Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

• Silke Fuchs ,

  Contributed equally to this work with: Silke Fuchs, William T. Garrood

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0001-8921-7422

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• William T. Garrood ,

  Contributed equally to this work with: Silke Fuchs, William T. Garrood

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0003-2743-2770

  ⨯
• Anna Beber,

  Roles Data curation, Investigation

  Affiliation Department of Biology, University of Padua, Padua, Italy

  ⨯
• Andrew Hammond,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Department of Life Sciences, Imperial College London, London, United Kingdom, Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America

  https://orcid.org/0000-0002-1757-5009

  ⨯
• Roberto Galizi,

  Roles Investigation, Writing – review & editing

  Affiliation Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

  https://orcid.org/0000-0003-3134-7480

  ⨯
• Matthew Gribble,

  Roles Data curation

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  ⨯
• Giulia Morselli,

  Roles Data curation

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  ⨯
• Tin-Yu J. Hui,

  Roles Formal analysis

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0002-1702-803X

  ⨯
• Katie Willis,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0001-5016-2380

  ⨯
• Nace Kranjc,

  Roles Formal analysis

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0001-7720-8430

  ⨯
• Austin Burt,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0001-5146-9640

  ⨯
• Andrea Crisanti ,

  Roles Conceptualization, Funding acquisition, Supervision

  * E-mail: acrs@imperial.ac.uk (AC); tony.nolan@lstmed.ac.uk (TN)

  Affiliations Department of Life Sciences, Imperial College London, London, United Kingdom, Department of Molecular Medicine, University of Padua, Padua, Italy

  https://orcid.org/0000-0002-2406-4426

  ⨯
• Tony Nolan

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: acrs@imperial.ac.uk (AC); tony.nolan@lstmed.ac.uk (TN)

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

  ⨯