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Table of Contents

November 2009

Cover

An Arabidopsis female organ ectopically expressing a chromatin modifier.
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The plant homeotic protein AGAMOUS controls the expression of the chromatin modifier GIANT KILLER, which fine-tunes the expression of multiple genes downstream of AGAMOUS in reproductive organ patterning and differentiation (see Ng et al., e1000251). A scanning electron micrograph of an Arabidopsis pistil shows that the ectopic expression of GIANT KILLER partially mimics the loss of function mutant of ETTIN (meaning "giant").

Image Credit: Kian-Hong Ng, Temasek Life Sciences Laboratory

Synopses

Migrating Brain Cells Stick Together

Mason Inman

PLOS Biology: published November 10, 2009 | https://doi.org/10.1371/journal.pbio.1000239

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Sly Represses Gene Expression in Sex Chromosomes

Caitlin Sedwick

PLOS Biology: published November 17, 2009 | https://doi.org/10.1371/journal.pbio.1000243

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A Simple Rule for Proteins to Follow

By Caitlin Sedwick

PLOS Biology: published November 3, 2009 | https://doi.org/10.1371/journal.pbio.1000232

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Perspectives

University Public-Access Mandates Are Good for Science

David Shulenburger

PLOS Biology: published November 10, 2009 | https://doi.org/10.1371/journal.pbio.1000237

Article-Level Metrics and the Evolution of Scientific Impact

Cameron Neylon, Shirley Wu

PLOS Biology: published November 17, 2009 | https://doi.org/10.1371/journal.pbio.1000242

Research Articles

Explaining the Linguistic Diversity of Sahul Using Population Models

Ger Reesink, Ruth Singer, Michael Dunn

PLOS Biology: published November 17, 2009 | https://doi.org/10.1371/journal.pbio.1000241

The Properties of Adaptive Walks in Evolving Populations of Fungus

Sijmen E. Schoustra, Thomas Bataillon, Danna R. Gifford, Rees Kassen

PLOS Biology: published November 24, 2009 | https://doi.org/10.1371/journal.pbio.1000250

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

Minhua Zhang, Michal Poplawski, Kelvin Yen, Hui Cheng, Erik Bloss, Xiao Zhu, Harshil Patel, Charles V. Mobbs

PLOS Biology: published November 17, 2009 | https://doi.org/10.1371/journal.pbio.1000245

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

Dorothee Mueller, María-Paz García-Cuéllar, Christian Bach, Sebastian Buhl, Emanuel Maethner, Robert K. Slany

PLOS Biology: published November 24, 2009 | https://doi.org/10.1371/journal.pbio.1000249

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart

Julien Vermot, Arian S. Forouhar, Michael Liebling, David Wu, Diane Plummer, Morteza Gharib, Scott E. Fraser

PLOS Biology: published November 17, 2009 | https://doi.org/10.1371/journal.pbio.1000246

Cadherin-2 Controls Directional Chain Migration of Cerebellar Granule Neurons

Sandra Rieger, Niklas Senghaas, Axel Walch, Reinhard W. Köster

PLOS Biology: published November 10, 2009 | https://doi.org/10.1371/journal.pbio.1000240

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  1. Migrating Brain Cells Stick Together

The Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after Meiosis

Julie Cocquet, Peter J. I. Ellis, Yasuhiro Yamauchi, Shantha K. Mahadevaiah, Nabeel A. Affara, Monika A. Ward, Paul S. Burgoyne

PLOS Biology: published November 17, 2009 | https://doi.org/10.1371/journal.pbio.1000244

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Patterning of the Dorsal-Ventral Axis in Echinoderms: Insights into the Evolution of the BMP-Chordin Signaling Network

François Lapraz, Lydia Besnardeau, Thierry Lepage

PLOS Biology: published November 24, 2009 | https://doi.org/10.1371/journal.pbio.1000248

AGAMOUS Controls GIANT KILLER, a Multifunctional Chromatin Modifier in Reproductive Organ Patterning and Differentiation

Kian-Hong Ng, Hao Yu, Toshiro Ito

PLOS Biology: published November 24, 2009 | https://doi.org/10.1371/journal.pbio.1000251

An aPKC-Exocyst Complex Controls Paxillin Phosphorylation and Migration through Localised JNK1 Activation

Carine Rosse, Etienne Formstecher, Katrina Boeckeler, Yingming Zhao, Joachim Kremerskothen, Michael D. White, Jacques H. Camonis, Peter J. Parker

PLOS Biology: published November 3, 2009 | https://doi.org/10.1371/journal.pbio.1000235

Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster

Sandra Goetze, Ermir Qeli, Christian Mosimann, An Staes, Bertran Gerrits, Bernd Roschitzki, Sonali Mohanty, Eva M. Niederer, Endre Laczko, Evy Timmerman, Vinzenz Lange, Ernst Hafen, Ruedi Aebersold, Joël Vandekerckhove, Konrad Basler, Christian H. Ahrens, Kris Gevaert, Erich Brunner

PLOS Biology: published November 3, 2009 | https://doi.org/10.1371/journal.pbio.1000236

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Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

David G. Hendrickson, Daniel J. Hogan, Heather L. McCullough, Jason W. Myers, Daniel Herschlag, James E. Ferrell, Patrick O. Brown

PLOS Biology: published November 10, 2009 | https://doi.org/10.1371/journal.pbio.1000238

Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation

Nicole L. Washington, Melissa A. Haendel, Christopher J. Mungall, Michael Ashburner, Monte Westerfield, Suzanna E. Lewis

PLOS Biology: published November 24, 2009 | https://doi.org/10.1371/journal.pbio.1000247