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Table of Contents

February 2009

Cover

The oral jaws of Pseudotropheus elongatus.
Issue Image

The jaws of vertebrates, their origins, and their associated dentitions have long been a topic of interest among both paleontologists and evolutionary developmental biologists. The modern diversity of Lake Malawi cichlids has been used here to offer a new perspective on the relationships between teeth on two sets of functional jaws—oral and pharyngeal—and the origins of the vertebrate dentition in the throat of jawless fishes some 500 million years ago (see Fraser et al., e1000031).

Image Credit: Photograph by Ryan F. Bloomquist (Georgia Institute of Technology).

Synopsis

In Mammalian Muscle, Axonal Wiring Takes Surprising Paths

Richard Robinson

PLOS Biology: published February 10, 2009 | https://doi.org/10.1371/journal.pbio.1000050

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Unsolved Mystery

Wings, Horns, and Butterfly Eyespots: How Do Complex Traits Evolve?

Antónia Monteiro, Ondrej Podlaha

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000037

Perspective

Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges

Katriina Aalto-Setälä, Bruce R Conklin, Bernard Lo

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000042

Primers

Mutation Patterns in the Human Genome: More Variable Than Expected

Laurent Duret

PLOS Biology: published February 3, 2009 | https://doi.org/10.1371/journal.pbio.1000028

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Causal Modelling and Brain Connectivity in Functional Magnetic Resonance Imaging

Karl Friston

PLOS Biology: published February 17, 2009 | https://doi.org/10.1371/journal.pbio.1000033

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  1. Identifying Neural Drivers with Functional MRI: An Electrophysiological Validation

Research Articles

Cryptic Variation in the Human Mutation Rate

Alan Hodgkinson, Emmanuel Ladoukakis, Adam Eyre-Walker

PLOS Biology: published February 3, 2009 | https://doi.org/10.1371/journal.pbio.1000027

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  1. Mutation Patterns in the Human Genome: More Variable Than Expected

An Ancient Gene Network Is Co-opted for Teeth on Old and New Jaws

Gareth J Fraser, C. Darrin Hulsey, Ryan F Bloomquist, Kristine Uyesugi, Nancy R Manley, J. Todd Streelman

PLOS Biology: published February 10, 2009 | https://doi.org/10.1371/journal.pbio.1000031

Gene Regulatory Network Interactions in Sea Urchin Endomesoderm Induction

Aditya J Sethi, Robert C Angerer, Lynne M Angerer

PLOS Biology: published February 3, 2009 | https://doi.org/10.1371/journal.pbio.1000029

The Interscutularis Muscle Connectome

Ju Lu, Juan Carlos Tapia, Olivia L White, Jeff W Lichtman

PLOS Biology: published February 10, 2009 | https://doi.org/10.1371/journal.pbio.1000032

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  1. In Mammalian Muscle, Axonal Wiring Takes Surprising Paths
  2. Correction: The Interscutularis Muscle Connectome

Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning

David Ng, Graham M Pitcher, Rachel K Szilard, Andréa Sertié, Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, Lorraine V Kalia, Daisy Joo, Colin McKerlie, Miguel Cortez, John C Roder, Michael W Salter, Roderick R McInnes

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000041

The Atonal Proneural Transcription Factor Links Differentiation and Tumor Formation in Drosophila

Wouter Bossuyt, Natalie De Geest, Stein Aerts, Iris Leenaerts, Peter Marynen, Bassem A Hassan

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000040

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  1. Atonal homolog 1 Is a Tumor Suppressor Gene

Atonal homolog 1 Is a Tumor Suppressor Gene

Wouter Bossuyt, Avedis Kazanjian, Natalie De Geest, Sofie Van Kelst, Gert De Hertogh, Karel Geboes, Greg P Boivin, Judith Luciani, Francois Fuks, Marinee Chuah, Thierry VandenDriessche, Peter Marynen, Jan Cools, Noah F Shroyer, Bassem A Hassan

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000039

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  1. The Atonal Proneural Transcription Factor Links Differentiation and Tumor Formation in Drosophila

Genome-Wide Control of the Distribution of Meiotic Recombination

Corinne Grey, Frédéric Baudat, Bernard de Massy

PLOS Biology: published February 17, 2009 | https://doi.org/10.1371/journal.pbio.1000035

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  2. The New Yeast Is a Mouse

Trans-Regulation of Mouse Meiotic Recombination Hotspots by Rcr1

Emil D Parvanov, Siemon H. S Ng, Petko M Petkov, Kenneth Paigen

PLOS Biology: published February 17, 2009 | https://doi.org/10.1371/journal.pbio.1000036

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Interaction with Phosphoinositides Confers Adaptation onto the TRPV1 Pain Receptor

Jing Yao, Feng Qin

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000046

Transcriptional Infidelity Promotes Heritable Phenotypic Change in a Bistable Gene Network

Alasdair J. E Gordon, Jennifer A Halliday, Matthew D Blankschien, Philip A Burns, Fumio Yatagai, Christophe Herman

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000044

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E Feldman, Beth Apsel, Aino Uotila, Robbie Loewith, Zachary A Knight, Davide Ruggero, Kevan M Shokat

PLOS Biology: published February 10, 2009 | https://doi.org/10.1371/journal.pbio.1000038

The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

Keith I Pardee, Xiaohui Xu, Jeff Reinking, Anja Schuetz, Aiping Dong, Suya Liu, Rongguang Zhang, Jens Tiefenbach, Gilles Lajoie, Alexander N Plotnikov, Alexey Botchkarev, Henry M Krause, Aled Edwards

PLOS Biology: published February 24, 2009 | https://doi.org/10.1371/journal.pbio.1000043

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

Marco D Mukrasch, Stefan Bibow, Jegannath Korukottu, Sadasivam Jeganathan, Jacek Biernat, Christian Griesinger, Eckhard Mandelkow, Markus Zweckstetter

PLOS Biology: published February 17, 2009 | https://doi.org/10.1371/journal.pbio.1000034