April 2007

The platypus (a monotreme) diverged from therian (marsupial and eutherian) mammals approximately 170 million years ago (MYA). Marsupials and eutherians separated about 125 MYA. By comparing the genomic sequence of a specific imprinted domain between these extant mammals, it is clear that imprinting in this region arose only after insertion of the retrotransposon-derived gene PEG10 around 125 MYA (see Suzuki et al., e55).

Image Credit: Photographs provided by D. Parer and E. Parer-Cook (platypus), the Australian Broadcasting Corporation Natural History Unit and M. B. Renfree (wallaby), and the University of Melbourne. Cover design by G. Shaw, University of Melbourne.

Review

Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?

Matthew D. W Piper, Linda Partridge

PLOS Genetics: published April 27, 2007 | https://doi.org/10.1371/journal.pgen.0030057

Research Articles

A Dinucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases

Lizhong Wang, Shili Lin, Kottil W Rammohan, Zhenqiu Liu, Jin-qing Liu, Run-hua Liu, Nikki Guinther, Judy Lima, Qunmin Zhou, Tony Wang, Xincheng Zheng, Dan J Birmingham, Brad H Rovin, Lee A Hebert, Yeeling Wu, D. Joanne Lynn, Glenn Cooke, C. Yung Yu, Pan Zheng, Yang Liu

PLOS Genetics: published April 6, 2007 | https://doi.org/10.1371/journal.pgen.0030049

Multiple-Pathway Analysis of Double-Strand Break Repair Mutations in Drosophila

Dena M Johnson-Schlitz, Carlos Flores, William R Engels

PLOS Genetics: published April 13, 2007 | https://doi.org/10.1371/journal.pgen.0030050

Generalized Analysis of Molecular Variance

Caroline M Nievergelt, Ondrej Libiger, Nicholas J Schork

PLOS Genetics: published April 6, 2007 | https://doi.org/10.1371/journal.pgen.0030051

CTG Trinucleotide Repeat “Big Jumps”: Large Expansions, Small Mice

Mário Gomes-Pereira, Laurent Foiry, Annie Nicole, Aline Huguet, Claudine Junien, Arnold Munnich, Geneviève Gourdon

PLOS Genetics: published April 6, 2007 | https://doi.org/10.1371/journal.pgen.0030052

A Tale of Two Oxidation States: Bacterial Colonization of Arsenic-Rich Environments

Daniel Muller, Claudine Médigue, Sandrine Koechler, Valérie Barbe, Mohamed Barakat, Emmanuel Talla, Violaine Bonnefoy, Evelyne Krin, Florence Arsène-Ploetze, Christine Carapito, Michael Chandler, Benoît Cournoyer, Stéphane Cruveiller, Caroline Dossat, Simon Duval, Michael Heymann, Emmanuelle Leize, Aurélie Lieutaud, Didier Lièvremont, Yuko Makita, Sophie Mangenot, Wolfgang Nitschke, Philippe Ortet, Nicolas Perdrial, Barbara Schoepp, Patricia Siguier, Diliana D Simeonova, Zoé Rouy, Béatrice Segurens, Evelyne Turlin, David Vallenet, Alain Van Dorsselaer, Stéphanie Weiss, Jean Weissenbach, Marie-Claire Lett, Antoine Danchin, Philippe N Bertin

PLOS Genetics: published April 13, 2007 | https://doi.org/10.1371/journal.pgen.0030053

Integration of Light and Temperature in the Regulation of Circadian Gene Expression in Drosophila

Catharine E Boothroyd, Herman Wijnen, Felix Naef, Lino Saez, Michael W Young

PLOS Genetics: published April 6, 2007 | https://doi.org/10.1371/journal.pgen.0030054

Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting

Shunsuke Suzuki, Ryuichi Ono, Takanori Narita, Andrew J Pask, Geoffrey Shaw, Changshan Wang, Takashi Kohda, Amber E Alsop, Jennifer A. Marshall Graves, Yuji Kohara, Fumitoshi Ishino, Marilyn B Renfree, Tomoko Kaneko-Ishino

PLOS Genetics: published April 13, 2007 | https://doi.org/10.1371/journal.pgen.0030055

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability

Sean P Curran, Gary Ruvkun

PLOS Genetics: published April 6, 2007 | https://doi.org/10.1371/journal.pgen.0030056

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

Cécile Libioulle, Edouard Louis, Sarah Hansoul, Cynthia Sandor, Frédéric Farnir, Denis Franchimont, Séverine Vermeire, Olivier Dewit, Martine de Vos, Anna Dixon, Bruno Demarche, Ivo Gut, Simon Heath, Mario Foglio, Liming Liang, Debby Laukens, Myriam Mni, Diana Zelenika, André Van Gossum, Paul Rutgeerts, Jacques Belaiche, Mark Lathrop, Michel Georges

PLOS Genetics: published April 20, 2007 | https://doi.org/10.1371/journal.pgen.0030058

Conservation of Regional Gene Expression in Mouse and Human Brain

Andrew D Strand, Aaron K Aragaki, Zachary C Baquet, Angela Hodges, Philip Cunningham, Peter Holmans, Kevin R Jones, Lesley Jones, Charles Kooperberg, James M Olson

PLOS Genetics: published April 20, 2007 | https://doi.org/10.1371/journal.pgen.0030059

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu, Gudmar Thorleifsson, Steinunn Gunnarsdottir, G. Bragi Walters, Unnur Thorsteinsdottir, Augustine Kong, Jeffrey Gulcher, Thuy Trang Nguyen, André Scherag, Arne Pfeufer, Thomas Meitinger, Günter Brönner, Winfried Rief, Manuel E Soto-Quiros, Lydiana Avila, Barbara Klanderman, Benjamin A Raby, Edwin K Silverman, Scott T Weiss, Nan Laird, Xiao Ding, Leif Groop, Tiinamaija Tuomi, Bo Isomaa, Kristina Bengtsson, Johannah L Butler, Richard S Cooper, Caroline S Fox, Christopher J O'Donnell, Caren Vollmert, Juan C Celedón, H. Erich Wichmann, Johannes Hebebrand, Kari Stefansson, Christoph Lange, Joel N Hirschhorn

PLOS Genetics: published April 27, 2007 | https://doi.org/10.1371/journal.pgen.0030061

A Mammal-Specific Doublesex Homolog Associates with Male Sex Chromatin and Is Required for Male Meiosis

Shinseog Kim, Satoshi H Namekawa, Lisa M Niswander, Jeremy O Ward, Jeannie T Lee, Vivian J Bardwell, David Zarkower

PLOS Genetics: published April 20, 2007 | https://doi.org/10.1371/journal.pgen.0030062

Population Stratification of a Common APOBEC Gene Deletion Polymorphism

Jeffrey M Kidd, Tera L Newman, Eray Tuzun, Rajinder Kaul, Evan E Eichler

PLOS Genetics: published April 20, 2007 | https://doi.org/10.1371/journal.pgen.0030063

PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

Gema Medina-Gomez, Sarah L Gray, Laxman Yetukuri, Kenju Shimomura, Sam Virtue, Mark Campbell, R. Keira Curtis, Mercedes Jimenez-Linan, Margaret Blount, Giles S. H Yeo, Miguel Lopez, Tuulikki Seppänen-Laakso, Frances M Ashcroft, Matej Orešič, Antonio Vidal-Puig

PLOS Genetics: published April 27, 2007 | https://doi.org/10.1371/journal.pgen.0030064

Cover

Mammalian genomic imprinting