About the Authors
- Shengping Li
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Contributed equally to this work with: Shengping Li, Ji Qian, Yuan Yang
Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Ji Qian
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Contributed equally to this work with: Shengping Li, Ji Qian, Yuan Yang
Affiliation State Key Laboratory of Genetic Engineering, Center for Fudan–VARI Genetic Epidemiology and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
- Yuan Yang
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Contributed equally to this work with: Shengping Li, Ji Qian, Yuan Yang
Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Wanting Zhao
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Affiliation Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore
- Juncheng Dai
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Affiliation MOE Key Laboratory of Modern Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
- Jin-Xin Bei
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Jia Nee Foo
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Affiliation Division of Genetics, Brigham and Women's Hospital, Harvard Medical School Boston and Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
- Paul J. McLaren
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Affiliation Division of Genetics, Brigham and Women's Hospital, Harvard Medical School Boston and Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
- Zhiqiang Li
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Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
- Jingmin Yang
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Affiliation State Key Laboratory of Genetic Engineering, Center for Fudan–VARI Genetic Epidemiology and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
- Feng Shen
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Li Liu
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Affiliation Department of Hepatobiliary Surgery, Nantong Tumor Hospital, Nantong, China
- Jiamei Yang
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Shuhong Li
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Shandong Pan
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Affiliation MOE Key Laboratory of Modern Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
- Yi Wang
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Wenjin Li
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Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
- Xiangjun Zhai
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Affiliation Department of Infection Diseases, Jiangsu Province Center for Disease Prevention and Control, Nanjing, China
- Boping Zhou
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Affiliation The Third People's Municipal Hospital of Shenzhen, Shenzhen, China
- Lehua Shi
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Xinchun Chen
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Affiliation The Third People's Municipal Hospital of Shenzhen, Shenzhen, China
- Minjie Chu
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Affiliation MOE Key Laboratory of Modern Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
- Yiqun Yan
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Jun Wang
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Shuqun Cheng
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Jiawei Shen
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Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
- Weihua Jia
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Jibin Liu
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Affiliation Department of Hepatobiliary Surgery, Nantong Tumor Hospital, Nantong, China
- Jiahe Yang
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Zujia Wen
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Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
- Aijun Li
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Ying Zhang
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Guoliang Zhang
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Affiliation The Third People's Municipal Hospital of Shenzhen, Shenzhen, China
- Xianrong Luo
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Affiliation No. 458 Hospital of Chinese People's Liberation Army, Guangzhou, China
- Hongbo Qin
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Affiliation The Eighth Municipal People's Hospital of Guangzhou, Guangzhou, China
- Minshan Chen
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Hua Wang
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Affiliation Department of Infection Diseases, Jiangsu Province Center for Disease Prevention and Control, Nanjing, China
- Li Jin
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Affiliation State Key Laboratory of Genetic Engineering, Center for Fudan–VARI Genetic Epidemiology and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
- Dongxin Lin
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Affiliation State Key Laboratory of Molecular Oncology and Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- Hongbing Shen
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Affiliation MOE Key Laboratory of Modern Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
- Lin He
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Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Paul I. W. de Bakker
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Affiliation Division of Genetics, Brigham and Women's Hospital, Harvard Medical School Boston and Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
- Hongyang Wang
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Yi-Xin Zeng
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Affiliation Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
- Mengchao Wu
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Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
- Zhibin Hu
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* E-mail: ehphwp@126.com (W Zhou); liuj3@gis.a-star.edu.sg (J Liu); shiyongyong@gmail.com (Y Shi); zhibin_hu@njmu.edu.cn (Z Hu)
Affiliation MOE Key Laboratory of Modern Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
- Yongyong Shi
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* E-mail: ehphwp@126.com (W Zhou); liuj3@gis.a-star.edu.sg (J Liu); shiyongyong@gmail.com (Y Shi); zhibin_hu@njmu.edu.cn (Z Hu)
Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
- Jianjun Liu
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* E-mail: ehphwp@126.com (W Zhou); liuj3@gis.a-star.edu.sg (J Liu); shiyongyong@gmail.com (Y Shi); zhibin_hu@njmu.edu.cn (Z Hu)
Affiliation Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore
- Weiping Zhou
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* E-mail: ehphwp@126.com (W Zhou); liuj3@gis.a-star.edu.sg (J Liu); shiyongyong@gmail.com (Y Shi); zhibin_hu@njmu.edu.cn (Z Hu)
Affiliation Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Study concept and design: Weiping Zhou, Shengping Li, Jianjun Liu, Zhibin Hu, Yongyong Shi, Ji Qian, Yuan Yang. Subject recruitment and sample preparation: Weiping Zhou, Yuan Yang, Ji Qian, Jingmin Yang, Feng Shen, Jiamei Yang, Yi Wang, Lehua Shi, Yiqun Yan, Shuqun Cheng, Jiahe Yang, Aijun Li, Li Jin (Shanghai samples); Shengping Li, Shuhong Li, Jun Wang, Boping Zhou, Weihua Jia, Ying Zhang, Xinchun Chen, Guoliang Zhang, Xianrong Luo, Hongbo Qin, Minshan Chen (Guangzhou samples); Zhibin Hu, Li Liu, Shandong Pan, Minjie Chu, Xiangjun Zhai, Jibin Liu, Hua Wang (Jiangsu samples). GWAS data processing: Zhiqiang Li, Jiawei Shen, Lehua Shi. Sample genotyping: Wenjin Li, Zujia Wen (GWAS Scan); Li Liu, Shandong Pan, Minjie Chu (Validation stages). Analysis and interpretation of data: Weiping Zhou, Shengping Li, Jianjun Liu, Zhibin Hu, Yongyong Shi, Ji Qian, Yuan Yang, Juncheng Dai, Wanting Zhao. Drafting of the manuscript: Jianjun Liu, Zhibin Hu. Critical revision of the manuscript for important intellectual content: Weiping Zhou, Shengping Li, Jianjun Liu, Zhibin Hu, Yongyong Shi, Jin-Xin Bei, Dongxin Lin, Hongbing Shen, Lin He, Hongyang Wang, Yi-Xin Zeng, Mengchao Wu. Statistical analysis: Jungheng Dai, Wanting Zhao, Jia Nee Foo, Paul J McLaren, Paul IW de Bakker, Zhibin Hu, Jianjun Liu. Obtained funding: Weiping Zhou, Shengping Li, Jianjun Liu, Zhibin Hu, Yongyong Shi, Ji Qian. Administrative, technical, or material support: Hongbing Shen, Lin He, Hongyang Wang, Yi-Xin Zeng, Mengchao Wu. Study supervision: Weiping Zhou, Shengping Li, Jianjun Liu, Zhibin Hu, Yongyong Shi, Ji Qian.