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Table of Contents

May 2021

As a part of growing up, immature orangutans must acquire vast repertoires of skills and knowledge, a process that takes several years of observational social learning and subsequent practice. Adult female and male orangutans show behavioral differences including sex-specific foraging patterns and male-biased dispersal. Ehmann et al. investigated how these differing life trajectories affect social interest and emerging ecological knowledge in immatures. They analyzed 15 years of detailed observational data on social learning, associations, and diet repertoires of 50 immatures (16 females and 34 males), from two orangutan populations. Specific to the feeding context, they found sex differences in the development of social interest: Throughout the dependency period, immature females direct most of their social attention at their mothers, whereas immature males show an increasing attentional preference for individuals other than their mothers. When attending to non-mother individuals, males show a significant bias toward immigrant individuals and a trend for a bias toward adult males; in contrast, females preferentially attend to neighboring residents. These results suggest that immature orangutans show attentional biases through which they learn from individuals with the most relevant ecological knowledge. Diversifying their skills and knowledge likely helps males when they move to a new area. The image shows Cinnamon peering at her mother Cissy, who is using a stick tool to get honey out of a tree hole.

Image Credit: Guilhem Duvot

Essays

Cell-level metadata are indispensable for documenting single-cell sequencing datasets

Sidhant Puntambekar, Jay R. Hesselberth, Kent A. Riemondy, Rui Fu

Perspectives

A generation of junior faculty is at risk from the impacts of COVID-19

Tiffany M. Lowe-Power, Louise Dyson, Abigail M. Polter

How hype and hyperbole distort the neuroscience of sex differences

Gina Rippon, Lise Eliot, Sarah Genon, Daphna Joel

Has GWAS lost its status as a paragon of open science?

Callie Burt, Marcus Munafò

Research Articles

Maximizing regional biodiversity requires a mosaic of protection levels

Nicolas Loiseau, Wilfried Thuiller, Rick D. Stuart-Smith, Vincent Devictor, Graham J. Edgar, Laure Velez, Joshua E. Cinner, Nicholas A. J. Graham, Julien Renaud, Andrew S. Hoey, Stephanie Manel, David Mouillot

Immature wild orangutans acquire relevant ecological knowledge through sex-specific attentional biases during social learning

Beatrice Ehmann, Carel P. van Schaik, Alison M. Ashbury, Julia Mörchen, Helvi Musdarlia, Suci Utami Atmoko, Maria A. van Noordwijk, Caroline Schuppli

The human visual system differentially represents subjectively and objectively invisible stimuli

Timo Stein, Daniel Kaiser, Johannes J. Fahrenfort, Simon van Gaal

RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity

Martina Proietti Onori, Linda M. C. Koene, Carmen B. Schäfer, Mark Nellist, Marcel de Brito van Velze, Zhenyu Gao, Ype Elgersma, Geeske M. van Woerden

Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak

Kenzo Ivanovitch, Pablo Soro-Barrio, Probir Chakravarty, Rebecca A. Jones, Donald M. Bell, S. Neda Mousavy Gharavy, Despina Stamataki, Julien Delile, James C. Smith, James Briscoe

Extracellular DJ-1 induces sterile inflammation in the ischemic brain

Koutarou Nakamura, Seiichiro Sakai, Jun Tsuyama, Akari Nakamura, Kento Otani, Kumiko Kurabayashi, Yoshiko Yogiashi, Hisao Masai, Takashi Shichita

Glyphosate inhibits melanization and increases susceptibility to infection in insects

Daniel F. Q. Smith, Emma Camacho, Raviraj Thakur, Alexander J. Barron, Yuemei Dong, George Dimopoulos, Nichole A. Broderick, Arturo Casadevall

Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease

Aleksandra Lubojemska, M. Irina Stefana, Sebastian Sorge, Andrew P. Bailey, Lena Lampe, Azumi Yoshimura, Alana Burrell, Lucy Collinson, Alex P. Gould

The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures

Hiroyuki Mori, Colleen E. Dugan, Akira Nishii, Ameena Benchamana, Ziru Li, Thomas S. Cadenhead IV, Arun K. Das, Charles R. Evans, Katherine A. Overmyer, Steven M. Romanelli, Sydney K. Peterson, Devika P. Bagchi, Callie A. Corsa, Julie Hardij, Brian S. Learman, Mahmoud El Azzouny, Joshua J. Coon, Ken Inoki, Ormond A. MacDougald

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition

Pau B. Esparza-Moltó, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Marta P. Pereira, Noelia Blanco, Beatriz Pardo, Georgina R. Bates, Carla Sánchez-Castillo, Rafael Artuch, Michael P. Murphy, José A. Esteban, José M. Cuezva

EfgA is a conserved formaldehyde sensor that leads to bacterial growth arrest in response to elevated formaldehyde

Jannell V. Bazurto, Dipti D. Nayak, Tomislav Ticak, Milya Davlieva, Jessica A. Lee, Chandler N. Hellenbrand, Leah B. Lambert, Olivia J. Benski, Caleb J. Quates, Jill L. Johnson, Jagdish Suresh Patel, F. Marty Ytreberg, Yousif Shamoo, Christopher J. Marx

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors

Alba Corman, Dimitris C. Kanellis, Patrycja Michalska, Maria Häggblad, Vanesa Lafarga, Jiri Bartek, Jordi Carreras-Puigvert, Oscar Fernandez-Capetillo

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough

Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Carla Zimmerman, Kunho Choi, Stephane Flibotte, Michel Roberge

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

Dan Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, Shu Shen, Jun Wu, Bo Li, Xin Li, Yaohui Fang, Jia Liu, Qiao Wang, Yunjiao Zhou, Wei Wang, Yufeng Li, Zhonghua Lu, Xiaoxiao Wang, Cui Nie, Yujie Tian, Da Chen, Yuan Wang, Xingdong Zhou, Qisheng Wang, Feng Yu, Chen Zhang, Changjing Deng, Liang Zhou, Guangkuo Guan, Na Shao, Zhiyong Lou, Fei Deng, Hongkai Zhang, Xinwen Chen, Manli Wang, Louis Liu, Zihe Rao, Yu Guo

Methods and Resources

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo

Alberto Sanchez-Aguilera, Diek W. Wheeler, Teresa Jurado-Parras, Manuel Valero, Miriam S. Nokia, Elena Cid, Ivan Fernandez-Lamo, Nate Sutton, Daniel García-Rincón, Liset M. de la Prida, Giorgio A. Ascoli

Integrated transcriptomics and epigenomics reveal chamber-specific and species-specific characteristics of human and mouse hearts

Junpeng Gao, Yuxuan Zheng, Lin Li, Minjie Lu, Xiangjian Chen, Yu Wang, Yanna Li, Xiaomeng Liu, Yun Gao, Yunuo Mao, Peng Zhao, Jinan Zhang, Fuchou Tang, Lei Song, Lu Wen, Jizheng Wang

Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2

Chantal B. F. Vogels, Mallery I. Breban, Isabel M. Ott, Tara Alpert, Mary E. Petrone, Anne E. Watkins, Chaney C. Kalinich, Rebecca Earnest, Jessica E. Rothman, Jaqueline Goes de Jesus, Ingra Morales Claro, Giulia Magalhães Ferreira, Myuki A. E. Crispim, Brazil-UK CADDE Genomic Network, Lavanya Singh, Houriiyah Tegally, Ugochukwu J. Anyaneji, Network for Genomic Surveillance in South Africa, Emma B. Hodcroft, Christopher E. Mason, Gaurav Khullar, Jessica Metti, Joel T. Dudley, Matthew J. MacKay, Megan Nash, Jianhui Wang, Chen Liu, Pei Hui, Steven Murphy, Caleb Neal, Eva Laszlo, Marie L. Landry, Anthony Muyombwe, Randy Downing, Jafar Razeq, Tulio de Oliveira, Nuno R. Faria, Ester C. Sabino, Richard A. Neher, Joseph R. Fauver, Nathan D. Grubaugh

Meta-Research Articles

Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research

Takuji Usui, Malcolm R. Macleod, Sarah K. McCann, Alistair M. Senior, Shinichi Nakagawa

Epidemiology and reporting characteristics of preclinical systematic reviews

Victoria T. Hunniford, Joshua Montroy, Dean A. Fergusson, Marc T. Avey, Kimberley E. Wever, Sarah K. McCann, Madison Foster, Grace Fox, Mackenzie Lafreniere, Mira Ghaly, Sydney Mannell, Karolina Godwinska, Avonae Gentles, Shehab Selim, Jenna MacNeil, Lindsey Sikora, Emily S. Sena, Matthew J. Page, Malcolm Macleod, David Moher, Manoj M. Lalu