About the Authors

Chris Church

Affiliation MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

Sheena Lee

Contributed equally to this work with: Sheena Lee, Eleanor A. L. Bagg, James S. McTaggart

Affiliation Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Eleanor A. L. Bagg

Contributed equally to this work with: Sheena Lee, Eleanor A. L. Bagg, James S. McTaggart

Affiliation Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

James S. McTaggart

Contributed equally to this work with: Sheena Lee, Eleanor A. L. Bagg, James S. McTaggart

Affiliation Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Robert Deacon

Affiliation Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom

Thomas Gerken

Affiliation Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

Angela Lee

Affiliation MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

Lee Moir

Affiliation MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

Jasmin Mecinović

Affiliation Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

Mohamed M. Quwailid

Affiliation MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

Christopher J. Schofield

These authors also contributed equally to this work.

Affiliation Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

Frances M. Ashcroft

These authors also contributed equally to this work.

Affiliation Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Roger D. Cox

r.cox@har.mrc.ac.uk

Affiliation MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

Competing Interests

CJS is a co-founder of ReOx, a company that aims to exploit discoveries on the hypoxic response for therapeutic benefit.

Author Contributions

Conceived and designed the experiments: CC CJS FMA RDC. Performed the experiments: CC SL EALB JSM RD TG AL LM JM MMQ. Analyzed the data: CC SL EALB JSM RD TG AL JM MMQ CJS FMA RDC. Wrote the paper: CC EALB CJS FMA RDC.