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Table of Contents

May 2016

Cover

Identifying Planarian Receptors Required for Germ Cell Maturation

Issue Image

This study by Saberi et al. reveals over 550 G protein-coupled receptors in the planarian Schmidtea mediterranea, including two with critical roles in germline development. The image presents planarian testis lobules composed of a pool of germline stem cells (orange) and spermatogonial cells (blue) on the periphery, giving rise to differentiating gametes in the middle. A population of somatic gonadal cells supports and regulates germ cells throughout differentiation. These cells express a novel chemoreceptor family member, ophis (magenta), which is essential for germ cell maturation.

Image Credit: Amir Saberi

Perspectives

Essential Features of Responsible Governance of Agricultural Biotechnology

Sarah Hartley, Frøydis Gillund, Lilian van Hove, Fern Wickson

PLOS Biology: published May 4, 2016 | https://doi.org/10.1371/journal.pbio.1002453

Tracking Career Outcomes for Postdoctoral Scholars: A Call to Action

Elizabeth A. Silva, Christine Des Jarlais, Bill Lindstaedt, Erik Rotman, Elizabeth S. Watkins

PLOS Biology: published May 6, 2016 | https://doi.org/10.1371/journal.pbio.1002458

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Scientists’ Reputations Are Based on Getting It Right, Not Being Right

Charles R. Ebersole, Jordan R. Axt, Brian A. Nosek

PLOS Biology: published May 12, 2016 | https://doi.org/10.1371/journal.pbio.1002460

Primer

Where to Go: Breaking the Symmetry in Cell Motility

Sui Huang

PLOS Biology: published May 19, 2016 | https://doi.org/10.1371/journal.pbio.1002463

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  2. Correction: Where to Go: Breaking the Symmetry in Cell Motility

Research Articles

GPCRs Direct Germline Development and Somatic Gonad Function in Planarians

Amir Saberi, Ayana Jamal, Isabel Beets, Liliane Schoofs, Phillip A. Newmark

PLOS Biology: published May 10, 2016 | https://doi.org/10.1371/journal.pbio.1002457

Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade

Hugo Gabilondo, Johannes Stratmann, Irene Rubio-Ferrera, Irene Millán-Crespo, Patricia Contero-García, Shahrzad Bahrampour, Stefan Thor, Jonathan Benito-Sipos

PLOS Biology: published May 5, 2016 | https://doi.org/10.1371/journal.pbio.1002450

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  1. Correction: Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination

Benjamin M. Laitman, Linnéa Asp, John N. Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G. Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A. Braun, Q. Richard Lu, Goutham Narla, Cedric S. Raine, Scott L. Friedman, Patrizia Casaccia, Gareth R. John

PLOS Biology: published May 23, 2016 | https://doi.org/10.1371/journal.pbio.1002467

Cued Reactivation of Motor Learning during Sleep Leads to Overnight Changes in Functional Brain Activity and Connectivity

James N. Cousins, Wael El-Deredy, Laura M. Parkes, Nora Hennies, Penelope A. Lewis

PLOS Biology: published May 3, 2016 | https://doi.org/10.1371/journal.pbio.1002451

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Ralf Watzlawick, Julian Rind, Emily S. Sena, Benedikt Brommer, Tian Zhang, Marcel A. Kopp, Ulrich Dirnagl, Malcolm R. Macleod, David W. Howells, Jan M. Schwab

PLOS Biology: published May 31, 2016 | https://doi.org/10.1371/journal.pbio.1002468

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra

PLOS Biology: published May 26, 2016 | https://doi.org/10.1371/journal.pbio.1002466

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Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines

Ashiq Hussain, Mo Zhang, Habibe K. Üçpunar, Thomas Svensson, Elsa Quillery, Nicolas Gompel, Rickard Ignell, Ilona C. Grunwald Kadow

PLOS Biology: published May 4, 2016 | https://doi.org/10.1371/journal.pbio.1002454

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  2. Correction: Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines
  3. Correction: Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines

Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila

Ashiq Hussain, Habibe K. Üçpunar, Mo Zhang, Laura F. Loschek, Ilona C. Grunwald Kadow

PLOS Biology: published May 4, 2016 | https://doi.org/10.1371/journal.pbio.1002455

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Platelets Guide Leukocytes to Their Sites of Extravasation

Gabriele Zuchtriegel, Bernd Uhl, Daniel Puhr-Westerheide, Michaela Pörnbacher, Kirsten Lauber, Fritz Krombach, Christoph Andreas Reichel

PLOS Biology: published May 6, 2016 | https://doi.org/10.1371/journal.pbio.1002459

Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs

Zixing Li, Rainer Waadt, Julian I. Schroeder

PLOS Biology: published May 18, 2016 | https://doi.org/10.1371/journal.pbio.1002461

Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes

Benjamin R. Jack, Austin G. Meyer, Julian Echave, Claus O. Wilke

PLOS Biology: published May 3, 2016 | https://doi.org/10.1371/journal.pbio.1002452

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

Guido Veit, Kathryn Oliver, Pirjo M. Apaja, Doranda Perdomo, Aurélien Bidaud-Meynard, Sheng-Ting Lin, Jingyu Guo, Mert Icyuz, Eric J. Sorscher, John L. Hartman IV, Gergely L. Lukacs

PLOS Biology: published May 11, 2016 | https://doi.org/10.1371/journal.pbio.1002462

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Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase

Satya Brata Routh, Komal Ishwar Pawar, Sadeem Ahmad, Swati Singh, Katta Suma, Mantu Kumar, Santosh Kumar Kuncha, Kranthikumar Yadav, Shobha P Kruparani, Rajan Sankaranarayanan

PLOS Biology: published May 25, 2016 | https://doi.org/10.1371/journal.pbio.1002465

Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO

Hande Boyaci, Tayyab Shah, Amanda Hurley, Bashkim Kokona, Zhijie Li, Christian Ventocilla, Philip D. Jeffrey, Martin F. Semmelhack, Robert Fairman, Bonnie L. Bassler, Frederick M. Hughson

PLOS Biology: published May 24, 2016 | https://doi.org/10.1371/journal.pbio.1002464

Meta-Research Article

Badges to Acknowledge Open Practices: A Simple, Low-Cost, Effective Method for Increasing Transparency

Mallory C. Kidwell, Ljiljana B. Lazarević, Erica Baranski, Tom E. Hardwicke, Sarah Piechowski, Lina-Sophia Falkenberg, Curtis Kennett, Agnieszka Slowik, Carina Sonnleitner, Chelsey Hess-Holden, Timothy M. Errington, Susann Fiedler, Brian A. Nosek

PLOS Biology: published May 12, 2016 | https://doi.org/10.1371/journal.pbio.1002456

Corrections

Correction: Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

Shuyun Dong, Allan Jacobson, Feng He

PLOS Biology: published May 12, 2016 | https://doi.org/10.1371/journal.pbio.1002470

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Correction: Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities

The PLOS Biology Staff

PLOS Biology: published May 19, 2016 | https://doi.org/10.1371/journal.pbio.1002471

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