Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene

• Kerstin U. Ludwig ,

  * E-mail: kerstin.ludwig@uni-bonn.de (KUL); heiko.peters@ncl.ac.uk (HP)

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany

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• Syeda Tasnim Ahmed,

  Affiliation Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom

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• Anne C. Böhmer,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany

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• Nasim Bahram Sangani,

  Affiliation Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom

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• Sheryil Varghese,

  Affiliation Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom

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• Johanna Klamt,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany

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• Hannah Schuenke,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany

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• Pinar Gültepe,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany

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• Andrea Hofmann,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany

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• Michele Rubini,

  Affiliation Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Italy

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• Khalid Ahmed Aldhorae,

  Affiliation Orthodontic Department, College of Dentistry, Thamar University, Thamar, Yemen

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• Regine P. Steegers-Theunissen,

  Affiliations Department of Obstetrics and Gynaecology, ErasmusMC, Rotterdam, Netherlands, Department of Epidemiology, Radboud University Medical Center, Nijmegen, Netherlands

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• Augusto Rojas-Martinez,

  Affiliation Department of Biochemistry and Molecular Medicine, School of Medicine, and Centro de Investigación y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico

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• Rudolf Reiter,

  Affiliation Department of Otolaryngology—Head and Neck Surgery, Section of Phoniatrics and Pedaudiology, University of Ulm, Ulm, Germany

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• Guntram Borck,

  Affiliation Institute of Human Genetics, University of Ulm, Ulm, Germany

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• Michael Knapp,

  Affiliation Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany

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• Mitsushiro Nakatomi,

  Affiliation Division of Anatomy, Kyushu Dental University, Kitakyushu, Japan

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• Daniel Graf,

  Affiliations Orofacial Development and Regeneration, Institute of Oral Biology, Center for Dental Medicine, University of Zurich, Zurich, Switzerland, Departments of Dentistry and Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada

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• Elisabeth Mangold,

  Affiliation Institute of Human Genetics, University of Bonn, Bonn, Germany

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•  [ ... ],
• Heiko Peters

  * E-mail: kerstin.ludwig@uni-bonn.de (KUL); heiko.peters@ncl.ac.uk (HP)

  Affiliation Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom

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