Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in Drosophila melanogaster

Erica E. Rosenbaum; Eva Vasiljevic; Kimberley S. Brehm; Nansi Jo Colley

doi:10.1371/journal.pgen.1004349

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Peer-reviewed

Research Article

Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in Drosophila melanogaster

Erica E. Rosenbaum,

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Eva Vasiljevic,

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Kimberley S. Brehm,

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Nansi Jo Colley

* E-mail: njcolley@wisc.edu

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯

Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in Drosophila melanogaster

Erica E. Rosenbaum,
Eva Vasiljevic,
Kimberley S. Brehm,
Nansi Jo Colley

Published: May 1, 2014
https://doi.org/10.1371/journal.pgen.1004349

About the Authors

Erica E. Rosenbaum

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Eva Vasiljevic

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Kimberley S. Brehm

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Nansi Jo Colley

* E-mail: njcolley@wisc.edu

Affiliation Department of Ophthalmology & Visual Sciences and Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NJC EER. Performed the experiments: EER EV KSB. Analyzed the data: NJC EER EV KSB. Wrote the paper: NJC EER.

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Drosophila melanogaster
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Lysosomes
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Biosynthesis
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Glycoproteins
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Hydrolases
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Mannose
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Sequence alignment
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Enzyme structure
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