Cover
Evolution on a chip.
The photograph shows a magnified view of a microfluidic chip in which billions of RNA enzymes were made to undergo hundreds of generations of Darwinian evolution, all under computer control. The active circuit, filled with blue dye, is 1 cm in diameter and contains five microvalves that are operated pneumatically (see Paegel and Joyce, e85).
Image Credit: Photograph by Brian Paegel, The Scripps Research Institute
Editorial
Progress toward Public Access to Science
PLOS Biology: published April 8, 2008 | https://doi.org/10.1371/journal.pbio.0060101
Synopses
What Killed the Woolly Mammoth?
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How Quickly Can a Rat Perceive Novel Odors?
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Primers
Cellular Conductors: Glial Cells as Guideposts during Neural Circuit Development
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Community Page
Rethinking Outreach: Teaching the Process of Science through Modeling
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Research Articles
Climate Change, Humans, and the Extinction of the Woolly Mammoth
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Compilation and Network Analyses of Cambrian Food Webs
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Chromosomal Gene Movements Reflect the Recent Origin and Biology of Therian Sex Chromosomes
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Rapid Encoding and Perception of Novel Odors in the Rat
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Bergmann Glia and the Recognition Molecule CHL1 Organize GABAergic Axons and Direct Innervation of Purkinje Cell Dendrites
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Control of Apoptosis by Asymmetric Cell Division
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A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis
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Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity
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Darwinian Evolution on a Chip
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Corrections
Correction: Distinct Mammalian Precursors Are Committed to Generate Neurons with Defined Dendritic Projection Patterns
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