Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

Emily A. King; J. Wade Davis; Jacob F. Degner

doi:10.1371/journal.pgen.1008489

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Open Access

Peer-reviewed

Research Article

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

Emily A. King ,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: emily.king@abbvie.com

Affiliation Department of Computational Genomics, AbbVie, North Chicago, Illinois, United States of America

http://orcid.org/0000-0003-1877-8673

⨯
J. Wade Davis,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing

Affiliation Department of Computational Genomics, AbbVie, North Chicago, Illinois, United States of America
⨯
Jacob F. Degner

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation Department of Computational Genomics, AbbVie, North Chicago, Illinois, United States of America
⨯

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

Emily A. King,
J. Wade Davis,
Jacob F. Degner

Published: December 12, 2019
https://doi.org/10.1371/journal.pgen.1008489

About the Authors

Emily A. King

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: emily.king@abbvie.com

Affiliation Department of Computational Genomics, AbbVie, North Chicago, Illinois, United States of America

http://orcid.org/0000-0003-1877-8673

J. Wade Davis

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing

Affiliation Department of Computational Genomics, AbbVie, North Chicago, Illinois, United States of America

Jacob F. Degner

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation Department of Computational Genomics, AbbVie, North Chicago, Illinois, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: All authors are employees of AbbVie. The design, study conduct, and financial support for this research were provided by AbbVie.

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Genetics
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Genome-wide association studies
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Drug discovery
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Human genetics
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Genetics of disease
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Medical risk factors
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