A sagittal section through an E12.5 Jag1 conditionally deleted mutant inner ear stained for SOX2, a marker of the prosensory domain. Signal is observed in the saccule (green) only, while other sensory regions are missing or reduced (nuclei are stained blue). These data establish the Notch ligand JAG1 as a protein required for early sensory development in the inner ear (see Kiernan et al.).

Image Credit: Photograph taken by Amy Kiernan using a Zeiss microscope and Zeiss Axiocam digital camera.