Integrated Genome-Scale Prediction of Detrimental Mutations in Transcription Networks

Mirko Francesconi; Rob Jelier; Ben Lehner

doi:10.1371/journal.pgen.1002077

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Open Access

Peer-reviewed

Research Article

Integrated Genome-Scale Prediction of Detrimental Mutations in Transcription Networks

Mirko Francesconi,

Affiliations EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona Spain, Dottorato di Ricerca in "Biotecnologie Cellulari e Molecolari," Dipartimento di Biochimica "G. Moruzzi," Università di Bologna, Bologna, Italy
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Rob Jelier,

Affiliation EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona Spain
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Ben Lehner

* E-mail: ben.lehner@crg.eu

Affiliations EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona Spain, Institució Catalana de Recerca i Estudis Avançats, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona, Spain
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Integrated Genome-Scale Prediction of Detrimental Mutations in Transcription Networks

Mirko Francesconi,
Rob Jelier,
Ben Lehner

Published: May 26, 2011
https://doi.org/10.1371/journal.pgen.1002077

About the Authors

Mirko Francesconi

Affiliations EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona Spain, Dottorato di Ricerca in "Biotecnologie Cellulari e Molecolari," Dipartimento di Biochimica "G. Moruzzi," Università di Bologna, Bologna, Italy

Rob Jelier

Affiliation EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona Spain

Ben Lehner

* E-mail: ben.lehner@crg.eu

Affiliations EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona Spain, Institució Catalana de Recerca i Estudis Avançats, Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MF RJ BL. Performed the experiments: MF. Analyzed the data: MF RJ BL. Contributed reagents/materials/analysis tools: RJ. Wrote the paper: MF BL.

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Gene regulation
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Regulator genes
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Transcription factors
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Genomics
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Binding analysis
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Transcriptional control
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Conservation science
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DNA transcription
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