chunmei Li, Peter N. Inglis, Carmen C. Leitch, Evgeni Efimenko, Norann A. Zaghloul, Calvin A. Mok, Erica E. Davis, Nathan J. Bialas, Michael P. Healey, Elise Héon, Mei Zhen, Peter Swoboda, Nicholas Katsanis, Michel R. Leroux

PLOS Genetics: published March 28, 2008 | https://doi.org/10.1371/journal.pgen.1000044

Global Chromatin Domain Organization of the Drosophila Genome

Elzo de Wit, Ulrich Braunschweig, Frauke Greil, Harmen J. Bussemaker, Bas van Steensel

PLOS Genetics: published March 28, 2008 | https://doi.org/10.1371/journal.pgen.1000045