Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

Najeeb M. Halabi; Alejandra Martinez; Halema Al-Farsi; Eliane Mery; Laurence Puydenus; Pascal Pujol; Hanif G. Khalak; Cameron McLurcan; Gwenael Ferron; Denis Querleu; Iman Al-Azwani; Eman Al-Dous; Yasmin A. Mohamoud; Joel A. Malek; Arash Rafii

doi:10.1371/journal.pgen.1005755

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Open Access

Peer-reviewed

Research Article

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

Najeeb M. Halabi,

Affiliation Department of Genetic Medicine, Weill-Cornell Medical College, New York, United States of America
⨯
Alejandra Martinez,

Affiliation Surgery Department, Institute Claudius Regaud, Toulouse, France
⨯
Halema Al-Farsi,

Affiliation Department of Genetic Medicine, Weill-Cornell Medical College, New York, United States of America
⨯
Eliane Mery,

Affiliation Pathology Department, Institute Claudius Regaud, Toulouse, France
⨯
Laurence Puydenus,

Affiliation Pathology Department, Institute Claudius Regaud, Toulouse, France
⨯
Pascal Pujol,

Affiliation Oncogenetics, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, France
⨯
Hanif G. Khalak,

Affiliation Advanced Computing, Weill-Cornell Medical College in Qatar, Doha, Qatar
⨯
Cameron McLurcan,

Affiliation Biosciences Department, University of Birmingham, Birmingham, United Kingdom
⨯
Gwenael Ferron,

Affiliation Surgery Department, Institute Claudius Regaud, Toulouse, France
⨯
Denis Querleu,

Affiliation Surgery Department, Institute Claudius Regaud, Toulouse, France
⨯
Iman Al-Azwani,

Affiliation Genomics Core, Weill-Cornell Medical in Qatar, Doha, Qatar
⨯
Eman Al-Dous,

Affiliation Genomics Core, Weill-Cornell Medical in Qatar, Doha, Qatar
⨯
Yasmin A. Mohamoud,

Affiliation Genomics Core, Weill-Cornell Medical in Qatar, Doha, Qatar
⨯
Joel A. Malek,

Affiliations Department of Genetic Medicine, Weill-Cornell Medical College, New York, United States of America, Genomics Core, Weill-Cornell Medical in Qatar, Doha, Qatar
⨯
Arash Rafii

* E-mail: jat2021@qatar-med.cornell.edu

Affiliations Department of Genetic Medicine, Weill-Cornell Medical College, New York, United States of America, Stem Cells and Microenvironment Laboratory, Weill-Cornell Medical College in Qatar, Doha, Qatar
⨯

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

Najeeb M. Halabi,
Alejandra Martinez,
Halema Al-Farsi,
Eliane Mery,
Laurence Puydenus,
Pascal Pujol,
Hanif G. Khalak,
Cameron McLurcan,
Gwenael Ferron,
Denis Querleu

Published: January 6, 2016
https://doi.org/10.1371/journal.pgen.1005755

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Alleles
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Ovarian cancer
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RNA sequencing
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Gene expression
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Somatic mutation
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Gastrointestinal cancers
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Cancer genomics
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