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February 2025

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Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila
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Transposons are parasitic genome elements that can also serve as raw material for the evolution of new cellular functions. However, how retrotransposons are selected and domesticated by host organisms to modulate synaptic plasticity remains largely unknown. M’Angale, Lemieux, Liu et al. show that the Ty1 retrotransposon Copia forms virus-like capsids in vivo and transfers between cells. Copia is enriched at the Drosophila neuromuscular junction and transported across synapses, and disrupting its expression promotes both synapse development and structural synaptic plasticity. The authors show that proper synaptic plasticity is maintained in Drosophila by the balance of Copia and the Arc1 homolog. High-resolution cryogenic-electron microscopy imaging shows that the structure of the Copia capsid has a large capacity and pores like retroviruses but is distinct from domesticated capsids such as dArc1. Their results suggest a fully functional transposon mediates synaptic plasticity, possibly representing an early stage of domestication of a retrotransposon. The image shows the structure of the Copia capsid, as determined by cryo-electronmicroscopy.

Image Credit: Travis Thomson and Brian Kelch

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