A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases

• Wei Liu ,

  Contributed equally to this work with: Wei Liu, Wenxuan Deng, Ming Chen

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0003-2558-1377

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• Wenxuan Deng ,

  Contributed equally to this work with: Wei Liu, Wenxuan Deng, Ming Chen

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America

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• Ming Chen ,

  Contributed equally to this work with: Wei Liu, Wenxuan Deng, Ming Chen

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America

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• Zihan Dong,

  Roles Formal analysis

  Affiliation Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America

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• Biqing Zhu,

  Roles Formal analysis

  Affiliation Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0002-7428-6297

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• Zhaolong Yu,

  Roles Formal analysis

  Affiliation Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

  ⨯
• Daiwei Tang,

  Roles Formal analysis

  Affiliation Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America

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• Maor Sauler,

  Roles Investigation

  Affiliation Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, United States of America

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• Chen Lin,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0001-9821-2578

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• Louise V. Wain,

  Roles Investigation

  Affiliations Department of Health Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

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• Michael H. Cho,

  Roles Funding acquisition, Investigation

  Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-4907-1657

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• Naftali Kaminski,

  Roles Funding acquisition, Investigation

  Affiliation Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0001-5917-4601

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• Hongyu Zhao

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: hongyu.zhao@yale.edu

  Affiliations Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0003-1195-9607

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