About the Authors

Hong Li

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Gustavo Glusman

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Hao Hu

Affiliation Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Shankaracharya

Affiliation Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Juan Caballero

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Robert Hubley

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

David Witherspoon

Affiliation Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Stephen L. Guthery

Affiliation Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Denise E. Mauldin

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Lynn B. Jorde

Affiliation Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Leroy Hood

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Jared C. Roach

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Chad D. Huff

chad@hufflab.org

Affiliation Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL CDH JCR LH. Performed the experiments: HL CDH HH S RH DW DEM. Contributed reagents/materials/analysis tools: HL JCR LH SLG CDH JC. Wrote the paper: CDH HL JCR LBJ DW GG SLG. Analyzed/interpreted the data: HL CDH HH S RH DW DEM LBJ GG. Generated the figures: HL HH. Designed algorithm and wrote software for ERSA 2.0: CDH. Wrote pedigree simulation software: JC. Participated in pedigree identification, recruitment, and validation: HL JCR LH SLG.