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Table of Contents

April 2010

Cover

Dramatic separation of the centrosomes and the nucleus in dynein-depleted human cells at the onset of mitosis.
Issue Image

A cell depleted of the dynein-heavy chain and stained for microtubules (green), centrosomes (red), and DNA (blue). Dynein activity at the nuclear envelope keeps the centrosomes closely tethered to the nucleus during mitotic entry. In the absence of dynein, centrosomes and the nucleus are actively displaced to opposite sides of the cell as a result of the antagonistic activity of kinesin-1, pushing the centrosomes and the nucleus apart (see Splinter et al., e1000350).

Image Credit: Marvin Tanenbaum, Department of Medical Oncology and Cancer Genomics Center, University Medical Center, Utrecht, The Netherlands

Synopsis

Multiple Sulfur Acceptors Dock at IscS

Kira Heller

PLOS Biology: published April 13, 2010 | https://doi.org/10.1371/journal.pbio.1000353

Related Articles

  1. Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions
  2. Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

Essay

Adaptation, Plasticity, and Extinction in a Changing Environment: Towards a Predictive Theory

Luis-Miguel Chevin, Russell Lande, Georgina M. Mace

PLOS Biology: published April 27, 2010 | https://doi.org/10.1371/journal.pbio.1000357

Perspective

The MAHB, the Culture Gap, and Some Really Inconvenient Truths

Paul R. Ehrlich

PLOS Biology: published April 6, 2010 | https://doi.org/10.1371/journal.pbio.1000330

Primer

The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times

Edward F. DeLong, Oded Béjà

PLOS Biology: published April 27, 2010 | https://doi.org/10.1371/journal.pbio.1000359

Related Articles

  1. Proteorhodopsin Phototrophy Promotes Survival of Marine Bacteria during Starvation
  2. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  3. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  4. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  5. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  6. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  7. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  8. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  9. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  10. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  11. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  12. Correction: The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  13. Proteorhodopsin Phototrophy Promotes Survival of Marine Bacteria during Starvation

Research Articles

Proteorhodopsin Phototrophy Promotes Survival of Marine Bacteria during Starvation

Laura Gómez-Consarnau, Neelam Akram, Kristoffer Lindell, Anders Pedersen, Richard Neutze, Debra L. Milton, José M. González, Jarone Pinhassi

PLOS Biology: published April 27, 2010 | https://doi.org/10.1371/journal.pbio.1000358

Related Articles

  1. The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times
  2. The Light-Driven Proton Pump Proteorhodopsin Enhances Bacterial Survival during Tough Times

Carbon Dioxide Sensing Modulates Lifespan and Physiology in Drosophila

Peter C. Poon, Tsung-Han Kuo, Nancy J. Linford, Gregg Roman, Scott D. Pletcher

PLOS Biology: published April 20, 2010 | https://doi.org/10.1371/journal.pbio.1000356

Environmental Change Enhances Cognitive Abilities in Fish

Alexander Kotrschal, Barbara Taborsky

PLOS Biology: published April 6, 2010 | https://doi.org/10.1371/journal.pbio.1000351

Cholinergic Activation of M2 Receptors Leads to Context-Dependent Modulation of Feedforward Inhibition in the Visual Thalamus

Miklos Antal, Claudio Acuna-Goycolea, R. Todd Pressler, Dawn M. Blitz, Wade G. Regehr

PLOS Biology: published April 6, 2010 | https://doi.org/10.1371/journal.pbio.1000348

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons

Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R. Kramer, Wolfgang Wurst, Rüdiger Klein

PLOS Biology: published April 6, 2010 | https://doi.org/10.1371/journal.pbio.1000349

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

Marta Gómez-Gonzalo, Gabriele Losi, Angela Chiavegato, Micaela Zonta, Mario Cammarota, Marco Brondi, Francesco Vetri, Laura Uva, Tullio Pozzan, Marco de Curtis, Gian Michele Ratto, Giorgio Carmignoto

PLOS Biology: published April 13, 2010 | https://doi.org/10.1371/journal.pbio.1000352

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design

Jean Mazella, Olivier Pétrault, Guillaume Lucas, Emmanuel Deval, Sophie Béraud-Dufour, Carine Gandin, Malika El-Yacoubi, Catherine Widmann, Alice Guyon, Eric Chevet, Said Taouji, Grégory Conductier, Alain Corinus, Thierry Coppola, Gabriella Gobbi, Jean-Louis Nahon, Catherine Heurteaux, Marc Borsotto

PLOS Biology: published April 13, 2010 | https://doi.org/10.1371/journal.pbio.1000355

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

Daniël Splinter, Marvin E. Tanenbaum, Arne Lindqvist, Dick Jaarsma, Annette Flotho, Ka Lou Yu, Ilya Grigoriev, Dieuwke Engelsma, Elize D. Haasdijk, Nanda Keijzer, Jeroen Demmers, Maarten Fornerod, Frauke Melchior, Casper C. Hoogenraad, René H. Medema, Anna Akhmanova

PLOS Biology: published April 6, 2010 | https://doi.org/10.1371/journal.pbio.1000350

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

Daniel J. Gough, Nicole L. Messina, Linda Hii, Jodee A. Gould, Kanaga Sabapathy, Ashley P. S. Robertson, Joseph A. Trapani, David E. Levy, Paul J. Hertzog, Christopher J. P. Clarke, Ricky W. Johnstone

PLOS Biology: published April 27, 2010 | https://doi.org/10.1371/journal.pbio.1000361

Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

Shuyun Dong, Allan Jacobson, Feng He

PLOS Biology: published April 27, 2010 | https://doi.org/10.1371/journal.pbio.1000360

Related Articles

  1. Correction: Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

Rong Shi, Ariane Proteau, Magda Villarroya, Ismaïl Moukadiri, Linhua Zhang, Jean-François Trempe, Allan Matte, M. Eugenia Armengod, Miroslaw Cygler

PLOS Biology: published April 13, 2010 | https://doi.org/10.1371/journal.pbio.1000354

Related Articles

  1. Multiple Sulfur Acceptors Dock at IscS
  2. Multiple Sulfur Acceptors Dock at IscS