Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle

Corinne Fasquelle; Arnaud Sartelet; Wanbo Li; Marc Dive; Nico Tamma; Charles Michaux; Tom Druet; Ivo J. Huijbers; Clare M. Isacke; Wouter Coppieters; Michel Georges; Carole Charlier

doi:10.1371/journal.pgen.1000666

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Open Access

Peer-reviewed

Research Article

Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle

Corinne Fasquelle ,

Contributed equally to this work with: Corinne Fasquelle, Arnaud Sartelet

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯
Arnaud Sartelet ,

Contributed equally to this work with: Corinne Fasquelle, Arnaud Sartelet

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯
Wanbo Li,

Current address: Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, NanChang, People's Republic of China.

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯
Marc Dive,

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
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Nico Tamma,

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯
Charles Michaux,

Affiliation Unit of Bioinformatics, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
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Tom Druet,

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
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Ivo J. Huijbers,

Affiliation Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
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Clare M. Isacke,

Affiliation Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
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Wouter Coppieters,

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯
Michel Georges,

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯
Carole Charlier

* E-mail: carole.charlier@ulg.ac.be

Affiliation Unit of Animal Genomics, GIGA-R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
⨯

Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle

Corinne Fasquelle,
Arnaud Sartelet,
Wanbo Li,
Marc Dive,
Nico Tamma,
Charles Michaux,
Tom Druet,
Ivo J. Huijbers,
Clare M. Isacke,
Wouter Coppieters

Published: September 25, 2009
https://doi.org/10.1371/journal.pgen.1000666

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