A cunning group of pathogens induce comet tails of actin in host cytoplasm to spread their infection from one cell to the next. Mueller et al. use electron tomography to elucidate the structure of and insect virus actin comets and provide new insights into the mechanism of actin-based pathogen propulsion.
Image Credit: IMBA graphics
Editorial
Open Science and Reporting Animal Studies: Who's Accountable?
PLOS Biology: published January 7, 2014 | https://doi.org/10.1371/journal.pbio.1001757
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Synopses
A Footnote to the Evolution of Digits
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Deep-Fried Signaling: tempura Gets Notch Cooking
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Actin Comets: Traversing the Cellular Universe
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Essays
Imre Festetics and the Sheep Breeders' Society of Moravia: Mendel's Forgotten “Research Network”
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Left Brain, Right Brain: Facts and Fantasies
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Limiting Damage during Infection: Lessons from Infection Tolerance for Novel Therapeutics
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Perspectives
Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies
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Troubleshooting Public Data Archiving: Suggestions to Increase Participation
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Revising the Economic Imperative for US STEM Education
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Primer
Some Salt with Your Statin, Professor?
PLOS Biology: published January 21, 2014 | https://doi.org/10.1371/journal.pbio.1001768
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Community Pages
Best Practices for Scientific Computing
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A Field Guide to Genomics Research
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Overcoming the Barriers to Greater Public Engagement
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Research Articles
Faster Speciation and Reduced Extinction in the Tropics Contribute to the Mammalian Latitudinal Diversity Gradient
PLOS Biology: published January 28, 2014 | https://doi.org/10.1371/journal.pbio.1001775
Different Levels of Catabolite Repression Optimize Growth in Stable and Variable Environments
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Nonindustry-Sponsored Preclinical Studies on Statins Yield Greater Efficacy Estimates Than Industry-Sponsored Studies: A Meta-Analysis
PLOS Biology: published January 21, 2014 | https://doi.org/10.1371/journal.pbio.1001770
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Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits
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A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo
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Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation
PLOS Biology: published January 7, 2014 | https://doi.org/10.1371/journal.pbio.1001759
Epigenetic Reprogramming of the Type III Interferon Response Potentiates Antiviral Activity and Suppresses Tumor Growth
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Mycobacterium tuberculosis Ser/Thr Protein Kinase B Mediates an Oxygen-Dependent Replication Switch
PLOS Biology: published January 7, 2014 | https://doi.org/10.1371/journal.pbio.1001746
Def1 Promotes the Degradation of Pol3 for Polymerase Exchange to Occur During DNA-Damage–Induced Mutagenesis in Saccharomyces cerevisiae
PLOS Biology: published January 21, 2014 | https://doi.org/10.1371/journal.pbio.1001771
Electron Tomography and Simulation of Baculovirus Actin Comet Tails Support a Tethered Filament Model of Pathogen Propulsion
PLOS Biology: published January 14, 2014 | https://doi.org/10.1371/journal.pbio.1001765
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Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation
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