DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

Sean C. Shadle; Jun Wen Zhong; Amy E. Campbell; Melissa L. Conerly; Sujatha Jagannathan; Chao-Jen Wong; Timothy D. Morello; Silvère M. van der Maarel; Stephen J. Tapscott

doi:10.1371/journal.pgen.1006658

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Open Access

Peer-reviewed

Research Article

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

Sean C. Shadle,

Affiliations Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Jun Wen Zhong,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

http://orcid.org/0000-0001-8033-7866

⨯
Amy E. Campbell,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

http://orcid.org/0000-0001-6513-5836

⨯
Melissa L. Conerly,

Affiliations Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

http://orcid.org/0000-0003-0151-4997

⨯
Sujatha Jagannathan,

Affiliations Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Chao-Jen Wong,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Timothy D. Morello,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Silvère M. van der Maarel,

Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands
⨯
Stephen J. Tapscott

* E-mail: stapscot@fredhutch.org

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

http://orcid.org/0000-0002-0319-0968

⨯

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

Sean C. Shadle,
Jun Wen Zhong,
Amy E. Campbell,
Melissa L. Conerly,
Sujatha Jagannathan,
Chao-Jen Wong,
Timothy D. Morello,
Silvère M. van der Maarel,
Stephen J. Tapscott

Published: March 8, 2017
https://doi.org/10.1371/journal.pgen.1006658

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Small interfering RNA
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Double stranded RNA
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Myoblasts
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