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March 2023

Our green planet is beginning to show a lot of signs of decay triggered by the demands of our modern lifestyle and constantly growing population numbers. It is our responsibility to try to balance these factors with a more sustainable way of life to keep our planet green. However, very often the proposed solutions are worse than the initial problems and trigger more damage. Focusing our efforts on technologies that take advantage of nature could be a more sensible approach to reach that aim. With that purpose, we have envisioned a collection for our magazine content exploring biological solutions that could be applied to reduce our CO2 emissions, get rid of plastics that are currently not degradable, produce food in a more sustainable manner or produce energy, among others. The image shows a close-up photograph of a leaf of Ficus lyrata.

Image Credit: Ines Alvarez-Garcia

Essay

The potential of biofuels from first to fourth generation

Philipp Cavelius, Selina Engelhart-Straub, Norbert Mehlmer, Johannes Lercher, Dania Awad, Thomas Brück

Research Articles

Bumblebees acquire alternative puzzle-box solutions via social learning

Alice D. Bridges, HaDi MaBouDi, Olga Procenko, Charlotte Lockwood, Yaseen Mohammed, Amelia Kowalewska, José Eric Romero González, Joseph L. Woodgate, Lars Chittka

A male-killing Wolbachia endosymbiont is concealed by another endosymbiont and a nuclear suppressor

Kelly M. Richardson, Perran A. Ross, Brandon S. Cooper, William R. Conner, Thomas L. Schmidt, Ary A. Hoffmann

Related Articles

Individuals with problem gambling and obsessive-compulsive disorder learn through distinct reinforcement mechanisms

Shinsuke Suzuki, Xiaoliu Zhang, Amir Dezfouli, Leah Braganza, Ben D. Fulcher, Linden Parkes, Leonardo F. Fontenelle, Ben J. Harrison, Carsten Murawski, Murat Yücel, Chao Suo

Illusory object recognition is either perceptual or cognitive in origin depending on decision confidence

Josipa Alilović, Eline Lampers, Heleen A. Slagter, Simon van Gaal

Local and global reward learning in the lateral frontal cortex show differential development during human adolescence

Marco K. Wittmann, Maximilian Scheuplein, Sophie G. Gibbons, MaryAnn P. Noonan

Suppression of distracting inputs by visual-spatial cues is driven by anticipatory alpha activity

Chenguang Zhao, Yuanjun Kong, Dongwei Li, Jing Huang, Lujiao Kong, Xiaoli Li, Ole Jensen, Yan Song

Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making

Joseph J. Ziminski, Polytimi Frangou, Vasilis M. Karlaftis, Uzay Emir, Zoe Kourtzi

Regulation of sleep by cholinergic neurons located outside the central brain in Drosophila

Joseph D. Jones, Brandon L. Holder, Kiran R. Eiken, Alex Vogt, Adriana I. Velarde, Alexandra J. Elder, Jennifer A. McEllin, Stephane Dissel

Hypothalamic Menin regulates systemic aging and cognitive decline

Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Tifei Yuan, Jie Zhang

Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish

Haibo Xie, Yunsi Kang, Junjun Liu, Min Huang, Zhicheng Dai, Jiale Shi, Shuo Wang, Lanqin Li, Yuan Li, Pengfei Zheng, Yi Sun, Qize Han, Jingjing Zhang, Zezhang Zhu, Leilei Xu, Pamela C. Yelick, Muqing Cao, Chengtian Zhao

FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila

Yuting Lei, Yuwei Huang, Ke Yang, Xueya Cao, Yuzhao Song, Enrique Martín-Blanco, José Carlos Pastor-Pareja

The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification

Yongqiang Xue, Aravindan Krishnan, Juan Sebastian Chahda, Robert Allen Schweickart, Rui Sousa-Neves, Claudia Mieko Mizutani

Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease

Hansol Im, Madison L. Pearson, Eriel Martinez, Kyle H. Cichos, Xiuhong Song, Katherine L. Kruckow, Rachel M. Andrews, Elie S. Ghanem, Carlos J. Orihuela

CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner

Mingjun Zhu, Jiahuang Lv, Wei Wang, Rongli Guo, Chunyan Zhong, Avan Antia, Qiru Zeng, Jizong Li, Qingtao Liu, Jinzhu Zhou, Xuejiao Zhu, Baochao Fan, Siyuan Ding, Bin Li

A succession of two viral lattices drives vaccinia virus assembly

Miguel Hernandez-Gonzalez, Thomas Calcraft, Andrea Nans, Peter B Rosenthal, Michael Way

Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer’s disease pathology in mice

Huilong Yin, Zhuan Ju, Minhua Zheng, Xiang Zhang, Wenjie Zuo, Yidi Wang, Xiaochen Ding, Xiaofang Zhang, Yingran Peng, Jiadi Li, Angang Yang, Rui Zhang

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, Karen Jansen-West, Yue A. Qi, Ziyi Li, Lillian M. Daughrity, Mei Yue, Yong-Jie Zhang, Casey N. Cook, Dennis W. Dickson, Michael Ward, Leonard Petrucelli, Mercedes Prudencio

Related Articles

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding

Tian-Yeh Lim, Blake R. Wilde, Mallory L. Thomas, Kristin E. Murphy, Jeffery M. Vahrenkamp, Megan E. Conway, Katherine E. Varley, Jason Gertz, Donald E. Ayer

Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage

Li Jianwei, Chacko Jobichen, Satoru Machida, Sun Meng, Randy J. Read, Chen Hongying, Shi Jian, Yuren Adam Yuan, J. Sivaraman

Short Reports

An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets

Natalia Moskal, Naomi P. Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N. Lewis, G. Angus McQuibban

EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation

Marcella Cesana, Gennaro Tufano, Francesco Panariello, Nicolina Zampelli, Susanna Ambrosio, Rossella De Cegli, Margherita Mutarelli, Lorenzo Vaccaro, Micheal J. Ziller, Davide Cacchiarelli, Diego L. Medina, Andrea Ballabio

Methods and Resources

The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification

Christopher J. Buswinka, Richard T. Osgood, Rubina G. Simikyan, David B. Rosenberg, Artur A. Indzhykulian

Meta-Research Article