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December 2014

Patterns of electrical activity in neurons (voltage traces, top) control skilled behaviors. Representing neural activity as binary "words" (middle) reveals how the brains of songbirds use these electrical patterns to produce vocal output. The precise timing of neural signals appears to be crucial in controlling the elaborate vocal patterns that have fascinated human listeners for centuries (bottom, excerpt from Olivier Messaien's Oiseaux exotiques, which was based on Messaien's transcriptions of birdsong). See Tang et al.

Image Credit: Sam Sober

Education

Structured Inquiry-Based Learning: Drosophila GAL4 Enhancer Trap Characterization in an Undergraduate Laboratory Course

Christopher R. Dunne, Anthony R. Cillo, Danielle R. Glick, Katherine John, Cody Johnson, Jaspinder Kanwal, Brian T. Malik, Kristina Mammano, Stefan Petrovic, William Pfister, Alexander S. Rascoe, Diane Schrom, Scott Shapiro, Jeffrey W. Simkins, David Strauss, Rene Talai, John P. Tomtishen III, Josephine Vargas, Tony Veloz, Thomas O. Vogler, Michael E. Clenshaw, Devin T. Gordon-Hamm, Kathryn L. Lee, Elizabeth C. Marin

Essay

Not Just a Theory—The Utility of Mathematical Models in Evolutionary Biology

Maria R. Servedio, Yaniv Brandvain, Sumit Dhole, Courtney L. Fitzpatrick, Emma E. Goldberg, Caitlin A. Stern, Jeremy Van Cleve, D. Justin Yeh

Research Articles

Coevolution Drives the Emergence of Complex Traits and Promotes Evolvability

Luis Zaman, Justin R. Meyer, Suhas Devangam, David M. Bryson, Richard E. Lenski, Charles Ofria

Selective Modulation of Interhemispheric Functional Connectivity by HD-tACS Shapes Perception

Randolph F. Helfrich, Hannah Knepper, Guido Nolte, Daniel Strüber, Stefan Rach, Christoph S. Herrmann, Till R. Schneider, Andreas K. Engel

Related Articles

Millisecond-Scale Motor Encoding in a Cortical Vocal Area

Claire Tang, Diala Chehayeb, Kyle Srivastava, Ilya Nemenman, Samuel J. Sober

Related Articles

Perception of Odors Linked to Precise Timing in the Olfactory System

Michelle R. Rebello, Thomas S. McTavish, David C. Willhite, Shaina M. Short, Gordon M. Shepherd, Justus V. Verhagen

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Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

Donatello Castellana, Ralf Paus, Mirna Perez-Moreno

Epidermal Growth Factor Signalling Controls Myosin II Planar Polarity to Orchestrate Convergent Extension Movements during Drosophila Tubulogenesis

Aditya Saxena, Barry Denholm, Stephanie Bunt, Marcus Bischoff, Krishnaswamy VijayRaghavan, Helen Skaer

Electrochemical Regulation of Budding Yeast Polarity

Armin Haupt, Alexis Campetelli, Daria Bonazzi, Matthieu Piel, Fred Chang, Nicolas Minc

Specific Phosphorylation of Histone Demethylase KDM3A Determines Target Gene Expression in Response to Heat Shock

Mo-bin Cheng, Yan Zhang, Chun-yu Cao, Wei-long Zhang, Ye Zhang, Yu-fei Shen

Genome-wide Association Mapping Identifies a New Arsenate Reductase Enzyme Critical for Limiting Arsenic Accumulation in Plants

Dai-Yin Chao, Yi Chen, Jiugeng Chen, Shulin Shi, Ziru Chen, Chengcheng Wang, John M. Danku, Fang-Jie Zhao, David E. Salt

Related Articles

Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

Kurt Vermeire, Thomas W. Bell, Victor Van Puyenbroeck, Anne Giraut, Sam Noppen, Sandra Liekens, Dominique Schols, Enno Hartmann, Kai-Uwe Kalies, Mark Marsh

The Robustness of a Signaling Complex to Domain Rearrangements Facilitates Network Evolution

Paloma M. Sato, Kogulan Yoganathan, Jae H. Jung, Sergio G. Peisajovich

A Structural Model of the Genome Packaging Process in a Membrane-Containing Double Stranded DNA Virus

Chuan Hong, Hanna M. Oksanen, Xiangan Liu, Joanita Jakana, Dennis H. Bamford, Wah Chiu