Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

• Cristian Pattaro ,

  Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

  Affiliation Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

  ⨯
• Anna Köttgen ,

  Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

  Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Renal Division, Freiburg University Clinic, Freiburg, Germany

  ⨯
• Alexander Teumer ,

  Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Maija Garnaas ,

  Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

  Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Carsten A. Böger ,

  Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

  Affiliation Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany

  ⨯
• Christian Fuchsberger,

  Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Matthias Olden,

  Affiliations Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany, Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany

  ⨯
• Ming-Huei Chen,

  Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Adrienne Tin,

  Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

  ⨯
• Daniel Taliun,

  Affiliation Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

  ⨯
• Man Li,

  Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

  ⨯
• Xiaoyi Gao,

  Affiliation Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Mathias Gorski,

  Affiliations Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Qiong Yang,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Claudia Hundertmark,

  Affiliation Renal Division, Freiburg University Clinic, Freiburg, Germany

  ⨯
• Meredith C. Foster,

  Affiliation National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

  ⨯
• Conall M. O'Seaghdha,

  Affiliations National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America, Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Nicole Glazer,

  Affiliation Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Aaron Isaacs,

  Affiliations Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Centre for Medical Systems Biology, Leiden, The Netherlands

  ⨯
• Ching-Ti Liu,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Albert V. Smith,

  Affiliations Icelandic Heart Association, Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• Jeffrey R. O'Connell,

  Affiliation Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America

  ⨯
• Maksim Struchalin,

  Affiliation Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands

  ⨯
• Toshiko Tanaka,

  Affiliation Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America

  ⨯
• Guo Li,

  Affiliation University of Washington, Seattle, Washington, United States of America

  ⨯
• Andrew D. Johnson,

  Affiliation National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

  ⨯
• Hinco J. Gierman,

  Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

  ⨯
• Mary Feitosa,

  Affiliation Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Shih-Jen Hwang,

  Affiliation National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

  ⨯
• Elizabeth J. Atkinson,

  Affiliation Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

  ⨯
• Kurt Lohman,

  Affiliation Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Marilyn C. Cornelis,

  Affiliation Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Åsa Johansson,

  Affiliation Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

  ⨯
• Anke Tönjes,

  Affiliations Department of Medicine, University of Leipzig, Leipzig, Germany, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany

  ⨯
• Abbas Dehghan,

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Vincent Chouraki,

  Affiliation Inserm UMR744, Institut Pasteur, Lille, France

  ⨯
• Elizabeth G. Holliday,

  Affiliations Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle, Australia

  ⨯
• Rossella Sorice,

  Affiliation Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy

  ⨯
• Zoltan Kutalik,

  Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

  ⨯
• Terho Lehtimäki,

  Affiliation Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere, Finland

  ⨯
• Tõnu Esko,

  Affiliations Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia, Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

  ⨯
• Harshal Deshmukh,

  Affiliation Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

  ⨯
• Sheila Ulivi,

  Affiliation Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy

  ⨯
• Audrey Y. Chu,

  Affiliation Brigham and Women's Hospital, Boston, Massachusetts, United States of America

  ⨯
• Federico Murgia,

  Affiliation Institute of Population Genetics – CNR, Sassari, Italy

  ⨯
• Stella Trompet,

  Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Medea Imboden,

  Affiliation Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

  ⨯
• Barbara Kollerits,

  Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

  ⨯
• Giorgio Pistis,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

  ⨯
• CARDIoGRAM Consortium,
• ICBP Consortium,
• CARe Consortium,
• Wellcome Trust Case Control Consortium 2 (WTCCC2),
• Tamara B. Harris,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America

  ⨯
• Lenore J. Launer,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America

  ⨯
• Thor Aspelund,

  Affiliations Icelandic Heart Association, Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• Gudny Eiriksdottir,

  Affiliation Icelandic Heart Association, Research Institute, Kopavogur, Iceland

  ⨯
• Braxton D. Mitchell,

  Affiliation Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America

  ⨯
• Eric Boerwinkle,

  Affiliation Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America

  ⨯
• Helena Schmidt,

  Affiliation Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz, Austria

  ⨯
• Margherita Cavalieri,

  Affiliation Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria

  ⨯
• Madhumathi Rao,

  Affiliation Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America

  ⨯
• Frank B. Hu,

  Affiliation Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Ayse Demirkan,

  Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Ben A. Oostra,

  Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Mariza de Andrade,

  Affiliation Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

  ⨯
• Stephen T. Turner,

  Affiliation Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America

  ⨯
• Jingzhong Ding,

  Affiliation Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Jeanette S. Andrews,

  Affiliation Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Barry I. Freedman,

  Affiliation Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Wolfgang Koenig,

  Affiliation Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany

  ⨯
• Thomas Illig,

  Affiliation Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Angela Döring,

  Affiliations Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• H.-Erich Wichmann,

  Affiliations Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Grosshadern, Neuherberg, Germany

  ⨯
• Ivana Kolcic,

  Affiliation Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

  ⨯
• Tatijana Zemunik,

  Affiliation Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

  ⨯
• Mladen Boban,

  Affiliation Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

  ⨯
• Cosetta Minelli,

  Affiliation Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

  ⨯
• Heather E. Wheeler,

  Affiliations Department of Genetics, Stanford University, Stanford, California, United States of America, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

  ⨯
• Wilmar Igl,

  Affiliation Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

  ⨯
• Ghazal Zaboli,

  Affiliation Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

  ⨯
• Sarah H. Wild,

  Affiliation Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

  ⨯
• Alan F. Wright,

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  ⨯
• Harry Campbell,

  Affiliation Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

  ⨯
• David Ellinghaus,

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

  ⨯
• Ute Nöthlings,

  Affiliations Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany, popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany

  ⨯
• Gunnar Jacobs,

  Affiliations Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany, popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany

  ⨯
• Reiner Biffar,

  Affiliation Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany

  ⨯
• Karlhans Endlich,

  Affiliation Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany

  ⨯
• Florian Ernst,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Georg Homuth,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Heyo K. Kroemer,

  Affiliation Institute of Pharmacology, University of Greifswald, Greifswald, Germany

  ⨯
• Matthias Nauck,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

  ⨯
• Sylvia Stracke,

  Affiliation Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany

  ⨯
• Uwe Völker,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Henry Völzke,

  Affiliation Institute for Community Medicine, University of Greifswald, Greifswald, Germany

  ⨯
• Peter Kovacs,

  Affiliation Department of Medicine, University of Leipzig, Leipzig, Germany

  ⨯
• Michael Stumvoll,

  Affiliations Department of Medicine, University of Leipzig, Leipzig, Germany, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany

  ⨯
• Reedik Mägi,

  Affiliations Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia, Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

  ⨯
• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Andre G. Uitterlinden,

  Affiliation Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Fernando Rivadeneira,

  Affiliation Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Yurii S. Aulchenko,

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Ozren Polasek,

  Affiliation Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

  ⨯
• Nick Hastie,

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  ⨯
• Veronique Vitart,

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  ⨯
• Catherine Helmer,

  Affiliations INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux, France, Université Bordeaux 2 Victor Segalen, Bordeaux, France

  ⨯
• Jie Jin Wang,

  Affiliations Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne, Australia

  ⨯
• Daniela Ruggiero,

  Affiliation Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy

  ⨯
• Sven Bergmann,

  Affiliation Swiss Institute of Bioinformatics, Lausanne, Switzerland

  ⨯
• Mika Kähönen,

  Affiliation Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

  ⨯
• Jorma Viikari,

  Affiliation Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

  ⨯
• Tiit Nikopensius,

  Affiliation Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

  ⨯
• Michael Province,

  Affiliation Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Shamika Ketkar,

  Affiliation Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Helen Colhoun,

  Affiliation Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

  ⨯
• Alex Doney,

  Affiliation NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

  ⨯
• Antonietta Robino,

  Affiliation Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy

  ⨯
• Franco Giulianini,

  Affiliation Brigham and Women's Hospital, Boston, Massachusetts, United States of America

  ⨯
• Bernhard K. Krämer,

  Affiliation University Medical Centre Mannheim, 5th Department of Medicine, Mannheim, Germany

  ⨯
• Laura Portas,

  Affiliation Institute of Population Genetics – CNR, Sassari, Italy

  ⨯
• Ian Ford,

  Affiliation Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Brendan M. Buckley,

  Affiliation Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland

  ⨯
• Martin Adam,

  Affiliation Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

  ⨯
• Gian-Andri Thun,

  Affiliation Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

  ⨯
• Bernhard Paulweber,

  Affiliation First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria

  ⨯
• Margot Haun,

  Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

  ⨯
• Cinzia Sala,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

  ⨯
• Marie Metzger,

  Affiliation Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif, France

  ⨯
• Paul Mitchell,

  Affiliation Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia

  ⨯
• Marina Ciullo,

  Affiliation Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy

  ⨯
• Stuart K. Kim,

  Affiliations Department of Developmental Biology, Stanford University, Stanford, California, United States of America, Department of Genetics, Stanford University, Stanford, California, United States of America

  ⨯
• Peter Vollenweider,

  Affiliation Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

  ⨯
• Olli Raitakari,

  Affiliation Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku, Finland

  ⨯
• Andres Metspalu,

  Affiliations Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia, Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

  ⨯
• Colin Palmer,

  Affiliation Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

  ⨯
• Paolo Gasparini,

  Affiliation Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy

  ⨯
• Mario Pirastu,

  Affiliation Institute of Population Genetics – CNR, Sassari, Italy

  ⨯
• J. Wouter Jukema,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands

  ⨯
• Nicole M. Probst-Hensch,

  Affiliation Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

  ⨯
• Florian Kronenberg,

  Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

  ⨯
• Daniela Toniolo,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

  ⨯
• Vilmundur Gudnason,

  Affiliations Icelandic Heart Association, Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• Alan R. Shuldiner,

  Affiliations Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America

  ⨯
• Josef Coresh,

  Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

  ⨯
• Reinhold Schmidt,

  Affiliation Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria

  ⨯
• Luigi Ferrucci,

  Affiliation Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America

  ⨯
• David S. Siscovick,

  Affiliation University of Washington, Seattle, Washington, United States of America

  ⨯
• Cornelia M. van Duijn,

  Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Ingrid Borecki,

  Affiliation Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Sharon L. R. Kardia,

  Affiliation Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Yongmei Liu,

  Affiliation Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Gary C. Curhan,

  Affiliation Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Igor Rudan,

  Affiliation Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

  ⨯
• Ulf Gyllensten,

  Affiliation Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

  ⨯
• James F. Wilson,

  Affiliation Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

  ⨯
• Andre Franke,

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

  ⨯
• Peter P. Pramstaller,

  Affiliation Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

  ⨯
• Rainer Rettig,

  Affiliation Institute of Physiology, University of Greifswald, Greifswald, Germany

  ⨯
• Inga Prokopenko,

  Affiliation Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

  ⨯
• Jacqueline C. M. Witteman,

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Caroline Hayward,

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  ⨯
• Paul Ridker,

  Affiliations Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Afshin Parsa,

  Affiliation Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland, United States of America

  ⨯
• Murielle Bochud,

  Affiliation University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland

  ⨯
• Iris M. Heid,

  Affiliations Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Wolfram Goessling ,

  ¶These authors were joint senior authors on this work.

  Affiliations Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

  ⨯
• Daniel I. Chasman ,

  ¶These authors were joint senior authors on this work.

  Affiliations Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• W. H. Linda Kao ,

  * E-mail: foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WHL Kao)

  ¶These authors were joint senior authors on this work.

  Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

  ⨯
•  [ ... ],
• Caroline S. Fox

  * E-mail: foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WHL Kao)

  ¶These authors were joint senior authors on this work.

  Affiliations National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America, Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
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