Phosphorylation of the Drosophila melanogaster RNA–Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity

Ronit Nir; Rona Grossman; Ze'ev Paroush; Talila Volk

doi:10.1371/journal.pgen.1002632

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Open Access

Peer-reviewed

Research Article

Phosphorylation of the Drosophila melanogaster RNA–Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity

Ronit Nir,

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Rona Grossman,

Affiliation Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, Jerusalem, Israel
⨯
Ze'ev Paroush,

Affiliation Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, Jerusalem, Israel
⨯
Talila Volk

* E-mail: lgvolk@weizmann.ac.il

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯

Phosphorylation of the Drosophila melanogaster RNA–Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity

Ronit Nir,
Rona Grossman,
Ze'ev Paroush,
Talila Volk

Published: March 29, 2012
https://doi.org/10.1371/journal.pgen.1002632

About the Authors

Ronit Nir

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

Rona Grossman

Affiliation Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, Jerusalem, Israel

Ze'ev Paroush

Affiliation Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, Jerusalem, Israel

Talila Volk

* E-mail: lgvolk@weizmann.ac.il

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RN TV ZP. Performed the experiments: RN RG. Analyzed the data: RN TV. Contributed reagents/materials/analysis tools: RN TV RG. Wrote the paper: RN TV ZP.

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Phosphorylation
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Immunoprecipitation
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Muscle proteins
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Larvae
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Dimerization
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Cardiac muscles
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Drosophila melanogaster
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RNA interference
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