About the Authors
- Nancy L. Heard-Costa
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
- M. Carola Zillikens
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
- Keri L. Monda
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
- Åsa Johansson
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
- Tamara B. Harris
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
- Mao Fu
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Talin Haritunians
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Mary F. Feitosa
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Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa
Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Thor Aspelund
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Affiliations Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland
- Gudny Eiriksdottir
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Affiliation Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland
- Melissa Garcia
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Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
- Lenore J. Launer
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Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
- Albert V. Smith
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Affiliation Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland
- Braxton D. Mitchell
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Affiliation Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Patrick F. McArdle
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Affiliation Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Alan R. Shuldiner
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Affiliation Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Suzette J. Bielinski
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Affiliation Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America
- Eric Boerwinkle
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Affiliation Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America
- Fred Brancati
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Affiliation Department of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America
- Ellen W. Demerath
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Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America
- James S. Pankow
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Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America
- Alice M. Arnold
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Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
- Yii-Der Ida Chen
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Nicole L. Glazer
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Affiliation Department of Internal Medicine, University of Washington, Seattle, Washington, United States of America
- Barbara McKnight
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Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
- Bruce M. Psaty
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Affiliation Department of Epidemiology, Medicine, & Health Services, University of Washington, Seattle, Washington, United States of America
- Jerome I. Rotter
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Najaf Amin
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Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Harry Campbell
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Affiliation Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom
- Ulf Gyllensten
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Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
- Cristian Pattaro
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Affiliation Institute of Genetic Medicine, European Academy Bozen/Bolzano,Bolzano, Italy
- Peter P. Pramstaller
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Affiliations Institute of Genetic Medicine, European Academy Bozen/Bolzano,Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany, Department of Neurology, Central Regional Hospital, Bolzano, Italy
- Igor Rudan
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Affiliations Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom, Croatian Centre for Global Health, University of Split Medical School, Split, Croatia, Institute for Clinical Medical Research, University Hospital “Sestre Milosrdnice,” Zagreb, Croatia
- Maksim Struchalin
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Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Veronique Vitart
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Affiliation Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, Scotland, United Kingdom
- Xiaoyi Gao
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Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Aldi Kraja
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Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Michael A. Province
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Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Qunyuan Zhang
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Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Larry D. Atwood
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Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
- Josée Dupuis
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Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
- Joel N. Hirschhorn
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Affiliation Program in Genomics and Divisions of Endocrinology and Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
- Cashell E. Jaquish
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Affiliation Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America
- Christopher J. O'Donnell
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Affiliation Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America
- Ramachandran S. Vasan
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Affiliations Boston University School of Medicine, Boston, Massachusetts, United States of America, The Framingham Heart Study, Framingham, Massachusetts, United States of America
- Charles C. White
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Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
- Yurii S. Aulchenko
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Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Karol Estrada
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Affiliation Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
- Albert Hofman
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Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Fernando Rivadeneira
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Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- André G. Uitterlinden
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Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Jacqueline C. M. Witteman
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Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Ben A. Oostra
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¶These authors are joint senior authors on this work.
Affiliation Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
- Robert C. Kaplan
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¶These authors are joint senior authors on this work.
Affiliation Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
- Vilmundur Gudnason
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¶These authors are joint senior authors on this work.
Affiliations Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland
- Jeffrey R. O'Connell
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¶These authors are joint senior authors on this work.
Affiliation Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Ingrid B. Borecki
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¶These authors are joint senior authors on this work.
Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Cornelia M. van Duijn
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¶These authors are joint senior authors on this work.
Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
- L. Adrienne Cupples
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¶These authors are joint senior authors on this work.
Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
- Caroline S. Fox
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* E-mail: foxca@nhlbi.nih.gov (CSF); knorth@email.unc.edu (KEN)
¶These authors are joint senior authors on this work.
Affiliations Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America, Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
- Kari E. North
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* E-mail: foxca@nhlbi.nih.gov (CSF); knorth@email.unc.edu (KEN)
¶These authors are joint senior authors on this work.
Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: NLHC MCZ TBH MF GE MG LJL BDM ARS EB FB JSP BMP JIR HC UG PPP IR MAP LDA JNH CEJ CJO AH FR AGU JCMW BAO RCK VG JRO IBB CMvD LAC CSF KEN. Analyzed the data: NLHC KLM ÅJ MF MFF TA AVS BDM PFM NLG BM NA CP MS VV XG AK MAP QZ JD CJO CCW YSA KE FR AGU VG JRO IBB CMvD LAC. Contributed reagents/materials/analysis tools: TBH TH TA GE LJL AVS BDM ARS SJB EB NLG BMP JIR HC UG PPP IR FR AGU JCMW VG KEN. Wrote the paper: NLHC MCZ KLM ÅJ TBH MF TH MFF FB EWD JSP AMA YDIC NLG JIR CJO RSV BAO RCK VG JRO IBB CMvD LAC CSF KEN.