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Table of Contents

January 2013

Cover

The fragmented Oxytricha trifallax macronuclear genome.

Issue Image

Oxytricha's two macronuclei (green) are shown schematically over a size-ranked map of some of its 16,000 tiny chromosomes. Alternatively processed chromosomes are shown in fuchsia and the 70 kb mitochondrial genome is shown in red for scale. Micronuclei are shown in dark blue. The macronuclear genome develops from the micronuclear genome by massive genome fragmentation and reassembly. See Swart et al. (e1001473) in this issue.

Image Credit: Estienne C. Swart and Laura F. Landweber

Synopses

Tantalizing Glimpses into a Fragmented Genome

Mary Hoff

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001470

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  1. The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes

Transforming a Stem into a Bush

Amy Coombs

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001476

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  1. Strigolactone Can Promote or Inhibit Shoot Branching by Triggering Rapid Depletion of the Auxin Efflux Protein PIN1 from the Plasma Membrane

Receptors on Neurons Help Shape Worm Development

Richard Robinson

PLOS Biology: published January 8, 2013 | https://doi.org/10.1371/journal.pbio.1001464

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  1. Neurons Refine the Caenorhabditis elegans Body Plan by Directing Axial Patterning by Wnts

Sesame Street Provides Lessons about Natural Brain Development in Children

Janelle Weaver

PLOS Biology: published January 3, 2013 | https://doi.org/10.1371/journal.pbio.1001463

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  1. Neural Activity during Natural Viewing of Sesame Street Statistically Predicts Test Scores in Early Childhood

Essay

Evolutionary Biology for the 21st Century

Jonathan B. Losos, Stevan J. Arnold, Gill Bejerano, E. D. Brodie III, David Hibbett, Hopi E. Hoekstra, David P. Mindell, Antónia Monteiro, Craig Moritz, H. Allen Orr, Dmitri A. Petrov, Susanne S. Renner, Robert E. Ricklefs, Pamela S. Soltis, Thomas L. Turner

PLOS Biology: published January 8, 2013 | https://doi.org/10.1371/journal.pbio.1001466

Community Pages

Barcoding Life's Matrix: Translating Biodiversity Genomics into High School Settings to Enhance Life Science Education

Linda Santschi, Robert H. Hanner, Sujeevan Ratnasingham, Michelle Riconscente, Ralph Imondi

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001471

Science Incubators: Synthesis Centers and Their Role in the Research Ecosystem

Allen Rodrigo, Susan Alberts, Karen Cranston, Joel Kingsolver, Hilmar Lapp, Craig McClain, Robin Smith, Todd Vision, Jory Weintraub, Brian Wiegmann

PLOS Biology: published January 15, 2013 | https://doi.org/10.1371/journal.pbio.1001468

Research Articles

The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes

Estienne C. Swart, John R. Bracht, Vincent Magrini, Patrick Minx, Xiao Chen, Yi Zhou, Jaspreet S. Khurana, Aaron D. Goldman, Mariusz Nowacki, Klaas Schotanus, Seolkyoung Jung, Robert S. Fulton, Amy Ly, Sean McGrath, Kevin Haub, Jessica L. Wiggins, Donna Storton, John C. Matese, Lance Parsons, Wei-Jen Chang, Michael S. Bowen, Nicholas A. Stover, Thomas A. Jones, Sean R. Eddy, Glenn A. Herrick, Thomas G. Doak, Richard K. Wilson, Elaine R. Mardis, Laura F. Landweber

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001473

Related Articles

  1. Tantalizing Glimpses into a Fragmented Genome

Strigolactone Can Promote or Inhibit Shoot Branching by Triggering Rapid Depletion of the Auxin Efflux Protein PIN1 from the Plasma Membrane

Naoki Shinohara, Catherine Taylor, Ottoline Leyser

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001474

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  1. Transforming a Stem into a Bush

Integration of Canonical and Noncanonical Wnt Signaling Pathways Patterns the Neuroectoderm Along the Anterior–Posterior Axis of Sea Urchin Embryos

Ryan C. Range, Robert C. Angerer, Lynne M. Angerer

PLOS Biology: published January 15, 2013 | https://doi.org/10.1371/journal.pbio.1001467

Radial Glial Neural Progenitors Regulate Nascent Brain Vascular Network Stabilization Via Inhibition of Wnt Signaling

Shang Ma, Hyo Jun Kwon, Heidi Johng, Keling Zang, Zhen Huang

PLOS Biology: published January 22, 2013 | https://doi.org/10.1371/journal.pbio.1001469

Neurons Refine the Caenorhabditis elegans Body Plan by Directing Axial Patterning by Wnts

Katarzyna Modzelewska, Amara Lauritzen, Stefan Hasenoeder, Louise Brown, John Georgiou, Nadeem Moghal

PLOS Biology: published January 8, 2013 | https://doi.org/10.1371/journal.pbio.1001465

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  1. Receptors on Neurons Help Shape Worm Development

Neural Activity during Natural Viewing of Sesame Street Statistically Predicts Test Scores in Early Childhood

Jessica F. Cantlon, Rosa Li

PLOS Biology: published January 3, 2013 | https://doi.org/10.1371/journal.pbio.1001462

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  1. Sesame Street Provides Lessons about Natural Brain Development in Children

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Roza Selimyan, Rachel M. Gerstein, Irina Ivanova, Patricia Precht, Ramesh Subrahmanyam, Thomas Perlot, Frederick W. Alt, Ranjan Sen

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001475

The Circadian Clock Coordinates Ribosome Biogenesis

Céline Jouffe, Gaspard Cretenet, Laura Symul, Eva Martin, Florian Atger, Felix Naef, Frédéric Gachon

PLOS Biology: published January 3, 2013 | https://doi.org/10.1371/journal.pbio.1001455

An Enzyme-Catalyzed Multistep DNA Refolding Mechanism in Hairpin Telomere Formation

Ke Shi, Wai Mun Huang, Hideki Aihara

PLOS Biology: published January 29, 2013 | https://doi.org/10.1371/journal.pbio.1001472