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Table of Contents

March 2010

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Beware of crossing axons.
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During development, growing axons frequently cross the midline of the body to connect the two sides of the nervous system. This process requires the Robo3 receptor, which is mutated in people suffering a rare congenital disorder. Conditional elimination of Robo3 from selected subsets of neurons in the mouse provides a model of this congenital strabismus and sheds light on the need for correct axon guidance in the development of specific behaviors (see Renier et al., e1000325).

Image Credit: Adrien Braure, modified by Alain Chédotal

Synopses

Identifying Genes that Help One Sex but Harm the Other

Robin Meadows

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000336

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A Fatal Switch for Corals?

Elizabeth Whiteman

PLOS Biology: published March 30, 2010 | https://doi.org/10.1371/journal.pbio.1000346

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  2. How Microbial Community Composition Regulates Coral Disease Development

Memory Is Enhanced at Behaviorally Relevant Times

Rachel Jones

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000338

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  2. Enhanced Memory for Scenes Presented at Behaviorally Relevant Points in Time

Location Matters: How Spatial Positioning of Regulatory Proteins Produces Divergent Outcomes

Richard Robinson

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000333

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  1. Spatial Epigenetic Control of Mono- and Bistable Gene Expression
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Reinforcing Reinforcement

William Mair

PLOS Biology: published March 23, 2010 | https://doi.org/10.1371/journal.pbio.1000340

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  2. Reinforcement of Gametic Isolation in Drosophila

Essay

Canine Morphology: Hunting for Genes and Tracking Mutations

Abigail L. Shearin, Elaine A. Ostrander

PLOS Biology: published March 2, 2010 | https://doi.org/10.1371/journal.pbio.1000310

Perspective

Indigenous Lands, Protected Areas, and Slowing Climate Change

Taylor H. Ricketts, Britaldo Soares-Filho, Gustavo A. B. da Fonseca, Daniel Nepstad, Alexander Pfaff, Annie Petsonk, Anthony Anderson, Doug Boucher, Andrea Cattaneo, Marc Conte, Ken Creighton, Lawrence Linden, Claudio Maretti, Paulo Moutinho, Roger Ullman, Ray Victurine

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000331

Primers

Studying Function and Behavior in the Fossil Record

Michael J. Benton

PLOS Biology: published March 2, 2010 | https://doi.org/10.1371/journal.pbio.1000321

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  1. Predation upon Hatchling Dinosaurs by a New Snake from the Late Cretaceous of India
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Centromeres Convert but Don't Cross

Paul B. Talbert, Steven Henikoff

PLOS Biology: published March 9, 2010 | https://doi.org/10.1371/journal.pbio.1000326

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Variable Transcription Factor Binding: A Mechanism of Evolutionary Change

Patricia J. Wittkopp

PLOS Biology: published March 23, 2010 | https://doi.org/10.1371/journal.pbio.1000342

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Research Articles

Predation upon Hatchling Dinosaurs by a New Snake from the Late Cretaceous of India

Jeffrey A. Wilson, Dhananjay M. Mohabey, Shanan E. Peters, Jason J. Head

PLOS Biology: published March 2, 2010 | https://doi.org/10.1371/journal.pbio.1000322

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Reinforcement of Gametic Isolation in Drosophila

Daniel R. Matute

PLOS Biology: published March 23, 2010 | https://doi.org/10.1371/journal.pbio.1000341

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The Sexually Antagonistic Genes of Drosophila melanogaster

Paolo Innocenti, Edward H. Morrow

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000335

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How Microbial Community Composition Regulates Coral Disease Development

Justin Mao-Jones, Kim B. Ritchie, Laura E. Jones, Stephen P. Ellner

PLOS Biology: published March 30, 2010 | https://doi.org/10.1371/journal.pbio.1000345

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Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Emily S. Sena, H. Bart van der Worp, Philip M. W. Bath, David W. Howells, Malcolm R. Macleod

PLOS Biology: published March 30, 2010 | https://doi.org/10.1371/journal.pbio.1000344

Enhanced Memory for Scenes Presented at Behaviorally Relevant Points in Time

Jeffrey Y. Lin, Amanda D. Pype, Scott O. Murray, Geoffrey M. Boynton

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000337

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Irradiation Selects for p53-Deficient Hematopoietic Progenitors

Andriy Marusyk, Christopher C. Porter, Vadym Zaberezhnyy, James DeGregori

PLOS Biology: published March 2, 2010 | https://doi.org/10.1371/journal.pbio.1000324

Genetic Dissection of the Function of Hindbrain Axonal Commissures

Nicolas Renier, Martijn Schonewille, Fabrice Giraudet, Aleksandra Badura, Marc Tessier-Lavigne, Paul Avan, Chris I. De Zeeuw, Alain Chédotal

PLOS Biology: published March 9, 2010 | https://doi.org/10.1371/journal.pbio.1000325

Widespread Gene Conversion in Centromere Cores

Jinghua Shi, Sarah E. Wolf, John M. Burke, Gernot G. Presting, Jeffrey Ross-Ibarra, R. Kelly Dawe

PLOS Biology: published March 9, 2010 | https://doi.org/10.1371/journal.pbio.1000327

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Binding Site Turnover Produces Pervasive Quantitative Changes in Transcription Factor Binding between Closely Related Drosophila Species

Robert K. Bradley, Xiao-Yong Li, Cole Trapnell, Stuart Davidson, Lior Pachter, Hou Cheng Chu, Leath A. Tonkin, Mark D. Biggin, Michael B. Eisen

PLOS Biology: published March 23, 2010 | https://doi.org/10.1371/journal.pbio.1000343

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Need-Based Up-Regulation of Protein Levels in Response to Deletion of Their Duplicate Genes

Alexander DeLuna, Michael Springer, Marc W. Kirschner, Roy Kishony

PLOS Biology: published March 30, 2010 | https://doi.org/10.1371/journal.pbio.1000347

Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network

Hugo Lavoie, Hervé Hogues, Jaideep Mallick, Adnane Sellam, André Nantel, Malcolm Whiteway

PLOS Biology: published March 9, 2010 | https://doi.org/10.1371/journal.pbio.1000329

Spatial Epigenetic Control of Mono- and Bistable Gene Expression

János Z. Kelemen, Prasuna Ratna, Simone Scherrer, Attila Becskei

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000332

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Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

Leila M. Luheshi, Wolfgang Hoyer, Teresa Pereira de Barros, Iris van Dijk Härd, Ann-Christin Brorsson, Bertil Macao, Cecilia Persson, Damian C. Crowther, David A. Lomas, Stefan Ståhl, Christopher M. Dobson, Torleif Härd

PLOS Biology: published March 16, 2010 | https://doi.org/10.1371/journal.pbio.1000334

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

Ohad Yogev, Orli Yogev, Esti Singer, Eitan Shaulian, Michal Goldberg, Thomas D. Fox, Ophry Pines

PLOS Biology: published March 9, 2010 | https://doi.org/10.1371/journal.pbio.1000328

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

Yuki Goto, Bo Li, Jan Claesen, Yanxiang Shi, Mervyn J. Bibb, Wilfred A. van der Donk

PLOS Biology: published March 23, 2010 | https://doi.org/10.1371/journal.pbio.1000339

Book Review%2FScience in the Media

Fire in the Quill

Armin Schneider

PLOS Biology: published March 9, 2010 | https://doi.org/10.1371/journal.pbio.1000323