Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

• Kathryn A. Jewett,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Department of Biology, Juniata College, Huntingdon, Pennsylvania, United States of America

  https://orcid.org/0000-0002-7029-7132

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• Ruth E. Thomas,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-9648-2339

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• Chi Q. Phan,

  Roles Formal analysis, Investigation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-5190-3910

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• Bernice Lin,

  Roles Investigation

  Affiliation VA Puget Sound Healthcare System, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-3262-5043

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• Gillian Milstein,

  Roles Formal analysis, Investigation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2825-9623

  ⨯
• Selina Yu,

  Roles Formal analysis, Investigation

  Affiliations Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, VA Puget Sound Healthcare System, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-9444-4360

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• Lisa F. Bettcher,

  Roles Investigation, Methodology

  Affiliation Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-6058-9337

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• Fausto Carnevale Neto,

  Roles Formal analysis

  Affiliation Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-9364-933X

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• Danijel Djukovic,

  Roles Investigation, Methodology

  Affiliation Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

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• Daniel Raftery,

  Roles Formal analysis, Funding acquisition

  Affiliation Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2467-8118

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• Leo J. Pallanck,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-5943-9339

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• Marie Y. Davis

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: myd@uw.edu

  Affiliations VA Puget Sound Healthcare System, Seattle, Washington, United States of America, Department of Neurology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2502-6293

  ⨯